{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:01:08Z","timestamp":1788393668289,"version":"build-2803163510"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To identify the role of gluconeogenesis in chondrocytes in osteoarthritis (OA).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>Cartilage samples were collected from OA patients and C57 mice and were stained with Safranin O-Fast Green to determine the severity of OA. Periodic acid Schiff staining was used to characterize the contents of polysaccharides and SA-\u03b2Gal staining was used to characterize the aging of chondrocytes. Immunohistochemistry and western blotting were used to detect fructose-bisphosphatase1 (FBP1), SOX9, MMP13, P21, and P16 in cartilage or chondrocyte. The mRNA levels of fbp1, mmp13, sox9, colX, and acan were analyzed by qPCR to evaluate the role of FBP1 in chondrocytes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The level of polysaccharides in cartilage was reduced in OA and the expression of FBP1 was also reduced. We treated the chondrocytes with IL-1\u03b2 to cause OA in vitro, and then made chondrocytes overexpress FBP1 with plasma. It shows that FBP1 alleviated the degeneration and senescence of chondrocytes in vitro and that it also showed the same effects in vivo experiments. To further understand the mechanism of FBP1, we screened the downstream protein of FBP1 and found that CRB3 was significantly downregulated. And we confirmed that CRB3 suppressed the degeneration and delayed senescence of chondrocytes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>FBP1 promoted the polysaccharide synthesis in cartilage and alleviated the degeneration of cartilage by regulating CRB3, so FBP1 is a potential target in treating OA.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13075-023-03221-5","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T08:02:37Z","timestamp":1701676957000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Fructose-bisphosphatase1 (FBP1) alleviates experimental osteoarthritis by regulating Protein crumbs homolog 3 (CRB3)"],"prefix":"10.1186","volume":"25","author":[{"given":"Zhuolun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongtian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbing","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rengui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daozhang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,4]]},"reference":[{"key":"3221_CR1","first-page":"481","volume":"49","author":"JA Buckwalter","year":"2000","unstructured":"Buckwalter JA, Martin J, Mankin HJ. Synovial joint degeneration and the syndrome of osteoarthritis. Instr Course Lect. 2000;49:481\u20139.","journal-title":"Instr Course Lect"},{"issue":"12","key":"3221_CR2","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1016\/j.joca.2012.07.022","volume":"20","author":"MC Hochberg","year":"2012","unstructured":"Hochberg MC. Osteoarthritis year 2012 in review: clinical. Osteoarthritis Cartilage. 2012;20(12):1465\u20139. https:\/\/doi.org\/10.1016\/j.joca.2012.07.022.","journal-title":"Osteoarthritis Cartilage"},{"issue":"9991","key":"3221_CR3","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","volume":"386","author":"S Glyn-Jones","year":"2015","unstructured":"Glyn-Jones S, Palmer AJ, Agricola R, et al. Osteoarthritis Lancet. 2015;386(9991):376\u201387. https:\/\/doi.org\/10.1016\/S0140-6736(14)60802-3.","journal-title":"Osteoarthritis Lancet"},{"issue":"9","key":"3221_CR4","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.joca.2013.03.018","volume":"21","author":"T Neogi","year":"2013","unstructured":"Neogi T. The epidemiology and impact of pain in osteoarthritis. Osteoarthritis Cartilage. 2013;21(9):1145\u201353. https:\/\/doi.org\/10.1016\/j.joca.2013.03.018.","journal-title":"Osteoarthritis Cartilage"},{"issue":"7","key":"3221_CR5","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/nrrheum.2014.44","volume":"10","author":"DJ Hunter","year":"2014","unstructured":"Hunter DJ, Schofield D, Callander E. The individual and socioeconomic impact of osteoarthritis. Nat Rev Rheumatol. 2014;10(7):437\u201341. https:\/\/doi.org\/10.1038\/nrrheum.2014.44.","journal-title":"Nat Rev Rheumatol"},{"issue":"3","key":"3221_CR6","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1002\/acr.22459","volume":"67","author":"PA Parmelee","year":"2015","unstructured":"Parmelee PA, Tighe CA, Dautovich ND. Sleep disturbance in osteoarthritis: linkages with pain, disability, and depressive symptoms. Arthritis Care Res (Hoboken). 2015;67(3):358\u201365. https:\/\/doi.org\/10.1002\/acr.22459.","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"11","key":"3221_CR7","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1038\/s12276-021-00710-y","volume":"53","author":"Y Cho","year":"2021","unstructured":"Cho Y, Jeong S, Kim H, et al. Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions. Exp Mol Med. 2021;53(11):1689\u201396. https:\/\/doi.org\/10.1038\/s12276-021-00710-y.","journal-title":"Exp Mol Med"},{"issue":"2","key":"3221_CR8","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.joca.2021.11.009","volume":"30","author":"Y Jiang","year":"2022","unstructured":"Jiang Y. Osteoarthritis year in review 2021: biology. Osteoarthritis Cartilage. 2022;30(2):207\u201315. https:\/\/doi.org\/10.1016\/j.joca.2021.11.009.","journal-title":"Osteoarthritis Cartilage"},{"key":"3221_CR9","doi-asserted-by":"publisher","unstructured":"Wieland HA, Michaelis M, Kirschbaum BJ, Rudolphi KA. Osteoarthritis - an untreatable disease? [published correction appears in Nat Rev Drug Discov. 2005 Jul;4(7):543]. Nat Rev Drug Discov. 2005;4(4):331\u2013344. https:\/\/doi.org\/10.1038\/nrd1693","DOI":"10.1038\/nrd1693"},{"key":"3221_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120555","volume":"268","author":"Z Peng","year":"2021","unstructured":"Peng Z, Sun H, Bunpetch V, et al. The regulation of cartilage extracellular matrix homeostasis in joint cartilage degeneration and regeneration. Biomaterials. 2021;268: 120555. https:\/\/doi.org\/10.1016\/j.biomaterials.2020.120555.","journal-title":"Biomaterials"},{"key":"3221_CR11","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.bcp.2019.02.033","volume":"165","author":"CJ Malemud","year":"2019","unstructured":"Malemud CJ. Inhibition of MMPs and ADAM\/ADAMTS. Biochem Pharmacol. 2019;165:33\u201340. https:\/\/doi.org\/10.1016\/j.bcp.2019.02.033.","journal-title":"Biochem Pharmacol"},{"key":"3221_CR12","doi-asserted-by":"publisher","unstructured":"Ji B, Ma Y, Wang H, Fang X, Shi P. Activation of the P38\/CREB\/MMP13 axis is associated with osteoarthritis. Drug Des Devel Ther. 2019;13:2195\u20132204. Published 2019 Jul 3. https:\/\/doi.org\/10.2147\/DDDT.S209626","DOI":"10.2147\/DDDT.S209626"},{"key":"3221_CR13","doi-asserted-by":"publisher","unstructured":"Varela-Eir\u00edn M, Varela-V\u00e1zquez A, Guiti\u00e1n-Caama\u00f1o A, et al. Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis. Cell Death Dis. 2018;9(12):1166. 2018. https:\/\/doi.org\/10.1038\/s41419-018-1225-2.","DOI":"10.1038\/s41419-018-1225-2"},{"key":"3221_CR14","doi-asserted-by":"publisher","unstructured":"Martin JA, Brown TD, Heiner AD, Buckwalter JA. Chondrocyte senescence, joint loading and osteoarthritis. Clin Orthop Relat Res. 2004;(427 Suppl):S96-S103. https:\/\/doi.org\/10.1097\/01.blo.0000143818.74887.b1","DOI":"10.1097\/01.blo.0000143818.74887.b1"},{"issue":"2","key":"3221_CR15","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/acel.12562","volume":"16","author":"K McCulloch","year":"2017","unstructured":"McCulloch K, Litherland GJ, Rai TS. Cellular senescence in osteoarthritis pathology. Aging Cell. 2017;16(2):210\u20138. https:\/\/doi.org\/10.1111\/acel.12562.","journal-title":"Aging Cell"},{"key":"3221_CR16","doi-asserted-by":"publisher","unstructured":"Felson DT, Lawrence RC, Dieppe PA, et al. Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med. 2000;133(8):635\u2013646. https:\/\/doi.org\/10.7326\/0003-4819-133-8-200010170-00016","DOI":"10.7326\/0003-4819-133-8-200010170-00016"},{"issue":"6","key":"3221_CR17","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","volume":"153","author":"C L\u00f3pez-Ot\u00edn","year":"2013","unstructured":"L\u00f3pez-Ot\u00edn C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153(6):1194\u2013217. https:\/\/doi.org\/10.1016\/j.cell.2013.05.039.","journal-title":"Cell"},{"issue":"12","key":"3221_CR18","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1038\/nprot.2009.191","volume":"4","author":"F Debacq-Chainiaux","year":"2009","unstructured":"Debacq-Chainiaux F, Erusalimsky JD, Campisi J, Toussaint O. Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo. Nat Protoc. 2009;4(12):1798\u2013806. https:\/\/doi.org\/10.1038\/nprot.2009.191.","journal-title":"Nat Protoc"},{"key":"3221_CR19","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/978-1-59745-361-5_3","volume":"371","author":"K Itahana","year":"2007","unstructured":"Itahana K, Campisi J, Dimri GP. Methods to detect biomarkers of cellular senescence: the senescence-associated beta-galactosidase assay. Methods Mol Biol. 2007;371:21\u201331. https:\/\/doi.org\/10.1007\/978-1-59745-361-5_3.","journal-title":"Methods Mol Biol"},{"issue":"17","key":"3221_CR20","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1038\/sj.onc.1203573","volume":"19","author":"BD Chang","year":"2000","unstructured":"Chang BD, Broude EV, Fang J, et al. p21Waf1\/Cip1\/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells. Oncogene. 2000;19(17):2165\u201370. https:\/\/doi.org\/10.1038\/sj.onc.1203573.","journal-title":"Oncogene"},{"issue":"42","key":"3221_CR21","doi-asserted-by":"publisher","first-page":"36396","DOI":"10.1074\/jbc.M111.257071","volume":"286","author":"JP Copp\u00e9","year":"2011","unstructured":"Copp\u00e9 JP, Rodier F, Patil CK, Freund A, Desprez PY, Campisi J. Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype. J Biol Chem. 2011;286(42):36396\u2013403. https:\/\/doi.org\/10.1074\/jbc.M111.257071.","journal-title":"J Biol Chem"},{"issue":"5","key":"3221_CR22","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.3892\/mmr.2020.11028","volume":"21","author":"K Ibaraki","year":"2020","unstructured":"Ibaraki K, Hayashi S, Kanzaki N, et al. Deletion of p21 expression accelerates cartilage tissue repair via chondrocyte proliferation. Mol Med Rep. 2020;21(5):2236\u201342. https:\/\/doi.org\/10.3892\/mmr.2020.11028.","journal-title":"Mol Med Rep"},{"issue":"1","key":"3221_CR23","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41584-020-00533-7","volume":"17","author":"PR Coryell","year":"2021","unstructured":"Coryell PR, Diekman BO, Loeser RF. Mechanisms and therapeutic implications of cellular senescence in osteoarthritis. Nat Rev Rheumatol. 2021;17(1):47\u201357. https:\/\/doi.org\/10.1038\/s41584-020-00533-7.","journal-title":"Nat Rev Rheumatol"},{"issue":"5","key":"3221_CR24","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.joca.2022.11.004","volume":"31","author":"X Wu","year":"2023","unstructured":"Wu X, Liyanage C, Plan M, et al. Dysregulated energy metabolism impairs chondrocyte function in osteoarthritis. Osteoarthritis Cartilage. 2023;31(5):613\u201326. https:\/\/doi.org\/10.1016\/j.joca.2022.11.004.","journal-title":"Osteoarthritis Cartilage"},{"issue":"8","key":"3221_CR25","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1136\/ard.2010.146399","volume":"70","author":"F Berenbaum","year":"2011","unstructured":"Berenbaum F. Diabetes-induced osteoarthritis: from a new paradigm to a new phenotype. Ann Rheum Dis. 2011;70(8):1354\u20136. https:\/\/doi.org\/10.1136\/ard.2010.146399.","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"3221_CR26","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1007\/s00256-018-3088-0","volume":"48","author":"J Neumann","year":"2019","unstructured":"Neumann J, Guimaraes JB, Heilmeier U, et al. Diabetics show accelerated progression of knee cartilage and meniscal lesions: data from the osteoarthritis initiative. Skeletal Radiol. 2019;48(6):919\u201330. https:\/\/doi.org\/10.1007\/s00256-018-3088-0.","journal-title":"Skeletal Radiol"},{"key":"3221_CR27","doi-asserted-by":"publisher","unstructured":"Li Q, Wen Y, Wang L, et al. Hyperglycemia-induced accumulation of advanced glycosylation end products in fibroblast-like synoviocytes promotes knee osteoarthritis [published correction appears in Exp Mol Med. 2022;54(6):862\u2013865]. Exp Mol Med. 2021;53(11):1735\u20131747. https:\/\/doi.org\/10.1038\/s12276-021-00697-6","DOI":"10.1038\/s12276-021-00697-6"},{"issue":"6","key":"3221_CR28","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202200485R","volume":"36","author":"K Li","year":"2022","unstructured":"Li K, Ji X, Seeley R, et al. Impaired glucose metabolism underlies articular cartilage degeneration in osteoarthritis. FASEB J. 2022;36(6): e22377. https:\/\/doi.org\/10.1096\/fj.202200485R.","journal-title":"FASEB J"},{"issue":"4","key":"3221_CR29","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.14670\/HH-17.1239","volume":"17","author":"A Mobasheri","year":"2002","unstructured":"Mobasheri A, Vannucci SJ, Bondy CA, et al. Glucose transport and metabolism in chondrocytes: a key to understanding chondrogenesis, skeletal development and cartilage degradation in osteoarthritis. Histol Histopathol. 2002;17(4):1239\u201367. https:\/\/doi.org\/10.14670\/HH-17.1239.","journal-title":"Histol Histopathol"},{"issue":"3","key":"3221_CR30","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s00441-002-0563-6","volume":"308","author":"R Rajpurohit","year":"2002","unstructured":"Rajpurohit R, Risbud MV, Ducheyne P, Vresilovic EJ, Shapiro IM. Phenotypic characteristics of the nucleus pulposus: expression of hypoxia inducing factor-1, glucose transporter-1 and MMP-2. Cell Tissue Res. 2002;308(3):401\u20137. https:\/\/doi.org\/10.1007\/s00441-002-0563-6.","journal-title":"Cell Tissue Res"},{"issue":"2","key":"3221_CR31","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s11914-019-00506-0","volume":"17","author":"JM Hollander","year":"2019","unstructured":"Hollander JM, Zeng L. The emerging role of glucose metabolism in cartilage development. Curr Osteoporos Rep. 2019;17(2):59\u201369. https:\/\/doi.org\/10.1007\/s11914-019-00506-0.","journal-title":"Curr Osteoporos Rep"},{"issue":"7","key":"3221_CR32","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1016\/j.biochi.2010.02.029","volume":"92","author":"M Cechowska-Pasko","year":"2010","unstructured":"Cechowska-Pasko M, Ba\u0144kowski E. Glucose deficiency inhibits glycosaminoglycans synthesis in fibroblast cultures. Biochimie. 2010;92(7):806\u201313. https:\/\/doi.org\/10.1016\/j.biochi.2010.02.029.","journal-title":"Biochimie"},{"issue":"9190","key":"3221_CR33","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1016\/s0140-6736(99)90195-2","volume":"354","author":"LC Rovati","year":"1999","unstructured":"Rovati LC, Annefeld M, Giacovelli G, Schmid K, Setnikar I. Glucosamine in osteoarthritis. Lancet. 1999;354(9190):1640\u20132. https:\/\/doi.org\/10.1016\/s0140-6736(99)90195-2.","journal-title":"Lancet"},{"key":"3221_CR34","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.carbpol.2014.03.033","volume":"109","author":"C Bottegoni","year":"2014","unstructured":"Bottegoni C, Muzzarelli RA, Giovannini F, Busilacchi A, Gigante A. Oral chondroprotection with nutraceuticals made of chondroitin sulphate plus glucosamine sulphate in osteoarthritis. Carbohydr Polym. 2014;109:126\u201338. https:\/\/doi.org\/10.1016\/j.carbpol.2014.03.033.","journal-title":"Carbohydr Polym"},{"key":"3221_CR35","doi-asserted-by":"publisher","unstructured":"Tan C, Li L, Han J, Xu K, Liu X. A new strategy for osteoarthritis therapy: Inhibition of glycolysis. Front Pharmacol. 2022;13:1057229. Published 2022 Nov 10. doi:https:\/\/doi.org\/10.3389\/fphar.2022.1057229","DOI":"10.3389\/fphar.2022.1057229"},{"key":"3221_CR36","doi-asserted-by":"publisher","unstructured":"Liu Y, Jiang Y, Wang N, et al. Invalidation of mitophagy by FBP1-mediated repression promotes apoptosis in breast cancer [published correction appears in Tumour Biol. 2019 Oct;41(10):1010428319885684]. Tumour Biol. 2017;39(6):1010428317708779. https:\/\/doi.org\/10.1177\/1010428317708779","DOI":"10.1177\/1010428317708779"},{"key":"3221_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119840","volume":"283","author":"P Zhang","year":"2021","unstructured":"Zhang P, Shao Y, Quan F, Liu L, Yang J. FBP1 enhances the radiosensitivity by suppressing glycolysis via the FBXW7\/mTOR axis in nasopharyngeal carcinoma cells. Life Sci. 2021;283: 119840. https:\/\/doi.org\/10.1016\/j.lfs.2021.119840.","journal-title":"Life Sci"},{"key":"3221_CR38","doi-asserted-by":"publisher","unstructured":"C, Yuan T, Wu Y, et al. Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell. 2013;23(3):316\u2013331. https:\/\/doi.org\/10.1016\/j.ccr.2013.01.022","DOI":"10.1016\/j.ccr.2013.01.022"},{"issue":"11","key":"3221_CR39","doi-asserted-by":"publisher","first-page":"3265","DOI":"10.1158\/0008-5472.CAN-15-2601","volume":"76","author":"H Hirata","year":"2016","unstructured":"Hirata H, Sugimachi K, Komatsu H, et al. Decreased expression of fructose-1,6-bisphosphatase associates with glucose metabolism and tumor progression in hepatocellular carcinoma. Cancer Res. 2016;76(11):3265\u201376. https:\/\/doi.org\/10.1158\/0008-5472.CAN-15-2601.","journal-title":"Cancer Res"},{"issue":"1","key":"3221_CR40","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/ng0195-15","volume":"9","author":"E Wright","year":"1995","unstructured":"Wright E, Hargrave MR, Christiansen J, et al. The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos. Nat Genet. 1995;9(1):15\u201320. https:\/\/doi.org\/10.1038\/ng0195-15.","journal-title":"Nat Genet"},{"issue":"1","key":"3221_CR41","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/8792","volume":"22","author":"W Bi","year":"1999","unstructured":"Bi W, Deng JM, Zhang Z, Behringer RR, de Crombrugghe B. Sox9 is required for cartilage formation. Nat Genet. 1999;22(1):85\u20139. https:\/\/doi.org\/10.1038\/8792.","journal-title":"Nat Genet"},{"key":"3221_CR42","doi-asserted-by":"publisher","unstructured":"Mao X, Li P, Wang Y, et al. CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells. Cell Death Dis. 2017;8(1):e2546. Published 2017 Jan 12. https:\/\/doi.org\/10.1038\/cddis.2016.478","DOI":"10.1038\/cddis.2016.478"},{"issue":"Pt 14","key":"3221_CR43","doi-asserted-by":"publisher","first-page":"2895","DOI":"10.1242\/jcs.00500","volume":"116","author":"MH Roh","year":"2003","unstructured":"Roh MH, Fan S, Liu CJ, Margolis B. The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells. J Cell Sci. 2003;116(Pt 14):2895\u2013906. https:\/\/doi.org\/10.1242\/jcs.00500.","journal-title":"J Cell Sci"},{"key":"3221_CR44","doi-asserted-by":"publisher","unstructured":"Pan J, Liu F, Xiao X, et al. METTL3 promotes colorectal carcinoma progression by regulating the m6A-CRB3-Hippo axis. J Exp Clin Cancer Res. 2022;41(1):19. Published 2022 Jan 10. https:\/\/doi.org\/10.1186\/s13046-021-02227-8","DOI":"10.1186\/s13046-021-02227-8"},{"key":"3221_CR45","doi-asserted-by":"publisher","unstructured":"Li P, Mao X, Ren Y, Liu P. Epithelial cell polarity determinant CRB3 in cancer development. Int J Biol Sci. 2015;11(1):31\u201337. Published 2015 Jan 1. https:\/\/doi.org\/10.7150\/ijbs.10615","DOI":"10.7150\/ijbs.10615"},{"issue":"6","key":"3221_CR46","doi-asserted-by":"publisher","first-page":"173","DOI":"10.3892\/ol.2022.13293","volume":"23","author":"Y Yokoyama","year":"2022","unstructured":"Yokoyama Y, Iioka H, Horii A, Kondo E. Crumbs3 is expressed in oral squamous cell carcinomas and promotes cell migration and proliferation by affecting RhoA activity. Oncol Lett. 2022;23(6):173. https:\/\/doi.org\/10.3892\/ol.2022.13293.","journal-title":"Oncol Lett"},{"issue":"7","key":"3221_CR47","doi-asserted-by":"publisher","first-page":"3423","DOI":"10.1111\/jcmm.13619","volume":"22","author":"P Li","year":"2018","unstructured":"Li P, Feng C, Chen H, et al. Elevated CRB3 expression suppresses breast cancer stemness by inhibiting \u03b2-catenin signalling to restore tamoxifen sensitivity. J Cell Mol Med. 2018;22(7):3423\u201333. https:\/\/doi.org\/10.1111\/jcmm.13619.","journal-title":"J Cell Mol Med"},{"key":"3221_CR48","doi-asserted-by":"publisher","unstructured":"Deng L, Yi S, Yin X, Li Y, Luan Q. MFN2 knockdown promotes osteogenic differentiation of iPSC-MSCs through aerobic glycolysis mediated by the Wnt\/\u03b2-catenin signaling pathway. Stem Cell Res Ther. 2022;13(1):162. Published 2022 Apr 12. https:\/\/doi.org\/10.1186\/s13287-022-02836-w","DOI":"10.1186\/s13287-022-02836-w"},{"key":"3221_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101091","volume":"42","author":"SWC Masson","year":"2020","unstructured":"Masson SWC, Sorrenson B, Shepherd PR, Merry TL. \u03b2-catenin regulates muscle glucose transport via actin remodelling and M-cadherin binding. Mol Metab. 2020;42: 101091. https:\/\/doi.org\/10.1016\/j.molmet.2020.101091.","journal-title":"Mol Metab"},{"key":"3221_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101594","volume":"66","author":"DJ Han","year":"2022","unstructured":"Han DJ, Aslam R, Misra PS, et al. Disruption of adipocyte YAP improves glucose homeostasis in mice and decreases adipose tissue fibrosis. Mol Metab. 2022;66: 101594. https:\/\/doi.org\/10.1016\/j.molmet.2022.101594.","journal-title":"Mol Metab"},{"key":"3221_CR51","doi-asserted-by":"publisher","unstructured":"Sun K, Guo J, Guo Z, et al. The roles of the Hippo-YAP signalling pathway in cartilage and osteoarthritis. Ageing Res Rev. 2023;90:102015.https:\/\/doi.org\/10.1016\/j.arr.2023.102015","DOI":"10.1016\/j.arr.2023.102015"},{"issue":"7","key":"3221_CR52","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.joca.2005.03.004","volume":"13","author":"S Kamekura","year":"2005","unstructured":"Kamekura S, Hoshi K, Shimoaka T, et al. Osteoarthritis development in novel experimental mouse models induced by knee joint instability. Osteoarthritis Cartilage. 2005;13(7):632\u201341. https:\/\/doi.org\/10.1016\/j.joca.2005.03.004.","journal-title":"Osteoarthritis Cartilage"}],"updated-by":[{"DOI":"10.1186\/s13075-023-03247-9","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000}}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-023-03221-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-023-03221-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-023-03221-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T12:02:33Z","timestamp":1703764953000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-023-03221-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,4]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["3221"],"URL":"https:\/\/doi.org\/10.1186\/s13075-023-03221-5","relation":{"correction":[{"id-type":"doi","id":"10.1186\/s13075-023-03247-9","asserted-by":"object"}]},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,4]]},"assertion":[{"value":"7 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2023","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1186\/s13075-023-03247-9","URL":"https:\/\/doi.org\/10.1186\/s13075-023-03247-9","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All patients gave informed consent to use their clinical information for scientific research. All methods were performed in accordance with the relevant guidelines and regulations. The protocol was approved by the Southern Medical University Animal Care and Use Review Board (Permit Number: 2020-Ethical review-039) (5 votes passed and 0 votes opposed). The study was performed in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"235"}}