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However, the role of N-acetyltransferase 10 (NAT10) in ankylosing spondylitis (AS) is still poorly elaborated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Fifty-six patients with New-Onset AS, 52 healthy controls (HC), 20 patients with rheumatoid arthritis (RA) and 16 patients with systemic lupus erythematosus (SLE) were recruited from The First Afliated Hospital of Nanchang University, and their clinical characteristics were recorded. The expression level of <jats:italic>NAT10<\/jats:italic> in peripheral blood mononuclear cell (PBMC) was examined using reverse transcription-quantitative PCR analysis. The correlations between the expression level of <jats:italic>NAT10<\/jats:italic> in the New-Onset AS patients and disease activity of AS were examined, and receiver operating characteristic (ROC) curves were built to evaluate predictive value in AS. Univariate analysis and multivariate regression analysis were used to analyze the risk factors and construct predictive model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The mRNA expressions of <jats:italic>NAT10<\/jats:italic> in PBMC from new-onset AS patients were significantly low and there were negative correlation between mRNA <jats:italic>NAT10<\/jats:italic> and ASDAS-CRP, BASDIA in new-onset AS patients. ROC analysis suggested that mRNA <jats:italic>NAT10<\/jats:italic> has value in distinguishing new-onset AS patients from HC, RA and SLE. Furthermore, a novel predictive model based on mRNA <jats:italic>NAT10<\/jats:italic> and neutrophil percentages (N%) was constructed for distinguishing new-onset AS patients from HC (AUC\u2009=\u20090.880, sensitivity\u2009=\u200984.62%, specificity\u2009=\u200976.92%) and the predictive model correlated with the activity of new-onset AS. Furthermore, the predictive model could distinguish new-onset AS patients from RA and SLE (AUC\u2009=\u20090.661, sensitivity\u2009=\u200990.38%, specificity\u2009=\u200947.22%). Moreover, the potential predictive value of the combination of predictive model-HLA-B27 for AS vs. HC with a sensitivity of 92.86% (39\/42), a specificity of 100.00% (52\/52) and an accuracy of 96.81% (91\/94) was superior to that of HLA-B27, which in turn had a sensitivity of 84.44% (38\/45), a specificity of 100.00% (52\/52) and an accuracy of 92.78% (90\/97).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The present study suggested that the decreased mRNA <jats:italic>NAT10<\/jats:italic> may play a role in AS pathogenesis and predictive model based on mRNA <jats:italic>NAT10<\/jats:italic> and N% act as bioindicator for forecast and progression of diseases.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13075-023-03250-0","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T10:02:58Z","timestamp":1704189778000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Decreased expression of NAT10 in peripheral blood mononuclear cells from new-onset ankylosing spondylitis and its clinical significance"],"prefix":"10.1186","volume":"26","author":[{"given":"Qing","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juxiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biqi","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zikun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,2]]},"reference":[{"issue":"7","key":"3250_CR1","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41584-021-00625-y","volume":"17","author":"D Mauro","year":"2021","unstructured":"Mauro D, Thomas R, Guggino G, Lories R, Brown MA, Ciccia F. 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