{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:47:30Z","timestamp":1788871650923,"version":"build-2803163510"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T00:00:00Z","timestamp":1714780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T00:00:00Z","timestamp":1714780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Rheumatoid arthritis (RA) related interstitial lung disease (ILD) impacts on the treatment strategy and its prognosis in patients with RA. However, the relationship between RA disease activity and the severity of comorbid ILD has not been fully investigated. This study aimed to investigate the impact of RA disease activity on the severity of comorbid ILD in detail based on currently established visual scoring method along with physiological severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients with RA visiting to our Rheumatology Centre between December 2020 and December 2023 were analysed. The radiological severity of ILD was evaluated by averaging the extent of the combined lesion of ground glass opacity, reticulation and honeycombing in 5% increments in six representative high-resolution computed tomography slices ranging from 0% (no involvement) to 100% (all lung fields affected) according to Goh and Walsh\u2019s method. Associations between the radiological and physiological severity of ILD and patients\u2019 features were investigated using linear regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 124 patients (32 men, 92 women), the median age was 70 years, and the median disease duration was 2.92 years. Radiological severity of ILD was 0% (without ILD) in 107 (86.2%), ILD with extent\u2009&lt;\u200910% in nine (7.2%), ILD with extent \u226510% and &lt;\u200920% in three (2.4%), ILD with extent \u226520% in five (4.0%). Both disease activity score (DAS)28-erythrocyte sedimentation rate (ESR) (standardized coefficient\u2009=\u20090.199,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.03) and rheumatoid factor titre (standardized coefficient\u2009=\u20090.247,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01) were significantly associated with the radiological quantitative severity of ILD in multivariate analysis adjusted for age, sex, disease duration, smoking status and anti-citrullinated peptide antibody titre. DAS28-ESR was significantly associated with forced vital capacity% predicted (standardized coefficient = -0.230,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.047).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Disease activity of RA was significantly associated with the severity of RA-ILD both radiologically and physiologically.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13075-024-03333-6","type":"journal-article","created":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T02:01:30Z","timestamp":1714788090000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Rheumatoid arthritis disease activity significantly impacts on the severity of interstitial lung disease"],"prefix":"10.1186","volume":"26","author":[{"given":"Yuhei","family":"Ito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutaka","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Murashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Sakuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,4]]},"reference":[{"key":"3333_CR1","doi-asserted-by":"publisher","first-page":"837133","DOI":"10.3389\/fmed.2022.837133","volume":"9","author":"A Laria","year":"2022","unstructured":"Laria A, Lurati AM, Zizzo G, Zaccara E, Mazzocchi D, Re KA, Marrazza M, Faggioli P, Mazzone A. Interstitial lung disease in rheumatoid arthritis: a practical review. Front Med (Lausanne). 2022;9:837133.","journal-title":"Front Med (Lausanne)"},{"issue":"5","key":"3333_CR2","doi-asserted-by":"publisher","first-page":"360","DOI":"10.3109\/03009741003604542","volume":"39","author":"A Nakajima","year":"2010","unstructured":"Nakajima A, Inoue E, Tanaka E, Singh G, Sato E, Hoshi D, Shidara K, Hara M, Momohara S, Taniguchi A, et al. Mortality and cause of death in Japanese patients with rheumatoid arthritis based on a large observational cohort, IORRA. Scand J Rheumatol. 2010;39(5):360\u20137.","journal-title":"Scand J Rheumatol"},{"issue":"2","key":"3333_CR3","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1183\/13993003.00357-2015","volume":"47","author":"JJ Solomon","year":"2016","unstructured":"Solomon JJ, Chung JH, Cosgrove GP, Demoruelle MK, Fernandez-Perez ER, Fischer A, Frankel SK, Hobbs SB, Huie TJ, Ketzer J, et al. Predictors of mortality in rheumatoid arthritis-associated interstitial lung disease. Eur Respir J. 2016;47(2):588\u201396.","journal-title":"Eur Respir J"},{"issue":"12","key":"3333_CR4","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1111\/resp.13848","volume":"25","author":"HC Kim","year":"2020","unstructured":"Kim HC, Lee JS, Lee EY, Ha YJ, Chae EJ, Han M, Cross G, Barnett J, Joseph J, Song JW. Risk prediction model in rheumatoid arthritis-associated interstitial lung disease. Respirology. 2020;25(12):1257\u201364.","journal-title":"Respirology"},{"issue":"1","key":"3333_CR5","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1080\/14397595.2018.1442170","volume":"29","author":"Y Ito","year":"2019","unstructured":"Ito Y, Arita M, Kumagai S, Takei R, Noyama M, Tokioka F, Nishimura K, Koyama T, Tachibana H, Ishida T. Radiological fibrosis score is strongly associated with worse survival in rheumatoid arthritis-related interstitial lung disease. Mod Rheumatol. 2019;29(1):98\u2013104.","journal-title":"Mod Rheumatol"},{"issue":"9","key":"3333_CR6","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1093\/rheumatology\/keu165","volume":"53","author":"CA Kelly","year":"2014","unstructured":"Kelly CA, Saravanan V, Nisar M, Arthanari S, Woodhead FA, Price-Forbes AN, Dawson J, Sathi N, Ahmad Y, Koduri G, et al. Rheumatoid arthritis-related interstitial lung disease: associations, prognostic factors and physiological and radiological characteristics\u2013a large multicentre UK study. Rheumatology (Oxford). 2014;53(9):1676\u201382.","journal-title":"Rheumatology (Oxford)"},{"key":"3333_CR7","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.rmed.2017.11.013","volume":"134","author":"HM Nurmi","year":"2018","unstructured":"Nurmi HM, Kettunen HP, Suoranta SK, Purokivi MK, K\u00e4rkk\u00e4inen MS, Selander TA, Kaarteenaho RL. Several high-resolution computed tomography findings associate with survival and clinical features in rheumatoid arthritis-associated interstitial lung disease. Respir Med. 2018;134:24\u201330.","journal-title":"Respir Med"},{"issue":"12","key":"3333_CR8","doi-asserted-by":"publisher","first-page":"4702","DOI":"10.1093\/rheumatology\/keac184","volume":"61","author":"JH Oh","year":"2022","unstructured":"Oh JH, Kim GHJ, Cross G, Barnett J, Jacob J, Hong S, Song JW. Automated quantification system predicts survival in rheumatoid arthritis-associated interstitial lung disease. Rheumatology (Oxford). 2022;61(12):4702\u201310.","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"3333_CR9","doi-asserted-by":"publisher","first-page":"e28501","DOI":"10.1097\/MD.0000000000028501","volume":"101","author":"KH Yu","year":"2022","unstructured":"Yu KH, Chen HH, Cheng TT, Jan YJ, Weng MY, Lin YJ, Chen HA, Cheng JT, Huang KY, Li KJ, et al. Consensus recommendations on managing the selected comorbidities including cardiovascular disease, osteoporosis, and interstitial lung disease in rheumatoid arthritis. Med (Baltim). 2022;101(1):e28501.","journal-title":"Med (Baltim)"},{"issue":"1","key":"3333_CR10","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1002\/art.38904","volume":"67","author":"J Chen","year":"2015","unstructured":"Chen J, Doyle TJ, Liu Y, Aggarwal R, Wang X, Shi Y, Ge SX, Huang H, Lin Q, Liu W, et al. Biomarkers of rheumatoid arthritis-associated interstitial lung disease. Arthritis Rheumatol. 2015;67(1):28\u201338.","journal-title":"Arthritis Rheumatol"},{"issue":"9","key":"3333_CR11","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1007\/s10067-015-3025-8","volume":"34","author":"JF Restrepo","year":"2015","unstructured":"Restrepo JF, del Rinc\u00f3n I, Battafarano DF, Haas RW, Doria M, Escalante A. Clinical and laboratory factors associated with interstitial lung disease in rheumatoid arthritis. Clin Rheumatol. 2015;34(9):1529\u201336.","journal-title":"Clin Rheumatol"},{"issue":"9","key":"3333_CR12","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1002\/art.40904","volume":"71","author":"JA Sparks","year":"2019","unstructured":"Sparks JA, He X, Huang J, Fletcher EA, Zaccardelli A, Friedlander HM, Gill RR, Hatabu H, Nishino M, Murphy DJ, et al. Rheumatoid arthritis Disease Activity Predicting Incident clinically apparent Rheumatoid Arthritis-Associated interstitial lung disease: a prospective cohort study. Arthritis Rheumatol. 2019;71(9):1472\u201382.","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"3333_CR13","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.reuma.2014.02.007","volume":"11","author":"R P\u00e9rez-D\u00f3rame","year":"2015","unstructured":"P\u00e9rez-D\u00f3rame R, Mej\u00eda M, Mateos-Toledo H, Rojas-Serrano J. Rheumatoid arthritis-associated interstitial lung disease: lung inflammation evaluated with high resolution computed tomography scan is correlated to rheumatoid arthritis disease activity. Reumatol Clin. 2015;11(1):12\u20136.","journal-title":"Reumatol Clin"},{"issue":"3","key":"3333_CR14","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1136\/thoraxjnl-2013-203843","volume":"69","author":"SL Walsh","year":"2014","unstructured":"Walsh SL, Sverzellati N, Devaraj A, Keir GJ, Wells AU, Hansell DM. Connective tissue disease related fibrotic lung disease: high resolution computed tomographic and pulmonary function indices as prognostic determinants. Thorax. 2014;69(3):216\u201322.","journal-title":"Thorax"},{"issue":"11","key":"3333_CR15","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1164\/rccm.200706-877OC","volume":"177","author":"NS Goh","year":"2008","unstructured":"Goh NS, Desai SR, Veeraraghavan S, Hansell DM, Copley SJ, Maher TM, Corte TJ, Sander CR, Ratoff J, Devaraj A, et al. Interstitial lung disease in systemic sclerosis: a simple staging system. Am J Respir Crit Care Med. 2008;177(11):1248\u201354.","journal-title":"Am J Respir Crit Care Med"},{"issue":"9","key":"3333_CR16","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1136\/ard.2010.138461","volume":"69","author":"D Aletaha","year":"2010","unstructured":"Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3rd, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League against Rheumatism collaborative initiative. Ann Rheum Dis. 2010;69(9):1580\u20138.","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"3333_CR17","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1164\/rccm.201604-0801CI","volume":"194","author":"HR Collard","year":"2016","unstructured":"Collard HR, Ryerson CJ, Corte TJ, Jenkins G, Kondoh Y, Lederer DJ, Lee JS, Maher TM, Wells AU, Antoniou KM, et al. Acute Exacerbation of Idiopathic Pulmonary Fibrosis. An International Working Group Report. Am J Respir Crit Care Med. 2016;194(3):265\u201375.","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"3333_CR18","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1002\/art.38098","volume":"65","author":"F van den Hoogen","year":"2013","unstructured":"van den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A, Matucci-Cerinic M, Naden RP, Medsger TA Jr., Carreira PE, et al. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European League against Rheumatism collaborative initiative. Arthritis Rheum. 2013;65(11):2737\u201347.","journal-title":"Arthritis Rheum"},{"issue":"9","key":"3333_CR19","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1002\/art.1780400928","volume":"40","author":"MC Hochberg","year":"1997","unstructured":"Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997;40(9):1725.","journal-title":"Arthritis Rheum"},{"issue":"7","key":"3333_CR20","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1056\/NEJM197502132920706","volume":"292","author":"A Bohan","year":"1975","unstructured":"Bohan A, Peter JB. Polymyositis and dermatomyositis (first of two parts). N Engl J Med. 1975;292(7):344\u20137.","journal-title":"N Engl J Med"},{"issue":"2","key":"3333_CR21","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/0002-9343(72)90064-2","volume":"52","author":"GC Sharp","year":"1972","unstructured":"Sharp GC, Irvin WS, Tan EM, Gould RG, Holman HR. Mixed connective tissue disease\u2013an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA). Am J Med. 1972;52(2):148\u201359.","journal-title":"Am J Med"},{"issue":"3","key":"3333_CR22","first-page":"328","volume":"16","author":"D Alarc\u00f3n-Segovia","year":"1989","unstructured":"Alarc\u00f3n-Segovia D, Cardiel MH. Comparison between 3 diagnostic criteria for mixed connective tissue disease. Study of 593 patients. J Rheumatol. 1989;16(3):328\u201334.","journal-title":"J Rheumatol"},{"issue":"6","key":"3333_CR23","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1002\/art.27405","volume":"62","author":"T Bongartz","year":"2010","unstructured":"Bongartz T, Nannini C, Medina-Velasquez YF, Achenbach SJ, Crowson CS, Ryu JH, Vassallo R, Gabriel SE, Matteson EL. Incidence and mortality of interstitial lung disease in rheumatoid arthritis: a population-based study. Arthritis Rheum. 2010;62(6):1583\u201391.","journal-title":"Arthritis Rheum"},{"issue":"10","key":"3333_CR24","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1164\/rccm.201903-0486OC","volume":"200","author":"AM Hoffmann-Vold","year":"2019","unstructured":"Hoffmann-Vold AM, Fretheim H, Halse AK, Seip M, Bitter H, Wallenius M, Garen T, Salberg A, Brunborg C, Midtvedt \u00d8, et al. Tracking impact of interstitial lung disease in systemic sclerosis in a Complete Nationwide Cohort. Am J Respir Crit Care Med. 2019;200(10):1258\u201366.","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"3333_CR25","doi-asserted-by":"publisher","first-page":"103056","DOI":"10.1016\/j.autrev.2022.103056","volume":"21","author":"M Akiyama","year":"2022","unstructured":"Akiyama M, Kaneko Y. Pathogenesis, clinical features, and treatment strategy for rheumatoid arthritis-associated interstitial lung disease. Autoimmun Rev. 2022;21(5):103056.","journal-title":"Autoimmun Rev"},{"issue":"3","key":"3333_CR26","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1093\/mr\/roab087","volume":"32","author":"T Sugihara","year":"2022","unstructured":"Sugihara T. Treatment strategies for elderly-onset rheumatoid arthritis in the new era. Mod Rheumatol. 2022;32(3):493\u20139.","journal-title":"Mod Rheumatol"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-024-03333-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-024-03333-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-024-03333-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T02:03:40Z","timestamp":1714788220000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-024-03333-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,4]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3333"],"URL":"https:\/\/doi.org\/10.1186\/s13075-024-03333-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3920083\/v1","asserted-by":"object"}]},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,4]]},"assertion":[{"value":"2 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the institutional review board of the Mie University Hospital (Approval number: H2020-242), and informed consent was obtained from all patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"None.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"95"}}