{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:49:36Z","timestamp":1789476576204,"version":"build-2803163510"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psoriatic arthritis (PsA) is a chronic, potentially debilitating inflammatory arthritis often associated with psoriasis. Understanding the epidemiology of PsA across diverse populations can provide valuable insights into its global burden and the role of genetic and environmental factors. This study aimed to estimate PsA\u2019s temporal trends, prevalence, and incidence, while assessing variations in age, gender, and ethnicity in Israel from 2016 to 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were sourced from the Clalit Health Services (CHS) database, covering over half of the Israeli population. Algorithm-based definitions for PsA and psoriasis cases were used. Demographic factors, including age, gender, socioeconomic status (SES), ethnicity, urban\/rural residence, BMI, and smoking status, were analyzed. Standardized prevalence and incidence rates were calculated. Logistic regression analyses examined associations of sociodemographic variables with PsA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 2022, the prevalence of PsA was 0.221%, with an incidence rate of 13.54 per 100,000 population. This prevalence has tripled since 2006, reflecting a rising trend in PsA over time. Females exhibited a higher prevalence (1.15; 95%CI 1.09\u20131.21), and PsA was more common in Jewish individuals (1.58; 95%CI 1.45\u20131.71) those with higher SES (1.4; 95% CI 1.31, 1.5), and those with obesity (2.17; 95%CI 2.04\u20132.31).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This comprehensive population-based study pointed to an increase prevalence of PsA, emphasizing the rising healthcare demands and economic burden faced by this patient population. Further research is essential to delve into the factors driving these trends.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13075-024-03339-0","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T01:01:47Z","timestamp":1716771707000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Epidemiological trends in psoriatic arthritis: a comprehensive population-based study"],"prefix":"10.1186","volume":"26","author":[{"given":"Amir","family":"Haddad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perach Chen","family":"Elkayam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nili","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Feldhamer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnon Dov","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Saliba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devy","family":"Zisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"3339_CR1","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.jaad.2005.03.046","volume":"53","author":"JM Gelfand","year":"2005","unstructured":"Gelfand JM, Gladman DD, Mease PJ, Smith N, Margolis DJ, Nijsten T. Epidemiology of psoriatic arthritis in the population of the United States. J Am Acad Dermatol. 2005;53:573.","journal-title":"J Am Acad Dermatol"},{"key":"3339_CR2","first-page":"1918","volume":"32","author":"TM Madland","year":"2005","unstructured":"Madland TM, Apalset EM, Johannessen AE, Rosseb\u00f6 B, Brun JG. Prevalence, disease manifestations, and treatment of psoriatic arthritis in Western Norway. J Rheumatol. 2005;32:1918\u201322.","journal-title":"J Rheumatol"},{"key":"3339_CR3","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.semarthrit.2018.01.003","volume":"48","author":"L Scotti","year":"2018","unstructured":"Scotti L, Franchi M, Marchesoni A, Corrao G. Prevalence and incidence of psoriatic arthritis: a systematic review and meta-analysis. Semin Arthritis Rheum. 2018;48:28\u201334.","journal-title":"Semin Arthritis Rheum"},{"issue":"2","key":"3339_CR4","doi-asserted-by":"publisher","first-page":"101692","DOI":"10.1016\/j.berh.2021.101692","volume":"35","author":"P Karmacharya","year":"2021","unstructured":"Karmacharya P, Chakradhar R, Ogdie A. The epidemiology of psoriatic arthritis: a literature review. Best Pract Res Clin Rheumatol. 2021;35(2):101692. https:\/\/doi.org\/10.1016\/j.berh.2021.101692. Epub 2021 May 18. PMID: 34016528.","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"3339_CR5","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1007\/s00296-010-1699-4","volume":"32","author":"N Cakir","year":"2012","unstructured":"Cakir N, Pamuk ON, Dervis E, Imeryuz N, Uslu H, Benian O, et al. The prevalences of some rheumatic diseases in western Turkey: Havsa study. Rheumatol Int. 2012;32:895\u2013908.","journal-title":"Rheumatol Int"},{"key":"3339_CR6","first-page":"162","volume":"11","author":"F Jamshidi","year":"2008","unstructured":"Jamshidi F, Bouzari N, Seirafi H, Farnaghi F, Firooz A. The prevalence of psoriatic arthritis in psoriatic patients in Tehran. Iran Arch Iran Med. 2008;11:162\u20135.","journal-title":"Iran Arch Iran Med"},{"issue":"1","key":"3339_CR7","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s13075-017-1497-4","volume":"20","author":"L Eder","year":"2018","unstructured":"Eder L, Cohen AD, Feldhamer I, Greenberg-Dotan S, Batat E, Zisman D. The epidemiology of psoriatic arthritis in Israel - a population-based study. Arthritis Res Ther. 2018;20(1):3.","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"3339_CR8","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3899\/jrheum.210159","volume":"49","author":"A Haddad","year":"2022","unstructured":"Haddad A, Saliba W, Lavi I, Batheesh A, Kasem S, Gazitt T, et al. Causes of death in Psoriatic Arthritis. J Rheumatol. 2022;49(2):165\u201370.","journal-title":"J Rheumatol"},{"key":"3339_CR9","unstructured":"Eder L, Cohen AD, Feldhamer I, Greenberg-Dotan S, Batat E, Zisman D. Validity of diagnostic codes and point prevalence of psoriatic arthritis in Israel \u2013 a population-based study [abstract 1697]. Arthritis Rheumatol. 2016;68(Suppl 10)."},{"key":"3339_CR10","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1159\/000111512","volume":"216","author":"AD Cohen","year":"2008","unstructured":"Cohen AD, Sherf M, Vidavsky L, Vardy DA, Shapiro J, Meyerovitch J. Association between psoriasis and the metabolic syndrome: a cross-sectional study. Dermatology. 2008;216:152\u20135.","journal-title":"Dermatology"},{"key":"3339_CR11","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/s12939-014-0115-1","volume":"13","author":"D Filc","year":"2014","unstructured":"Filc D, Davidovich N, Novack L, Balicer RD. Is socioeconomic status associated with utilization of health care services in a single-payer universal health care system? Int J Equity Health. 2014;13:115. https:\/\/doi.org\/10.1186\/s12939-014-0115-1.","journal-title":"Int J Equity Health"},{"key":"3339_CR12","unstructured":"Statistical Abstract of Israel 2006. Israeli Central Bureau of Statistics. https:\/\/www.cbs.gov.il\/he\/publications\/pages\/2006  \u05d0\u05d5\u05db\u05dc\u05d5\u05e1\u05d9\u05d9\u05d4 - \u05e9\u05e0\u05ea\u05d5\u05df \u05e1\u05d8\u05d8\u05d9\u05e1\u05d8\u05d9 \u05dc\u05d9\u05e9\u05e8\u05d0\u05dc 2006 - \u05de\u05e1\u05e4\u05e8 57 (cbs.gov.il)."},{"key":"3339_CR13","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.jaad.2005.03.046","volume":"53","author":"JM Gelfand","year":"2005","unstructured":"Gelfand JM, Gladman DD, Mease PJ, Smith N, Margolis DJ, Nijsten T, et al. Epidemiology of psoriatic arthritis in the population of the United States. J Am Acad Dermatol. 2005;53:573.","journal-title":"J Am Acad Dermatol"},{"issue":"8","key":"3339_CR14","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1002\/acr.23743","volume":"71","author":"L Eder","year":"2019","unstructured":"Eder L, Widdifield J, Rosen CF, Cook R, Lee KA, et al. Trends in the prevalence and incidence of Psoriasis and Psoriatic Arthritis in Ontario, Canada: a Population-based study. Arthritis Care Res (Hoboken). 2019;71(8):1084\u201391.","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"3339_CR15","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1136\/ard.2010.141598","volume":"70","author":"E Haglund","year":"2011","unstructured":"Haglund E, Bremander AB, Petersson IF, Strombeck B, Bergman S, Jacobsson LT, et al. Prevalence of spondyloarthritis and its subtypes in southern Sweden. Ann Rheum Dis. 2011;70:943\u20138.","journal-title":"Ann Rheum Dis"},{"key":"3339_CR16","first-page":"1918","volume":"32","author":"TM Madland","year":"2005","unstructured":"Madland TM, Apalset EM, Johannessen AE, Rossebo B, Brun JG. Prevalence, disease manifestations, and treatment of psoriatic arthritis in Western Norway. J Rheumatol. 2005;32:1918\u201322.","journal-title":"J Rheumatol"},{"key":"3339_CR17","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1136\/annrheumdis-2013-203862","volume":"74","author":"M Hoff","year":"2015","unstructured":"Hoff M, Gulati AM, Romundstad PR, Kavanaugh A, Haugeberg G. Prevalence and incidence rates of psoriatic arthritis in central Norway: data from the Nord-Trondelag health study (HUNT). Ann Rheum Dis. 2015;74:60\u20134.","journal-title":"Ann Rheum Dis"},{"key":"3339_CR18","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1093\/rheumatology\/kes324","volume":"52","author":"A Ogdie","year":"2013","unstructured":"Ogdie A, Langan S, Love T, Haynes K, Shin D, Seminara N, et al. Prevalence and treatment patterns of psoriatic arthritis in the UK. Rheumatology (Oxford). 2013;52:568\u201375.","journal-title":"Rheumatology (Oxford)"},{"key":"3339_CR19","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1007\/s00296-010-1699-4","volume":"32","author":"N Cakir","year":"2012","unstructured":"Cakir N, Pamuk ON, Dervis E, Imeryuz N, Uslu H, Benian O, et al. The prevalences of some rheumatic diseases in western Turkey: Havsa study. Rheumatol Int. 2012;32:895\u2013908.","journal-title":"Rheumatol Int"},{"key":"3339_CR20","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s10067-005-1106-9","volume":"24","author":"P Trontzas","year":"2005","unstructured":"Trontzas P, Andrianakos A, Miyakis S, Pantelidou K, Vafiadou E, Garantziotou V, et al. Seronegative spondyloarthropathies in Greece: a population-based study of prevalence, clinical pattern, and management. ESORDIG Study Clin Rheumatol. 2005;24:583\u20139.","journal-title":"ESORDIG Study Clin Rheumatol"},{"key":"3339_CR21","first-page":"2641","volume":"30","author":"Y Alamanos","year":"2003","unstructured":"Alamanos Y, Papadopoulos NG, Voulgari PV, Siozos C, Psychos DN, Tympanidou M, et al. Epidemiology of psoriatic arthritis in northwest Greece, 1982\u20132001. J Rheumatol. 2003;30:2641\u20134.","journal-title":"J Rheumatol"},{"key":"3339_CR22","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.jaad.2018.06.027","volume":"80","author":"F Alinaghi","year":"2019","unstructured":"Alinaghi F, Calov M, Kristensen LE, Gladman DD, Coates LC, Jullien D. Prevalence of psoriatic arthritis in patients with psoriasis: a systematic review and meta-analysis of observational and clinical studies. J Am Acad Dermatol. 2019;80:251\u201365. e19.","journal-title":"J Am Acad Dermatol"},{"key":"3339_CR23","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1136\/annrheumdis-2016-210963","volume":"76","author":"A Egeberg","year":"2017","unstructured":"Egeberg A, Kristensen LE, Thyssen JP, Gislason GH, Gottlieb AB, Coates LC. Incidence and prevalence of psoriatic arthritis in Denmark: a nationwide register linkage study. Ann Rheum Dis. 2017;76:1591\u20137.","journal-title":"Ann Rheum Dis"},{"key":"3339_CR24","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.jdermsci.2016.08.535","volume":"84","author":"TS Wang","year":"2016","unstructured":"Wang TS, Hsieh CF, Tsai TF. Epidemiology of psoriatic disease and current treatment patterns from 2003 to 2013: a nationwide, population-based observational study in Taiwan. J Dermatol Sci. 2016;84:340\u20135. https:\/\/doi.org\/10.1016\/j.jdermsci.2016.08.535.","journal-title":"J Dermatol Sci"},{"key":"3339_CR25","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1111\/bjd.12230","volume":"168","author":"K Danielsen","year":"2013","unstructured":"Danielsen K, Olsen AO, Wilsgaard T, Furberg AS. Is the prevalence of psoriasis increasing? A 30-year follow-up of a population-based cohort. Br J Dermatol. 2013;168:1303\u201310. https:\/\/doi.org\/10.1111\/bjd.12230.","journal-title":"Br J Dermatol"},{"key":"3339_CR26","unstructured":"\u05e1\u05e7\u05e8 \u05d1\u05e8\u05d9\u05d0\u05d5\u05ea. \u05dc\u05d0\u05d5\u05de\u05d9 \u05d1\u05d9\u05e9\u05e8\u05d0\u05dc INHIS-4 2018\u20132020 (http:\/\/www.gov.il)."},{"key":"3339_CR27","unstructured":"inhis_2.pdf (health.gov.il)."},{"key":"3339_CR28","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1136\/annrheumdis-2017-211979","volume":"77","author":"P Sewerin","year":"2018","unstructured":"Sewerin P, Haase I, Schneider M, Ostendorf B, Brinks R. Incidence of psoriatic arthritis in Germany: analysis of claims data from 65 million people from 2009 to 2012. Ann Rheum Dis. 2018;77:1201.","journal-title":"Ann Rheum Dis"},{"key":"3339_CR29","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1136\/annrheumdis-2012-201299","volume":"71","author":"TJ Love","year":"2012","unstructured":"Love TJ, Zhu Y, Zhang Y, Wall-Burns L, Ogdie A, Gelfand JM, et al. Obesity and the risk of psoriatic arthritis: a population-based study. Ann Rheum Dis. 2012;71:1273\u20137. https:\/\/doi.org\/10.1136\/annrheumdis-2012-201299.","journal-title":"Ann Rheum Dis"},{"key":"3339_CR30","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1002\/acr.24121","volume":"73","author":"RS Thomsen","year":"2021","unstructured":"Thomsen RS, Nilsen TI, Haugeberg G, Gulati AM, Kavanaugh A, Hoff M. Adiposity and physical activity as risk factors for developing psoriatic arthritis. Longitudinal data from a population-based study in Norway. Arthritis Care Res. 2021;73:432\u201341.","journal-title":"Arthritis Care Res"},{"key":"3339_CR31","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1136\/ard.2010.147793","volume":"71","author":"L Eder","year":"2012","unstructured":"Eder L, Shanmugarajah S, Thavaneswaran A, Chandran V, Rosen CF, Cook RJ. The association between smoking and the development of psoriatic arthritis among psoriasis patients. Ann Rheum Dis. 2012;71:219\u201324.","journal-title":"Ann Rheum Dis"},{"key":"3339_CR32","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1136\/annrheumdis-2011-200416","volume":"71","author":"W Li","year":"2012","unstructured":"Li W, Han J, Qureshi AA. Smoking and risk of incident psoriatic arthritis in US women. Ann Rheum Dis. 2012;71:804\u20138.","journal-title":"Ann Rheum Dis"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-024-03339-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-024-03339-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-024-03339-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T01:04:02Z","timestamp":1716771842000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-024-03339-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,27]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3339"],"URL":"https:\/\/doi.org\/10.1186\/s13075-024-03339-0","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,27]]},"assertion":[{"value":"22 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the research ethics board of Carmel Medical Center. All data in this study were anonymous to the investigators; therefore, no consent was required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"108"}}