{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:48:17Z","timestamp":1793908097936,"version":"4.8.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Fonds National Suisse de la recherche scientifique, Switzerland","award":["310030_173134"],"award-info":[{"award-number":["310030_173134"]}]},{"name":"Fonds National Suisse de la recherche scientifique, Switzerland","award":["310030_173134"],"award-info":[{"award-number":["310030_173134"]}]},{"name":"Fonds National Suisse de la recherche scientifique, Switzerland","award":["310030_173134"],"award-info":[{"award-number":["310030_173134"]}]},{"name":"Fonds National Suisse de la recherche scientifique, Switzerland","award":["310030_173134"],"award-info":[{"award-number":["310030_173134"]}]},{"name":"Fonds National Suisse de la recherche scientifique, Switzerland","award":["310030_173134"],"award-info":[{"award-number":["310030_173134"]}]},{"name":"Fonds National Suisse de la recherche scientifique, Switzerland","award":["310030_173134"],"award-info":[{"award-number":["310030_173134"]}]},{"name":"Fonds National Suisse de la recherche scientifique, Switzerland","award":["310030_173134"],"award-info":[{"award-number":["310030_173134"]}]},{"name":"Fonds National Suisse de la recherche scientifique, Switzerland","award":["310030_173134"],"award-info":[{"award-number":["310030_173134"]}]},{"name":"Fonds National Suisse de la recherche scientifique, Switzerland","award":["310030_173134"],"award-info":[{"award-number":["310030_173134"]}]},{"name":"Fonds National Suisse de la recherche scientifique, Switzerland","award":["310030_173134"],"award-info":[{"award-number":["310030_173134"]}]},{"name":"Fonds National Suisse de la recherche scientifique, Switzerland","award":["310030_173134"],"award-info":[{"award-number":["310030_173134"]}]},{"name":"Fonds National Suisse de la recherche scientifique, Switzerland","award":["310030_173134"],"award-info":[{"award-number":["310030_173134"]}]},{"name":"Fonds National Suisse de la recherche scientifique, Switzerland","award":["310030_173134"],"award-info":[{"award-number":["310030_173134"]}]},{"DOI":"10.13039\/501100006390","name":"University of Lausanne","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006390","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>In gout, monosodium urate crystals are taken up by macrophages, triggering the activation of the NLRP3 inflammasome and the maturation of IL-1\u03b2. This study aimed to investigate the role of integrin CD11b in inflammasome activation in macrophages stimulated by MSU.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>BMDM from WT and CD11b KO mice were stimulated in vitro with MSU crystals. Cellular supernatants were collected to assess the expression of the inflammatory cytokines by enzyme-linked immunosorbent assay and western blot methods. The role of integrin CD11b in MSU-induced gouty arthritis in vivo was investigated by intra-articular injection of MSU crystals. Real-time extracellular acidification rate and oxygen consumption rate of BMDMs were measured by Seahorse Extracellular Flux Analyzer.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We demonstrate that CD11b-deficient mice developed exacerbated gouty arthritis with increased recruitment of leukocytes in the joint and higher IL-1\u03b2 levels in the sera. In macrophages, genetic deletion of CD11b induced a shift of macrophage metabolism from oxidative phosphorylation to glycolysis, thus decreasing the overall generation of intracellular ATP. Upon MSU stimulation, CD11b-deficient macrophages showed an exacerbated secretion of IL-1\u03b2. Treating wild-type macrophages with a CD11b agonist, LA1, inhibited MSU-induced release of IL-1\u03b2 <jats:italic>in vitro<\/jats:italic> and\u00a0attenuated the severity of experimental gouty arthritis. Importantly, LA1, was also effective in human cells as it inhibited MSU-induced release of IL-1\u03b2 by peripheral blood mononuclear cells from healthy donors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our data identified the CD11b integrin as a principal cell membrane receptor that modulates NLRP3 inflammasome activation by MSU crystal in macrophages, which could be a potential therapeutic target to treat gouty arthritis in human patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13075-024-03350-5","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T07:02:37Z","timestamp":1718089357000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The integrin CD11b inhibits MSU-induced NLRP3 inflammasome activation in macrophages and protects mice against MSU-induced joint inflammation"],"prefix":"10.1186","volume":"26","author":[{"given":"Driss","family":"Ehirchiou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Bernabei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnuprabu Durairaj","family":"Pandian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Nasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Chobaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariela","family":"Castelblanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"So","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Martinon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Acha-Orbea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hugle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Busso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"issue":"11","key":"3350_CR1","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/nrrheum.2017.155","volume":"13","author":"AK So","year":"2017","unstructured":"So AK, Martinon F. Inflammation in gout: mechanisms and therapeutic targets. Nat Rev Rheumatol. 2017;13(11):639\u201347.","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"3350_CR2","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41572-019-0115-y","volume":"5","author":"N Dalbeth","year":"2019","unstructured":"Dalbeth N, et al. Gout Nat Rev Dis Primers. 2019;5(1):69.","journal-title":"Gout. Nat Rev Dis Primers"},{"issue":"4","key":"3350_CR3","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.rdc.2019.08.001","volume":"45","author":"F Perez-Ruiz","year":"2019","unstructured":"Perez-Ruiz F, Dalbeth N. Gout. Rheum Dis Clin North Am. 2019;45(4):583\u201391.","journal-title":"Rheum Dis Clin North Am"},{"issue":"Suppl 1","key":"3350_CR4","doi-asserted-by":"publisher","first-page":"S43","DOI":"10.2119\/molmed.2014.00232","volume":"20","author":"CA Dinarello","year":"2014","unstructured":"Dinarello CA. An expanding role for interleukin-1 blockade from gout to cancer. Mol Med. 2014;20(Suppl 1):S43-58.","journal-title":"Mol Med"},{"issue":"11","key":"3350_CR5","doi-asserted-by":"publisher","first-page":"3237","DOI":"10.1002\/art.27667","volume":"62","author":"LA Joosten","year":"2010","unstructured":"Joosten LA, et al. Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1beta production via the ASC\/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis. Arthritis Rheum. 2010;62(11):3237\u201348.","journal-title":"Arthritis Rheum"},{"issue":"7081","key":"3350_CR6","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nature04516","volume":"440","author":"F Martinon","year":"2006","unstructured":"Martinon F, et al. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006;440(7081):237\u201341.","journal-title":"Nature"},{"issue":"5","key":"3350_CR7","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","volume":"157","author":"M Lamkanfi","year":"2014","unstructured":"Lamkanfi M, Dixit VM. Mechanisms and functions of inflammasomes. Cell. 2014;157(5):1013\u201322.","journal-title":"Cell"},{"issue":"2","key":"3350_CR8","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/cmi.2015.95","volume":"13","author":"EK Jo","year":"2016","unstructured":"Jo EK, et al. Molecular mechanisms regulating NLRP3 inflammasome activation. Cell Mol Immunol. 2016;13(2):148\u201359.","journal-title":"Cell Mol Immunol"},{"issue":"7","key":"3350_CR9","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nri.2016.58","volume":"16","author":"P Broz","year":"2016","unstructured":"Broz P, Dixit VM. Inflammasomes: mechanism of assembly, regulation and signalling. Nat Rev Immunol. 2016;16(7):407\u201320.","journal-title":"Nat Rev Immunol"},{"issue":"9","key":"3350_CR10","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/nrd.2018.149","volume":"17","author":"MSJ Mangan","year":"2018","unstructured":"Mangan MSJ, et al. Targeting the NLRP3 inflammasome in inflammatory diseases. Nat Rev Drug Discov. 2018;17(9):688.","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"3350_CR11","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/imr.12608","volume":"281","author":"MM Hughes","year":"2018","unstructured":"Hughes MM, O\u2019Neill LAJ. Metabolic regulation of NLRP3. Immunol Rev. 2018;281(1):88\u201398.","journal-title":"Immunol Rev"},{"key":"3350_CR12","doi-asserted-by":"publisher","first-page":"6555","DOI":"10.1038\/ncomms7555","volume":"6","author":"A Ives","year":"2015","unstructured":"Ives A, et al. Xanthine oxidoreductase regulates macrophage IL1beta secretion upon NLRP3 inflammasome activation. Nat Commun. 2015;6:6555.","journal-title":"Nat Commun"},{"key":"3350_CR13","first-page":"420","volume":"5","author":"S Galvan-Pena","year":"2014","unstructured":"Galvan-Pena S, O\u2019Neill LA. Metabolic reprograming in macrophage polarization. Front Immunol. 2014;5:420.","journal-title":"Front Immunol"},{"issue":"1","key":"3350_CR14","doi-asserted-by":"publisher","first-page":"4034","DOI":"10.1038\/s41598-019-40619-1","volume":"9","author":"OM Finucane","year":"2019","unstructured":"Finucane OM, et al. The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1beta-dependent manner in macrophages. Sci Rep. 2019;9(1):4034.","journal-title":"Sci Rep"},{"key":"3350_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.662164","volume":"12","author":"C Lamers","year":"2021","unstructured":"Lamers C, Pluss CJ, Ricklin D. The Promiscuous Profile of Complement Receptor 3 in Ligand Binding, Immune Modulation, and Pathophysiology. Front Immunol. 2021;12: 662164.","journal-title":"Front Immunol"},{"issue":"1","key":"3350_CR16","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1111\/imr.12373","volume":"269","author":"F Rosetti","year":"2016","unstructured":"Rosetti F, Mayadas TN. The many faces of Mac-1 in autoimmune disease. Immunol Rev. 2016;269(1):175\u201393.","journal-title":"Immunol Rev"},{"issue":"5","key":"3350_CR17","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/nrn.2018.13","volume":"19","author":"MA Petersen","year":"2018","unstructured":"Petersen MA, Ryu JK, Akassoglou K. Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics. Nat Rev Neurosci. 2018;19(5):283\u2013301.","journal-title":"Nat Rev Neurosci"},{"issue":"7","key":"3350_CR18","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1038\/s41590-023-01522-0","volume":"24","author":"AS Mendiola","year":"2023","unstructured":"Mendiola AS, et al. Defining blood-induced microglia functions in neurodegeneration through multiomic profiling. Nat Immunol. 2023;24(7):1173\u201387.","journal-title":"Nat Immunol"},{"key":"3350_CR19","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.3389\/fimmu.2017.01866","volume":"8","author":"L Schittenhelm","year":"2017","unstructured":"Schittenhelm L, Hilkens CM, Morrison VL. beta(2) Integrins As Regulators of Dendritic Cell, Monocyte, and Macrophage Function. Front Immunol. 2017;8:1866.","journal-title":"Front Immunol"},{"issue":"2","key":"3350_CR20","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1182\/blood-2005-12-023044","volume":"109","author":"G Varga","year":"2007","unstructured":"Varga G, et al. Active MAC-1 (CD11b\/CD18) on DCs inhibits full T-cell activation. Blood. 2007;109(2):661\u20139.","journal-title":"Blood"},{"issue":"3","key":"3350_CR21","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1182\/blood-2005-12-4812","volume":"108","author":"M Skoberne","year":"2006","unstructured":"Skoberne M, et al. The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function. Blood. 2006;108(3):947\u201355.","journal-title":"Blood"},{"issue":"8","key":"3350_CR22","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1038\/ni.1908","volume":"11","author":"C Han","year":"2010","unstructured":"Han C, et al. Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b. Nat Immunol. 2010;11(8):734\u201342.","journal-title":"Nat Immunol"},{"issue":"7","key":"3350_CR23","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1084\/jem.20062292","volume":"204","author":"D Ehirchiou","year":"2007","unstructured":"Ehirchiou D, et al. CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation. J Exp Med. 2007;204(7):1519\u201324.","journal-title":"J Exp Med"},{"key":"3350_CR24","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1038\/ncomms3813","volume":"4","author":"C Ding","year":"2013","unstructured":"Ding C, et al. Integrin CD11b negatively regulates BCR signalling to maintain autoreactive B cell tolerance. Nat Commun. 2013;4:2813.","journal-title":"Nat Commun"},{"issue":"9","key":"3350_CR25","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1056\/NEJMoa0707865","volume":"358","author":"G Hom","year":"2008","unstructured":"Hom G, et al. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med. 2008;358(9):900\u20139.","journal-title":"N Engl J Med"},{"issue":"2","key":"3350_CR26","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/ng.71","volume":"40","author":"SK Nath","year":"2008","unstructured":"Nath SK, et al. A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus. Nat Genet. 2008;40(2):152\u20134.","journal-title":"Nat Genet"},{"issue":"11","key":"3350_CR27","doi-asserted-by":"publisher","first-page":"2907","DOI":"10.1002\/art.38117","volume":"65","author":"Y Zhou","year":"2013","unstructured":"Zhou Y, et al. Multiple lupus-associated ITGAM variants alter Mac-1 functions on neutrophils. Arthritis Rheum. 2013;65(11):2907\u201316.","journal-title":"Arthritis Rheum"},{"issue":"3","key":"3350_CR28","doi-asserted-by":"publisher","first-page":"e92051","DOI":"10.1371\/journal.pone.0092051","volume":"9","author":"LD Chaves","year":"2014","unstructured":"Chaves LD, et al. Loss of CD11b exacerbates murine complement-mediated tubulointerstitial nephritis. PLoS One. 2014;9(3):e92051.","journal-title":"PLoS One"},{"issue":"4","key":"3350_CR29","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1002\/eji.201646565","volume":"47","author":"M Stevanin","year":"2017","unstructured":"Stevanin M, et al. CD11b regulates the Treg\/Th17 balance in murine arthritis via IL-6. Eur J Immunol. 2017;47(4):637\u201345.","journal-title":"Eur J Immunol"},{"issue":"7","key":"3350_CR30","doi-asserted-by":"publisher","first-page":"3714","DOI":"10.4049\/jimmunol.1201594","volume":"189","author":"F Rosetti","year":"2012","unstructured":"Rosetti F, et al. Human lupus serum induces neutrophil-mediated organ damage in mice that is enabled by Mac-1 deficiency. J Immunol. 2012;189(7):3714\u201323.","journal-title":"J Immunol"},{"issue":"499","key":"3350_CR31","doi-asserted-by":"publisher","first-page":"eaau9240","DOI":"10.1126\/scitranslmed.aau9240","volume":"11","author":"RZ Panni","year":"2019","unstructured":"Panni RZ, et al. Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies. Sci Transl Med. 2019;11(499):eaau9240.","journal-title":"Sci Transl Med"},{"issue":"189","key":"3350_CR32","doi-asserted-by":"publisher","first-page":"ra57","DOI":"10.1126\/scisignal.2001811","volume":"4","author":"D Maiguel","year":"2011","unstructured":"Maiguel D, et al. Small molecule-mediated activation of the integrin CD11b\/CD18 reduces inflammatory disease. Sci Signal. 2011;4(189):ra57.","journal-title":"Sci Signal"},{"issue":"6","key":"3350_CR33","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1165\/rcmb.2014-0422OC","volume":"53","author":"J Jagarapu","year":"2015","unstructured":"Jagarapu J, et al. Efficacy of Leukadherin-1 in the Prevention of Hyperoxia-Induced Lung Injury in Neonatal Rats. Am J Respir Cell Mol Biol. 2015;53(6):793\u2013801.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"6","key":"3350_CR34","doi-asserted-by":"publisher","first-page":"3696","DOI":"10.1016\/j.bbagen.2013.02.018","volume":"1830","author":"MH Faridi","year":"2013","unstructured":"Faridi MH, et al. Small molecule agonists of integrin CD11b\/CD18 do not induce global conformational changes and are significantly better than activating antibodies in reducing vascular injury. Biochim Biophys Acta. 2013;1830(6):3696\u2013710.","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"3350_CR35","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/s13075-018-1664-2","volume":"20","author":"C Marchetti","year":"2018","unstructured":"Marchetti C, et al. NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis. Arthritis Res Ther. 2018;20(1):169.","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"3350_CR36","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1084\/jem.20162011","volume":"214","author":"E Czirr","year":"2017","unstructured":"Czirr E, et al. Microglial complement receptor 3 regulates brain Abeta levels through secreted proteolytic activity. J Exp Med. 2017;214(4):1081\u201392.","journal-title":"J Exp Med"},{"issue":"8","key":"3350_CR37","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1038\/nmeth.3047","volume":"11","author":"NE Sanjana","year":"2014","unstructured":"Sanjana NE, Shalem O, Zhang F. Improved vectors and genome-wide libraries for CRISPR screening. Nat Methods. 2014;11(8):783\u20134.","journal-title":"Nat Methods"},{"issue":"6166","key":"3350_CR38","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1126\/science.1247005","volume":"343","author":"O Shalem","year":"2014","unstructured":"Shalem O, et al. Genome-scale CRISPR-Cas9 knockout screening in human cells. Science. 2014;343(6166):84\u20137.","journal-title":"Science"},{"key":"3350_CR39","doi-asserted-by":"publisher","first-page":"7074","DOI":"10.1021\/ac201267k","volume":"83","author":"T Fuhrer","year":"2011","unstructured":"Fuhrer T, et al. High-Throughput, Accurate Mass Metabolome Profiling of Cellular Extracts by Flow Injection - Time-of-Flight Mass Spectrometry. Analytical chemistry. 2011;83:7074\u201380.","journal-title":"Analytical chemistry"},{"issue":"7","key":"3350_CR40","doi-asserted-by":"publisher","first-page":"683","DOI":"10.2217\/14622416.8.7.683","volume":"8","author":"DS Wishart","year":"2007","unstructured":"Wishart DS. Human Metabolome Database: completing the \u201chuman parts list.\u201d Pharmacogenomics. 2007;8(7):683\u20136.","journal-title":"Pharmacogenomics"},{"issue":"1","key":"3350_CR41","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000;28(1):27\u201330.","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"3350_CR42","doi-asserted-by":"publisher","first-page":"5718","DOI":"10.4049\/jimmunol.1402512","volume":"195","author":"J Nomura","year":"2015","unstructured":"Nomura J, et al. Intracellular ATP Decrease Mediates NLRP3 Inflammasome Activation upon Nigericin and Crystal Stimulation. J Immunol. 2015;195(12):5718\u201324.","journal-title":"J Immunol"},{"key":"3350_CR43","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.611757","volume":"8","author":"D Ehirchiou","year":"2020","unstructured":"Ehirchiou D, et al. CD11b Signaling Prevents Chondrocyte Mineralization and Attenuates the Severity of Osteoarthritis. Front Cell Dev Biol. 2020;8: 611757.","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"3350_CR44","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1096\/fasebj.12.2.209","volume":"12","author":"F Barabe","year":"1998","unstructured":"Barabe F, et al. Crystal-induced neutrophil activation VI. Involvment of FcgammaRIIIB (CD16) and CD11b in response to inflammatory microcrystals. FASEB J. 1998;12(2):209\u201320.","journal-title":"FASEB J"},{"issue":"7444","key":"3350_CR45","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nature11986","volume":"496","author":"GM Tannahill","year":"2013","unstructured":"Tannahill GM, et al. Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha. Nature. 2013;496(7444):238\u201342.","journal-title":"Nature"},{"issue":"11","key":"3350_CR46","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1136\/annrheumdis-2020-217342","volume":"79","author":"F Renaudin","year":"2020","unstructured":"Renaudin F, et al. Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1beta activation on macrophages. Ann Rheum Dis. 2020;79(11):1506\u201314.","journal-title":"Ann Rheum Dis"},{"key":"3350_CR47","doi-asserted-by":"publisher","first-page":"2927","DOI":"10.3389\/fimmu.2019.02927","volume":"10","author":"R Correa","year":"2019","unstructured":"Correa R, et al. Lysophosphatidylcholine Induces NLRP3 Inflammasome-Mediated Foam Cell Formation and Pyroptosis in Human Monocytes and Endothelial Cells. Front Immunol. 2019;10:2927.","journal-title":"Front Immunol"},{"issue":"4","key":"3350_CR48","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1161\/ATVBAHA.117.310581","volume":"38","author":"T Karasawa","year":"2018","unstructured":"Karasawa T, et al. Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages. Arterioscler Thromb Vasc Biol. 2018;38(4):744\u201356.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"8","key":"3350_CR49","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.it.2011.05.004","volume":"32","author":"D De Nardo","year":"2011","unstructured":"De Nardo D, Latz E. NLRP3 inflammasomes link inflammation and metabolic disease. Trends Immunol. 2011;32(8):373\u20139.","journal-title":"Trends Immunol"},{"key":"3350_CR50","doi-asserted-by":"publisher","first-page":"561","DOI":"10.3389\/fimmu.2018.00561","volume":"9","author":"KV Hoang","year":"2018","unstructured":"Hoang KV, et al. Complement Receptor 3-Mediated Inhibition of Inflammasome Priming by Ras GTPase-Activating Protein During Francisella tularensis Phagocytosis by Human Mononuclear Phagocytes. Front Immunol. 2018;9:561.","journal-title":"Front Immunol"},{"issue":"2","key":"3350_CR51","doi-asserted-by":"publisher","first-page":"e13","DOI":"10.4110\/in.2021.21.e13","volume":"21","author":"H Sim","year":"2021","unstructured":"Sim H, et al. CD11b Deficiency Exacerbates Methicillin-Resistant Staphylococcus aureus-Induced Sepsis by Upregulating Inflammatory Responses of Macrophages. Immune Netw. 2021;21(2):e13.","journal-title":"Immune Netw"},{"issue":"5","key":"3350_CR52","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1007\/s11064-020-02984-6","volume":"45","author":"XF Cai","year":"2020","unstructured":"Cai XF, et al. Integrin CD11b Deficiency Aggravates Retinal Microglial Activation and RGCs Degeneration After Acute Optic Nerve Injury. Neurochem Res. 2020;45(5):1072\u201385.","journal-title":"Neurochem Res"},{"issue":"5","key":"3350_CR53","first-page":"2519","volume":"193","author":"S Ganesan","year":"2014","unstructured":"Ganesan S, et al. Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1beta production in response to beta-glucans and the fungal pathogen. Candida albicans J Immunol. 2014;193(5):2519\u201330.","journal-title":"Candida albicans. J Immunol"},{"issue":"1","key":"3350_CR54","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s12974-020-01823-3","volume":"17","author":"L Hou","year":"2020","unstructured":"Hou L, et al. Integrin CD11b mediates locus coeruleus noradrenergic neurodegeneration in a mouse Parkinson\u2019s disease model. J Neuroinflammation. 2020;17(1):148.","journal-title":"J Neuroinflammation"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-024-03350-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-024-03350-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-024-03350-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T08:10:14Z","timestamp":1718093414000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-024-03350-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,11]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3350"],"URL":"https:\/\/doi.org\/10.1186\/s13075-024-03350-5","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,11]]},"assertion":[{"value":"5 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Experiments on mice were performed in strict accordance to the Swiss Federal Regulations. The protocol was approved by the \u201cService de la consommation et des affaires v\u00e9t\u00e9rinaires du Canton de Vaud,\u201d Switzerland. All efforts were made to minimize suffering and minimize the number of mice needed to assess statistical significance and experimental reproducibility.Human samples were obtained with the approval of the Centre Hospitalier Universitaire Vaudois ethical committee and patients\u2019 written informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"119"}}