{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:39:40Z","timestamp":1792096780845,"version":"4.4.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"DOI":"10.1186\/s13075-024-03409-3","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T06:01:51Z","timestamp":1728540111000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Changes and associations between synovial fluid and magnetic resonance imaging markers of osteoarthritis after high tibial osteotomy"],"prefix":"10.1186","volume":"26","author":[{"given":"Jenna M.","family":"Schulz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor B.","family":"Birmingham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly T.","family":"Philpott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Thomas","family":"Appleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayden F.","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Robert","family":"Giffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Beier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"3409_CR1","first-page":"15","volume":"4","author":"AY Hui","year":"2012","unstructured":"Hui AY, McCarty WJ, Masuda K, et al. A systems biology approach to synovial joint lubrication in health, injury, and disease. Wiley Interdiscip Rev: Syst Biol Med. 2012;4:15\u201337.","journal-title":"Wiley Interdiscip Rev: Syst Biol Med"},{"key":"3409_CR2","doi-asserted-by":"publisher","unstructured":"Mathiessen A, Conaghan PG. Synovitis in osteoarthritis: Current understanding with therapeutic implications. Arthritis Research and Therapy; 19. Epub ahead of print 2 February 2017. https:\/\/doi.org\/10.1186\/s13075-017-1229-9.","DOI":"10.1186\/s13075-017-1229-9"},{"key":"3409_CR3","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.rdc.2004.04.002","volume":"30","author":"T Aigner","year":"2004","unstructured":"Aigner T, Kim HA, Roach HI. Apoptosis in osteoarthritis. Rheum Dis Clin North Am. 2004;30:639\u201353.","journal-title":"Rheum Dis Clin North Am"},{"key":"3409_CR4","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.joca.2012.11.012","volume":"21","author":"F Berenbaum","year":"2013","unstructured":"Berenbaum F. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthritis Cartilage. 2013;21:16\u201321.","journal-title":"Osteoarthritis Cartilage"},{"key":"3409_CR5","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/nrrheum.2010.159","volume":"6","author":"J Sellam","year":"2010","unstructured":"Sellam J, Berenbaum F. The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat Rev Rheumatol. 2010;6:625\u201335.","journal-title":"Nat Rev Rheumatol"},{"key":"3409_CR6","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.joca.2012.09.012","volume":"21","author":"DT Felson","year":"2013","unstructured":"Felson DT. Osteoarthritis as a disease of mechanics. Osteoarthritis Cartilage. 2013;21:10\u20135.","journal-title":"Osteoarthritis Cartilage"},{"key":"3409_CR7","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/j.berh.2011.11.013","volume":"25","author":"F Guilak","year":"2011","unstructured":"Guilak F. Biomechanical factors in osteoarthritis. Best Pract Res Clin Rheumatol. 2011;25:815\u201323.","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"3409_CR8","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.joca.2021.10.013","volume":"30","author":"HT Philpott","year":"2022","unstructured":"Philpott HT, Carter MM, Birmingham TB, et al. Synovial tissue perivascular edema is associated with altered gait patterns in patients with knee osteoarthritis. Osteoarthritis Cartilage. 2022;30:42\u201351.","journal-title":"Osteoarthritis Cartilage"},{"key":"3409_CR9","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.joca.2020.11.007","volume":"29","author":"HF Atkinson","year":"2021","unstructured":"Atkinson HF, Birmingham TB, Primeau CA, et al. Association between changes in knee load and effusion-synovitis: evidence of mechano-inflammation in knee osteoarthritis using high tibial osteotomy as a model. Osteoarthritis Cartilage. 2021;29:222\u20139.","journal-title":"Osteoarthritis Cartilage"},{"key":"3409_CR10","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1007\/s00167-021-06516-9","volume":"30","author":"HF Atkinson","year":"2022","unstructured":"Atkinson HF, Birmingham TB, Schulz JM, et al. High tibial osteotomy to neutral alignment improves medial knee articular cartilage composition. Knee Surg Sports Traumatol Arthrosc. 2022;30:1065\u201374.","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"3409_CR11","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1002\/acr.23096","volume":"69","author":"R Moyer","year":"2017","unstructured":"Moyer R, Wirth W, Eckstein F. Longitudinal changes in magnetic resonance imaging-based measures of femorotibial cartilage thickness as a function of alignment and obesity: data from the osteoarthritis initiative. Arthritis Care Res (Hoboken). 2017;69:959\u201365.","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"3409_CR12","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.joca.2019.12.005","volume":"28","author":"FE Watt","year":"2020","unstructured":"Watt FE, Hamid B, Garriga C, et al. The molecular profile of synovial fluid changes upon joint distraction and is associated with clinical response in knee osteoarthritis. Osteoarthritis Cartilage. 2020;28:324\u201333.","journal-title":"Osteoarthritis Cartilage"},{"key":"3409_CR13","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1016\/j.joca.2021.03.013","volume":"29","author":"K Kumagai","year":"2021","unstructured":"Kumagai K, Fujimaki H, Yamada S, et al. Changes of synovial fluid biomarker levels after opening wedge high tibial osteotomy in patients with knee osteoarthritis. Osteoarthritis Cartilage. 2021;29:1020\u20138.","journal-title":"Osteoarthritis Cartilage"},{"key":"3409_CR14","doi-asserted-by":"publisher","first-page":"10868","DOI":"10.1038\/s41598-020-67730-y","volume":"10","author":"C-H Chou","year":"2020","unstructured":"Chou C-H, Jain V, Gibson J, et al. Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis. Sci Rep. 2020;10:10868.","journal-title":"Sci Rep"},{"key":"3409_CR15","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1016\/j.joca.2017.08.017","volume":"25","author":"TB Birmingham","year":"2017","unstructured":"Birmingham TB, Moyer R, Leitch K, et al. Changes in biomechanical risk factors for knee osteoarthritis and their association with 5-year clinically important improvement after limb realignment surgery. Osteoarthritis Cartilage. 2017;25:1999\u20132006.","journal-title":"Osteoarthritis Cartilage"},{"key":"3409_CR16","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1002\/jor.25403","volume":"41","author":"E De Pieri","year":"2023","unstructured":"De Pieri E, N\u00fcesch C, Pagenstert G, et al. High tibial osteotomy effectively redistributes compressive knee loads during walking. J Orthop Res\u00ae. 2023;41:591\u2013600.","journal-title":"J Orthop Res\u00ae"},{"key":"3409_CR17","unstructured":"Hulley S, Cummings S, Browner W, et al. Designing clinical research: an epidemiological approach. Philadephia, USA: Lippincott Williams & Wilkins; 2013, p. 79."},{"key":"3409_CR18","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1002\/art.1780290816","volume":"29","author":"R Altman","year":"1986","unstructured":"Altman R, Asch E, Bloch D, et al. Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee. Arthritis Rheum. 1986;29:1039\u201349.","journal-title":"Arthritis Rheum"},{"key":"3409_CR19","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1136\/ard.16.4.494","volume":"16","author":"JH Kellgren","year":"1957","unstructured":"Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957;16:494\u2013502.","journal-title":"Ann Rheum Dis"},{"issue":"Suppl A","key":"3409_CR20","doi-asserted-by":"publisher","first-page":"A1","DOI":"10.1016\/j.joca.2006.11.009","volume":"15","author":"RD Altman","year":"2007","unstructured":"Altman RD, Gold GE. Atlas of individual radiographic features in osteoarthritis, revised. Osteoarthritis Cartilage. 2007;15(Suppl A):A1\u201356.","journal-title":"Osteoarthritis Cartilage"},{"key":"3409_CR21","doi-asserted-by":"publisher","first-page":"88","DOI":"10.2519\/jospt.1998.28.2.88","volume":"28","author":"EM Roos","year":"1998","unstructured":"Roos EM, Roos HP, Lohmander LS, et al. Knee Injury and Osteoarthritis Outcome Score (KOOS)\u2013development of a self-administered outcome measure. J Orthop Sports Phys Ther. 1998;28:88\u201396.","journal-title":"J Orthop Sports Phys Ther"},{"key":"3409_CR22","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1503\/cmaj.200934","volume":"1","author":"CA Primeau","year":"2021","unstructured":"Primeau CA, Birmingham TB, Leitch KM, et al. Total knee replacement after high tibial osteotomy: time-to-event analysis and predictors. CMAJ. 2021;1:158\u201366.","journal-title":"CMAJ"},{"key":"3409_CR23","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1007\/s10334-019-00766-y","volume":"32","author":"R Moyer","year":"2019","unstructured":"Moyer R, Birmingham T, Eckstein F, et al. Validation of a novel blinding method for measuring postoperative knee articular cartilage using magnetic resonance imaging. Magn Reson Mater Phys, Biol Med. 2019;32:693\u2013702.","journal-title":"Magn Reson Mater Phys, Biol Med"},{"key":"3409_CR24","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/j.mri.2012.05.001","volume":"30","author":"A Fedorov","year":"2012","unstructured":"Fedorov A, Beichel R, Kalpathy-Cramer J, et al. 3D Slicer as an image computing platform for the Quantitative Imaging Network. Magn Reson Imaging. 2012;30:1323\u201341.","journal-title":"Magn Reson Imaging"},{"key":"3409_CR25","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1109\/TMI.2007.907323","volume":"27","author":"W Wirth","year":"2008","unstructured":"Wirth W, Eckstein F. A technique for regional analysis of femorotibial cartilage thickness based on quantitative magnetic resonance imaging. IEEE Trans Med Imaging. 2008;27:737\u201344.","journal-title":"IEEE Trans Med Imaging"},{"key":"3409_CR26","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1097\/00005650-199007000-00008","volume":"28","author":"MH Liang","year":"1990","unstructured":"Liang MH, Fossel AH, Larson MG. Comparisons of five health status instruments for orthopedic evaluation. Med Care. 1990;28:632\u201342.","journal-title":"Med Care"},{"key":"3409_CR27","volume-title":"Statistical power analysis for behavioural sciences","author":"J Cohen","year":"1988","unstructured":"Cohen J. Statistical power analysis for behavioural sciences. 2nd ed. Hillsdale NJ: Lawrence Earbaum Assoicates; 1988.","edition":"2"},{"key":"3409_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12864-016-2888-7","volume":"17","author":"TK Rausch","year":"2016","unstructured":"Rausch TK, Schillert A, Ziegler A, et al. Comparison of pre-processing methods for multiplex bead-based immunoassays. BMC Genomics. 2016;17:1\u201310.","journal-title":"BMC Genomics"},{"key":"3409_CR29","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005;102:15545\u201350.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3409_CR30","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/ng1180","volume":"34","author":"VK Mootha","year":"2003","unstructured":"Mootha VK, Lindgren CM, Eriksson K-F, et al. PGC-1\u03b1-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 2003;34:267\u201373.","journal-title":"Nat Genet"},{"key":"3409_CR31","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1002\/pmic.200900412","volume":"10","author":"R Isserlin","year":"2010","unstructured":"Isserlin R, Merico D, Alikhani-Koupaei R, et al. Pathway analysis of dilated cardiomyopathy using global proteomic profiling and enrichment maps. Proteomics. 2010;10:1316\u201327.","journal-title":"Proteomics"},{"key":"3409_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v067.i01","volume":"67","author":"D Bates","year":"2015","unstructured":"Bates D, M\u00e4chler M, Bolker B, et al. Fitting Linear Mixed-Effects Models Using lme4. J Stat Softw. 2015;67:1\u201348.","journal-title":"J Stat Softw"},{"key":"3409_CR33","doi-asserted-by":"publisher","unstructured":"Chen Q, Jin M, Yang F, et al. Matrix metalloproteinases: Inflammatory regulators of cell behaviors in vascular formation and remodeling. Mediators Inflamm; 2013. Epub ahead of print 2013. https:\/\/doi.org\/10.1155\/2013\/928315.","DOI":"10.1155\/2013\/928315"},{"key":"3409_CR34","doi-asserted-by":"publisher","first-page":"2732","DOI":"10.1002\/art.30451","volume":"63","author":"JH Ryu","year":"2011","unstructured":"Ryu JH, Yang S, Shin Y, et al. Interleukin-6 plays an essential role in hypoxia-inducible factor 2\u03b1-induced experimental osteoarthritic cartilage destruction in mice. Arthritis Rheum. 2011;63:2732\u201343.","journal-title":"Arthritis Rheum"},{"key":"3409_CR35","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1136\/annrheumdis-2016-209757","volume":"76","author":"A Latourte","year":"2017","unstructured":"Latourte A, Cherifi C, Maillet J, et al. Systemic inhibition of IL-6\/Stat3 signalling protects against experimental osteoarthritis. Ann Rheum Dis. 2017;76:748\u201355.","journal-title":"Ann Rheum Dis"},{"key":"3409_CR36","doi-asserted-by":"publisher","first-page":"R60","DOI":"10.1186\/ar4233","volume":"15","author":"JB Shepard","year":"2013","unstructured":"Shepard JB, Jeong JW, Maihle NJ, et al. Transient anabolic effects accompany epidermal growth factor receptor signal activation in articular cartilage in vivo. Arthritis Res Ther. 2013;15:R60.","journal-title":"Arthritis Res Ther"},{"key":"3409_CR37","doi-asserted-by":"publisher","unstructured":"Qin L, Beier F. EGFR signaling: friend or foe for cartilage? JBMR Plus; 3. Epub ahead of print 1 February 2019. https:\/\/doi.org\/10.1002\/jbm4.10177.","DOI":"10.1002\/jbm4.10177"},{"key":"3409_CR38","doi-asserted-by":"publisher","first-page":"509","DOI":"10.7326\/M20-0527","volume":"173","author":"M Schieker","year":"2020","unstructured":"Schieker M, Conaghan PG, Mindeholm L, et al. Effects of interleukin-1\u03b2 inhibition on incident hip and knee replacement\u202f: exploratory analyses from a randomized, double-blind. Placebo-Controlled Trial Ann Intern Med. 2020;173:509\u201315.","journal-title":"Placebo-Controlled Trial Ann Intern Med"},{"key":"3409_CR39","doi-asserted-by":"publisher","first-page":"S36","DOI":"10.1016\/j.semarthrit.2019.09.018","volume":"49","author":"TL Vincent","year":"2019","unstructured":"Vincent TL. Mechanoflammation in osteoarthritis pathogenesis. Semin Arthritis Rheum. 2019;49:S36\u20138.","journal-title":"Semin Arthritis Rheum"},{"key":"3409_CR40","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1080\/08941939.2021.1931576","volume":"35","author":"B Zhao","year":"2021","unstructured":"Zhao B, Xiao Q, Liu B. Effects of high tibial osteotomy combined with arthroscopy on pain and inflammation markers in patients with medial knee osteoarthritis. J Invest Surg. 2021;35:891\u20137.","journal-title":"J Invest Surg"},{"key":"3409_CR41","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1097\/AIA.0b013e318034194e","volume":"45","author":"J-M Zhang","year":"2007","unstructured":"Zhang J-M, An J. Cytokines, inflammation and pain. Int Anesthesiol Clin. 2007;45:27\u201337.","journal-title":"Int Anesthesiol Clin"},{"key":"3409_CR42","doi-asserted-by":"publisher","unstructured":"Wojdasiewicz P, Poniatowski \u0141A, Szukiewicz D. The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis. Mediators Inflamm; 2014. Epub ahead of print 2014. https:\/\/doi.org\/10.1155\/2014\/561459.","DOI":"10.1155\/2014\/561459"},{"key":"3409_CR43","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.freeradbiomed.2018.09.025","volume":"132","author":"P Lepetsos","year":"2019","unstructured":"Lepetsos P, Papavassiliou KA, Papavassiliou AG. Redox and NF-\u03baB signaling in osteoarthritis. Free Radic Biol Med. 2019;132:90\u2013100.","journal-title":"Free Radic Biol Med"},{"key":"3409_CR44","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1615\/JLongTermEffMedImplants.2014011295","volume":"24","author":"Y Takakubo","year":"2014","unstructured":"Takakubo Y, Barreto G, Konttinen YT, et al. Role of innate immune sensors, TLRs, and NALP3 in rheumatoid arthritis and osteoarthritis. J Long Term Eff Med Implants. 2014;24:243\u201352.","journal-title":"J Long Term Eff Med Implants"},{"key":"3409_CR45","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s11926-013-0323-5","volume":"15","author":"R Liu-Bryan","year":"2013","unstructured":"Liu-Bryan R. Synovium and the innate inflammatory network in osteoarthritis progression. Curr Rheumatol Rep. 2013;15:323.","journal-title":"Curr Rheumatol Rep"},{"key":"3409_CR46","first-page":"1","volume":"9","author":"G Barreto","year":"2020","unstructured":"Barreto G, Manninen M, Eklund KK. Osteoarthritis and toll-like receptors: When innate immunity meets chondrocyte apoptosis. Biology (Basel). 2020;9:1\u201315.","journal-title":"Biology (Basel)"},{"key":"3409_CR47","doi-asserted-by":"publisher","unstructured":"del Sordo L, Blackler GB, Philpott HT, et al. Impaired efferocytosis by synovial macrophages in patients with knee osteoarthritis. Arthritis Rheumatol. Epub ahead of print 30 November 2022. https:\/\/doi.org\/10.1002\/art.42412.","DOI":"10.1002\/art.42412"},{"key":"3409_CR48","doi-asserted-by":"publisher","unstructured":"Liu J, Dong X, Liu Y, et al. The identified hub gene GlcN in osteoarthritis progression and treatment. Comput Math Methods Med; 2021. Epub ahead of print 2021. https:\/\/doi.org\/10.1155\/2021\/5499450.","DOI":"10.1155\/2021\/5499450"},{"key":"3409_CR49","doi-asserted-by":"publisher","first-page":"8908","DOI":"10.1002\/jcp.27557","volume":"234","author":"ZF Li","year":"2019","unstructured":"Li ZF, Zhang RQ, Yang XL, et al. Analysis of gene expression and methylation datasets identified ADAMTS9, FKBP5, and PFKBF3 as biomarkers for osteoarthritis. J Cell Physiol. 2019;234:8908\u201317.","journal-title":"J Cell Physiol"},{"key":"3409_CR50","doi-asserted-by":"publisher","first-page":"3136","DOI":"10.4238\/2013.March.11.3","volume":"12","author":"CQ Yi","year":"2013","unstructured":"Yi CQ, Ma CH, Xie ZP, et al. Comparative genome-wide gene expression analysis of rheumatoid arthritis and osteoarthritis. Genet Mol Res. 2013;12:3136\u201345.","journal-title":"Genet Mol Res"}],"container-title":["Arthritis Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-024-03409-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-024-03409-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-024-03409-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T17:07:13Z","timestamp":1728580033000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-024-03409-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,10]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3409"],"URL":"https:\/\/doi.org\/10.1186\/s13075-024-03409-3","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,10]]},"assertion":[{"value":"9 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Western Health Sciences Ethics Research Board (#1187). Written informed consent was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"CTA is a consultant for Abbvie, Amgen, Bristol Myers Squibb, Celgene, Fresenius Kabi, Gilead, Janssen, Merck, Novartis, Pfizer, Hoffmaan LaRoche, Sandoz, Sanofi-Genzyme, and UCB.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"176"}}