{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:42:49Z","timestamp":1792521769111,"version":"4.5.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the National Key R&D Program of China","award":["2022YFC3601800"],"award-info":[{"award-number":["2022YFC3601800"]}]},{"name":"the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences","award":["2022-RC310-04"],"award-info":[{"award-number":["2022-RC310-04"]}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["CIFMS, 2021-I2M-1-059"],"award-info":[{"award-number":["CIFMS, 2021-I2M-1-059"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 82030097 and No. 32141004"],"award-info":[{"award-number":["No. 82030097 and No. 32141004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"DOI":"10.1186\/s13075-024-03414-6","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T11:02:44Z","timestamp":1729594964000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Oxysterols contribute to immune cell recruitment in SLE skin lesions"],"prefix":"10.1186","volume":"26","author":[{"given":"Xiaoyun","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianlian","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujie","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"3414_CR1","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1038\/nrrheum.2015.106","volume":"11","author":"GM Deng","year":"2015","unstructured":"Deng GM, Tsokos GC. Pathogenesis and targeted treatment of skin injury in SLE. Nat Rev Rheumatol. 2015;11:663\u20139.","journal-title":"Nat Rev Rheumatol"},{"key":"3414_CR2","doi-asserted-by":"crossref","unstructured":"M QLHWWL. Z, V C, L L, A comprehensive review of immune-mediated dermatopathology in systemic lupus erythematosus. J Autoimmun. 2018 Sep;93:1\u201315.","DOI":"10.1016\/j.jaut.2018.07.007"},{"key":"3414_CR3","doi-asserted-by":"crossref","unstructured":"Chen X, Wu Y, Jia S, Zhao M. Fibroblast: a Novel Target for Autoimmune and inflammatory skin diseases therapeutics. Clin Rev Allerg Immu. 2024 Jun;66(3):274\u2013293.","DOI":"10.1007\/s12016-024-08997-1"},{"key":"3414_CR4","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/s41586-021-04221-8","volume":"601","author":"Z Xu","year":"2022","unstructured":"Xu Z, Chen D, Hu Y, Jiang K, Huang H, Du Y, et al. Anatomically distinct fibroblast subsets determine skin autoimmune patterns. Nature. 2022;601:118\u201324.","journal-title":"Nature"},{"key":"3414_CR5","doi-asserted-by":"publisher","first-page":"e20231425","DOI":"10.1084\/jem.20231425","volume":"221","author":"KJ Cavagnero","year":"2024","unstructured":"Cavagnero KJ, Li F, Dokoshi T, Nakatsuji T, O\u2019Neill AM, Aguilera C, et al. CXCL12\u2009+\u2009dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17. J Exp Med. 2024;221:e20231425.","journal-title":"J Exp Med"},{"key":"3414_CR6","doi-asserted-by":"crossref","unstructured":"Yi T, Wang X, Kelly LM, An J, Xu Y, Sailer AW et al. Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. Immunity. 2012;37:535\u201348.","DOI":"10.1016\/j.immuni.2012.06.015"},{"key":"3414_CR7","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jaut.2014.10.001","volume":"56","author":"F Chalmin","year":"2015","unstructured":"Chalmin F, Rochemont V, Lippens C, Clottu A, Sailer AW, Merkler D, et al. Oxysterols regulate encephalitogenic CD4(+) T cell trafficking during central nervous system autoimmunity. J Autoimmun. 2015;56:45\u201355.","journal-title":"J Autoimmun"},{"key":"3414_CR8","doi-asserted-by":"crossref","unstructured":"Liu C, Yang XV, Wu J, Kuei C, Mani NS, Zhang L et al. Oxysterols direct B-cell migration through EBI2. Nature2011;475:519\u201323.","DOI":"10.1038\/nature10226"},{"key":"3414_CR9","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.cmet.2023.03.010","volume":"35","author":"Q Zeng","year":"2023","unstructured":"Zeng Q, Wang S, Li M, Wang S, Guo C, Ruan X, et al. Spleen fibroblastic reticular cell-derived acetylcholine promotes lipid metabolism to drive autoreactive B cell responses. Cell Metab. 2023;35:837\u2013e8548.","journal-title":"Cell Metab"},{"key":"3414_CR10","doi-asserted-by":"publisher","first-page":"2314","DOI":"10.1002\/art.41883","volume":"73","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Gui M, Wang Y, Mani N, Chaudhuri S, Gao B, et al. Inositol-requiring enzyme 1\u03b1-Mediated synthesis of Monounsaturated fatty acids as a driver of B cell differentiation and lupus-like Autoimmune Disease. Arthritis Rheumatol. 2021;73:2314\u201326.","journal-title":"Arthritis Rheumatol"},{"key":"3414_CR11","doi-asserted-by":"crossref","unstructured":"Frascoli M, Ferraj E, Miu B, Malin J, Spidale NA, Cowan J et al. Skin \u03b3\u03b4 T cell inflammatory responses are hardwired in the thymus by oxysterol sensing via GPR183 and calibrated by dietary cholesterol. Immunity 2023;S1074761323000377.","DOI":"10.1016\/j.immuni.2023.01.025"},{"key":"3414_CR12","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/s41385-019-0140-x","volume":"12","author":"A Wyss","year":"2019","unstructured":"Wyss A, Raselli T, Perkins N, Ruiz F, Schmelczer G, Klinke G, et al. The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis. Mucosal Immunol. 2019;12:733\u201345.","journal-title":"Mucosal Immunol"},{"key":"3414_CR13","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/nature17947","volume":"533","author":"J Li","year":"2016","unstructured":"Li J, Lu E, Yi T, Cyster JG. EBI2 augments tfh cell fate by promoting interaction with IL-2-quenching dendritic cells. Nature. 2016;533:110\u20134.","journal-title":"Nature"},{"key":"3414_CR14","doi-asserted-by":"publisher","first-page":"7489","DOI":"10.1038\/s41467-022-35209-1","volume":"13","author":"M Zheng","year":"2022","unstructured":"Zheng M, Hu Z, Mei X, Ouyang L, Song Y, Zhou W, et al. Single-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosus. Nat Commun. 2022;13:7489.","journal-title":"Nat Commun"},{"key":"3414_CR15","doi-asserted-by":"publisher","first-page":"1258018","DOI":"10.3389\/fphar.2023.1258018","volume":"14","author":"T Wu","year":"2023","unstructured":"Wu T, Ye L, Wang S, Huang J, Zhang J. Association of lipid lowering drugs and the risk of systemic lupus erythematosus: a drug target mendelian randomization. Front Pharmacol. 2023;14:1258018.","journal-title":"Front Pharmacol"},{"key":"3414_CR16","doi-asserted-by":"publisher","first-page":"104802","DOI":"10.1016\/j.ebiom.2023.104802","volume":"96","author":"F Urbain","year":"2023","unstructured":"Urbain F, Ponnaiah M, Ichou F, Lhomme M, Materne C, Galier S, et al. Impaired metabolism predicts coronary artery calcification in women with systemic lupus erythematosus. Ebiomedicine. 2023;96:104802.","journal-title":"Ebiomedicine"},{"key":"3414_CR17","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/s41586-019-0920-1","volume":"566","author":"WS Choi","year":"2019","unstructured":"Choi WS, Lee G, Song WH, Koh JT, Yang J, Kwak JS, et al. The CH25H-CYP7B1-ROR\u03b1 axis of cholesterol metabolism regulates osteoarthritis. Nature. 2019;566:254\u20138.","journal-title":"Nature"},{"key":"3414_CR18","doi-asserted-by":"publisher","first-page":"984045","DOI":"10.3389\/fimmu.2022.984045","volume":"13","author":"S Cordier-Dirikoc","year":"2022","unstructured":"Cordier-Dirikoc S, Pedretti N, Garnier J, Clarhaut-Charreau S, Ryffel B, Morel F, et al. Dermal fibroblasts are the key sensors of aseptic skin inflammation through interleukin 1 release by lesioned keratinocytes. Front Immunol. 2022;13:984045.","journal-title":"Front Immunol"},{"key":"3414_CR19","doi-asserted-by":"publisher","first-page":"109197","DOI":"10.1016\/j.intimp.2022.109197","volume":"112","author":"Z Shi","year":"2022","unstructured":"Shi Z, Zhang YP, Hong D, Qiu X, Zheng L, Bian L, et al. Anti-galectin-3 antibodies induce skin vascular inflammation via promoting local production of IL-1\u03b2 in systemic lupus erythematosus. Int Immunopharmacol. 2022;112:109197.","journal-title":"Int Immunopharmacol"},{"key":"3414_CR20","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1002\/art.41953","volume":"73","author":"A Winkler","year":"2021","unstructured":"Winkler A, Sun W, De S, Jiao A, Sharif MN, Symanowicz PT, et al. The Interleukin-1 receptor-Associated kinase 4 inhibitor PF-06650833 blocks inflammation in Preclinical models of Rheumatic Disease and in humans enrolled in a Randomized Clinical Trial. Arthritis Rheumatol. 2021;73:2206\u201318.","journal-title":"Arthritis Rheumatol"},{"key":"3414_CR21","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1158\/2159-8290.CD-18-0710","volume":"9","author":"G Biffi","year":"2019","unstructured":"Biffi G, Oni TE, Spielman B, Hao Y, Elyada E, Park Y, et al. IL1-Induced JAK\/STAT signaling is antagonized by TGF\u03b2 to shape CAF heterogeneity in pancreatic ductal adenocarcinoma. Cancer Discov. 2019;9:282\u2013301.","journal-title":"Cancer Discov"},{"key":"3414_CR22","doi-asserted-by":"crossref","unstructured":"Foo CX, Bartlett S, Chew KY, Ngo MD, Bielefeldt-Ohmann H, Arachchige BJ et al. GPR183 antagonism reduces macrophage infiltration in influenza and SARS-CoV-2 infection. Eur Respir J. 2023 Mar 9;61(3):2201306.","DOI":"10.1183\/13993003.01306-2022"},{"key":"3414_CR23","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.immuni.2017.11.020","volume":"48","author":"J Emg\u00e5rd","year":"2018","unstructured":"Emg\u00e5rd J, Kammoun H, Garc\u00eda-Cassani B, Chesn\u00e9 J, Parigi SM, Jacob JM, et al. Oxysterol sensing through the receptor GPR183 promotes the lymphoid-tissue-inducing function of innate lymphoid cells and colonic inflammation. Immunity. 2018;48:120\u2013e1328.","journal-title":"Immunity"},{"key":"3414_CR24","doi-asserted-by":"crossref","unstructured":"Zhao M, Mei Y, Zhao Z, Cao P, Xin Y, Guo Y et al. Abnormal lower expression of GPR183 in peripheral blood T and B cell subsets of systemic lupus erythematosus patients. Autoimmunity. 2022;55:429\u201342.","DOI":"10.1080\/08916934.2022.2103119"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-024-03414-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-024-03414-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-024-03414-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T11:05:10Z","timestamp":1729595110000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-024-03414-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,22]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3414"],"URL":"https:\/\/doi.org\/10.1186\/s13075-024-03414-6","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,22]]},"assertion":[{"value":"27 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Human skin biopsies were obtained from the Second Xiangya Hospital of Central South University. Approval was obtained from the ethics committee of Second Xiangya Hospital of Central South University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"181"}}