{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T18:39:40Z","timestamp":1789324780837,"version":"build-2803163510"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82101841"],"award-info":[{"award-number":["82101841"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82171779"],"award-info":[{"award-number":["82171779"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scientific and Technological Projects of Xiamen City","award":["3502Z20244ZD1034"],"award-info":[{"award-number":["3502Z20244ZD1034"]}]},{"name":"Scientific and Technological Projects of Xiamen City","award":["2022XMSLCYX01"],"award-info":[{"award-number":["2022XMSLCYX01"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"DOI":"10.1186\/s13075-024-03459-7","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T03:57:45Z","timestamp":1734580665000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A non-invasive model for diagnosis of primary Sjogren\u2019s disease based on salivary biomarkers, serum autoantibodies, and Schirmer\u2019s test"],"prefix":"10.1186","volume":"26","author":[{"given":"Xinwei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangdi","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangchun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aodi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingying","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chubing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoqiong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuwei","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiju","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guixiu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"issue":"6","key":"3459_CR1","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1111\/1756-185x.13839","volume":"23","author":"J Wang","year":"2020","unstructured":"Wang J, Zhou L, Liu B. Update on disease pathogenesis, diagnosis, and management of primary Sj\u00f6gren\u2019s syndrome. Int J Rheum Dis. 2020;23(6):723\u201327. https:\/\/doi.org\/10.1111\/1756-185x.13839. [published Online First: 2020\/04\/17].","journal-title":"Int J Rheum Dis"},{"issue":"6","key":"3459_CR2","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1136\/ard.61.6.554","volume":"61","author":"C Vitali","year":"2002","unstructured":"Vitali C, Bombardieri S, Jonsson R, et al. Classification criteria for Sj\u00f6gren\u2019s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis. 2002;61(6):554\u20138. https:\/\/doi.org\/10.1136\/ard.61.6.554. [published Online First: 2002\/05\/15].","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"3459_CR3","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1002\/acr.21591","volume":"64","author":"SC Shiboski","year":"2012","unstructured":"Shiboski SC, Shiboski CH, Criswell L, et al. American College of Rheumatology classification criteria for Sj\u00f6gren\u2019s syndrome: a data-driven, expert consensus approach in the Sj\u00f6gren\u2019s International Collaborative Clinical Alliance cohort. Arthritis Care Res. 2012;64(4):475\u201387. https:\/\/doi.org\/10.1002\/acr.21591. [published Online First: 2012\/05\/09].","journal-title":"Arthritis Care Res"},{"issue":"1","key":"3459_CR4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1136\/annrheumdis-2016-210571","volume":"76","author":"CH Shiboski","year":"2017","unstructured":"Shiboski CH, Shiboski SC, Seror R, et al. 2016 American College of Rheumatology\/European League Against Rheumatism classification criteria for primary Sj\u00f6gren\u2019s syndrome: a consensus and data-driven methodology involving three international patient cohorts. Ann Rheum Dis. 2017;76(1):9\u201316. https:\/\/doi.org\/10.1136\/annrheumdis-2016-210571. [published Online First: 2016\/11\/01].","journal-title":"Ann Rheum Dis"},{"issue":"12","key":"3459_CR5","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1136\/annrheumdis-2016-210758","volume":"76","author":"H Tsuboi","year":"2017","unstructured":"Tsuboi H, Hagiwara S, Asashima H, et al. Comparison of performance of the 2016 ACR-EULAR classification criteria for primary Sj\u00f6gren\u2019s syndrome with other sets of criteria in Japanese patients. Ann Rheum Dis. 2017;76(12):1980\u201385. https:\/\/doi.org\/10.1136\/annrheumdis-2016-210758. [published Online First: 2017\/03\/24].","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"3459_CR6","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1136\/annrheumdis-2016-210448","volume":"76","author":"BA Fisher","year":"2017","unstructured":"Fisher BA, Jonsson R, Daniels T, et al. Standardisation of labial salivary gland histopathology in clinical trials in primary Sj\u00f6gren\u2019s syndrome. Ann Rheum Dis. 2017;76(7):1161\u201368. https:\/\/doi.org\/10.1136\/annrheumdis-2016-210448. [published Online First: 2016\/12\/15].","journal-title":"Ann Rheum Dis"},{"issue":"8","key":"3459_CR7","doi-asserted-by":"publisher","first-page":"e713","DOI":"10.4317\/jced.56562","volume":"12","author":"EM Varoni","year":"2020","unstructured":"Varoni EM, Villani G, Lombardi N, et al. Local complications associated with labial salivary gland biopsy for diagnosis of Sj\u00f6gren\u2019s syndrome: a retrospective cohort study. J Clin Experimental Dentistry. 2020;12(8):e713\u201318. https:\/\/doi.org\/10.4317\/jced.56562. [published Online First: 2020\/09\/12].","journal-title":"J Clin Experimental Dentistry"},{"issue":"2","key":"3459_CR8","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1586\/1744666x.2016.1109449","volume":"12","author":"P Brito-Zer\u00f3n","year":"2016","unstructured":"Brito-Zer\u00f3n P, Theander E, Baldini C, et al. Early diagnosis of primary Sj\u00f6gren\u2019s syndrome: EULAR-SS task force clinical recommendations. Expert Rev Clin Immunol. 2016;12(2):137\u201356. https:\/\/doi.org\/10.1586\/1744666x.2016.1109449. [published Online First: 2015\/12\/23].","journal-title":"Expert Rev Clin Immunol"},{"issue":"2","key":"3459_CR9","doi-asserted-by":"publisher","first-page":"177","DOI":"10.11613\/bm.2015.018","volume":"25","author":"LA Nunes","year":"2015","unstructured":"Nunes LA, Mussavira S, Bindhu OS. Clinical and diagnostic utility of saliva as a non-invasive diagnostic fluid: a systematic review. Biochemia Med. 2015;25(2):177\u201392. https:\/\/doi.org\/10.11613\/bm.2015.018. [published Online First: 2015\/06\/26].","journal-title":"Biochemia Med"},{"issue":"5","key":"3459_CR10","first-page":"785","volume":"30","author":"C Baldini","year":"2012","unstructured":"Baldini C, Gallo A, Perez P, et al. Saliva as an ideal milieu for emerging diagnostic approaches in primary Sj\u00f6gren\u2019s syndrome. Clin Exp Rheumatol. 2012;30(5):785\u201390. [published Online First: 2012\/09\/27].","journal-title":"Clin Exp Rheumatol"},{"issue":"4","key":"3459_CR11","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1128\/cmr.00021-13","volume":"26","author":"JM Yoshizawa","year":"2013","unstructured":"Yoshizawa JM, Schafer CA, Schafer JJ, et al. Salivary biomarkers: toward future clinical and diagnostic utilities. Clin Microbiol Rev. 2013;26(4):781\u201391. https:\/\/doi.org\/10.1128\/cmr.00021-13. [published Online First: 2013\/10\/05].","journal-title":"Clin Microbiol Rev"},{"issue":"4","key":"3459_CR12","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1002\/art.39015","volume":"67","author":"N Delaleu","year":"2015","unstructured":"Delaleu N, Mydel P, Kwee I, et al. High fidelity between saliva proteomics and the biologic state of salivary glands defines biomarker signatures for primary Sj\u00f6gren\u2019s syndrome. Arthritis Rheumatol (Hoboken NJ). 2015;67(4):1084\u201395. https:\/\/doi.org\/10.1002\/art.39015. [published Online First: 2014\/12\/30].","journal-title":"Arthritis Rheumatol (Hoboken NJ)"},{"issue":"6","key":"3459_CR13","doi-asserted-by":"publisher","first-page":"R194","DOI":"10.1186\/ar3523","volume":"13","author":"C Baldini","year":"2011","unstructured":"Baldini C, Giusti L, Ciregia F, et al. Proteomic analysis of saliva: a unique tool to distinguish primary Sj\u00f6gren\u2019s syndrome from secondary Sj\u00f6gren\u2019s syndrome and other sicca syndromes. Arthritis Res Therapy. 2011;13(6):R194. https:\/\/doi.org\/10.1186\/ar3523. [published Online First: 2011\/11\/29].","journal-title":"Arthritis Res Therapy"},{"issue":"19\u201320","key":"3459_CR14","doi-asserted-by":"publisher","first-page":"3113","DOI":"10.1002\/pmic.201200208","volume":"12","author":"KS Ambatipudi","year":"2012","unstructured":"Ambatipudi KS, Swatkoski S, Moresco JJ, et al. Quantitative proteomics of parotid saliva in primary Sj\u00f6gren\u2019s syndrome. Proteomics. 2012;12(19\u201320):3113\u201320. https:\/\/doi.org\/10.1002\/pmic.201200208. [published Online First: 2012\/08\/14].","journal-title":"Proteomics"},{"issue":"8","key":"3459_CR15","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/s41584-024-01135-3","volume":"20","author":"C Baldini","year":"2024","unstructured":"Baldini C, Fulvio G, La Rocca G, et al. Update on the pathophysiology and treatment of primary Sj\u00f6gren syndrome. Nat Rev Rheumatol. 2024;20(8):473\u201391. https:\/\/doi.org\/10.1038\/s41584-024-01135-3.","journal-title":"Nat Rev Rheumatol"},{"key":"3459_CR16","doi-asserted-by":"publisher","first-page":"103877","DOI":"10.1016\/j.jprot.2020.103877","volume":"225","author":"ML Sembler-M\u00f8ller","year":"2020","unstructured":"Sembler-M\u00f8ller ML, Belstr\u00f8m D, Locht H, et al. Proteomics of saliva, plasma, and salivary gland tissue in Sj\u00f6gren\u2019s syndrome and non-Sj\u00f6gren patients identify novel biomarker candidates. J Proteom. 2020;225:103877. https:\/\/doi.org\/10.1016\/j.jprot.2020.103877.","journal-title":"J Proteom"},{"issue":"1","key":"3459_CR17","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13075-017-1228-x","volume":"19","author":"LA Aqrawi","year":"2017","unstructured":"Aqrawi LA, Galtung HK, Vestad B, et al. Identification of potential saliva and tear biomarkers in primary Sj\u00f6gren\u2019s syndrome, utilising the extraction of extracellular vesicles and proteomics analysis. Arthritis Res Ther. 2017;19(1):14. https:\/\/doi.org\/10.1186\/s13075-017-1228-x.","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"3459_CR18","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1186\/s13075-019-1961-4","volume":"21","author":"LA Aqrawi","year":"2019","unstructured":"Aqrawi LA, Galtung HK, Guerreiro EM, et al. Proteomic and histopathological characterisation of sicca subjects and primary Sj\u00f6gren\u2019s syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers. Arthritis Res Ther. 2019;21(1):181. https:\/\/doi.org\/10.1186\/s13075-019-1961-4.","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"3459_CR19","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1080\/14789450.2017.1333904","volume":"14","author":"C Baldini","year":"2017","unstructured":"Baldini C, Cecchettini A, Gallo A, et al. Updates on Sj\u00f6gren\u2019s syndrome: from proteomics to protein biomarkers. Expert Rev Proteom. 2017;14(6):491\u201398. https:\/\/doi.org\/10.1080\/14789450.2017.1333904.","journal-title":"Expert Rev Proteom"},{"issue":"8","key":"3459_CR20","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/nrrheum.2012.75","volume":"8","author":"G Sturfelt","year":"2012","unstructured":"Sturfelt G, Truedsson L. Complement in the immunopathogenesis of rheumatic disease. Nat Rev Rheumatol. 2012;8(8):458\u201368. https:\/\/doi.org\/10.1038\/nrrheum.2012.75.","journal-title":"Nat Rev Rheumatol"},{"key":"3459_CR21","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-024-07611-4","author":"E Azoulay","year":"2024","unstructured":"Azoulay E, Zuber J, Bousfiha AA, et al. Complement system activation: bridging physiology, pathophysiology, and therapy. Intensive Care Med. 2024. https:\/\/doi.org\/10.1007\/s00134-024-07611-4.","journal-title":"Intensive Care Med"},{"key":"3459_CR22","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.jaut.2018.10.013","volume":"95","author":"T Lung","year":"2018","unstructured":"Lung T, Risch L, Risch M, et al. The utility of complement assays in clinical immunology: a comprehensive review. J Autoimmun. 2018;95:191\u2013200. https:\/\/doi.org\/10.1016\/j.jaut.2018.10.013.","journal-title":"J Autoimmun"},{"issue":"40","key":"3459_CR23","doi-asserted-by":"publisher","first-page":"38214","DOI":"10.1074\/jbc.C300252200","volume":"278","author":"G Santilli","year":"2003","unstructured":"Santilli G, Aronow BJ, Sala A. Essential requirement of apolipoprotein J (clusterin) signaling for IkappaB expression and regulation of NF-kappaB activity. J Biol Chem. 2003;278(40):38214\u201319.","journal-title":"J Biol Chem"},{"issue":"18","key":"3459_CR24","doi-asserted-by":"publisher","first-page":"7123","DOI":"10.1073\/pnas.86.18.7123","volume":"86","author":"DE Jenne","year":"1989","unstructured":"Jenne DE, Tschopp J. Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid. Proc Natl Acad Sci U S A. 1989;86(18):7123\u201327.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"3459_CR25","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1083\/jcb.201006052","volume":"191","author":"V Papayannopoulos","year":"2010","unstructured":"Papayannopoulos V, Metzler KD, Hakkim A, et al. Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps. J Cell Biol. 2010;191(3):677\u201391. https:\/\/doi.org\/10.1083\/jcb.201006052.","journal-title":"J Cell Biol"},{"issue":"2","key":"3459_CR26","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.biochi.2007.10.009","volume":"90","author":"B Korkmaz","year":"2008","unstructured":"Korkmaz B, Moreau T, Gauthier F. Neutrophil elastase, proteinase 3 and cathepsin G: physicochemical properties, activity and physiopathological functions. Biochimie. 2008;90(2):227\u201342.","journal-title":"Biochimie"},{"issue":"11","key":"3459_CR27","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1093\/intimm\/12.11.1539","volume":"12","author":"S Basu","year":"2000","unstructured":"Basu S, Binder RJ, Suto R, et al. Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway. Int Immunol. 2000;12(11):1539\u201346.","journal-title":"Int Immunol"},{"key":"3459_CR28","doi-asserted-by":"publisher","unstructured":"Fucikova J, Spisek R, Kroemer G, et al. Calreticulin and cancer. Cell Res. 2021;31(1). https:\/\/doi.org\/10.1038\/s41422-020-0383-9.","DOI":"10.1038\/s41422-020-0383-9"},{"key":"3459_CR29","doi-asserted-by":"publisher","first-page":"205031211985039","DOI":"10.1177\/2050312119850390","volume":"7","author":"E Larssen","year":"2019","unstructured":"Larssen E, Brede C, Hjelle A, et al. Fatigue in primary Sj\u00f6gren\u2019s syndrome: a proteomic pilot study of cerebrospinal fluid. SAGE Open Med. 2019;7:2050312119850390. https:\/\/doi.org\/10.1177\/2050312119850390.","journal-title":"SAGE Open Med"},{"key":"3459_CR30","doi-asserted-by":"publisher","first-page":"702755","DOI":"10.3389\/fimmu.2021.702755","volume":"12","author":"CS de Paiva","year":"2021","unstructured":"de Paiva CS, Trujillo-Vargas CM, Schaefer L, et al. Differentially expressed Gene pathways in the Conjunctiva of Sj\u00f6gren Syndrome Keratoconjunctivitis Sicca. Front Immunol. 2021;12:702755. https:\/\/doi.org\/10.3389\/fimmu.2021.702755.","journal-title":"Front Immunol"},{"key":"3459_CR31","doi-asserted-by":"crossref","unstructured":"Zhang K, Liu K, Yu D et al. The therapeutic and prognostic role of clusterin in diverse musculoskeletal diseases: a mini review. Physiol Res 2022.","DOI":"10.33549\/physiolres.934908"},{"key":"3459_CR32","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.3389\/fimmu.2019.02527","volume":"10","author":"L Qiao","year":"2019","unstructured":"Qiao L, Deng C, Wang Q, et al. Serum clusterin and complement factor H may be biomarkers differentiate primary Sj\u00f6gren\u2019s syndrome with and without neuromyelitis Optica Spectrum Disorder. Front Immunol. 2019;10:2527. https:\/\/doi.org\/10.3389\/fimmu.2019.02527.","journal-title":"Front Immunol"},{"key":"3459_CR33","doi-asserted-by":"publisher","unstructured":"Novak T, Fortune F, Bergmeier L, et al. Neutrophil elastase and endogenous inhibitors in Beh\u00e7et\u2019s disease saliva. Clin Exp Immunol. 2020;202(1). https:\/\/doi.org\/10.1111\/cei.13483.","DOI":"10.1111\/cei.13483"},{"key":"3459_CR34","doi-asserted-by":"publisher","first-page":"686480","DOI":"10.3389\/fimmu.2021.686480","volume":"12","author":"L Garreto","year":"2021","unstructured":"Garreto L, Charneau S, Mandacaru SC, et al. Mapping salivary proteases in Sj\u00f6gren\u2019s syndrome patients reveals overexpression of Dipeptidyl Peptidase-4\/CD26. Front Immunol. 2021;12:686480. https:\/\/doi.org\/10.3389\/fimmu.2021.686480.","journal-title":"Front Immunol"},{"issue":"Suppl 126","key":"3459_CR35","first-page":"283","volume":"38","author":"L de Wolff","year":"2020","unstructured":"de Wolff L, Arends S, van Nimwegen JF, et al. Ten years of the ESSDAI: is it fit for purpose? Clin Exp Rheumatol. 2020;38(Suppl 126):283\u201390.","journal-title":"Clin Exp Rheumatol"},{"issue":"Suppl 112","key":"3459_CR36","first-page":"210","volume":"36","author":"A Alunno","year":"2018","unstructured":"Alunno A, Bartoloni E, Valentini V, et al. Discrepancy between subjective symptoms, objective measures and disease activity indexes: the lesson of primary Sj\u00f6gren\u2019s syndrome. Clin Exp Rheumatol. 2018;36(Suppl 112):210\u201314.","journal-title":"Clin Exp Rheumatol"},{"key":"3459_CR37","doi-asserted-by":"publisher","unstructured":"Wang B, Chen S, Li Y et al. Targeted Therapy for Primary Sj\u00f6gren\u2019s Syndrome: Where are We Now? BioDrugs 2021;35(6):593\u2013610. https:\/\/doi.org\/10.1007\/s40259-021-00505-7","DOI":"10.1007\/s40259-021-00505-7"},{"issue":"3","key":"3459_CR38","doi-asserted-by":"publisher","first-page":"72","DOI":"10.5005\/jcdp-9-3-72","volume":"9","author":"PDV de Almeida","year":"2008","unstructured":"de Almeida PDV, Gr\u00e9gio AMT, Machado MAN, et al. Saliva composition and functions: a comprehensive review. J Contemp Dent Pract. 2008;9(3):72\u201380.","journal-title":"J Contemp Dent Pract"},{"key":"3459_CR39","doi-asserted-by":"publisher","unstructured":"Nizamuddin I, Koulen P, McArthur CP. Contribution of HIV infection, AIDS, and antiretroviral therapy to Exocrine Pathogenesis in salivary and lacrimal glands. Int J Mol Sci. 2018;19(9). https:\/\/doi.org\/10.3390\/ijms19092747.","DOI":"10.3390\/ijms19092747"},{"issue":"12","key":"3459_CR40","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.55563\/clinexprheumatol\/43z8gu","volume":"40","author":"V Manfr\u00e8","year":"2022","unstructured":"Manfr\u00e8 V, Chatzis LG, Cafaro G, et al. Sj\u00f6gren\u2019s syndrome: one year in review 2022. Clin Exp Rheumatol. 2022;40(12):2211\u201324. https:\/\/doi.org\/10.55563\/clinexprheumatol\/43z8gu.","journal-title":"Clin Exp Rheumatol"},{"issue":"9","key":"3459_CR41","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1038\/nrrheum.2013.110","volume":"9","author":"G Nocturne","year":"2013","unstructured":"Nocturne G, Mariette X. Advances in understanding the pathogenesis of primary Sj\u00f6gren\u2019s syndrome. Nat Rev Rheumatol. 2013;9(9):544\u201356. https:\/\/doi.org\/10.1038\/nrrheum.2013.110.","journal-title":"Nat Rev Rheumatol"},{"issue":"9","key":"3459_CR42","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1002\/art.39214","volume":"67","author":"E Theander","year":"2015","unstructured":"Theander E, Jonsson R, Sj\u00f6str\u00f6m B, et al. Prediction of Sj\u00f6gren\u2019s Syndrome years before diagnosis and identification of patients with early onset and severe Disease Course by Autoantibody Profiling. Arthritis Rheumatol. 2015;67(9):2427\u201336. https:\/\/doi.org\/10.1002\/art.39214.","journal-title":"Arthritis Rheumatol"},{"issue":"3","key":"3459_CR43","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","volume":"15","author":"F Stapleton","year":"2017","unstructured":"Stapleton F, Alves M, Bunya VY, et al. TFOS DEWS II Epidemiology Report. Ocul Surf. 2017;15(3):334\u201365. https:\/\/doi.org\/10.1016\/j.jtos.2017.05.003.","journal-title":"Ocul Surf"}],"container-title":["Arthritis Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-024-03459-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-024-03459-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-024-03459-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T05:16:48Z","timestamp":1734585408000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-024-03459-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3459"],"URL":"https:\/\/doi.org\/10.1186\/s13075-024-03459-7","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,19]]},"assertion":[{"value":"9 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was reviewed and approved by the Local Ethical Committee of the First Affiliated Hospital of Xiamen University (KY2017-034). All patients provided written informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"217"}}