{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:55:03Z","timestamp":1788177303089,"version":"build-2803163510"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82160307"],"award-info":[{"award-number":["82160307"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82160308"],"award-info":[{"award-number":["82160308"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Jiangxi Provincial Natural Science Foundation of China","award":["20224BAB216038"],"award-info":[{"award-number":["20224BAB216038"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"DOI":"10.1186\/s13075-024-03461-z","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T23:10:25Z","timestamp":1734563425000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["KLF2 controls the apoptosis of neutrophils and is associated with disease activity of systemic lupus erythematosus"],"prefix":"10.1186","volume":"26","author":[{"given":"Hongshuai","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaichuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayue","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"issue":"11","key":"3461_CR1","doi-asserted-by":"publisher","first-page":"ITC81","DOI":"10.7326\/AITC202006020","volume":"172","author":"M Kiriakidou","year":"2020","unstructured":"Kiriakidou M, Ching CL. Systemic Lupus Erythematosus. Ann Intern Med. 2020;172(11):ITC81\u201396. https:\/\/doi.org\/10.7326\/AITC202006020.","journal-title":"Ann Intern Med"},{"issue":"11","key":"3461_CR2","first-page":"343","volume":"61","author":"JJ Manson","year":"2003","unstructured":"Manson JJ, Isenberg DA. The pathogenesis of systemic lupus erythematosus. Neth J Med. 2003;61(11):343\u20136.","journal-title":"Neth J Med"},{"issue":"9957","key":"3461_CR3","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1016\/S0140-6736(14)60128-8","volume":"384","author":"L Lisnevskaia","year":"2014","unstructured":"Lisnevskaia L, Murphy G, Isenberg D. Systemic lupus erythematosus. Lancet. 2014;384(9957):1878\u201388. https:\/\/doi.org\/10.1016\/S0140-6736(14)60128-8.","journal-title":"Lancet"},{"issue":"8","key":"3461_CR4","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1056\/NEJMcibr1107085","volume":"365","author":"X Bosch","year":"2011","unstructured":"Bosch X. Systemic lupus erythematosus and the neutrophil. N Engl J Med. 2011;365(8):758\u201360. https:\/\/doi.org\/10.1056\/NEJMcibr1107085.","journal-title":"N Engl J Med"},{"issue":"5","key":"3461_CR5","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1097\/00002281-200309000-00005","volume":"15","author":"V Pascual","year":"2003","unstructured":"Pascual V, Banchereau J, Palucka AK. The central role of dendritic cells and interferon-alpha in SLE. Curr Opin Rheumatol. 2003;15(5):548\u201356. https:\/\/doi.org\/10.1097\/00002281-200309000-00005.","journal-title":"Curr Opin Rheumatol"},{"issue":"4","key":"3461_CR6","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s00281-013-0364-x","volume":"35","author":"ML Gabelloni","year":"2013","unstructured":"Gabelloni ML, Trevani AS, Sabatt\u00e9 J, Geffner J. Mechanisms regulating neutrophil survival and cell death. Semin Immunopathol. 2013;35(4):423\u201337. https:\/\/doi.org\/10.1007\/s00281-013-0364-x.","journal-title":"Semin Immunopathol"},{"key":"3461_CR7","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1146\/annurev-immunol-020711-074942","volume":"30","author":"B Amulic","year":"2012","unstructured":"Amulic B, Cazalet C, Hayes GL, Metzler KD, Zychlinsky A. Neutrophil function: from mechanisms to disease. Annu Rev Immunol. 2012;30:459\u201389. https:\/\/doi.org\/10.1146\/annurev-immunol-020711-074942.","journal-title":"Annu Rev Immunol"},{"key":"3461_CR8","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1034\/j.1600-065x.2000.17706.x","volume":"177","author":"P Scapini","year":"2000","unstructured":"Scapini P, Lapinet-Vera JA, Gasperini S, Calzetti F, Bazzoni F, Cassatella MA. The neutrophil as a cellular source of chemokines. Immunol Rev. 2000;177:195\u2013203. https:\/\/doi.org\/10.1034\/j.1600-065x.2000.17706.x.","journal-title":"Immunol Rev"},{"issue":"73","key":"3461_CR9","doi-asserted-by":"publisher","first-page":"73ra20","DOI":"10.1126\/scitranslmed.3001201","volume":"3","author":"GS Garcia-Romo","year":"2011","unstructured":"Garcia-Romo GS, Caielli S, Vega B, et al. Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. Sci Transl Med. 2011;3(73):73ra20. https:\/\/doi.org\/10.1126\/scitranslmed.3001201.","journal-title":"Sci Transl Med"},{"issue":"2","key":"3461_CR10","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.imlet.2015.09.016","volume":"168","author":"SK Chauhan","year":"2015","unstructured":"Chauhan SK, Rai R, Singh VV, Rai M, Rai G. Differential clearance mechanisms, neutrophil extracellular trap degradation and phagocytosis, are operative in systemic lupus erythematosus patients with distinct autoantibody specificities. Immunol Lett. 2015;168(2):254\u20139. https:\/\/doi.org\/10.1016\/j.imlet.2015.09.016.","journal-title":"Immunol Lett"},{"issue":"8","key":"3461_CR11","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.1002\/art.24634","volume":"60","author":"A Midgley","year":"2009","unstructured":"Midgley A, McLaren Z, Moots RJ, Edwards SW, Beresford MW. The role of neutrophil apoptosis in juvenile-onset systemic lupus erythematosus. Arthritis Rheum. 2009;60(8):2390\u2013401. https:\/\/doi.org\/10.1002\/art.24634.","journal-title":"Arthritis Rheum"},{"issue":"12","key":"3461_CR12","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1080\/15548627.2019.1596491","volume":"15","author":"D Laha","year":"2019","unstructured":"Laha D, Deb M, Das H. KLF2 (kruppel-like factor 2 [lung]) regulates osteoclastogenesis by modulating autophagy. Autophagy. 2019;15(12):2063\u201375. https:\/\/doi.org\/10.1080\/15548627.2019.1596491.","journal-title":"Autophagy"},{"issue":"11","key":"3461_CR13","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.3390\/ijms18112383","volume":"18","author":"P Jha","year":"2017","unstructured":"Jha P, Das H. KLF2 in Regulation of NF-\u03baB-Mediated Immune Cell Function and Inflammation. Int J Mol Sci. 2017;18(11):2383. https:\/\/doi.org\/10.3390\/ijms18112383.","journal-title":"Int J Mol Sci"},{"issue":"17","key":"3461_CR14","doi-asserted-by":"publisher","first-page":"6653","DOI":"10.1073\/pnas.0508235103","volume":"103","author":"H Das","year":"2006","unstructured":"Das H, Kumar A, Lin Z, et al. Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes. Proc Natl Acad Sci U S A. 2006;103(17):6653\u20138. https:\/\/doi.org\/10.1073\/pnas.0508235103.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5334","key":"3461_CR15","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1126\/science.277.5334.1986","volume":"277","author":"CT Kuo","year":"1997","unstructured":"Kuo CT, Veselits ML, Leiden JM. LKLF: A transcriptional regulator of single-positive T cell quiescence and survival. Science. 1997;277(5334):1986\u201390. https:\/\/doi.org\/10.1126\/science.277.5334.1986.","journal-title":"Science"},{"issue":"10","key":"3461_CR16","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1161\/CIRCRESAHA.112.267310","volume":"110","author":"JB Lingrel","year":"2012","unstructured":"Lingrel JB, Pilcher-Roberts R, Basford JE, et al. Myeloid-specific Kr\u00fcppel-like factor 2 inactivation increases macrophage and neutrophil adhesion and promotes atherosclerosis. Circ Res. 2012;110(10):1294\u2013302. https:\/\/doi.org\/10.1161\/CIRCRESAHA.112.267310.","journal-title":"Circ Res"},{"issue":"9","key":"3461_CR17","doi-asserted-by":"publisher","first-page":"4407","DOI":"10.1093\/rheumatology\/keab016","volume":"60","author":"Q Song","year":"2021","unstructured":"Song Q, Lei Y, Shao L, et al. Genome-wide association study on Northern Chinese identifies KLF2, DOT1L and STAB2 associated with systemic lupus erythematosus. Rheumatology (Oxford). 2021;60(9):4407\u201317. https:\/\/doi.org\/10.1093\/rheumatology\/keab016.","journal-title":"Rheumatology (Oxford)"},{"issue":"7","key":"3461_CR18","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1136\/ard-2023-224953","volume":"83","author":"MK Singh","year":"2024","unstructured":"Singh MK, Rallabandi HR, Zhou XJ, et al. KLF2 enhancer variant rs4808485 increases lupus risk by modulating inflammasome machinery and cellular homoeostasis. Ann Rheum Dis. 2024;83(7):879\u201388. https:\/\/doi.org\/10.1136\/ard-2023-224953. Published 2024 Jun 12.","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"3461_CR19","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1002\/art.41632","volume":"73","author":"PM Izmirly","year":"2021","unstructured":"Izmirly PM, Parton H, Wang L, et al. Prevalence of Systemic Lupus Erythematosus in the United States: Estimates From a Meta-Analysis of the Centers for Disease Control and Prevention National Lupus Registries. Arthritis Rheumatol. 2021;73(6):991\u20136. https:\/\/doi.org\/10.1002\/art.41632.","journal-title":"Arthritis Rheumatol"},{"key":"3461_CR20","doi-asserted-by":"publisher","first-page":"1121359","DOI":"10.3389\/fgene.2023.1121359","volume":"14","author":"X Zhang","year":"2023","unstructured":"Zhang X, Zhang J, Pan Z, et al. Transcriptome sequencing reveals novel molecular features of SLE severity. Front Genet. 2023;14:1121359. https:\/\/doi.org\/10.3389\/fgene.2023.1121359.","journal-title":"Front Genet"},{"issue":"1","key":"3461_CR21","doi-asserted-by":"publisher","first-page":"e000078","DOI":"10.1136\/lupus-2014-000078","volume":"2","author":"A Fayyaz","year":"2015","unstructured":"Fayyaz A, Igoe A, Kurien BT, et al. Haematological manifestations of lupus. Lupus Sci Med. 2015;2(1):e000078. https:\/\/doi.org\/10.1136\/lupus-2014-000078.","journal-title":"Lupus Sci Med"},{"issue":"5","key":"3461_CR22","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1136\/ard.58.5.309","volume":"58","author":"PA Courtney","year":"1999","unstructured":"Courtney PA, Crockard AD, Williamson K, Irvine AE, Kennedy RJ, Bell AL. Increased apoptotic peripheral blood neutrophils in systemic lupus erythematosus: relations with disease activity, antibodies to double stranded DNA, and neutropenia. Ann Rheum Dis. 1999;58(5):309\u201314. https:\/\/doi.org\/10.1136\/ard.58.5.309.","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"3461_CR23","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1165\/rcmb.2007-0282OC","volume":"38","author":"MT Saavedra","year":"2008","unstructured":"Saavedra MT, Patterson AD, West J, et al. Abrogation of anti-inflammatory transcription factor LKLF in neutrophil-dominated airways. Am J Respir Cell Mol Biol. 2008;38(6):679\u201388. https:\/\/doi.org\/10.1165\/rcmb.2007-0282OC.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"3","key":"3461_CR24","doi-asserted-by":"publisher","first-page":"e147191","DOI":"10.1172\/JCI147191","volume":"132","author":"X Tang","year":"2022","unstructured":"Tang X, Wang P, Zhang R, et al. KLF2 regulates neutrophil activation and thrombosis in cardiac hypertrophy and heart failure progression. J Clin Invest. 2022;132(3):e147191. https:\/\/doi.org\/10.1172\/JCI147191.","journal-title":"J Clin Invest"},{"issue":"14","key":"3461_CR25","doi-asserted-by":"publisher","first-page":"6511","DOI":"10.1111\/jcmm.16650","volume":"25","author":"A Le","year":"2021","unstructured":"Le A, Wu Y, Liu W, et al. MiR-144-induced KLF2 inhibition and NF-kappaB\/CXCR1 activation promote neutrophil extracellular trap-induced transfusion-related acute lung injury. J Cell Mol Med. 2021;25(14):6511\u201323. https:\/\/doi.org\/10.1111\/jcmm.16650.","journal-title":"J Cell Mol Med"},{"issue":"8","key":"3461_CR26","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.autrev.2019.06.011","volume":"18","author":"E Frangou","year":"2019","unstructured":"Frangou E, Vassilopoulos D, Boletis J, Boumpas DT. An emerging role of neutrophils and NETosis in chronic inflammation and fibrosis in systemic lupus erythematosus (SLE) and ANCA-associated vasculitides (AAV): Implications for the pathogenesis and treatment. Autoimmun Rev. 2019;18(8):751\u201360. https:\/\/doi.org\/10.1016\/j.autrev.2019.06.011.","journal-title":"Autoimmun Rev"},{"issue":"8","key":"3461_CR27","doi-asserted-by":"publisher","first-page":"597","DOI":"10.3109\/08916934.2012.719953","volume":"45","author":"YM Bouts","year":"2012","unstructured":"Bouts YM, Wolthuis DF, Dirkx MF, et al. Apoptosis and NET formation in the pathogenesis of SLE. Autoimmunity. 2012;45(8):597\u2013601. https:\/\/doi.org\/10.3109\/08916934.2012.719953.","journal-title":"Autoimmunity"},{"issue":"14","key":"3461_CR28","doi-asserted-by":"publisher","first-page":"5893","DOI":"10.1128\/MCB.25.14.5893-5903.2005","volume":"25","author":"A Kumar","year":"2005","unstructured":"Kumar A, Lin Z, SenBanerjee S, Jain MK. Tumor necrosis factor alpha-mediated reduction of KLF2 is due to inhibition of MEF2 by NF-kappaB and histone deacetylases. Mol Cell Biol. 2005;25(14):5893\u2013903. https:\/\/doi.org\/10.1128\/MCB.25.14.5893-5903.2005.","journal-title":"Mol Cell Biol"},{"issue":"2","key":"3461_CR29","doi-asserted-by":"publisher","first-page":"265","DOI":"10.5937\/jomb0-45870","volume":"43","author":"X Gu","year":"2024","unstructured":"Gu X, Chen H, Li R, Guo D. Roles of mir155hg and TNF-\u03b1 in evaluation of prognosis of patients with systemic lupus erythematosus. J Med Biochem. 2024;43(2):265\u201372. https:\/\/doi.org\/10.5937\/jomb0-45870.","journal-title":"J Med Biochem"},{"issue":"2","key":"3461_CR30","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1182\/blood.V93.2.674","volume":"93","author":"K Yamashita","year":"1999","unstructured":"Yamashita K, Takahashi A, Kobayashi S, et al. Caspases mediate tumor necrosis factor-alpha-induced neutrophil apoptosis and downregulation of reactive oxygen production. Blood. 1999;93(2):674\u201385.","journal-title":"Blood"},{"issue":"5","key":"3461_CR31","doi-asserted-by":"publisher","first-page":"3476","DOI":"10.4049\/jimmunol.166.5.3476","volume":"166","author":"G Salamone","year":"2001","unstructured":"Salamone G, Giordano M, Trevani AS, et al. Promotion of neutrophil apoptosis by TNF-alpha. J Immunol. 2001;166(5):3476\u201383. https:\/\/doi.org\/10.4049\/jimmunol.166.5.3476.","journal-title":"J Immunol"}],"container-title":["Arthritis Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-024-03461-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-024-03461-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-024-03461-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:16:47Z","timestamp":1734567407000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-024-03461-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3461"],"URL":"https:\/\/doi.org\/10.1186\/s13075-024-03461-z","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4975864\/v1","asserted-by":"object"}]},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,19]]},"assertion":[{"value":"26 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Human Ethics Committee of The First Affiliated Hospital of Nanchang University (Ethical Review No. (2024) CDYFYYLK (06\u2013028)). Informed consent was approved to be exempt.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"222"}}