{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T15:27:07Z","timestamp":1780673227800,"version":"3.54.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["A2021237"],"award-info":[{"award-number":["A2021237"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhuhai Science and Technology Innovation Bureau","award":["2220004000250"],"award-info":[{"award-number":["2220004000250"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"DOI":"10.1186\/s13075-025-03479-x","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T08:45:38Z","timestamp":1737103538000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The serum level of sclerostin decreases in radiographic axial spondyloarthritis patients with fatty lesions"],"prefix":"10.1186","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1557-7369","authenticated-orcid":false,"given":"Xuegang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1953-1948","authenticated-orcid":false,"given":"Haijian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2188-1138","authenticated-orcid":false,"given":"Xu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1803-0948","authenticated-orcid":false,"given":"Shuping","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"issue":"11","key":"3479_CR1","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1038\/s41584-023-01034-z","volume":"19","author":"W Bautista-Molano","year":"2023","unstructured":"Bautista-Molano W, Fern\u00e1ndez-\u00c1vila DG, Brance ML, \u00c1vila Pedretti MG, Burgos-Vargas R, Corbacho I, Cosentino VL, D\u00edaz Coto JF, Giraldo Ho E, Gomes Resende G, et al. Pan American League of Associations for Rheumatology recommendations for the management of axial spondyloarthritis. Nat Rev Rheumatol. 2023;19(11):724\u201337.","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"3479_CR2","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s13018-019-1100-6","volume":"14","author":"A Tian","year":"2019","unstructured":"Tian A, Ma J, Feng K, Liu Z, Chen L, Jia H, Ma X. Reference markers of bone turnover for prediction of fracture: a meta-analysis. J Orthop Surg Res. 2019;14(1):68.","journal-title":"J Orthop Surg Res"},{"issue":"3","key":"3479_CR3","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1007\/s00774-019-01057-1","volume":"38","author":"J Takada","year":"2020","unstructured":"Takada J, Dinavahi R, Miyauchi A, Hamaya E, Hirama T, Libanati C, Nakamura Y, Milmont CE, Grauer A. Relationship between P1NP, a biochemical marker of bone turnover, and bone mineral density in patients transitioned from alendronate to romosozumab or teriparatide: a post hoc analysis of the STRUCTURE trial. J Bone Min Metab. 2020;38(3):310\u201315.","journal-title":"J Bone Min Metab"},{"key":"3479_CR4","doi-asserted-by":"publisher","first-page":"9101964","DOI":"10.1155\/2018\/9101964","volume":"2018","author":"FM Perrotta","year":"2018","unstructured":"Perrotta FM, Ceccarelli F, Barbati C, Colasanti T, De Socio A, Scriffignano S, Alessandri C, Lubrano E. Serum Sclerostin as a possible biomarker in Ankylosing spondylitis: a case-control study. J Immunol Res. 2018;2018:9101964.","journal-title":"J Immunol Res"},{"issue":"10","key":"3479_CR5","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1136\/annrheumdis-2013-203345","volume":"72","author":"XX Chen","year":"2013","unstructured":"Chen XX, Baum W, Dwyer D, Stock M, Schwabe K, Ke HZ, Stolina M, Schett G, Bozec A. Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis. Ann Rheum Dis. 2013;72(10):1732\u20136.","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"3479_CR6","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/s41584-022-00764-w","volume":"18","author":"B So\u00f3s","year":"2022","unstructured":"So\u00f3s B, Szentp\u00e9tery \u00c1, Raterman HG, Lems WF, Bhattoa HP, Szekanecz Z. Effects of targeted therapies on bone in rheumatic and musculoskeletal diseases. Nat Rev Rheumatol. 2022;18(5):249\u201357.","journal-title":"Nat Rev Rheumatol"},{"issue":"8","key":"3479_CR7","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1136\/annrheumdis-2015-208011","volume":"75","author":"PM Machado","year":"2016","unstructured":"Machado PM, Baraliakos X, van der Heijde D, Braun J, Landew\u00e9 R. MRI vertebral corner inflammation followed by fat deposition is the strongest contributor to the development of new bone at the same vertebral corner: a multilevel longitudinal analysis in patients with ankylosing spondylitis. Ann Rheum Dis. 2016;75(8):1486\u201393.","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"3479_CR8","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1002\/art.1780270401","volume":"27","author":"S van der Linden","year":"1984","unstructured":"van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum. 1984;27(4):361\u20138.","journal-title":"Arthritis Rheum"},{"issue":"1","key":"3479_CR9","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1136\/ard.2008.094870","volume":"68","author":"C Lukas","year":"2009","unstructured":"Lukas C, Landew\u00e9 R, Sieper J, Dougados M, Davis J, Braun J, van der Linden S, van der Heijde D. Development of an ASAS-endorsed disease activity score (ASDAS) in patients with ankylosing spondylitis. Ann Rheum Dis. 2009;68(1):18\u201324.","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"3479_CR10","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.ejrad.2009.04.034","volume":"71","author":"CE Althoff","year":"2009","unstructured":"Althoff CE, Feist E, Burova E, Eshed I, Bollow M, Hamm B, Hermann KG. Magnetic resonance imaging of active sacroiliitis: do we really need gadolinium? Eur J Radiol. 2009;71(2):232\u20136.","journal-title":"Eur J Radiol"},{"issue":"6","key":"3479_CR11","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1136\/annrheumdis-2012-201545","volume":"72","author":"CE Althoff","year":"2013","unstructured":"Althoff CE, Sieper J, Song IH, Haibel H, Wei\u00df A, Diekhoff T, Rudwaleit M, Freundlich B, Hamm B, Hermann KG. Active inflammation and structural change in early active axial spondyloarthritis as detected by whole-body MRI. Ann Rheum Dis. 2013;72(6):967\u201373.","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"3479_CR12","doi-asserted-by":"publisher","first-page":"473","DOI":"10.3899\/jrheum.130581","volume":"41","author":"M Krohn","year":"2014","unstructured":"Krohn M, Braum LS, Sieper J, Song IH, Weiss A, Callhoff J, Althoff CE, Hamm B, Hermann KG. Erosions and fatty lesions of sacroiliac joints in patients with axial spondyloarthritis: evaluation of different MRI techniques and two scoring methods. J Rheumatol. 2014;41(3):473\u201380.","journal-title":"J Rheumatol"},{"issue":"1","key":"3479_CR13","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1186\/s13075-019-1970-3","volume":"21","author":"HK Min","year":"2019","unstructured":"Min HK, Lee J, Ju JH, Park SH, Kwok SK. Alcohol consumption as a predictor of the progression of spinal structural damage in axial spondyloarthritis: data from the catholic Axial Spondyloarthritis COhort (CASCO). Arthritis Res Ther. 2019;21(1):187.","journal-title":"Arthritis Res Ther"},{"issue":"5","key":"3479_CR14","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1002\/art.33465","volume":"64","author":"D Poddubnyy","year":"2012","unstructured":"Poddubnyy D, Haibel H, Listing J, M\u00e4rker-Hermann E, Zeidler H, Braun J, Sieper J, Rudwaleit M. Baseline radiographic damage, elevated acute-phase reactant levels, and cigarette smoking status predict spinal radiographic progression in early axial spondylarthritis. Arthritis Rheum. 2012;64(5):1388\u201398.","journal-title":"Arthritis Rheum"},{"issue":"1","key":"3479_CR15","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1136\/annrheumdis-2013-204055","volume":"74","author":"S Ramiro","year":"2015","unstructured":"Ramiro S, Stolwijk C, van Tubergen A, van der Heijde D, Dougados M, van den Bosch F, Landew\u00e9 R. Evolution of radiographic damage in ankylosing spondylitis: a 12 year prospective follow-up of the OASIS study. Ann Rheum Dis. 2015;74(1):52\u20139.","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"3479_CR16","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1093\/rheumatology\/kez025","volume":"58","author":"J Rademacher","year":"2019","unstructured":"Rademacher J, Tietz LM, Le L, Hartl A, Hermann KA, Sieper J, Mansmann U, Rudwaleit M, Poddubnyy D. Added value of biomarkers compared with clinical parameters for the prediction of radiographic spinal progression in axial spondyloarthritis. Rheumatology (Oxford). 2019;58(9):1556\u201364.","journal-title":"Rheumatology (Oxford)"},{"key":"3479_CR17","doi-asserted-by":"publisher","first-page":"151974","DOI":"10.1016\/j.semarthrit.2022.151974","volume":"53","author":"J Rademacher","year":"2022","unstructured":"Rademacher J, Siderius M, Gellert L, Wink FR, Verba M, Maas F, Tietz LM, Poddubnyy D, Spoorenberg A, Arends S. Baseline serum biomarkers of inflammation, bone turnover and adipokines predict spinal radiographic progression in ankylosing spondylitis patients on TNF inhibitor therapy. Semin Arthritis Rheum. 2022;53:151974.","journal-title":"Semin Arthritis Rheum"},{"issue":"6","key":"3479_CR18","doi-asserted-by":"publisher","first-page":"e99685","DOI":"10.1371\/journal.pone.0099685","volume":"9","author":"S Arends","year":"2014","unstructured":"Arends S, Spoorenberg A, Efde M, Bos R, Leijsma MK, Bootsma H, Veeger NJ, Brouwer E, van der Veer E. Higher bone turnover is related to spinal radiographic damage and low bone mineral density in ankylosing spondylitis patients with active disease: a cross-sectional analysis. PLoS ONE. 2014;9(6):e99685.","journal-title":"PLoS ONE"},{"issue":"9","key":"3479_CR19","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1007\/s10067-016-3198-9","volume":"35","author":"M Serdaro\u011flu Beyazal","year":"2016","unstructured":"Serdaro\u011flu Beyazal M, Erdo\u011fan T, T\u00fcrky\u0131lmaz AK, Devrimsel G, C\u00fcre MC, Beyazal M, Sahin I. Relationship of serum osteoprotegerin with arterial stiffness, preclinical atherosclerosis, and disease activity in patients with ankylosing spondylitis. Clin Rheumatol. 2016;35(9):2235\u201341.","journal-title":"Clin Rheumatol"},{"issue":"1","key":"3479_CR20","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s00223-019-00542-z","volume":"105","author":"J Yang","year":"2019","unstructured":"Yang J, Xu S, Chen M, Yuan Y, Zhang X, Ma Y, Wu M, Han R, Hu X, Liu R, et al. Serum sclerostin and bone morphogenetic Protein-2 levels in patients with Ankylosing spondylitis: a Meta-analysis. Calcif Tissue Int. 2019;105(1):37\u201350.","journal-title":"Calcif Tissue Int"},{"issue":"11","key":"3479_CR21","doi-asserted-by":"publisher","first-page":"3257","DOI":"10.1002\/art.24888","volume":"60","author":"H Appel","year":"2009","unstructured":"Appel H, Ruiz-Heiland G, Listing J, Zwerina J, Herrmann M, Mueller R, Haibel H, Baraliakos X, Hempfing A, Rudwaleit M, et al. Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis. Arthritis Rheum. 2009;60(11):3257\u201362.","journal-title":"Arthritis Rheum"},{"key":"3479_CR22","doi-asserted-by":"publisher","first-page":"1227196","DOI":"10.3389\/fendo.2024.1227196","volume":"15","author":"I G\u00f3mez-Garc\u00eda","year":"2024","unstructured":"G\u00f3mez-Garc\u00eda I, Ladehesa-Pineda ML, Diaz-Tocados JM, L\u00f3pez-Medina C, Abalos-Aguilera MC, Ruiz-Vilches D, Paz-Lopez G, Gonzalez-Jimenez A, Ranea JAG, Escudero-Contreras A, et al. Bone metabolism and inflammatory biomarkers in radiographic and non-radiographic axial spondyloarthritis patients: a comprehensive evaluation. Front Endocrinol (Lausanne). 2024;15:1227196.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"12","key":"3479_CR23","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1007\/s00296-020-04708-z","volume":"40","author":"O Iaremenko","year":"2020","unstructured":"Iaremenko O, Shynkaruk I, Fedkov D, Iaremenko K, Petelytska L. Bone turnover biomarkers, disease activity, and MRI changes of sacroiliac joints in patients with spondyloarthritis. Rheumatol Int. 2020;40(12):2057\u201363.","journal-title":"Rheumatol Int"},{"issue":"5","key":"3479_CR24","doi-asserted-by":"publisher","first-page":"R216","DOI":"10.1186\/ar4055","volume":"14","author":"CG Saad","year":"2012","unstructured":"Saad CG, Ribeiro AC, Moraes JC, Takayama L, Goncalves CR, Rodrigues MB, de Oliveira RM, Silva CA, Bonfa E, Pereira RM. Low sclerostin levels: a predictive marker of persistent inflammation in ankylosing spondylitis during anti-tumor necrosis factor therapy? Arthritis Res Ther. 2012;14(5):R216.","journal-title":"Arthritis Res Ther"},{"issue":"5","key":"3479_CR25","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1007\/s00296-019-04298-5","volume":"39","author":"O Gercik","year":"2019","unstructured":"Gercik O, Solmaz D, Coban E, Iptec BO, Avcioglu G, Bayindir O, Kabadayi G, Topal FE, Kozaci D, Akar S. Evaluation of serum fibroblast growth factor-23 in patients with axial spondyloarthritis and its association with sclerostin, inflammation, and spinal damage. Rheumatol Int. 2019;39(5):835\u201340.","journal-title":"Rheumatol Int"},{"issue":"3","key":"3479_CR26","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1093\/rheumatology\/keaa296","volume":"60","author":"E Descamps","year":"2021","unstructured":"Descamps E, Molto A, Borderie D, Lories R, Richard CM, Pons M, Roux C, Briot K. Changes in bone formation regulator biomarkers in early axial spondyloarthritis. Rheumatology (Oxford). 2021;60(3):1185\u201394.","journal-title":"Rheumatology (Oxford)"},{"issue":"4","key":"3479_CR27","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1007\/s10067-018-4356-z","volume":"38","author":"W Sun","year":"2019","unstructured":"Sun W, Tian L, Jiang L, Zhang S, Zhou M, Zhu J, Xue J. Sclerostin rather than Dickkopf-1 is associated with mSASSS but not with disease activity score in patients with ankylosing spondylitis. Clin Rheumatol. 2019;38(4):989\u201395.","journal-title":"Clin Rheumatol"},{"issue":"6","key":"3479_CR28","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1007\/s10067-023-06541-8","volume":"42","author":"Y Guo","year":"2023","unstructured":"Guo Y, Jiang D, Mai Z, Chen Y, Li T, Gao G. Imrecoxib and celecoxib affect sacroiliac joint inflammation in axSpA by regulating bone metabolism and angiogenesis. Clin Rheumatol. 2023;42(6):1585\u201392.","journal-title":"Clin Rheumatol"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-025-03479-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-025-03479-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-025-03479-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T08:45:44Z","timestamp":1737103544000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-025-03479-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,16]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3479"],"URL":"https:\/\/doi.org\/10.1186\/s13075-025-03479-x","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,16]]},"assertion":[{"value":"26 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Patients were informed of the clinical requirements and potential risks associated with all operations before this study. Informed consent forms were obtained and any details that could potentially reveal the identity of the subjects under study were omitted. This study was approved by the Ethics Committee of the Fifth Affiliated Hospital of Sun Yat-Sen University (Approval number: K269-1).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"No individual person\u2019s data were used in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"10"}}