{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:27:24Z","timestamp":1791228444328,"version":"4.1.0"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T00:00:00Z","timestamp":1741392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T00:00:00Z","timestamp":1741392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100936"],"award-info":[{"award-number":["82100936"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272485"],"award-info":[{"award-number":["82272485"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Taishan Scholars Foundation of Shandong Province","award":["tsqnz20221170"],"award-info":[{"award-number":["tsqnz20221170"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Quercetagetin, a flavonoid derived from the natural herb Flos eriocauli, is used in traditional Chinese medicine for its fire-purging (anti-inflammation) and wind-expelling (pain-alleviating) properties. However, its potential effects concerning rheumatoid arthritis (RA) remain underexplored. This study was designed to elucidate the potential associations between Quercetagetin and RA, establishing the therapeutic potential of Quercetagetin and related mechanisms in RA treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Network pharmacology was conducted to decipher related targets and signaling pathways between Quercetagetin and RA. In vitro assays were then conducted to explore the effects of Quercetagetin on osteoclast cell behaviors and corresponding signaling pathways. In vivo study further validated the therapeutic effect of Quercetagetin in collagen antibody-induced arthritis (CAIA) mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The network pharmacological analysis indicated an intimate correlation of Quercetagetin with RA-related inflammatory osteolysis treatment. Pertaining to biological validations, 2 \u00b5M of Quercetagetin successfully inhibited LPS-driven osteoclast differentiation and function. qPCR assay and Western blot analyses denoted parallel changes in osteoclastic marker genes and proteins. Further mechanism study uncovered the effect of Quercetagetin in stimulating the Nrf2\/Keap1 signaling pathway and moderating the Pten\/AKT\/Nfatc1 axis in osteoclasts. In vivo study revealed 40\u00a0mg\/kg Quercetagetin every day could significantly relief joint destruction in CAIA mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study presents Quercetagetin \u2018s therapeutic potential in treating RA, outlining its effects and potential mechanisms in suppressing LPS-induced osteoclast activity, and alleviating inflammatory bone destruction in CAIA model, thereby laying the groundwork for further translational research on Quercetagetin and Flos eriocauli in RA treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13075-025-03522-x","type":"journal-article","created":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T00:04:52Z","timestamp":1741392292000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Quercetagetin alleviates inflammatory osteoclastogenesis and collagen antibody-induced arthritis via Nrf2 signaling and Pten\/AKT\/Nfatc1 axis"],"prefix":"10.1186","volume":"27","author":[{"given":"Haojue","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingpeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengju","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne Yuk-wai","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,8]]},"reference":[{"issue":"1","key":"3522_CR1","doi-asserted-by":"publisher","first-page":"ITC1","DOI":"10.7326\/AITC201901010","volume":"170","author":"JA Sparks","year":"2019","unstructured":"Sparks JA. Rheumatoid arthritis. Ann Intern Med. 2019;170(1):ITC1\u201316.","journal-title":"Ann Intern Med"},{"issue":"10416","key":"3522_CR2","first-page":"2019","volume":"402","author":"A Di Matteo","year":"2023","unstructured":"Di Matteo A, Bathon JM, Emery P. Rheumatoid Arthritis Lancet. 2023;402(10416):2019\u201333.","journal-title":"Rheumatoid Arthritis Lancet"},{"issue":"4","key":"3522_CR3","doi-asserted-by":"publisher","first-page":"102776","DOI":"10.1016\/j.autrev.2021.102776","volume":"20","author":"FA Figus","year":"2021","unstructured":"Figus FA, et al. Rheumatoid arthritis: Extra-articular manifestations and comorbidities. Autoimmun Rev. 2021;20(4):102776.","journal-title":"Autoimmun Rev"},{"issue":"6","key":"3522_CR4","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1056\/NEJMra2103726","volume":"388","author":"EM Gravallese","year":"2023","unstructured":"Gravallese EM, Firestein GS. Rheumatoid Arthritis - Common origins, divergent mechanisms. N Engl J Med. 2023;388(6):529\u201342.","journal-title":"N Engl J Med"},{"key":"3522_CR5","first-page":"e070856","volume":"384","author":"P Brown","year":"2024","unstructured":"Brown P, Pratt AG, Hyrich KL. Therapeutic Adv Rheumatoid Arthritis BMJ. 2024;384:e070856.","journal-title":"Therapeutic Adv Rheumatoid Arthritis BMJ"},{"key":"3522_CR6","doi-asserted-by":"crossref","unstructured":"Maeda K et al. Inflammation and bone metabolism in rheumatoid arthritis: molecular mechanisms of joint destruction and Pharmacological treatments. Int J Mol Sci, 2022. 23(5).","DOI":"10.3390\/ijms23052871"},{"issue":"6","key":"3522_CR7","doi-asserted-by":"publisher","first-page":"e351","DOI":"10.1016\/S2665-9913(23)00094-2","volume":"5","author":"PC Taylor","year":"2023","unstructured":"Taylor PC. Pain in the joints and beyond; the challenge of rheumatoid arthritis. Lancet Rheumatol. 2023;5(6):e351\u201360.","journal-title":"Lancet Rheumatol"},{"key":"3522_CR8","first-page":"p","volume":"103437","author":"M Cutolo","year":"2023","unstructured":"Cutolo M, et al. To treat or not to treat rheumatoid arthritis with glucocorticoids? A reheated debate. Autoimmun Rev. 2023;103437:p.","journal-title":"Autoimmun Rev"},{"issue":"4","key":"3522_CR9","doi-asserted-by":"publisher","first-page":"e14092","DOI":"10.1111\/acel.14092","volume":"23","author":"H Wang","year":"2024","unstructured":"Wang H, et al. Osteoclasts and osteoarthritis: novel intervention targets and therapeutic potentials during aging. Aging Cell. 2024;23(4):e14092.","journal-title":"Aging Cell"},{"issue":"7","key":"3522_CR10","doi-asserted-by":"publisher","first-page":"e358","DOI":"10.1038\/emm.2017.100","volume":"49","author":"J Lee","year":"2017","unstructured":"Lee J, et al. Stimulation of osteoclast migration and bone resorption by C-C chemokine ligands 19 and 21. Exp Mol Med. 2017;49(7):e358.","journal-title":"Exp Mol Med"},{"issue":"11","key":"3522_CR11","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.7150\/ijbs.28609","volume":"15","author":"SC Kwak","year":"2019","unstructured":"Kwak SC, et al. Umbelliferone prevents Lipopolysaccharide-Induced bone loss and suppresses RANKL-Induced osteoclastogenesis by attenuating Akt-c-Fos-NFATc1 signaling. Int J Biol Sci. 2019;15(11):2427\u201337.","journal-title":"Int J Biol Sci"},{"issue":"5","key":"3522_CR12","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1189\/jlb.3A1016-433R","volume":"101","author":"F Stralberg","year":"2017","unstructured":"Stralberg F, et al. Inhibition of lipopolysaccharide-induced osteoclast formation and bone resorption in vitro and in vivo by cysteine proteinase inhibitors. J Leukoc Biol. 2017;101(5):1233\u201343.","journal-title":"J Leukoc Biol"},{"issue":"26","key":"3522_CR13","doi-asserted-by":"publisher","first-page":"e20458","DOI":"10.1097\/MD.0000000000020458","volume":"99","author":"S Siebert","year":"2020","unstructured":"Siebert S, et al. Targeting the rheumatoid arthritis synovial fibroblast via Cyclin dependent kinase Inhibition: an early phase trial. Med (Baltim). 2020;99(26):e20458.","journal-title":"Med (Baltim)"},{"issue":"5","key":"3522_CR14","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.semarthrit.2018.07.009","volume":"48","author":"DS Dalal","year":"2019","unstructured":"Dalal DS, et al. Efficacy and safety of biological agents in the older rheumatoid arthritis patients compared to young: A systematic review and meta-analysis. Semin Arthritis Rheum. 2019;48(5):799\u2013807.","journal-title":"Semin Arthritis Rheum"},{"issue":"5","key":"3522_CR15","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1038\/nrrheum.2017.51","volume":"13","author":"KL Winthrop","year":"2017","unstructured":"Winthrop KL. The emerging safety profile of JAK inhibitors in rheumatic disease. Nat Rev Rheumatol. 2017;13(5):320.","journal-title":"Nat Rev Rheumatol"},{"issue":"3","key":"3522_CR16","doi-asserted-by":"publisher","first-page":"336","DOI":"10.3109\/14397595.2015.1101200","volume":"26","author":"V Torrente-Segarra","year":"2016","unstructured":"Torrente-Segarra V, et al. RENACER study: assessment of 12-month efficacy and safety of 168 certolizumab PEGol rheumatoid arthritis-treated patients from a Spanish multicenter National database. Mod Rheumatol. 2016;26(3):336\u201341.","journal-title":"Mod Rheumatol"},{"issue":"5","key":"3522_CR17","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1111\/joim.13537","volume":"292","author":"PJ Jakobsson","year":"2022","unstructured":"Jakobsson PJ, et al. Where traditional Chinese medicine Meets Western medicine in the prevention of rheumatoid arthritis. J Intern Med. 2022;292(5):745\u201363.","journal-title":"J Intern Med"},{"key":"3522_CR18","unstructured":"Gavahian M et al. Fenugreek bioactive compounds: A review of applications and extraction based on emerging technologies. Crit Rev Food Sci Nutr, 2023: pp. 1\u201317."},{"issue":"11","key":"3522_CR19","doi-asserted-by":"publisher","first-page":"102884","DOI":"10.1016\/j.dsx.2023.102884","volume":"17","author":"A Gupta","year":"2023","unstructured":"Gupta A, et al. A systematic review exploring the mechanisms by which citrus bioflavonoid supplementation benefits blood glucose levels and metabolic complications in type 2 diabetes mellitus. Diabetes Metab Syndr. 2023;17(11):102884.","journal-title":"Diabetes Metab Syndr"},{"issue":"10","key":"3522_CR20","first-page":"13","volume":"21","author":"T Huang","year":"2015","unstructured":"Huang T, et al. Investigation of antioxidant activity of eriocauli Flos extract. Chin J Experimental Traditional Med Formulae. 2015;21(10):13\u20135.","journal-title":"Chin J Experimental Traditional Med Formulae"},{"issue":"4","key":"3522_CR21","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.jfda.2017.01.002","volume":"25","author":"IJ Lee","year":"2017","unstructured":"Lee IJ, et al. Morphological and chemical analyses of eriocauli Flos sold in Taiwan markets. J Food Drug Anal. 2017;25(4):939\u201345.","journal-title":"J Food Drug Anal"},{"key":"3522_CR22","doi-asserted-by":"crossref","unstructured":"Rufino AT et al. Rheumatoid arthritis molecular targets and their importance to flavonoid-based therapy. Med Res Rev, 2023.","DOI":"10.1002\/med.21990"},{"issue":"17","key":"3522_CR23","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.1080\/10408398.2016.1246413","volume":"57","author":"SD Hughes","year":"2017","unstructured":"Hughes SD, Ketheesan N, Haleagrahara N. The therapeutic potential of plant flavonoids on rheumatoid arthritis. Crit Rev Food Sci Nutr. 2017;57(17):3601\u201313.","journal-title":"Crit Rev Food Sci Nutr"},{"key":"3522_CR24","doi-asserted-by":"publisher","first-page":"155098","DOI":"10.1016\/j.phymed.2023.155098","volume":"121","author":"P Thakur","year":"2023","unstructured":"Thakur P, et al. Network Pharmacology on mechanistic role of Thymus linearis Benth. Against Gastrointestinal and neurological diseases. Phytomedicine. 2023;121:155098.","journal-title":"Phytomedicine"},{"key":"3522_CR25","doi-asserted-by":"crossref","unstructured":"Cui Z et al. Network Pharmacology Deciphers the Action of Bioactive Polypeptide in Attenuating Inflammatory Osteolysis via the Suppression of Oxidative Stress and Restoration of Bone Remodeling Balance. Oxid Med Cell Longev, 2022. 2022: p. 4913534.","DOI":"10.1155\/2022\/4913534"},{"key":"3522_CR26","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1758-2946-6-13","volume":"6","author":"J Ru","year":"2014","unstructured":"Ru J, et al. TCMSP: a database of systems Pharmacology for drug discovery from herbal medicines. J Cheminform. 2014;6:13.","journal-title":"J Cheminform"},{"issue":"D1","key":"3522_CR27","doi-asserted-by":"publisher","first-page":"D506","DOI":"10.1093\/nar\/gky1049","volume":"47","author":"C UniProt","year":"2019","unstructured":"UniProt C. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019;47(D1):D506\u201315.","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"3522_CR28","doi-asserted-by":"publisher","first-page":"D607","DOI":"10.1093\/nar\/gky1131","volume":"47","author":"D Szklarczyk","year":"2019","unstructured":"Szklarczyk D, et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47(D1):D607\u201313.","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"3522_CR29","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498\u2013504.","journal-title":"Genome Res"},{"issue":"W1","key":"3522_CR30","doi-asserted-by":"publisher","first-page":"W216","DOI":"10.1093\/nar\/gkac194","volume":"50","author":"BT Sherman","year":"2022","unstructured":"Sherman BT, et al. DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update). Nucleic Acids Res. 2022;50(W1):W216\u201321.","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"3522_CR31","doi-asserted-by":"publisher","first-page":"D1388","DOI":"10.1093\/nar\/gkaa971","volume":"49","author":"S Kim","year":"2021","unstructured":"Kim S, et al. PubChem in 2021: new data content and improved web interfaces. Nucleic Acids Res. 2021;49(D1):D1388\u201395.","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"3522_CR32","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1038\/nsb1203-980","volume":"10","author":"H Berman","year":"2003","unstructured":"Berman H, Henrick K, Nakamura H. Announcing the worldwide protein data bank. Nat Struct Biol. 2003;10(12):980.","journal-title":"Nat Struct Biol"},{"issue":"2","key":"3522_CR33","doi-asserted-by":"publisher","first-page":"100452","DOI":"10.1016\/j.xpro.2021.100452","volume":"2","author":"C Chevalier","year":"2021","unstructured":"Chevalier C, et al. Primary mouse osteoblast and osteoclast culturing and analysis. STAR Protoc. 2021;2(2):100452.","journal-title":"STAR Protoc"},{"key":"3522_CR34","doi-asserted-by":"publisher","first-page":"p113158","DOI":"10.1016\/j.intimp.2024.113158","volume":"142Pt B","author":"Q Lu","year":"2024","unstructured":"Lu Q, et al. Corydaline attenuates osteolysis in rheumatoid arthritis via mitigating reactive oxygen species production and suppressing calcineurin-Nfatc1 signaling. Int Immunopharmacol. 2024;142Pt B:p113158.","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"3522_CR35","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1007\/s10753-023-01933-z","volume":"47","author":"Y Wang","year":"2024","unstructured":"Wang Y, et al. Inhibition of protein disulfide isomerase attenuates osteoclast differentiation and function via the readjustment of cellular redox state in postmenopausal osteoporosis. Inflammation. 2024;47(2):626\u201348.","journal-title":"Inflammation"},{"issue":"1","key":"3522_CR36","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s10020-024-00880-1","volume":"30","author":"T Yuan","year":"2024","unstructured":"Yuan T, et al. Inhibition of insulin degrading enzyme suppresses osteoclast hyperactivity via enhancing Nrf2-dependent antioxidant response in glucocorticoid-induced osteonecrosis of the femoral head. Mol Med. 2024;30(1):111.","journal-title":"Mol Med"},{"issue":"2","key":"3522_CR37","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1136\/ard-2022-222708","volume":"82","author":"J Tu","year":"2023","unstructured":"Tu J, et al. PU.1 promotes development of rheumatoid arthritis via repressing FLT3 in macrophages and fibroblast-like synoviocytes. Ann Rheum Dis. 2023;82(2):198\u2013211.","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"3522_CR38","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1038\/nprot.2007.173","volume":"2","author":"DD Brand","year":"2007","unstructured":"Brand DD, Latham KA, Rosloniec EF. Collagen-induced Arthritis Nat Protoc. 2007;2(5):1269\u201375.","journal-title":"Collagen-induced Arthritis Nat Protoc"},{"key":"3522_CR39","doi-asserted-by":"publisher","first-page":"106041","DOI":"10.1016\/j.compbiomed.2022.106041","volume":"149","author":"M Ko","year":"2022","unstructured":"Ko M, et al. Network Pharmacology and molecular Docking approaches to elucidate the potential compounds and targets of Saeng-Ji-Hwang-Ko for treatment of type 2 diabetes mellitus. Comput Biol Med. 2022;149:106041.","journal-title":"Comput Biol Med"},{"key":"3522_CR40","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.jot.2020.07.008","volume":"26","author":"M Chu","year":"2021","unstructured":"Chu M, et al. Lingzhi and San-Miao-San with hyaluronic acid gel mitigate cartilage degeneration in anterior cruciate ligament transection induced osteoarthritis. J Orthop Translat. 2021;26:132\u201340.","journal-title":"J Orthop Translat"},{"key":"3522_CR41","doi-asserted-by":"publisher","first-page":"107516","DOI":"10.1016\/j.jmgm.2019.107516","volume":"96","author":"M Singh","year":"2020","unstructured":"Singh M, et al. A classification model for blood brain barrier penetration. J Mol Graph Model. 2020;96:107516.","journal-title":"J Mol Graph Model"},{"key":"3522_CR42","doi-asserted-by":"publisher","first-page":"106400","DOI":"10.1016\/j.phrs.2022.106400","volume":"184","author":"L Wei","year":"2022","unstructured":"Wei L, et al. Alpinetin ameliorates bone loss in LPS-induced inflammation osteolysis via ROS mediated P38\/PI3K signaling pathway. Pharmacol Res. 2022;184:106400.","journal-title":"Pharmacol Res"},{"issue":"15","key":"3522_CR43","doi-asserted-by":"publisher","first-page":"e35374","DOI":"10.1016\/j.heliyon.2024.e35374","volume":"10","author":"T Yuan","year":"2024","unstructured":"Yuan T, et al. Suppressing ERp57 diminishes osteoclast activity and ameliorates ovariectomy-induced bone loss via the intervention in calcium Oscillation and the calmodulin\/calcineurin\/Nfatc1 pathway. Heliyon. 2024;10(15):e35374.","journal-title":"Heliyon"},{"issue":"8","key":"3522_CR44","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1016\/j.cmet.2024.03.005","volume":"36","author":"Y Dong","year":"2024","unstructured":"Dong Y, et al. A clinical-stage Nrf2 activator suppresses osteoclast differentiation via the iron-ornithine axis. Cell Metab. 2024;36(8):1679\u2013e16956.","journal-title":"Cell Metab"},{"issue":"3","key":"3522_CR45","doi-asserted-by":"publisher","first-page":"103979","DOI":"10.1016\/j.isci.2022.103979","volume":"25","author":"Y Cheng","year":"2022","unstructured":"Cheng Y, et al. Bone erosion in inflammatory arthritis is attenuated by Trichinella spiralis through inhibiting M1 monocyte\/macrophage polarization. iScience. 2022;25(3):103979.","journal-title":"iScience"},{"issue":"11","key":"3522_CR46","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1002\/art.41005","volume":"71","author":"S Flammier","year":"2019","unstructured":"Flammier S, et al. Osteoclast-Derived autotaxin, a distinguishing factor for inflammatory bone loss. Arthritis Rheumatol. 2019;71(11):1801\u201311.","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"3522_CR47","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s13045-023-01512-7","volume":"16","author":"J Liu","year":"2023","unstructured":"Liu J, et al. Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy. J Hematol Oncol. 2023;16(1):116.","journal-title":"J Hematol Oncol"},{"key":"3522_CR48","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s11658-017-0047-z","volume":"22","author":"G Gutierrez-Venegas","year":"2017","unstructured":"Gutierrez-Venegas G, et al. Luteolin, Quercetin, genistein and Quercetagetin inhibit the effects of lipopolysaccharide obtained from Porphyromonas gingivalis in H9c2 cardiomyoblasts. Cell Mol Biol Lett. 2017;22:19.","journal-title":"Cell Mol Biol Lett"},{"key":"3522_CR49","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.antiviral.2016.07.009","volume":"133","author":"R Lani","year":"2016","unstructured":"Lani R, et al. Antiviral activity of selected flavonoids against Chikungunya virus. Antiviral Res. 2016;133:50\u201361.","journal-title":"Antiviral Res"},{"issue":"6","key":"3522_CR50","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1172\/JCI93356","volume":"127","author":"G Mbalaviele","year":"2017","unstructured":"Mbalaviele G, et al. Inflammatory osteolysis: a conspiracy against bone. J Clin Invest. 2017;127(6):2030\u20139.","journal-title":"J Clin Invest"},{"key":"3522_CR51","doi-asserted-by":"crossref","unstructured":"Xie X et al. IKK\/NF-kappaB and ROS signal axes are involved in Tenacissoside H mediated inhibitory effects on LPS-induced inflammatory osteolysis. Cell Prolif, 2023: p. e13535.","DOI":"10.1111\/cpr.13535"},{"issue":"7","key":"3522_CR52","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/s41584-022-00793-5","volume":"18","author":"N Komatsu","year":"2022","unstructured":"Komatsu N, Takayanagi H. Mechanisms of joint destruction in rheumatoid arthritis - immune cell-fibroblast-bone interactions. Nat Rev Rheumatol. 2022;18(7):415\u201329.","journal-title":"Nat Rev Rheumatol"},{"key":"3522_CR53","doi-asserted-by":"crossref","unstructured":"Zhang W et al. alpha-Mangostin inhibits LPS-induced bone resorption by restricting osteoclastogenesis via NF-kappaB and MAPK signaling. Chin Med, 2022. 17(1): p. 34.","DOI":"10.1186\/s13020-022-00589-5"},{"issue":"11","key":"3522_CR54","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1016\/j.it.2021.09.006","volume":"42","author":"V Tiku","year":"2021","unstructured":"Tiku V, Tan MW. Host immunity and cellular responses to bacterial outer membrane vesicles. Trends Immunol. 2021;42(11):1024\u201336.","journal-title":"Trends Immunol"},{"issue":"4","key":"3522_CR55","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1007\/s10753-020-01207-y","volume":"43","author":"G Yan","year":"2020","unstructured":"Yan G, et al. N-Acetylcysteine attenuates Lipopolysaccharide-Induced osteolysis by restoring bone remodeling balance via reduction of reactive oxygen species formation during osteoclastogenesis. Inflammation. 2020;43(4):1279\u201392.","journal-title":"Inflammation"},{"issue":"8","key":"3522_CR56","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1002\/cyto.a.22495","volume":"85","author":"A Pierzynska-Mach","year":"2014","unstructured":"Pierzynska-Mach A, Janowski PA, Dobrucki JW. Evaluation of acridine orange, lysotracker red, and quinacrine as fluorescent probes for long-term tracking of acidic vesicles. Cytometry A. 2014;85(8):729\u201337.","journal-title":"Cytometry A"},{"issue":"6","key":"3522_CR57","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.7150\/thno.30206","volume":"9","author":"K Chen","year":"2019","unstructured":"Chen K, et al. Pseurotin A inhibits osteoclastogenesis and prevents Ovariectomized-Induced bone loss by suppressing reactive oxygen species. Theranostics. 2019;9(6):1634\u201350.","journal-title":"Theranostics"},{"issue":"10","key":"3522_CR58","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1093\/abbs\/gmaa098","volume":"52","author":"H Tao","year":"2020","unstructured":"Tao H, et al. ROS signaling cascades: dual regulations for osteoclast and osteoblast. Acta Biochim Biophys Sin (Shanghai). 2020;52(10):1055\u201362.","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"3522_CR59","doi-asserted-by":"publisher","first-page":"641277","DOI":"10.3389\/fphar.2021.641277","volume":"12","author":"W Liu","year":"2021","unstructured":"Liu W, et al. 6\u2019-O-Galloylpaeoniflorin attenuates Osteoclasto-genesis and relieves Ovariectomy-Induced osteoporosis by inhibiting reactive oxygen species and MAPKs\/c-Fos\/NFATc1 signaling pathway. Front Pharmacol. 2021;12:641277.","journal-title":"Front Pharmacol"},{"issue":"6759","key":"3522_CR60","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/46303","volume":"402","author":"YY Kong","year":"1999","unstructured":"Kong YY, et al. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature. 1999;402(6759):304\u20139.","journal-title":"Nature"},{"issue":"12","key":"3522_CR61","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.1084\/jem.20061775","volume":"203","author":"K Sato","year":"2006","unstructured":"Sato K, et al. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med. 2006;203(12):2673\u201382.","journal-title":"J Exp Med"},{"issue":"1","key":"3522_CR62","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1111\/nyas.13407","volume":"1401","author":"AS Marchev","year":"2017","unstructured":"Marchev AS, et al. Oxidative stress and chronic inflammation in osteoarthritis: can NRF2 counteract these partners in crime? Ann N Y Acad Sci. 2017;1401(1):114\u201335.","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"3522_CR63","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1084\/jem.20050538","volume":"202","author":"T Rangasamy","year":"2005","unstructured":"Rangasamy T, et al. Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. J Exp Med. 2005;202(1):47\u201359.","journal-title":"J Exp Med"},{"key":"3522_CR64","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1146\/annurev.pharmtox.46.120604.141046","volume":"47","author":"TW Kensler","year":"2007","unstructured":"Kensler TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol. 2007;47:89\u2013116.","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"3522_CR65","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.redox.2017.03.001","volume":"12","author":"H Lv","year":"2017","unstructured":"Lv H, et al. Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK\/GSK3beta-Nrf2 signal axis. Redox Biol. 2017;12:311\u201324.","journal-title":"Redox Biol"},{"issue":"8","key":"3522_CR66","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1038\/aps.2017.143","volume":"39","author":"ST Li","year":"2018","unstructured":"Li ST, et al. Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK\/NF-kappaB signaling pathway and activating the PI3K\/Akt\/Nrf2 pathway. Acta Pharmacol Sin. 2018;39(8):1294\u2013304.","journal-title":"Acta Pharmacol Sin"},{"issue":"8","key":"3522_CR67","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1038\/s12276-022-00829-6","volume":"54","author":"Q Xiang","year":"2022","unstructured":"Xiang Q, et al. The Nrf2 antioxidant defense system in intervertebral disc degeneration: molecular insights. Exp Mol Med. 2022;54(8):1067\u201375.","journal-title":"Exp Mol Med"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-025-03522-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-025-03522-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-025-03522-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T00:37:25Z","timestamp":1741394245000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-025-03522-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,8]]},"references-count":67,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3522"],"URL":"https:\/\/doi.org\/10.1186\/s13075-025-03522-x","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,8]]},"assertion":[{"value":"15 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experiments involving mice were performed following the protocol approved by the Institutional Animal Care and Use Committee (IACUC) of the Shandong Provincial Hospital Affiliated to Shandong First Medical University (Shandong, China; No.2023-015). All efforts were made to minimize suffering and minimize the number of mice needed to assess statistical significance and experimental reproducibility.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"54"}}