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The study was conducted in compliance with the Declaration of Helsinki. All subjects provided signed consent forms.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Author YH, JS, MK, and ACBJ are employees of Nordic Bioscience and own stocks in Nordic Bioscience. S. Kubo has received speaking fees from Eli Lilly, Bristol-Myers, GlaxoSmithKline, Abbvie, and also research grants from Daiichi-Sankyo, Abbvie, and Boehringer Ingelheim. Y. Miyazaki has received consulting fees from Astra-Zeneca, speaking fees, and\/or honoraria from Eli Lilly and GlaxoSmithKline. Y. Tanaka has received speaker fees and\/or honoraria from Eli Lilly, AstraZeneca, Abbvie, Gilead, Chugai, Behringer-Ingelheim, GlaxoSmithKline, Eisai, Taisho, Bristol-Myers, Pfizer, Taiho, received research grants from Mitsubishi-Tanabe, Eisai, Chugai, Taisho.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"58"}}