{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:13:05Z","timestamp":1791227585850,"version":"4.1.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82071834"],"award-info":[{"award-number":["82071834"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Dalian Medical University Interdisciplinary Research Cooperation Project Team Funding","award":["JCHZ2023010"],"award-info":[{"award-number":["JCHZ2023010"]}]},{"name":"the Natural Science Funding of Jilin province","award":["20200201548JC"],"award-info":[{"award-number":["20200201548JC"]}]},{"name":"Medicine & Health Funding of Jilin province","award":["20200404145YY"],"award-info":[{"award-number":["20200404145YY"]}]},{"name":"International Collabration Funding of Jilin province","award":["20200801045GH"],"award-info":[{"award-number":["20200801045GH"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"DOI":"10.1186\/s13075-025-03527-6","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T03:09:01Z","timestamp":1745896141000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Resistin upregulates fatty acid oxidation in synoviocytes of metabolic syndrome-associated knee osteoarthritis via CAP1\/PKA\/CREB to promote inflammation and catabolism"],"prefix":"10.1186","volume":"27","author":[{"given":"Lu","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Yi","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Fan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Zeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Ran","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Wei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Li","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"3527_CR1","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1002\/art.34453","volume":"64","author":"RF Loeser","year":"2012","unstructured":"Loeser RF, Goldring SR, Scanzello CR, Goldring MB. Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum. 2012;64:1697\u2013707. https:\/\/doi.org\/10.1002\/art.34453.","journal-title":"Arthritis Rheum"},{"key":"3527_CR2","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1016\/j.pmrj.2012.01.007","volume":"4","author":"P Suri","year":"2012","unstructured":"Suri P, Morgenroth DC, Hunter DJ. Epidemiology of osteoarthritis and associated comorbidities. PM R. 2012;4:S10\u20139. https:\/\/doi.org\/10.1016\/j.pmrj.2012.01.007.","journal-title":"PM R"},{"key":"3527_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2023.05.014","author":"W Walrabenstein","year":"2023","unstructured":"Walrabenstein W, Wagenaar CA, van de Put M, van der Leeden M, Gerritsen M, Twisk JWR, et al. A multidisciplinary lifestyle program for metabolic syndrome-associated osteoarthritis: the plants for joints randomized controlled trial. Osteoarthritis Cartilage. 2023. https:\/\/doi.org\/10.1016\/j.joca.2023.05.014.","journal-title":"Osteoarthritis Cartilage"},{"key":"3527_CR4","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/S0140-6736(05)66378-7","volume":"365","author":"RH Eckel","year":"2005","unstructured":"Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet. 2005;365:1415\u201328.","journal-title":"Lancet"},{"key":"3527_CR5","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s13098-020-00547-x","volume":"12","author":"SY Liu","year":"2020","unstructured":"Liu SY, Zhu WT, Chen BW, Chen YH, Ni GX. Bidirectional association between metabolic syndrome and osteoarthritis: a meta-analysis of observational studies. Diabetol Metab Syndr. 2020;12:38. https:\/\/doi.org\/10.1186\/s13098-020-00547-x.","journal-title":"Diabetol Metab Syndr"},{"key":"3527_CR6","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.joca.2012.11.012","volume":"21","author":"F Berenbaum","year":"2013","unstructured":"Berenbaum F. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthritis Cartilage. 2013;21:16\u201321. https:\/\/doi.org\/10.1016\/j.joca.2012.11.012.","journal-title":"Osteoarthritis Cartilage"},{"key":"3527_CR7","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/nrrheum.2010.159","volume":"6","author":"J Sellam","year":"2010","unstructured":"Sellam J, Berenbaum F. The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat Rev Rheumatol. 2010;6:625\u201335. https:\/\/doi.org\/10.1038\/nrrheum.2010.159.","journal-title":"Nat Rev Rheumatol"},{"key":"3527_CR8","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.semcdb.2019.12.006","volume":"101","author":"T Pap","year":"2020","unstructured":"Pap T, Dankbar B, Wehmeyer C, Korb-Pap A, Sherwood J. Synovial fibroblasts and articular tissue remodelling: role and mechanisms. Semin Cell Dev Biol. 2020;101:140\u20135. https:\/\/doi.org\/10.1016\/j.semcdb.2019.12.006.","journal-title":"Semin Cell Dev Biol"},{"key":"3527_CR9","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.2147\/DMSO.S249025","volume":"13","author":"L Ding","year":"2020","unstructured":"Ding L, Gao YH, Li YR, Huang YF, Wang XY, Qi X. Metabolic score for insulin resistance is correlated to adipokine disorder and inflammatory activity in female knee osteoarthritis patients in a Chinese population. Diabetes Metab Syndr Obes. 2020;13:2109\u201318. https:\/\/doi.org\/10.2147\/DMSO.S249025.","journal-title":"Diabetes Metab Syndr Obes"},{"key":"3527_CR10","doi-asserted-by":"publisher","first-page":"2894","DOI":"10.1002\/art.30527","volume":"63","author":"EA Bostrom","year":"2011","unstructured":"Bostrom EA, Svensson M, Andersson S, Jonsson IM, Ekwall AK, Eisler T, et al. Resistin and insulin\/insulin-like growth factor signaling in rheumatoid arthritis. Arthritis Rheum. 2011;63:2894\u2013904. https:\/\/doi.org\/10.1002\/art.30527.","journal-title":"Arthritis Rheum"},{"key":"3527_CR11","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1111\/j.1582-4934.2008.00337.x","volume":"13","author":"N Di Simone","year":"2009","unstructured":"Di Simone N, Di Nicuolo F, Marzioni D, Castellucci M, Sanguinetti M, D\u2019Lppolito S, et al. Resistin modulates glucose uptake and glucose transporter-1 (GLUT-1) expression in trophoblast cells. J Cell Mol Med. 2009;13:388\u201397. https:\/\/doi.org\/10.1111\/j.1582-4934.2008.00337.x.","journal-title":"J Cell Mol Med"},{"key":"3527_CR12","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1159\/000489546","volume":"46","author":"F He","year":"2018","unstructured":"He F, Jin JQ, Qin QQ, Zheng YQ, Li TT, Zhang Y, et al. Resistin regulates fatty acid Beta oxidation by suppressing expression of peroxisome proliferator activator receptor Gamma-Coactivator 1alpha (PGC-1alpha). Cell Physiol Biochem. 2018;46:2165\u201372. https:\/\/doi.org\/10.1159\/000489546.","journal-title":"Cell Physiol Biochem"},{"key":"3527_CR13","doi-asserted-by":"publisher","first-page":"5049","DOI":"10.1016\/j.febslet.2005.08.011","volume":"579","author":"R Palanivel","year":"2005","unstructured":"Palanivel R, Sweeney G. Regulation of fatty acid uptake and metabolism in L6 skeletal muscle cells by resistin. FEBS Lett. 2005;579:5049\u201354. https:\/\/doi.org\/10.1016\/j.febslet.2005.08.011.","journal-title":"FEBS Lett"},{"key":"3527_CR14","doi-asserted-by":"publisher","first-page":"5884","DOI":"10.1111\/febs.12514","volume":"280","author":"Y Ikeda","year":"2013","unstructured":"Ikeda Y, Tsuchiya H, Hama S, Kajimoto K, Kogure K. Resistin affects lipid metabolism during adipocyte maturation of 3T3-L1 cells. FEBS J. 2013;280:5884\u201395. https:\/\/doi.org\/10.1111\/febs.12514.","journal-title":"FEBS J"},{"key":"3527_CR15","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1172\/JCI94584","volume":"128","author":"CJ Hall","year":"2018","unstructured":"Hall CJ, Sanderson LE, Lawrence LM, Pool B, van der Kroef M, Ashimbayeva E, et al. Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation. J Clin Invest. 2018;128:1752\u201371. https:\/\/doi.org\/10.1172\/JCI94584.","journal-title":"J Clin Invest"},{"issue":"4","key":"3527_CR16","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1111\/j.1365-2559.2006.02508.x","volume":"49","author":"V Krenn","year":"2006","unstructured":"Krenn V, Morawietz L, Burmester GR, Kinne RW, Mueller-Ladner U, Muller B, Haupl T. Synovitis score: discrimination between chronic low-grade and high-grade synovitis. Histopathology. 2006;49(4):358\u201364. https:\/\/doi.org\/10.1111\/j.1365-2559.2006.02508.x.","journal-title":"Histopathology"},{"key":"3527_CR17","doi-asserted-by":"publisher","unstructured":"ZCW, GYH, SWX, LB, DL, DN, et al. An update on the emerging role of resistin on the pathogenesis of osteoarthritis. Mediators Inflamm. 2019;2019:1532164. https:\/\/doi.org\/10.1155\/2019\/1532164.","DOI":"10.1155\/2019\/1532164"},{"key":"3527_CR18","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1002\/art.39707","volume":"68","author":"C Reyes","year":"2016","unstructured":"Reyes C, Leyland KM, Peat G, Cooper C, Arden NK, Prieto-Alhambra D. Association between overweight and obesity and risk of clinically diagnosed knee, hip, and hand osteoarthritis: A Population-Based cohort study. Arthritis Rheumatol. 2016;68:1869\u201375. https:\/\/doi.org\/10.1002\/art.39707.","journal-title":"Arthritis Rheumatol"},{"key":"3527_CR19","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1093\/rheumatology\/kew389","volume":"56","author":"T Hugle","year":"2017","unstructured":"Hugle T, Geurts J. What drives osteoarthritis?-synovial versus subchondral bone pathology. Rheumatology (Oxford). 2017;56:1461\u201371. https:\/\/doi.org\/10.1093\/rheumatology\/kew389.","journal-title":"Rheumatology (Oxford)"},{"key":"3527_CR20","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1186\/s13075-017-1473-z","volume":"19","author":"A Larranaga-Vera","year":"2017","unstructured":"Larranaga-Vera A, Lamuedra A, Perez-Baos S, Prieto-Potin I, Pena L, Herrero-Beaumont G, et al. Increased synovial lipodystrophy induced by high fat diet aggravates synovitis in experimental osteoarthritis. Arthritis Res Ther. 2017;19:264. https:\/\/doi.org\/10.1186\/s13075-017-1473-z.","journal-title":"Arthritis Res Ther"},{"key":"3527_CR21","doi-asserted-by":"publisher","first-page":"e0183693","DOI":"10.1371\/journal.pone.0183693","volume":"12","author":"AR Sun","year":"2017","unstructured":"Sun AR, Panchal SK, Friis T, Sekar S, Crawford R, Brown L, et al. Obesity-associated metabolic syndrome spontaneously induces infiltration of pro-inflammatory macrophage in synovium and promotes osteoarthritis. PLoS ONE. 2017;12:e0183693. https:\/\/doi.org\/10.1371\/journal.pone.0183693.","journal-title":"PLoS ONE"},{"key":"3527_CR22","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1002\/jor.23712","volume":"36","author":"HM de Visser","year":"2018","unstructured":"de Visser HM, Mastbergen SC, Kozijn AE, Coeleveld K, Pouran B, van Rijen MH, et al. Metabolic dysregulation accelerates injury-induced joint degeneration, driven by local inflammation; an in vivo rat study. J Orthop Res. 2018;36:881\u201390. https:\/\/doi.org\/10.1002\/jor.23712.","journal-title":"J Orthop Res"},{"key":"3527_CR23","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.joca.2012.01.021","volume":"20","author":"KR Baker","year":"2012","unstructured":"Baker KR, Matthan NR, Lichtenstein AH, Niu J, Guermazi A, Roemer F, et al. Association of plasma n-6 and n-3 polyunsaturated fatty acids with synovitis in the knee: the MOST study. Osteoarthritis Cartilage. 2012;20:382\u20137. https:\/\/doi.org\/10.1016\/j.joca.2012.01.021.","journal-title":"Osteoarthritis Cartilage"},{"key":"3527_CR24","doi-asserted-by":"publisher","first-page":"44315","DOI":"10.1038\/srep44315","volume":"7","author":"CL Wu","year":"2017","unstructured":"Wu CL, Kimmerling KA, Little D, Guilak F. Serum and synovial fluid lipidomic profiles predict obesity-associated osteoarthritis, synovitis, and wound repair. Sci Rep. 2017;7:44315. https:\/\/doi.org\/10.1038\/srep44315.","journal-title":"Sci Rep"},{"key":"3527_CR25","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1002\/art.38399","volume":"66","author":"O Alvarez-Garcia","year":"2014","unstructured":"Alvarez-Garcia O, Rogers NH, Smith RG, Lotz MK. Palmitate has proapoptotic and Proinflammatory effects on articular cartilage and synergizes with interleukin-1. Arthritis Rheumatol. 2014;66:1779\u201388. https:\/\/doi.org\/10.1002\/art.38399.","journal-title":"Arthritis Rheumatol"},{"key":"3527_CR26","doi-asserted-by":"publisher","first-page":"e0122904","DOI":"10.1371\/journal.pone.0122904","volume":"10","author":"D de Seny","year":"2015","unstructured":"de Seny D, Cobraiville G, Charlier E, Neuville S, Lutteri L, Le Goff C, et al. Apolipoprotein-A1 as a damage-associated molecular patterns protein in osteoarthritis: ex vivo and in vitro pro-inflammatory properties. PLoS ONE. 2015;10:e0122904. https:\/\/doi.org\/10.1371\/journal.pone.0122904.","journal-title":"PLoS ONE"},{"key":"3527_CR27","doi-asserted-by":"publisher","first-page":"13177","DOI":"10.1002\/jcb.28592","volume":"120","author":"T Gui","year":"2019","unstructured":"Gui T, Lin YK, Huan SW, Li YH, Wang BH, Yang J, et al. Elevated expression of ICAM-1 in synovium is associated with early inflammatory response for cartilage degeneration in type 2 diabetes mellitus. J Cell Biochem. 2019;120:13177\u201386. https:\/\/doi.org\/10.1002\/jcb.28592.","journal-title":"J Cell Biochem"},{"key":"3527_CR28","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1007\/s10753-020-01178-0","volume":"43","author":"L Qiao","year":"2020","unstructured":"Qiao L, Li Y, Sun S. Insulin exacerbates inflammation in Fibroblast-Like synoviocytes. Inflammation. 2020;43:916\u201336. https:\/\/doi.org\/10.1007\/s10753-020-01178-0.","journal-title":"Inflammation"},{"key":"3527_CR29","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1038\/s12276-021-00697-6","volume":"53","author":"Q Li","year":"2021","unstructured":"Li Q, Wen Y, Wang L, Chen B, Chen J, Wang H, et al. Hyperglycemia-induced accumulation of advanced glycosylation end products in fibroblast-like synoviocytes promotes knee osteoarthritis. Exp Mol Med. 2021;53:1735\u201347. https:\/\/doi.org\/10.1038\/s12276-021-00697-6.","journal-title":"Exp Mol Med"},{"key":"3527_CR30","doi-asserted-by":"publisher","first-page":"13671","DOI":"10.1096\/fj.202001071R","volume":"34","author":"WC Chen","year":"2020","unstructured":"Chen WC, Lu YC, Kuo SJ, Lin CY, Tsai CH, Liu SC, et al. Resistin enhances IL-1beta and TNF-alpha expression in human osteoarthritis synovial fibroblasts by inhibiting miR-149 expression via the MEK and ERK pathways. FASEB J. 2020;34:13671\u201384. https:\/\/doi.org\/10.1096\/fj.202001071R.","journal-title":"FASEB J"},{"key":"3527_CR31","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.bcp.2019.03.030","volume":"165","author":"V Francisco","year":"2019","unstructured":"Francisco V, Ruiz-Fernandez C, Pino J, Mera A, Gonzalez-Gay MA, Gomez R, et al. Adipokines: linking metabolic syndrome, the immune system, and arthritic diseases. Biochem Pharmacol. 2019;165:196\u2013206. https:\/\/doi.org\/10.1016\/j.bcp.2019.03.030.","journal-title":"Biochem Pharmacol"},{"key":"3527_CR32","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/35053000","volume":"409","author":"CM Steppan","year":"2001","unstructured":"Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, et al. The hormone resistin links obesity to diabetes. Nature. 2001;409:307\u201312. https:\/\/doi.org\/10.1038\/35053000.","journal-title":"Nature"},{"key":"3527_CR33","doi-asserted-by":"publisher","first-page":"4961","DOI":"10.2174\/1381612819666131206103102","volume":"20","author":"N Abate","year":"2014","unstructured":"Abate N, Sallam HS, Rizzo M, Nikolic D, Obradovic M, Bjelogrlic P, et al. Resistin: an inflammatory cytokine. Role in cardiovascular diseases, diabetes and the metabolic syndrome. Curr Pharm Des. 2014;20:4961\u20139. https:\/\/doi.org\/10.2174\/1381612819666131206103102.","journal-title":"Curr Pharm Des"},{"key":"3527_CR34","doi-asserted-by":"publisher","first-page":"501","DOI":"10.55563\/clinexprheumatol\/avcj31","volume":"40","author":"CW Zhao","year":"2022","unstructured":"Zhao CW, Song WX, Liu B, Gao YH, Ding L, Huang YF, et al. Resistin induces chemokine and matrix metalloproteinase production via CAP1 receptor and activation of p38-MAPK and NF-kappaB signalling pathways in human chondrocytes. Clin Exp Rheumatol. 2022;40:501\u201313. https:\/\/doi.org\/10.55563\/clinexprheumatol\/avcj31.","journal-title":"Clin Exp Rheumatol"},{"key":"3527_CR35","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1016\/j.jamda.2019.07.001","volume":"20","author":"W Han","year":"2019","unstructured":"Han W, Aitken D, Zheng S, Wang B, Wluka AE, Zhu Z, et al. Higher serum levels of resistin are associated with knee synovitis and structural abnormalities in patients with symptomatic knee osteoarthritis. J Am Med Dir Assoc. 2019;20:1242\u20136. https:\/\/doi.org\/10.1016\/j.jamda.2019.07.001.","journal-title":"J Am Med Dir Assoc"},{"key":"3527_CR36","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1016\/j.joca.2012.05.002","volume":"20","author":"TN de Boer","year":"2012","unstructured":"de Boer TN, van Spil WE, Huisman AM, Polak AA, Bijlsma JW, Lafeber FP, et al. Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage. Osteoarthritis Cartilage. 2012;20:846\u201353. https:\/\/doi.org\/10.1016\/j.joca.2012.05.002.","journal-title":"Osteoarthritis Cartilage"},{"key":"3527_CR37","doi-asserted-by":"publisher","first-page":"408","DOI":"10.33594\/000000029","volume":"52","author":"WC Chen","year":"2019","unstructured":"Chen WC, Wang SW, Lin CY, Tsai CH, Fong YC, Lin TY, et al. Resistin enhances monocyte chemoattractant Protein-1 production in human synovial fibroblasts and facilitates monocyte migration. Cell Physiol Biochem. 2019;52:408\u201320. https:\/\/doi.org\/10.33594\/000000029.","journal-title":"Cell Physiol Biochem"},{"key":"3527_CR38","doi-asserted-by":"publisher","unstructured":"Cheleschi S, Gallo I, Barbarino M, Giannotti S, Mondanelli N, Giordano A, et al. MicroRNA mediate visfatin and resistin induction of oxidative stress in human Osteoarthritic synovial fibroblasts via NF-kappaB pathway. Int J Mol Sci. 2019;20. https:\/\/doi.org\/10.3390\/ijms20205200.","DOI":"10.3390\/ijms20205200"},{"key":"3527_CR39","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s40618-015-0408-2","volume":"39","author":"X Huang","year":"2016","unstructured":"Huang X, Yang Z. Resistin\u2019s, obesity and insulin resistance: the continuing disconnect between rodents and humans. J Endocrinol Invest. 2016;39:607\u201315. https:\/\/doi.org\/10.1007\/s40618-015-0408-2.","journal-title":"J Endocrinol Invest"},{"key":"3527_CR40","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.cmet.2014.01.013","volume":"19","author":"S Lee","year":"2014","unstructured":"Lee S, Lee HC, Kwon YW, Lee SE, Cho Y, Kim J, et al. Adenylyl cyclase-associated protein 1 is a receptor for human resistin and mediates inflammatory actions of human monocytes. Cell Metab. 2014;19:484\u201397. https:\/\/doi.org\/10.1016\/j.cmet.2014.01.013.","journal-title":"Cell Metab"},{"key":"3527_CR41","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.steroids.2009.10.006","volume":"75","author":"C Grossmann","year":"2010","unstructured":"Grossmann C, Ruhs S, Seiferth A, Gekle M. Interaction between mineralocorticoid receptor and cAMP\/CREB signaling. Steroids. 2010;75:539\u201343. https:\/\/doi.org\/10.1016\/j.steroids.2009.10.006.","journal-title":"Steroids"},{"key":"3527_CR42","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1016\/j.cellsig.2004.05.001","volume":"16","author":"M Johannessen","year":"2004","unstructured":"Johannessen M, Delghandi MP, Moens U. What turns CREB on? Cell Signal. 2004;16:1211\u201327. https:\/\/doi.org\/10.1016\/j.cellsig.2004.05.001.","journal-title":"Cell Signal"},{"key":"3527_CR43","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.bbrc.2014.04.028","volume":"447","author":"B Wang","year":"2014","unstructured":"Wang B, Zhu L, Sui S, Sun C, Jiang H, Ren D. Cilostazol induces mitochondrial fatty acid beta-oxidation in C2C12 myotubes. Biochem Biophys Res Commun. 2014;447:441\u20135. https:\/\/doi.org\/10.1016\/j.bbrc.2014.04.028.","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Arthritis Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-025-03527-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-025-03527-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-025-03527-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T03:09:02Z","timestamp":1745896142000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-025-03527-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,29]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3527"],"URL":"https:\/\/doi.org\/10.1186\/s13075-025-03527-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4886384\/v1","asserted-by":"object"}]},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,29]]},"assertion":[{"value":"9 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"99"}}