{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T10:36:12Z","timestamp":1793270172825,"version":"4.5.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["916.12.109"],"award-info":[{"award-number":["916.12.109"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["916.12.109"],"award-info":[{"award-number":["916.12.109"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["916.12.109"],"award-info":[{"award-number":["916.12.109"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["916.12.109"],"award-info":[{"award-number":["916.12.109"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["916.12.109"],"award-info":[{"award-number":["916.12.109"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["916.12.109"],"award-info":[{"award-number":["916.12.109"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["916.12.109"],"award-info":[{"award-number":["916.12.109"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["916.12.109"],"award-info":[{"award-number":["916.12.109"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["916.12.109"],"award-info":[{"award-number":["916.12.109"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["101007757"],"award-info":[{"award-number":["101007757"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["101007757"],"award-info":[{"award-number":["101007757"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["101007757"],"award-info":[{"award-number":["101007757"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["101007757"],"award-info":[{"award-number":["101007757"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["101007757"],"award-info":[{"award-number":["101007757"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["847551"],"award-info":[{"award-number":["847551"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["847551"],"award-info":[{"award-number":["847551"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["101007757"],"award-info":[{"award-number":["101007757"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["101007757"],"award-info":[{"award-number":["101007757"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lymph node (LN) studies in anti-cyclic citrullinated protein antibodies (ACPA) positive rheumatoid arthritis (RA) patients have revealed notable alterations in adaptive immune cell populations. However, it remains unclear whether similar changes occur in seronegative inflammatory arthritis, such as psoriatic arthritis (PsA) or ACPA-negative RA. This study investigates molecular and cellular alterations in LN biopsies from ACPA-positive RA patients, ACPA-negative inflammatory arthritis (IA) patients, and healthy controls (HCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ultrasound-guided LN biopsies were collected from 25 HCs, 14 ACPA positive RA patients and 45 ACPA negative IA patients (including various IA subtypes). Whole LN tissue biopsies were analyzed by transcriptome analyses, quantitative PCR and immunohistochemistry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Distinct LN gene expression profiles were identified in ACPA-positive RA and ACPA-negative IA patients compared to HCs. ACPA-positive RA patients exhibited upregulation of genes associated with adaptive immunity, while ACPA-negative IA patients showed higher expression of genes related to innate immune cell function. Subsequent qPCR analysis confirmed increased mRNA expression of Cathepsin G, a serine protease highly expressed by neutrophils, in ACPA negative IA patients. Immunohistochemistry demonstrated significantly elevated CD15\u2009+\u2009neutrophil presence in LNs from IA patients compared to HCs, irrespective of ACPA status and diagnosis (RA or PsA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides novel insights into the immune landscape of lymph nodes in inflammatory arthritis, emphasizing an unexpected role for neutrophils in IA patients. Future research should explore the functional implications of neutrophils within these uninfected lymph nodes to better understand their contribution to the pathogenesis of inflammatory arthritis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13075-025-03557-0","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T02:18:14Z","timestamp":1745374694000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Divergent gene signatures and neutrophil enrichment in lymph nodes of inflammatory arthritis patients"],"prefix":"10.1186","volume":"27","author":[{"given":"Aoife M.","family":"O\u2019Byrne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne W.","family":"Bolt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaja M.J.","family":"van Ansenwoude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn","family":"van der Heide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna F.","family":"Semmelink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Jongejan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry D.","family":"Moerland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Maas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marleen G.H.","family":"van de Sande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa G.M.","family":"van Baarsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"issue":"1","key":"3557_CR1","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1136\/annrheumdis-2015-208980","volume":"76","author":"AH Hensvold","year":"2017","unstructured":"Hensvold AH, Frisell T, Magnusson PK, Holmdahl R, Askling J, Catrina AI. How well do ACPA discriminate and predict RA in the general population: a study based on 12 590 population-representative Swedish twins. Ann Rheum Dis. 2017;76(1):119\u201325.","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"3557_CR2","doi-asserted-by":"publisher","first-page":"2741","DOI":"10.1002\/art.11223","volume":"48","author":"S Rantapaa-Dahlqvist","year":"2003","unstructured":"Rantapaa-Dahlqvist S, de Jong BA, Berglin E, Hallmans G, Wadell G, Stenlund H, et al. Antibodies against Cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003;48(10):2741\u20139.","journal-title":"Arthritis Rheum"},{"issue":"12","key":"3557_CR3","doi-asserted-by":"publisher","first-page":"2812","DOI":"10.1002\/eji.201646393","volume":"46","author":"TH Ramwadhdoebe","year":"2016","unstructured":"Ramwadhdoebe TH, H\u00e4hnlein J, Maijer KI, van Boven LJ, Gerlag DM, Tak PP, et al. Lymph node biopsy analysis reveals an altered immunoregulatory balance already during the at-risk phase of autoantibody positive rheumatoid arthritis. Eur J Immunol. 2016;46(12):2812\u201321.","journal-title":"Eur J Immunol"},{"key":"3557_CR4","doi-asserted-by":"crossref","unstructured":"Baeten D, Kruithof E, De Rycke L, et al. Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy. Arthritis Res Ther. 2005;7(2):R359\u2013R369.","DOI":"10.1186\/ar1501"},{"key":"3557_CR5","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1186\/ar1182","volume":"6","author":"AY Goedkoop","year":"2004","unstructured":"Goedkoop AY, Kraan MC, Picavet DI, De Rie MA, Bm Teunissen M, Bos JD, et al. Open access deactivation of endothelium and reduction in angiogenesis in psoriatic skin and synovium by low dose Infliximab therapy in combination with stable methotrexate therapy: a prospective single-centre study. Arthritis Res Ther. 2004;6:326\u201334.","journal-title":"Arthritis Res Ther"},{"issue":"8","key":"3557_CR6","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1136\/ard.2008.091389","volume":"68","author":"AW van Kuijk","year":"2009","unstructured":"van Kuijk AW, Gerlag DM, Vos K, Wolbink G, de Groot M, de Rie MA, et al. A prospective, randomised, placebo-controlled study to identify biomarkers associated with active treatment in psoriatic arthritis: effects of adalimumab treatment on synovial tissue. Ann Rheum Dis. 2009;68(8):1303\u20139.","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"3557_CR7","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1136\/ard.2003.018085","volume":"63","author":"AY Goedkoop","year":"2004","unstructured":"Goedkoop AY, Kraan MC, Teunissen MB, Picavet DI, de Rie MA, Bos JD, et al. Early effects of tumour necrosis factor alpha Blockade on skin and synovial tissue in patients with active psoriasis and psoriatic arthritis. Ann Rheum Dis. 2004;63(7):769\u201373.","journal-title":"Ann Rheum Dis"},{"issue":"12","key":"3557_CR8","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1002\/art.40581","volume":"70","author":"LJJ van Mens","year":"2018","unstructured":"van Mens LJJ, van de Sande MGH, Menegatti S, Chen S, Blijdorp ICJ, de Jong HM, et al. Brief report: Interleukin-17 Blockade with Secukinumab in peripheral spondyloarthritis impacts synovial immunopathology without compromising systemic immune responses. Arthritis Rheumatol. 2018;70(12):1994\u20132002.","journal-title":"Arthritis Rheumatol"},{"issue":"11","key":"3557_CR9","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1136\/annrheumdis-2012-201540","volume":"71","author":"MJ de Hair","year":"2012","unstructured":"de Hair MJ, Zijlstra IA, Boumans MJ, van de Sande MG, Maas M, Gerlag DM, et al. Hunting for the pathogenesis of rheumatoid arthritis: core-needle biopsy of inguinal lymph nodes as a new research tool. Ann Rheum Dis. 2012;71(11):1911\u20132.","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"3557_CR10","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1002\/art.33396","volume":"64","author":"T Noordenbos","year":"2012","unstructured":"Noordenbos T, Yeremenko N, Gofita I, van de Sande M, Tak PP, Canete JD, et al. Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis. Arthritis Rheum. 2012;64(1):99\u2013109.","journal-title":"Arthritis Rheum"},{"key":"3557_CR11","doi-asserted-by":"crossref","unstructured":"Ramwadhdoebe TH, Hahnlein J, Van Kuijk BJ, Choi IY, Van Boven LJ, Gerlag DM et al. Human lymph-node CD8\u2009+\u2009T cells display an altered phenotype during systemic autoimmunity. Clin Translational Immunol. 2016;5.","DOI":"10.1038\/cti.2016.8"},{"issue":"1","key":"3557_CR12","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/art.39811","volume":"69","author":"J Rodriguez-Carrio","year":"2017","unstructured":"Rodriguez-Carrio J, Hahnlein JS, Ramwadhdoebe TH, Semmelink JF, Choi IY, van Lienden KP, et al. Brief report: altered innate lymphoid cell subsets in human lymph node biopsy specimens obtained during the At-Risk and earliest phases of rheumatoid arthritis. Arthritis Rheumatol. 2017;69(1):70\u20136.","journal-title":"Arthritis Rheumatol"},{"key":"3557_CR13","doi-asserted-by":"crossref","unstructured":"Anang DC, Ramwadhdoebe TH, Hahnlein JS, van Kuijk B, Smits N, van Lienden KP et al. Increased Frequency of CD4(+) Follicular Helper T and CD8(+) Follicular T Cells in Human Lymph Node Biopsies during the Earliest Stages of Rheumatoid Arthritis. Cells. 2022;11(7).","DOI":"10.3390\/cells11071104"},{"issue":"8","key":"3557_CR14","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1136\/annrheumdis-2012-202990","volume":"72","author":"LGM Van Baarsen","year":"2013","unstructured":"Van Baarsen LGM, De Hair MJH, Ramwadhdoebe TH, Zijlstra IJAJ, Maas M, Gerlag DM, et al. The cellular composition of lymph nodes in the earliest phase of inflammatory arthritis. Ann Rheum Dis. 2013;72(8):1420\u20134.","journal-title":"Ann Rheum Dis"},{"key":"3557_CR15","doi-asserted-by":"crossref","unstructured":"Ramwadhdoebe TH, Ramos MI, Maijer KI, van Lienden KP, Maas M, Gerlag DM et al. Myeloid dendritic cells are enriched in lymph node tissue of early rheumatoid arthritis patients but not in at risk individuals. Cells. 2019;8(7).","DOI":"10.3390\/cells8070756"},{"issue":"1","key":"3557_CR16","doi-asserted-by":"publisher","first-page":"5360","DOI":"10.1038\/s41598-023-32428-4","volume":"13","author":"KY Cunningham","year":"2023","unstructured":"Cunningham KY, Hur B, Gupta VK, Arment CA, Wright KA, Mason TG, et al. Patients with ACPA-positive and ACPA-negative rheumatoid arthritis show different serological autoantibody repertoires and autoantibody associations with disease activity. Sci Rep. 2023;13(1):5360.","journal-title":"Sci Rep"},{"issue":"1","key":"3557_CR17","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1038\/nri.2016.124","volume":"17","author":"V Malmstrom","year":"2017","unstructured":"Malmstrom V, Catrina AI, Klareskog L. The Immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting. Nat Rev Immunol. 2017;17(1):60\u201375.","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"3557_CR18","first-page":"183","volume":"46","author":"GS Firestein","year":"2017","unstructured":"Firestein GS, McInnes IB. Immunopathogenesis Rheumatoid Arthritis Immun. 2017;46(2):183\u201396.","journal-title":"Immunopathogenesis Rheumatoid Arthritis Immun"},{"issue":"1","key":"3557_CR19","doi-asserted-by":"publisher","first-page":"4977","DOI":"10.1038\/s41467-021-25246-7","volume":"12","author":"X Wu","year":"2021","unstructured":"Wu X, Liu Y, Jin S, Wang M, Jiao Y, Yang B, et al. Single-cell sequencing of immune cells from anticitrullinated peptide antibody positive and negative rheumatoid arthritis. Nat Commun. 2021;12(1):4977.","journal-title":"Nat Commun"},{"key":"3557_CR20","doi-asserted-by":"crossref","unstructured":"Floudas A, Canavan M, McGarry T, Mullan R, Nagpal S, Veale DJ et al. ACPA status correlates with differential immune profile in patients with rheumatoid arthritis. Cells. 2021;10(3).","DOI":"10.3390\/cells10030647"},{"key":"3557_CR21","doi-asserted-by":"crossref","unstructured":"Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3, et al. 2010 Rheumatoid arthritis classification criteria: an American college of rheumatology\/european league against rheumatism collaborative initiative. Arthritis Rheum. 2010;62(9):2569\u201381.","DOI":"10.1002\/art.27584"},{"issue":"8","key":"3557_CR22","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.1002\/art.21972","volume":"54","author":"W Taylor","year":"2006","unstructured":"Taylor W, Gladman D, Helliwell P, Marchesoni A, Mease P, Mielants H, et al. Classification criteria for psoriatic arthritis: development of new criteria from a large international study. Arthritis Rheum. 2006;54(8):2665\u201373.","journal-title":"Arthritis Rheum"},{"issue":"8","key":"3557_CR23","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.1002\/art.34473","volume":"64","author":"M Petri","year":"2012","unstructured":"Petri M, Orbai AM, Alarc\u00f5n GS, Gordon C, Merrill JT, Fortin PR, et al. Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum. 2012;64(8):2677\u201386.","journal-title":"Arthritis Rheum"},{"issue":"17","key":"3557_CR24","doi-asserted-by":"publisher","first-page":"e133","DOI":"10.1093\/nar\/gks461","volume":"40","author":"D Wu","year":"2012","unstructured":"Wu D, Smyth GK. Camera: a competitive gene set test accounting for inter-gene correlation. Nucleic Acids Res. 2012;40(17):e133.","journal-title":"Nucleic Acids Res"},{"key":"3557_CR25","doi-asserted-by":"crossref","unstructured":"Hampton HR, Bailey J, Tomura M, Brink R, Chtanova T. Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes. Nat Commun. 2015;6.","DOI":"10.1038\/ncomms8139"},{"issue":"38","key":"3557_CR26","doi-asserted-by":"publisher","first-page":"19083","DOI":"10.1073\/pnas.1905054116","volume":"116","author":"LSC Lok","year":"2019","unstructured":"Lok LSC, Dennison TW, Mahbubani KM, Saeb-Parsy K, Chilvers ER, Clatworthy MR. Phenotypically distinct neutrophils patrol uninfected human and mouse lymph nodes. Proc Natl Acad Sci USA. 2019;116(38):19083\u20139.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"3557_CR27","doi-asserted-by":"publisher","first-page":"2552","DOI":"10.4049\/jimmunol.2000022","volume":"204","author":"A Bogoslowski","year":"2020","unstructured":"Bogoslowski A, Wijeyesinghe S, Lee WY, Chen CS, Alanani S, Jenne C, et al. Neutrophils recirculate through lymph nodes to survey tissues for pathogens. J Immunol. 2020;204(9):2552\u201361.","journal-title":"J Immunol"},{"issue":"3","key":"3557_CR28","doi-asserted-by":"publisher","first-page":"R569","DOI":"10.1186\/ar1698","volume":"7","author":"E Kruithof","year":"2005","unstructured":"Kruithof E, Baeten D, De Rycke L, Vandooren B, Foell D, Roth J, et al. Synovial histopathology of psoriatic arthritis, both oligo- and polyarticular, resembles spondyloarthropathy more than it does rheumatoid arthritis. Arthritis Res Ther. 2005;7(3):R569\u201380.","journal-title":"Arthritis Res Ther"},{"issue":"5","key":"3557_CR29","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1023\/A:1022354212121","volume":"22","author":"D Biasi","year":"1998","unstructured":"Biasi D, Carletto A, Caramaschi P, Bellavite P, Maleknia T, Scambi C, et al. Neutrophil functions and IL-8 in psoriatic arthritis and in cutaneous psoriasis. Inflammation. 1998;22(5):533\u201343.","journal-title":"Inflammation"},{"key":"3557_CR30","doi-asserted-by":"crossref","unstructured":"Stavre Z, Bridgewood C, Zhou Q, Maeda Y, Huang Tt, Karman J et al. A role for neutrophils in early enthesitis in spondyloarthritis. Arthritis Res Therapy. 2022;24(1).","DOI":"10.1186\/s13075-021-02693-7"},{"issue":"3","key":"3557_CR31","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1002\/art.41156","volume":"72","author":"KJA Steel","year":"2020","unstructured":"Steel KJA, Srenathan U, Ridley M, Durham LE, Wu SY, Ryan SE, et al. Polyfunctional, proinflammatory, Tissue-Resident memory phenotype and function of synovial Interleukin-17A\u2009+\u2009CD8\u2009+\u2009T cells in psoriatic arthritis. Arthritis Rheumatol. 2020;72(3):435\u201347.","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"3557_CR32","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1002\/1529-0131(200101)44:1<186::AID-ANR25>3.0.CO;2-B","volume":"44","author":"D Baeten","year":"2001","unstructured":"Baeten D, Kruithof E, Van den Bosch F, Demetter P, Van Damme N, Cuvelier C, et al. Immunomodulatory effects of anti-tumor necrosis factor alpha therapy on synovium in spondylarthropathy: histologic findings in eight patients from an open-label pilot study. Arthritis Rheum. 2001;44(1):186\u201395.","journal-title":"Arthritis Rheum"},{"issue":"4","key":"3557_CR33","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1159\/000343290","volume":"225","author":"M de Groot","year":"2012","unstructured":"de Groot M, Picavet DI, van Kuijk AW, Tak PP, Bos JD, de Rie MA, et al. A prospective, randomized, placebo-controlled study to identify biomarkers associated with active treatment in psoriatic arthritis: effects of adalimumab treatment on lesional and nonlesional skin. Dermatology. 2012;225(4):298\u2013303.","journal-title":"Dermatology"},{"issue":"8","key":"3557_CR34","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1136\/ard.2006.061507","volume":"66","author":"H Wittkowski","year":"2007","unstructured":"Wittkowski H, Foell D, af Klint E, De Rycke L, De Keyser F, Frosch M, et al. Effects of intra-articular corticosteroids and anti-TNF therapy on neutrophil activation in rheumatoid arthritis. Ann Rheum Dis. 2007;66(8):1020\u20135.","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"3557_CR35","doi-asserted-by":"publisher","first-page":"3094","DOI":"10.1182\/blood-2006-04-016659","volume":"108","author":"BA Maletto","year":"2006","unstructured":"Maletto BA, Ropolo AS, Alignani DO, Liscovsky MV, Ranocchia RP, Moron VG, et al. Presence of neutrophil-bearing antigen in lymphoid organs of immune mice. Blood. 2006;108(9):3094\u2013102.","journal-title":"Blood"},{"key":"3557_CR36","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3389\/fimmu.2019.00105","volume":"10","author":"SD Castell","year":"2019","unstructured":"Castell SD, Harman MF, Moron G, Maletto BA, Pistoresi-Palencia MC. Neutrophils which migrate to lymph nodes modulate CD4(+) T cell response by a PD-L1 dependent mechanism. Front Immunol. 2019;10:105.","journal-title":"Front Immunol"},{"issue":"5","key":"3557_CR37","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1189\/jlb.0905526","volume":"79","author":"AM Megiovanni","year":"2006","unstructured":"Megiovanni AM, Sanchez F, Robledo-Sarmiento M, Morel C, Gluckman JC, Boudaly S. Polymorphonuclear neutrophils deliver activation signals and antigenic molecules to dendritic cells: a new link between leukocytes upstream of T lymphocytes. J Leukoc Biol. 2006;79(5):977\u201388.","journal-title":"J Leukoc Biol"},{"issue":"12","key":"3557_CR38","doi-asserted-by":"publisher","first-page":"e29300","DOI":"10.1371\/journal.pone.0029300","volume":"6","author":"C Alfaro","year":"2011","unstructured":"Alfaro C, Suarez N, Onate C, Perez-Gracia JL, Martinez-Forero I, Hervas-Stubbs S, et al. Dendritic cells take up and present antigens from viable and apoptotic polymorphonuclear leukocytes. PLoS ONE. 2011;6(12):e29300.","journal-title":"PLoS ONE"}],"updated-by":[{"DOI":"10.1186\/s13075-026-03936-1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:00:00Z","timestamp":1793059200000}}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-025-03557-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-025-03557-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-025-03557-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T10:03:38Z","timestamp":1793268218000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-025-03557-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,23]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3557"],"URL":"https:\/\/doi.org\/10.1186\/s13075-025-03557-0","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,23]]},"assertion":[{"value":"7 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised: the author\u2019s name Martijn van der Heide was incorrectly written as Martijn van der Heijde.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2026","order":8,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":9,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1186\/s13075-026-03936-1","URL":"https:\/\/doi.org\/10.1186\/s13075-026-03936-1","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All patients provided written informed consent prior to enrolment, the study protocol was approved by the Ethics Committee of the Amsterdam Medical Center, Amsterdam, the Netherlands.","order":1,"name":"Ethics","label":"Ethical approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"94"}}