{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:39:37Z","timestamp":1793691577163,"version":"4.5.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024QH552"],"award-info":[{"award-number":["ZR2024QH552"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202735"],"award-info":[{"award-number":["82202735"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172467"],"award-info":[{"award-number":["82172467"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Guangdong Province of China","award":["2023A1515010142, 2024A1515011189"],"award-info":[{"award-number":["2023A1515010142, 2024A1515011189"]}]},{"name":"Guangdong Natural Science Funds for Distinguished Young Scholars of China","award":["2021B1515020008"],"award-info":[{"award-number":["2021B1515020008"]}]},{"name":"First Affiliated Hospital of Sun Yat-sen University Ke Ling Funding Program for Novel and Distinguished Talents","award":["R07005"],"award-info":[{"award-number":["R07005"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"DOI":"10.1186\/s13075-025-03573-0","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T08:31:51Z","timestamp":1747297911000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Chondrocyte lysates activate NLRP3 inflammasome-induced pyroptosis in synovial fibroblasts to exacerbate knee synovitis by downregulating caveolin-1"],"prefix":"10.1186","volume":"27","author":[{"given":"Xue","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruonan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongrui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"issue":"1","key":"3573_CR1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41392-023-01330-w","volume":"8","author":"Q Yao","year":"2023","unstructured":"Yao Q, Wu X, Tao C, Gong W, Chen M, Qu M, Zhong Y, He T, Chen S, Xiao G. Osteoarthritis: pathogenic signaling pathways and therapeutic targets. Signal Transduct Target Ther. 2023;8(1):56.","journal-title":"Signal Transduct Target Ther"},{"issue":"4","key":"3573_CR2","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.coi.2005.06.002","volume":"17","author":"JJ Oppenheim","year":"2005","unstructured":"Oppenheim JJ, Yang D. Alarmins: chemotactic activators of immune responses. Curr Opin Immunol. 2005;17(4):359\u201365.","journal-title":"Curr Opin Immunol"},{"issue":"Suppl 120","key":"3573_CR3","first-page":"48","volume":"37","author":"M Millerand","year":"2019","unstructured":"Millerand M, Berenbaum F, Jacques C. Danger signals and inflammaging in osteoarthritis. Clin Exp Rheumatol. 2019;37(Suppl 120):48\u201356.","journal-title":"Clin Exp Rheumatol"},{"issue":"11","key":"3573_CR4","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/nrrheum.2016.162","volume":"12","author":"M Nefla","year":"2016","unstructured":"Nefla M, Holzinger D, Berenbaum F, Jacques C. The danger from within: alarmins in arthritis. Nat Rev Rheumatol. 2016;12(11):669\u201383.","journal-title":"Nat Rev Rheumatol"},{"issue":"Pt A","key":"3573_CR5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.arr.2014.10.004","volume":"24","author":"J Huang","year":"2015","unstructured":"Huang J, Xie Y, Sun X, Zeh HJ 3rd, Kang R, Lotze MT, Tang D. DAMPs, ageing, and cancer: the \u2018DAMP hypothesis\u2019. Ageing Res Rev. 2015;24(Pt A):3\u201316.","journal-title":"Ageing Res Rev"},{"issue":"1\u20132","key":"3573_CR6","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s11010-017-3047-4","volume":"434","author":"JH Rosenberg","year":"2017","unstructured":"Rosenberg JH, Rai V, Dilisio MF, Agrawal DK. Damage-associated molecular patterns in the pathogenesis of osteoarthritis: potentially novel therapeutic targets. Mol Cell Biochem. 2017;434(1\u20132):171\u20139.","journal-title":"Mol Cell Biochem"},{"issue":"2","key":"3573_CR7","doi-asserted-by":"publisher","first-page":"367","DOI":"10.14336\/AD.2018.0324","volume":"10","author":"HY Chung","year":"2019","unstructured":"Chung HY, Kim DH, Lee EK, Chung KW, Chung S, Lee B, Seo AY, Chung JH, Jung YS, Im E, et al. Redefining chronic inflammation in aging and age-related diseases: proposal of the senoinflammation concept. Aging Dis. 2019;10(2):367\u201382.","journal-title":"Aging Dis"},{"issue":"5","key":"3573_CR8","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.14336\/AD.2019.1127","volume":"11","author":"S An","year":"2020","unstructured":"An S, Hu H, Li Y, Hu Y. Pyroptosis plays a role in osteoarthritis. Aging Dis. 2020;11(5):1146\u201357.","journal-title":"Aging Dis"},{"key":"3573_CR9","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.coi.2019.11.007","volume":"62","author":"S Christgen","year":"2020","unstructured":"Christgen S, Kanneganti TD. Inflammasomes and the fine line between defense and disease. Curr Opin Immunol. 2020;62:39\u201344.","journal-title":"Curr Opin Immunol"},{"issue":"7","key":"3573_CR10","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nri.2016.58","volume":"16","author":"P Broz","year":"2016","unstructured":"Broz P, Dixit VM. Inflammasomes: mechanism of assembly, regulation and signalling. Nat Rev Immunol. 2016;16(7):407\u201320.","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"3573_CR11","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.cell.2016.03.046","volume":"165","author":"VA Rathinam","year":"2016","unstructured":"Rathinam VA, Fitzgerald KA. Inflammasome complexes: emerging mechanisms and effector functions. Cell. 2016;165(4):792\u2013800.","journal-title":"Cell"},{"key":"3573_CR12","doi-asserted-by":"crossref","unstructured":"Chen C, Xu P. Activation and pharmacological regulation of inflammasomes. Biomolecules. 2022;12(7).","DOI":"10.3390\/biom12071005"},{"key":"3573_CR13","doi-asserted-by":"publisher","first-page":"282","DOI":"10.3389\/fphar.2017.00282","volume":"8","author":"S Nasi","year":"2017","unstructured":"Nasi S, Ea HK, So A, Busso N. Revisiting the role of interleukin-1 pathway in osteoarthritis: interleukin-1alpha and\u2013\u20091beta, and NLRP3 inflammasome are not involved in the pathological features of the murine menisectomy model of osteoarthritis. Front Pharmacol. 2017;8:282.","journal-title":"Front Pharmacol"},{"key":"3573_CR14","doi-asserted-by":"crossref","unstructured":"Wang Q, Onuma K, Liu C, Wong H, Bloom MS, Elliott EE, Cao RR, Hu N, Lingampalli N, Sharpe O et al. Dysregulated integrin alphaVbeta3 and CD47 signaling promotes joint inflammation, cartilage breakdown, and progression of osteoarthritis. JCI Insight. 2019;4(18).","DOI":"10.1172\/jci.insight.128616"},{"issue":"9","key":"3573_CR15","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1002\/jor.24340","volume":"37","author":"EG Estell","year":"2019","unstructured":"Estell EG, Silverstein AM, Stefani RM, Lee AJ, Murphy LA, Shah RP, Ateshian GA, Hung CT. Cartilage wear particles induce an inflammatory response similar to cytokines in human fibroblast-like synoviocytes. J Orthop Res. 2019;37(9):1979\u201387.","journal-title":"J Orthop Res"},{"key":"3573_CR16","doi-asserted-by":"publisher","first-page":"676173","DOI":"10.3389\/fimmu.2021.676173","volume":"12","author":"JY Mimpen","year":"2021","unstructured":"Mimpen JY, Baldwin MJ, Cribbs AP, Philpott M, Carr AJ, Dakin SG, Snelling SJB. Interleukin-17A causes osteoarthritis-like transcriptional changes in human osteoarthritis-derived chondrocytes and synovial fibroblasts in vitro. Front Immunol. 2021;12:676173.","journal-title":"Front Immunol"},{"issue":"2\u20133","key":"3573_CR17","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.placenta.2005.12.005","volume":"28","author":"F Rashid-Doubell","year":"2007","unstructured":"Rashid-Doubell F, Tannetta D, Redman CW, Sargent IL, Boyd CA, Linton EA. Caveolin-1 and lipid rafts in confluent bewo trophoblasts: evidence for Rock-1 association with caveolin-1. Placenta. 2007;28(2\u20133):139\u201351.","journal-title":"Placenta"},{"issue":"2","key":"3573_CR18","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.semcdb.2005.01.007","volume":"16","author":"S Martin","year":"2005","unstructured":"Martin S, Parton RG. Caveolin, cholesterol, and lipid bodies. Semin Cell Dev Biol. 2005;16(2):163\u201374.","journal-title":"Semin Cell Dev Biol"},{"key":"3573_CR19","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/978-1-4614-1222-9_3","volume":"729","author":"C Boscher","year":"2012","unstructured":"Boscher C, Nabi IR. Caveolin-1: role in cell signaling. Adv Exp Med Biol. 2012;729:29\u201350.","journal-title":"Adv Exp Med Biol"},{"issue":"3","key":"3573_CR20","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.tcb.2015.10.010","volume":"26","author":"JPX Cheng","year":"2016","unstructured":"Cheng JPX, Nichols BJ. Caveolae: one function or many?? Trends Cell Biol. 2016;26(3):177\u201389.","journal-title":"Trends Cell Biol"},{"issue":"4","key":"3573_CR21","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.apsb.2020.11.020","volume":"11","author":"C Yang","year":"2021","unstructured":"Yang C, He B, Dai W, Zhang H, Zheng Y, Wang X, Zhang Q. The role of caveolin-1 in the biofate and efficacy of anti-tumor drugs and their nano-drug delivery systems. Acta Pharm Sin B. 2021;11(4):961\u201377.","journal-title":"Acta Pharm Sin B"},{"key":"3573_CR22","doi-asserted-by":"publisher","first-page":"174324","DOI":"10.1016\/j.ejphar.2021.174324","volume":"908","author":"W Jiang","year":"2021","unstructured":"Jiang W, Wang J, Xue W, Xin J, Shi C, Wen J, Feng X, Huang Y, Hu C. Caveolin-1 attenuates acetaminophen aggravated lipid accumulation in alcoholic fatty liver by activating mitophagy via the Pink-1\/Parkin pathway. Eur J Pharmacol. 2021;908:174324.","journal-title":"Eur J Pharmacol"},{"issue":"1\u20132","key":"3573_CR23","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.jsbmb.2010.03.002","volume":"121","author":"C Buitrago","year":"2010","unstructured":"Buitrago C, Boland R. Caveolae and caveolin-1 are implicated in 1alpha,25(OH)2-vitamin D3-dependent modulation of Src, MAPK cascades and VDR localization in skeletal muscle cells. J Steroid Biochem Mol Biol. 2010;121(1\u20132):169\u201375.","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"5","key":"3573_CR24","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1007\/s12031-022-01989-w","volume":"72","author":"W Liu","year":"2022","unstructured":"Liu W, Jiang P, Qiu L. Blocking of caveolin-1 attenuates morphine-induced inflammation, hyperalgesia, and analgesic tolerance via inhibiting NLRP3 inflammasome and ERK\/c-JUN pathway. J Mol Neurosci. 2022;72(5):1047\u201357.","journal-title":"J Mol Neurosci"},{"issue":"9","key":"3573_CR25","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1038\/cdd.2016.21","volume":"23","author":"Z Li","year":"2016","unstructured":"Li Z, Scott MJ, Fan EK, Li Y, Liu J, Xiao G, Li S, Billiar TR, Wilson MA, Jiang Y, et al. Tissue damage negatively regulates LPS-induced macrophage necroptosis. Cell Death Differ. 2016;23(9):1428\u201347.","journal-title":"Cell Death Differ"},{"key":"3573_CR26","doi-asserted-by":"publisher","first-page":"109558","DOI":"10.1016\/j.intimp.2022.109558","volume":"114","author":"X Jiang","year":"2023","unstructured":"Jiang X, Li Y, Fu D, You T, Wu S, Xin J, Wen J, Huang Y, Hu C. Caveolin-1 ameliorates acetaminophen-aggravated inflammatory damage and lipid deposition in non-alcoholic fatty liver disease via the ROS\/TXNIP\/NLRP3 pathway. Int Immunopharmacol. 2023;114:109558.","journal-title":"Int Immunopharmacol"},{"key":"3573_CR27","doi-asserted-by":"publisher","first-page":"106236","DOI":"10.1016\/j.ejps.2022.106236","volume":"175","author":"V Menzel","year":"2022","unstructured":"Menzel V, Ziegler M, Hante N, Sake JA, Santos-Martinez MJ, Ehrhardt C, Kasper M, Barth K. Fyn-kinase and caveolin-1 in the alveolar epithelial junctional adherence complex contribute to the early stages of pulmonary fibrosis. Eur J Pharm Sci. 2022;175:106236.","journal-title":"Eur J Pharm Sci"},{"issue":"3","key":"3573_CR28","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1002\/art.21639","volume":"54","author":"SM Dai","year":"2006","unstructured":"Dai SM, Shan ZZ, Nakamura H, Masuko-Hongo K, Kato T, Nishioka K, Yudoh K. Catabolic stress induces features of chondrocyte senescence through overexpression of caveolin 1: possible involvement of caveolin 1-induced down-regulation of articular chondrocytes in the pathogenesis of osteoarthritis. Arthritis Rheum. 2006;54(3):818\u201331.","journal-title":"Arthritis Rheum"},{"issue":"8","key":"3573_CR29","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.7150\/ijms.35611","volume":"16","author":"YJ Chen","year":"2019","unstructured":"Chen YJ, Chang WA, Wu LY, Huang CF, Chen CH, Kuo PL. Identification of novel genes in osteoarthritic fibroblast-like synoviocytes using next-generation sequencing and bioinformatics approaches. Int J Med Sci. 2019;16(8):1057\u201371.","journal-title":"Int J Med Sci"},{"issue":"10","key":"3573_CR30","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1136\/ard.2009.121426","volume":"69","author":"K Baker","year":"2010","unstructured":"Baker K, Grainger A, Niu J, Clancy M, Guermazi A, Crema M, Hughes L, Buckwalter J, Wooley A, Nevitt M, et al. Relation of synovitis to knee pain using contrast-enhanced MRIs. Ann Rheum Dis. 2010;69(10):1779\u201383.","journal-title":"Ann Rheum Dis"},{"key":"3573_CR31","doi-asserted-by":"crossref","unstructured":"Ma J, Yang P, Zhou Z, Song T, Jia L, Ye X, et al. GYY4137-induced p65 sulfhydration protects synovial macrophages against pyroptosis by improving mitochondrial function in osteoarthritis development. J Adv Res. 2025;71:173\u201388.","DOI":"10.1016\/j.jare.2024.05.033"},{"issue":"9","key":"3573_CR32","doi-asserted-by":"publisher","first-page":"130660","DOI":"10.1016\/j.bbagen.2024.130660","volume":"1868","author":"SC Hsiao","year":"2024","unstructured":"Hsiao SC, Liao WH, Chang HA, Lai YS, Chan TW, Chen YC, Chiu WT. Caveolin-1 differentially regulates the transforming growth factor-beta and epidermal growth factor signaling pathways in MDCK cells. Biochim Biophys Acta Gen Subj. 2024;1868(9):130660.","journal-title":"Biochim Biophys Acta Gen Subj"},{"issue":"4","key":"3573_CR33","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s13105-019-00703-6","volume":"75","author":"C Zhang","year":"2019","unstructured":"Zhang C, Wu Q, Huang H, Chen X, Huang T, Li W, Liu Y, Zhang J. Caveolin-1 promotes Rfng expression via Erk-Jnk-p38 signaling pathway in mouse hepatocarcinoma cells. J Physiol Biochem. 2019;75(4):549\u201359.","journal-title":"J Physiol Biochem"},{"issue":"1","key":"3573_CR34","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.ymthe.2020.09.002","volume":"29","author":"Y Wu","year":"2021","unstructured":"Wu Y, Hong Z, Xu W, Chen J, Wang Q, Chen J, Ni W, Mei Z, Xie Z, Ma Y, et al. Circular RNA circPDE4D protects against osteoarthritis by binding to miR-103a-3p and regulating FGF18. Mol Ther. 2021;29(1):308\u201323.","journal-title":"Mol Ther"},{"key":"3573_CR35","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.bone.2016.01.019","volume":"85","author":"M Rahmati","year":"2016","unstructured":"Rahmati M, Mobasheri A, Mozafari M. Inflammatory mediators in osteoarthritis: a critical review of the state-of-the-art, current prospects, and future challenges. Bone. 2016;85:81\u201390.","journal-title":"Bone"},{"issue":"2","key":"3573_CR36","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.bone.2012.02.012","volume":"51","author":"CR Scanzello","year":"2012","unstructured":"Scanzello CR, Goldring SR. The role of synovitis in osteoarthritis pathogenesis. Bone. 2012;51(2):249\u201357.","journal-title":"Bone"},{"issue":"8","key":"3573_CR37","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1016\/j.joca.2017.03.015","volume":"25","author":"AM Silverstein","year":"2017","unstructured":"Silverstein AM, Stefani RM, Sobczak E, Tong EL, Attur MG, Shah RP, Bulinski JC, Ateshian GA, Hung CT. Toward understanding the role of cartilage particulates in synovial inflammation. Osteoarthritis Cartilage. 2017;25(8):1353\u201361.","journal-title":"Osteoarthritis Cartilage"},{"issue":"5","key":"3573_CR38","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.joca.2018.02.901","volume":"26","author":"MJ McAllister","year":"2018","unstructured":"McAllister MJ, Chemaly M, Eakin AJ, Gibson DS, McGilligan VE. NLRP3 as a potentially novel biomarker for the management of osteoarthritis. Osteoarthritis Cartilage. 2018;26(5):612\u20139.","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"3573_CR39","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1186\/s13075-019-2085-6","volume":"21","author":"Z Chen","year":"2019","unstructured":"Chen Z, Zhong H, Wei J, Lin S, Zong Z, Gong F, Huang X, Sun J, Li P, Lin H, et al. Inhibition of Nrf2\/HO-1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis. Arthritis Res Ther. 2019;21(1):300.","journal-title":"Arthritis Res Ther"},{"key":"3573_CR40","doi-asserted-by":"crossref","unstructured":"Goutas A, Papathanasiou I, Mourmoura E, Tsesmelis K, Tsezou A, Trachana V. Oxidative stress response is mediated by overexpression and spatiotemporal regulation of caveolin-1. Antioxid (Basel). 2020;9(8).","DOI":"10.3390\/antiox9080766"},{"issue":"7610","key":"3573_CR41","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/nature18590","volume":"535","author":"J Ding","year":"2016","unstructured":"Ding J, Wang K, Liu W, She Y, Sun Q, Shi J, Sun H, Wang DC, Shao F. Pore-forming activity and structural autoinhibition of the gasdermin family. Nature. 2016;535(7610):111\u20136.","journal-title":"Nature"},{"issue":"6","key":"3573_CR42","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1016\/j.immuni.2019.05.020","volume":"50","author":"N Van Opdenbosch","year":"2019","unstructured":"Van Opdenbosch N, Lamkanfi M. Caspases in cell death, inflammation, and disease. Immunity. 2019;50(6):1352\u201364.","journal-title":"Immunity"},{"key":"3573_CR43","doi-asserted-by":"crossref","unstructured":"Chan AH, Schroder K. Inflammasome signaling and regulation of interleukin-1 family cytokines. J Exp Med. 2020;217(1).","DOI":"10.1084\/jem.20190314"},{"key":"3573_CR44","doi-asserted-by":"crossref","unstructured":"Zhang L, Xing R, Huang Z, Zhang N, Zhang L, Li X, Wang P. Inhibition of synovial macrophage pyroptosis alleviates synovitis and fibrosis in knee osteoarthritis. Mediators Inflamm. 2019;2019:2165918.","DOI":"10.1155\/2019\/2165918"},{"issue":"10","key":"3573_CR45","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1002\/jbmr.4669","volume":"37","author":"X Liu","year":"2022","unstructured":"Liu X, Zhao J, Jiang H, Guo H, Li Y, Li H, Feng Y, Ke J, Long X. ALPK1 accelerates the pathogenesis of osteoarthritis by activating NLRP3 signaling. J Bone Min Res. 2022;37(10):1973\u201385.","journal-title":"J Bone Min Res"},{"key":"3573_CR46","doi-asserted-by":"crossref","unstructured":"Xin Y, Wang W, Mao E, Yang H, Li S. Targeting NLRP3 Inflammasome alleviates synovitis by reducing pyroptosis in rats with experimental temporomandibular joint osteoarthritis. Mediators Inflamm. 2022;2022:2581151.","DOI":"10.1155\/2022\/2581151"},{"issue":"5","key":"3573_CR47","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1517\/14728222.10.5.709","volume":"10","author":"KL van Golen","year":"2006","unstructured":"van Golen KL. Is caveolin-1 a viable therapeutic target to reduce cancer metastasis? Expert Opin Ther Targets. 2006;10(5):709\u201321.","journal-title":"Expert Opin Ther Targets"},{"issue":"8","key":"3573_CR48","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.18632\/aging.101007","volume":"8","author":"J Platas","year":"2016","unstructured":"Platas J, Guillen MI, Del Perez MD, Gomar F, Castejon MA, Mirabet V, Alcaraz MJ. Paracrine effects of human adipose-derived mesenchymal stem cells in inflammatory stress-induced senescence features of osteoarthritic chondrocytes. Aging. 2016;8(8):1703\u201317.","journal-title":"Aging"},{"issue":"4","key":"3573_CR49","doi-asserted-by":"publisher","first-page":"C1241","DOI":"10.1152\/ajpcell.2001.281.4.C1241","volume":"281","author":"B Razani","year":"2001","unstructured":"Razani B, Lisanti MP. Two distinct caveolin-1 domains mediate the functional interaction of caveolin-1 with protein kinase A. Am J Physiol Cell Physiol. 2001;281(4):C1241\u20131250.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"10","key":"3573_CR50","doi-asserted-by":"publisher","first-page":"3401","DOI":"10.1096\/fj.11-184861","volume":"25","author":"P Wang","year":"2011","unstructured":"Wang P, Zhu F, Tong Z, Konstantopoulos K. Response of chondrocytes to shear stress: antagonistic effects of the binding partners toll-like receptor 4 and caveolin-1. FASEB J. 2011;25(10):3401\u201315.","journal-title":"FASEB J"},{"issue":"1","key":"3573_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2121-6-1","volume":"6","author":"MM Petit","year":"2005","unstructured":"Petit MM, Meulemans SM, Alen P, Ayoubi TA, Jansen E, Van de Ven WJ. The tumor suppressor scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus. BMC Cell Biol. 2005;6(1):1.","journal-title":"BMC Cell Biol"},{"issue":"4","key":"3573_CR52","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1074\/jbc.M206106200","volume":"278","author":"MM Petit","year":"2003","unstructured":"Petit MM, Meulemans SM, Van de Ven WJ. The focal adhesion and nuclear targeting capacity of the LIM-containing lipoma-preferred partner (LPP) protein. J Biol Chem. 2003;278(4):2157\u201368.","journal-title":"J Biol Chem"},{"issue":"Pt 7","key":"3573_CR53","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1242\/jcs.00309","volume":"116","author":"B Li","year":"2003","unstructured":"Li B, Zhuang L, Reinhard M, Trueb B. The lipoma preferred partner LPP interacts with alpha-actinin. J Cell Sci. 2003;116(Pt 7):1359\u201366.","journal-title":"J Cell Sci"},{"key":"3573_CR54","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.omto.2022.01.008","volume":"24","author":"H Wang","year":"2022","unstructured":"Wang H, Wu J, Ling R, Li F, Yang Q, He J, Lei X, Wu C, Zhang G, Zheng B, et al. Fibroblast-derived LPP as a biomarker for treatment response and therapeutic target in gastric cancer. Mol Ther Oncolytics. 2022;24:547\u201360.","journal-title":"Mol Ther Oncolytics"}],"container-title":["Arthritis Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-025-03573-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-025-03573-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-025-03573-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T09:03:00Z","timestamp":1747299780000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-025-03573-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,15]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3573"],"URL":"https:\/\/doi.org\/10.1186\/s13075-025-03573-0","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,15]]},"assertion":[{"value":"16 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experiments involving animal and patient samples in this study adhered to ethical policies and procedures approved by the Ethics Committee of the First Affiliated Hospital of Sun Yat-Sen University, China. (Approval no. IRB: IIT-2021-667; SYSU-IACUC-2020-000504).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication was obtained from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"104"}}