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Our objective was to evaluate (1) compliance with the World Health Organization (WHO) PA recommendations, (2) specific types and duration of PA performed by patients, and (3) association of PA with health status and quality of life (QoL) in two large Dutch cohorts of axSpA patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In the GLAS and LUMC patient cohorts, the modified (m) and original Short QUestionnaire to ASess Health-enhancing PA (SQUASH) was used to determine fulfillment of recommendations on aerobic and muscle-strengthening PA. Univariable and multivariable linear regressions were used to analyze PA in relation to health status (ASAS-HI) and QoL (ASQoL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the GLAS (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009148) and LUMC (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009193) cohorts, patients were 49\u2009\u00b1\u200913 and 56\u2009\u00b1\u200914 years old, time since diagnosis was median 11 (IQR 5\u201321) and 23 (IQR 8\u201335) years and 59% and 69% were male, respectively. In total, 72% and 77% patients fulfilled the aerobic component, 40% and 36% the muscle-strengthening component and 37% and 34% both components of the WHO PA recommendations. Walking, cycling and gym or aquatic exercises were done most often. Higher (m)SQUASH score was associated with better outcome in disease-related health status (ASAS-HI) and QoL (ASQoL), also after adjusting for age, sex, BMI, disease activity and physical function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The minority of axSpA patients fulfilled the WHO PA recommendations. Patients were less likely to meet the muscle strengthening component than the aerobic component. A higher level of PA was associated with better disease-related health status and QoL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13075-025-03575-y","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T04:47:51Z","timestamp":1747802871000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Physical activity in relation to health status, quality of life and compliance with World Health Organization recommendations in patients with axial spondyloarthritis"],"prefix":"10.1186","volume":"27","author":[{"given":"M.","family":"Carbo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Hilberdink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Paap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Wink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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All patients provided written informed consent according to the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"112"}}