{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:59:12Z","timestamp":1794002352326,"version":"4.8.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR071644"],"award-info":[{"award-number":["AR071644"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"DOI":"10.1186\/s13075-025-03595-8","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T10:04:01Z","timestamp":1752141841000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Identification of serum exosome proteins in systemic sclerosis with interstitial lung disease by aptamer proteomics"],"prefix":"10.1186","volume":"27","author":[{"given":"Sonsoles","family":"Piera-Velazquez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon T.","family":"Dillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Towia A.","family":"Libermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio A.","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"3595_CR1","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1056\/NEJMra0806188","volume":"360","author":"A Gabrielli","year":"2009","unstructured":"Gabrielli A, Avvedimento EV, Krieg T, Scleroderma. N Engl J Med. 2009;360:1989\u20132003.","journal-title":"N Engl J Med"},{"key":"3595_CR2","doi-asserted-by":"publisher","first-page":"15002","DOI":"10.1038\/nrdp.2015.2","volume":"1","author":"Y Allanore","year":"2015","unstructured":"Allanore Y, Simms R, Distler O, Trojanowska M, Pope J, Denton CP, Varga J. Systemic sclerosis. Nat Rev Dis Prim. 2015;1:15002.","journal-title":"Nat Rev Dis Prim"},{"key":"3595_CR3","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1016\/S0140-6736(17)30933-9","volume":"390","author":"CP Denton","year":"2017","unstructured":"Denton CP, Khanna D. Systemic sclerosis. Lancet. 2017;390:1685\u201399.","journal-title":"Lancet"},{"key":"3595_CR4","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1111\/1346-8138.14153","volume":"45","author":"Y Asano","year":"2018","unstructured":"Asano Y. Systemic sclerosis. J Dermatol. 2018;45:128\u201338.","journal-title":"J Dermatol"},{"key":"3595_CR5","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1146\/annurev-pathol-011110-130312","volume":"28","author":"TR Katsumoto","year":"2011","unstructured":"Katsumoto TR, Whitfield ML, Connolly MK. The pathogenesis of systemic sclerosis. Annu Rev Pathol. 2011;28:509\u201337.","journal-title":"Annu Rev Pathol"},{"key":"3595_CR6","doi-asserted-by":"publisher","first-page":"272","DOI":"10.3389\/fimmu.2015.00272","volume":"6","author":"D Pattanaik","year":"2015","unstructured":"Pattanaik D, Brown M, Postlethwaite BC, Postlethwaite AE. Pathogenesis of systemic sclerosis. Front Immunol. 2015;6:272.","journal-title":"Front Immunol"},{"key":"3595_CR7","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1080\/1744666X.2019.1614915","volume":"15","author":"M Cutolo","year":"2019","unstructured":"Cutolo M, Soldano S, Smith V. Pathophysiology of systemic sclerosis: current Understanding and new insights. Expert Rev Clin Immunol. 2019;15:753\u201364.","journal-title":"Expert Rev Clin Immunol"},{"key":"3595_CR8","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.semarthrit.2014.05.010","volume":"44","author":"M Rubio-Rivas","year":"2014","unstructured":"Rubio-Rivas M, Royo C, Sime\u00f3n CP, Corbella X, Fonollosa V. Mortality and survival in systemic sclerosis: systematic review and meta-analysis. Semin Arthritis Rheum. 2014;44:208\u201319.","journal-title":"Semin Arthritis Rheum"},{"key":"3595_CR9","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1186\/s13075-021-02548-1","volume":"23","author":"S Jaafar","year":"2021","unstructured":"Jaafar S, Lescoat A, Huang S, Gordon J, Hinchcliff M, Shah AA, et al. Clinical characteristics, visceral involvement, and mortality in at-risk or early diffuse systemic sclerosis: a longitudinal analysis of an observational prospective multicenter US cohort. Arthritis Res Ther. 2021;23:170.","journal-title":"Arthritis Res Ther"},{"key":"3595_CR10","doi-asserted-by":"publisher","first-page":"133","DOI":"10.2217\/bmm.09.79","volume":"4","author":"SV Castro","year":"2010","unstructured":"Castro SV, Jimenez SA. Biomarkers in systemic sclerosis. Biomark Med. 2010;4:133\u201347.","journal-title":"Biomark Med"},{"key":"3595_CR11","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1586\/1744666X.2013.848792","volume":"9","author":"FV Castelino","year":"2013","unstructured":"Castelino FV, Varga J. Current status of systemic sclerosis biomarkers: applications for diagnosis, management and drug development. Expert Rev Clin Immunol. 2013;9:1077\u201390.","journal-title":"Expert Rev Clin Immunol"},{"key":"3595_CR12","doi-asserted-by":"publisher","first-page":"3388","DOI":"10.3390\/jcm9113388","volume":"9","author":"A Utsunomiya","year":"2020","unstructured":"Utsunomiya A, Oyama N, Hasegawa M. Potential biomarkers in systemic sclerosis: A literature review and update. J Clin Med. 2020;9:3388.","journal-title":"J Clin Med"},{"key":"3595_CR13","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1097\/BOR.0000000000000827","volume":"33","author":"JR Arron","year":"2021","unstructured":"Arron JR. Biomarkers in systemic sclerosis: mechanistic insights into pathogenesis and treatment. Curr Opin Rheumatol. 2021;33:480\u20135.","journal-title":"Curr Opin Rheumatol"},{"key":"3595_CR14","doi-asserted-by":"publisher","first-page":"345","DOI":"10.3109\/1354750X.2014.920046","volume":"19","author":"P B\u0103l\u0103nescu","year":"2014","unstructured":"B\u0103l\u0103nescu P, L\u0103daru A, B\u0103l\u0103nescu E, B\u0103icu\u015f C, Dan GA. Systemic sclerosis biomarkers discovered using mass-spectrometry-based proteomics: a systematic review. Biomarkers. 2014;19:345\u201355.","journal-title":"Biomarkers"},{"key":"3595_CR15","first-page":"5","volume":"74","author":"EN Brody","year":"2000","unstructured":"Brody EN, Gold L. Aptamers as therapeutic and diagnostic agents. J Biotechnol. 2000;74:5\u201313.","journal-title":"J Biotechnol"},{"key":"3595_CR16","doi-asserted-by":"publisher","first-page":"424","DOI":"10.3390\/microarrays4030424","volume":"4","author":"L Gold","year":"2015","unstructured":"Gold L, Ayers D, Bertino J, Bock C, Bock A, Brody EN, et al. Aptamer-Based screens of human body fluids for biomarkers. Microarrays (Basel). 2015;4:424\u201331.","journal-title":"Microarrays (Basel)"},{"key":"3595_CR17","first-page":"569","volume":"2","author":"C Thery","year":"2002","unstructured":"Thery C, Zitvogel L, Amigorena S. Exosomes: composition, biogenesis and function, nature reviews. Immunology. 2002;2:569\u201379.","journal-title":"Immunology"},{"key":"3595_CR18","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.bbagen.2012.03.017","volume":"1820","author":"AV Vlassov","year":"2012","unstructured":"Vlassov AV, Magdaleno S, Setterquist R, Conrad R. Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochem Biophys Acta. 2012;1820:940\u20138.","journal-title":"Biochem Biophys Acta"},{"key":"3595_CR19","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","volume":"30","author":"M Colombo","year":"2014","unstructured":"Colombo M, Raposo G, Th\u00e9ry C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol. 2014;30:255\u201389.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"3595_CR20","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1146\/annurev-biochem-013118-111902","volume":"88","author":"DM Pegtel","year":"2019","unstructured":"Pegtel DM, Gould SJ, Exosomes. Annu Rev Biochem. 2019;88:487\u2013514.","journal-title":"Annu Rev Biochem"},{"issue":"6478","key":"3595_CR21","doi-asserted-by":"publisher","first-page":"eaau6977","DOI":"10.1126\/science.aau6977","volume":"367","author":"R Kalluri","year":"2020","unstructured":"Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020;367(6478):eaau6977.","journal-title":"Science"},{"key":"3595_CR22","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1002\/prca.201400114","volume":"9","author":"N Riaz","year":"2015","unstructured":"Riaz N, Wolden SL, Gelblum DY, Eric J. Exosomes in bodily fluids are a highly stable resource of disease biomarkers. Proteom Clin Appl. 2015;9:358\u201367.","journal-title":"Proteom Clin Appl"},{"key":"3595_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.acc.2020.02.011","volume":"99","author":"AS Schou","year":"2020","unstructured":"Schou AS, Nielsen JE, Askeland A, J\u00f8rgensen MM. Extracellular vesicle-associated proteins as potential biomarkers. Adv Clin Chem. 2020;99:1\u201348.","journal-title":"Adv Clin Chem"},{"key":"3595_CR24","doi-asserted-by":"publisher","first-page":"4496","DOI":"10.2174\/1381612825666191209161443","volume":"25","author":"M Li","year":"2019","unstructured":"Li M, Jiang M, Meng J, Tao L. Exosomes: carriers of Pro-Fibrotic signals and therapeutic targets in fibrosis. Curr Pharm Des. 2019;25:4496\u2013509.","journal-title":"Curr Pharm Des"},{"key":"3595_CR25","doi-asserted-by":"publisher","first-page":"697","DOI":"10.2217\/bmm-2019-0368","volume":"14","author":"XJ Qin","year":"2020","unstructured":"Qin XJ, Zhang JX, Wang RL. Exosomes as mediators and biomarkers in fibrosis. Biomark Med. 2020;14:697\u2013712.","journal-title":"Biomark Med"},{"key":"3595_CR26","doi-asserted-by":"publisher","first-page":"4337","DOI":"10.3390\/ijms20184337","volume":"20","author":"M Colletti","year":"2019","unstructured":"Colletti M, Galardi A, De Santis M, Guidelli GM, Di Giannatale A, Di Luigi L, Antinozzi C. Exosomes in systemic sclerosis: messengers between immune, vascular and fibrotic components?? Int J Mol Sc. 2019;20:4337.","journal-title":"Int J Mol Sc"},{"key":"3595_CR27","first-page":"21","volume":"35","author":"PJ Wermuth","year":"2017","unstructured":"Wermuth PJ, Piera-Velazquez S, Jimenez SA. Exosomes isolated from serum of systemic sclerosis patients display alterations in their content of profibrotic and antifibrotic MicroRNA and induce a profibrotic phenotype in cultured normal dermal fibroblasts. Clin Exp Rheumatol. 2017;35:21\u201330.","journal-title":"Clin Exp Rheumatol"},{"key":"3595_CR28","doi-asserted-by":"publisher","first-page":"1902026","DOI":"10.1183\/13993003.02026-2019","volume":"55","author":"O Distler","year":"2020","unstructured":"Distler O, Assassi S, Cottin V, Cutolo M, Danoff SK, Denton CP, et al. Predictors of progression in systemic sclerosis patients with interstitial lung disease. Eur Respir J. 2020;55:1902026.","journal-title":"Eur Respir J"},{"key":"3595_CR29","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1164\/rccm.201903-0563CI","volume":"201","author":"D Khanna","year":"2020","unstructured":"Khanna D, Tashkin DP, Denton CP, Renzoni EA, Desai SR, Varga J, Etiology. Risk factors, and biomarkers in systemic sclerosis with interstitial lung disease. Am J Respir Crit Care Med. 2020;201:650\u201360.","journal-title":"Am J Respir Crit Care Med"},{"key":"3595_CR30","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1136\/annrheumdis-2013-204424","volume":"72","author":"F Van den Hoogen","year":"2013","unstructured":"Van den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A, et al. 2013 classification criteria for systemic sclerosis: an American college of rheumatology\/european league against rheumatism collaborative initiative. Ann Rheum Dis. 2013;72:1747\u201355.","journal-title":"Ann Rheum Dis"},{"issue":"8","key":"3595_CR31","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1002\/art.38702","volume":"66","author":"EL Herzog","year":"2014","unstructured":"Herzog EL, Mathur A, Tager AM, Feghali-Bostwick C, Schneider F, Varga J. Review: interstitial lung disease associated with systemic sclerosis and idiopathic pulmonary fibrosis: how similar and distinct? Arthritis Rheumatol. 2014;66(8):1967\u201378.","journal-title":"Arthritis Rheumatol"},{"key":"3595_CR32","doi-asserted-by":"publisher","first-page":"e15004","DOI":"10.1371\/journal.pone.0015004","volume":"5","author":"L Gold","year":"2010","unstructured":"Gold L, Ayers D, Bertino J, Bock CH, Bock A, Brody EN, et al. Aptamer-based multiplexed proteomic technology for biomarker discovery. PLoS ONE. 2010;5:e15004.","journal-title":"PLoS ONE"},{"key":"3595_CR33","first-page":"543","volume":"29","author":"L Gold","year":"2012","unstructured":"Gold L, Walker JJ, Wilcox SK, Williams S. Advances in human proteomics at high scale with the SOMAscan proteomics platform. Nat Biotechnol. 2012;29:543\u20139.","journal-title":"Nat Biotechnol"},{"key":"3595_CR34","doi-asserted-by":"publisher","first-page":"8382","DOI":"10.1038\/s41598-018-26640-w","volume":"8","author":"CH Kim","year":"2018","unstructured":"Kim CH, Tworoger SS, Stampfer MJ, Dillon ST, Gu X, Sawyer SJ, et al. Stability and reproducibility of proteomic profiles measured with an aptamer-based platform. Sci Rep. 2018;8:8382.","journal-title":"Sci Rep"},{"key":"3595_CR35","doi-asserted-by":"publisher","first-page":"e2100170","DOI":"10.1002\/pmic.202100170","volume":"22","author":"DE Haslam","year":"2022","unstructured":"Haslam DE, Li J, Dillon ST, Gu X, Cao Y, Zeleznik OA, et al. Stability and reproducibility of proteomic profiles in epidemiological studies: comparing the Olink and SOMAscan platforms. Proteomics. 2022;22:e2100170.","journal-title":"Proteomics"},{"key":"3595_CR36","doi-asserted-by":"publisher","first-page":"100835","DOI":"10.1016\/j.mex.2020.100835","volume":"7","author":"NP Vidal","year":"2020","unstructured":"Vidal NP, Manful CF, Pham TH, Stewart P, Keough D, Thomas R. The use of XLSTAT in conducting principal component analysis (PCA) when evaluating the relationships between sensory and quality attributes in grilled foods. MethodsX. 2020;7:100835.","journal-title":"MethodsX"},{"key":"3595_CR37","doi-asserted-by":"publisher","first-page":"D607","DOI":"10.1093\/nar\/gky1131","volume":"47","author":"D Szklarczyk","year":"2019","unstructured":"Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47:D607\u201313.","journal-title":"Nucleic Acids Res"},{"key":"3595_CR38","doi-asserted-by":"publisher","first-page":"104243","DOI":"10.1016\/j.jprot.2021.104243","volume":"242","author":"RT Kendall","year":"2021","unstructured":"Kendall RT, Renaud L, Baatz JE, Malaab M, Nguyen XX, Feghali-Bostwick CA. Systemic sclerosis biomarkers detection in the secretome of TGF\u03b21-activated primary human lung fibroblasts. J Proteom. 2021;242:104243.","journal-title":"J Proteom"},{"key":"3595_CR39","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1136\/annrheumdis-2020-217455","volume":"80","author":"AM Hoffmann-Vold","year":"2021","unstructured":"Hoffmann-Vold AM, Allanore Y, Alves M, Brunborg C, Air\u00f3 P, Ananieva LP, et al. EUSTAR collaborators. Progressive interstitial lung disease in patients with systemic sclerosis-associated interstitial lung disease in the EUSTAR database. Ann Rheum Dis. 2021;80:219\u201327.","journal-title":"Ann Rheum Dis"},{"key":"3595_CR40","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1093\/rheumatology\/ken370","volume":"47","author":"N Aden","year":"2008","unstructured":"Aden N, Shiwen X, Aden D, Black C, Nuttall A, Denton CP, et al. Proteomic analysis of scleroderma lesional skin reveals activated wound healing phenotype of epidermal cell layer. Rheumatology (Oxford). 2008;47:1754\u201360.","journal-title":"Rheumatology (Oxford)"},{"key":"3595_CR41","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s13075-020-02196-x","volume":"22","author":"P Chairta","year":"2020","unstructured":"Chairta P, Nicolaou P, Sokratous K, Galant C, Houssiau F, Oulas A, et al. Comparative analysis of affected and unaffected areas of systemic sclerosis skin biopsies by high-throughput proteomic approaches. Arthritis Res Ther. 2020;22:107.","journal-title":"Arthritis Res Ther"},{"key":"3595_CR42","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1093\/rheumatology\/kex404","volume":"57","author":"PJ Wermuth","year":"2018","unstructured":"Wermuth PJ, Piera-Velazquez S, Jimenez SA. Identification of novel systemic sclerosis biomarkers employing aptamer proteomic analysis. Rheumatology (Oxford). 2018;57:1698\u2013706.","journal-title":"Rheumatology (Oxford)"},{"key":"3595_CR43","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jid.2016.08.027","volume":"137","author":"LM Rice","year":"2017","unstructured":"Rice LM, Mantero JC, Stifano G, Ziemek J, Simms RW, Gordon J, et al. A Proteome-Derived longitudinal pharmacodynamic biomaker for diffuse systemic sclerosis skin. J Invest Dermatol. 2017;137:62\u201370.","journal-title":"J Invest Dermatol"},{"key":"3595_CR44","doi-asserted-by":"publisher","first-page":"e0279461","DOI":"10.1371\/journal.pone.0279461","volume":"17","author":"S Piera-Velazquez","year":"2022","unstructured":"Piera-Velazquez S, Dillon ST, Gu X, Libermann TA, Jimenez SA. Aptamer proteomics of serum exosomes from patients with primary raynaud\u2019s and patients with raynaud\u2019s at risk of evolving into systemic sclerosis. PLoS ONE. 2022;17:e0279461.","journal-title":"PLoS ONE"},{"key":"3595_CR45","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s13075-023-02989-w","volume":"25","author":"C Bellocchi","year":"2023","unstructured":"Bellocchi C, Assassi S, Lyons M, Marchini M, Mohan C, Santaniello A, et al. Proteomic aptamer analysis reveals serum markers that characterize preclinical systemic sclerosis (SSc) patients at risk for progression toward definite SSc. Arthritis Res Ther. 2023;25:15.","journal-title":"Arthritis Res Ther"},{"key":"3595_CR46","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1136\/ard-2022-223237","volume":"82","author":"S Sanges","year":"2023","unstructured":"Sanges S, Rice L, Tu L, Valenzi E, Cracowski JL, Montani D, et al. Biomarkers of haemodynamic severity of systemic sclerosis-associated pulmonary arterial hypertension by serum proteome analysis. Ann Rheum Dis. 2023;82:365\u201373.","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"3595_CR47","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.humimm.2017.06.002","volume":"78","author":"A Olewicz-Gawlik","year":"2017","unstructured":"Olewicz-Gawlik A, Trzybulska D, Graniczna K, Kuznar-Kaminska B, Katulska K, Batura-Gabryel H, Frydrychowicz M, Danczak-Pazdrowska A, Mozer-Lisewska I. Serum alarm antiproteases in systemic sclerosis patients. Hum Immunol. 2017;78(9):559\u201364.","journal-title":"Hum Immunol"},{"issue":"6894","key":"3595_CR48","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/nature00858","volume":"418","author":"P Scaffidi","year":"2002","unstructured":"Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature. 2002;418(6894):191\u20135.","journal-title":"Nature"},{"issue":"1","key":"3595_CR49","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s13075-020-02195-y","volume":"22","author":"JN Zheng","year":"2020","unstructured":"Zheng JN, Li Y, Yan YM, Yu Y, Shao WQ, Wang Q. Increased serum Calpain activity is associated with HMGB1 levels in systemic sclerosis. Arthritis Res Ther. 2020;22(1):110.","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"3595_CR50","doi-asserted-by":"publisher","first-page":"794","DOI":"10.3390\/antiox12040794","volume":"12","author":"Y Al-Adwi","year":"2023","unstructured":"Al-Adwi Y, Atzeni IM, Doornbos-van der Meer B, Abdulle AE, van Roon AM, Stel A, et al. Release of High-Mobility group Box-1 after a raynaud\u2019s attack leads to fibroblast activation and Interferon-\u03b3 induced Protein-10 production: role in systemic sclerosis pathogenesis. Antioxid (Basel). 2023;12(4):794.","journal-title":"Antioxid (Basel)"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-025-03595-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-025-03595-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-025-03595-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T05:35:02Z","timestamp":1757223302000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-025-03595-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,10]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3595"],"URL":"https:\/\/doi.org\/10.1186\/s13075-025-03595-8","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,10]]},"assertion":[{"value":"18 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors have read and agreed to its content and are accountable for all aspects of the accuracy and integrity of the manuscript in accordance with ICMJE criteria.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"This article is original and has not been published or currently under consideration by another journal. The authors agree to the terms of the BioMed Central Copyright and License Agreement,","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"146"}}