{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T18:06:54Z","timestamp":1768414014758,"version":"3.49.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100032091","name":"Royal Free Charity","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100032091","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"DOI":"10.1186\/s13075-025-03704-7","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T09:08:30Z","timestamp":1765357710000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A composite biomarker score to predict modified Rodnan skin score in systemic sclerosis: insight from autologous stem cell transplantation international scleroderma trial"],"prefix":"10.1186","volume":"28","author":[{"given":"Stefano","family":"Rodolfi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahja Ahmed","family":"Abdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elen","family":"Roblin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Medha","family":"Kanitkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Voon H.","family":"Ong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre E.","family":"Voskuyl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeska K.","family":"De Vries-Bouwstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob M.","family":"van Laar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher P.","family":"Denton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Spierings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"3704_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.5301\/jsrd.5000231","volume":"2","author":"D Khanna","year":"2017","unstructured":"Khanna D, et al. Standardization of the modified Rodnan skin score for use in clinical trials of systemic sclerosis. J Scleroderma Relat Disord. 2017;2:11\u20138.","journal-title":"J Scleroderma Relat Disord"},{"key":"3704_CR2","doi-asserted-by":"publisher","first-page":"e507","DOI":"10.1016\/S2665-9913(22)00094-7","volume":"4","author":"KEN Clark","year":"2022","unstructured":"Clark KEN, et al. Integrated analysis of dermal blister fluid proteomics and genome-wide skin gene expression in systemic sclerosis: an observational study. Lancet Rheumatol. 2022;4:e507\u201316.","journal-title":"Lancet Rheumatol"},{"key":"3704_CR3","doi-asserted-by":"publisher","DOI":"10.1093\/rap\/rkae039","volume":"8","author":"E Roblin","year":"2024","unstructured":"Roblin E, Clark KEN, Beesley C, Ong VH, Denton CP. Testing a candidate composite serum protein marker of skin severity in systemic sclerosis. Rheumatol Adv Pract. 2024;8:rkae039.","journal-title":"Rheumatol Adv Pract"},{"key":"3704_CR4","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.1001\/jama.2014.6368","volume":"311","author":"JM van Laar","year":"2014","unstructured":"van Laar JM, et al. Autologous hematopoietic stem cell transplantation vs intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis: a randomized clinical trial. JAMA. 2014;311:2490\u20138.","journal-title":"JAMA"},{"key":"3704_CR5","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1001\/jama.2013.281053","volume":"310","author":"World Medical Association","year":"2013","unstructured":"World Medical Association. World medical association declaration of helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310:2191\u20134.","journal-title":"JAMA"},{"key":"3704_CR6","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/1346-8138.13564","volume":"44","author":"S-I Motegi","year":"2017","unstructured":"Motegi S-I, Sekiguchi A, Fujiwara C, Toki S, Ishikawa O. Possible association of elevated serum collagen type IV level with skin sclerosis in systemic sclerosis. J Dermatol. 2017;44:167\u201372.","journal-title":"J Dermatol"},{"key":"3704_CR7","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1016\/j.jid.2023.09.288","volume":"144","author":"H Zhu","year":"2024","unstructured":"Zhu H, et al. Fibroblast subpopulations in systemic sclerosis \u2013 functional implications of individual subpopulations and correlations with clinical features. J Invest Dermatol. 2024;144:1251-1261.e13.","journal-title":"J Invest Dermatol"},{"key":"3704_CR8","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1136\/ard.2007.082099","volume":"67","author":"R Hesselstrand","year":"2008","unstructured":"Hesselstrand R, Kassner A, Heineg\u00e5rd D, Saxne T. COMP: a candidate molecule in the pathogenesis of systemic sclerosis with a potential as a disease marker. Ann Rheum Dis. 2008;67:1242\u20138.","journal-title":"Ann Rheum Dis"},{"key":"3704_CR9","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1002\/art.27220","volume":"62","author":"G Farina","year":"2010","unstructured":"Farina G, Lafyatis D, Lemaire R, Lafyatis R. A four-gene biomarker predicts skin disease in patients with diffuse cutaneous systemic sclerosis. Arthritis Rheum. 2010;62:580\u20138.","journal-title":"Arthritis Rheum"},{"key":"3704_CR10","doi-asserted-by":"publisher","first-page":"1326922","DOI":"10.3389\/fimmu.2024.1326922","volume":"15","author":"MM Yang","year":"2024","unstructured":"Yang MM, et al. Gene expression meta-analysis reveals aging and cellular senescence signatures in scleroderma-associated interstitial lung disease. Front Immunol. 2024;15:1326922.","journal-title":"Front Immunol"},{"key":"3704_CR11","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1093\/rheumatology\/ker442","volume":"51","author":"R Hesselstrand","year":"2012","unstructured":"Hesselstrand R, et al. Increased serum COMP predicts mortality in SSc: results from a longitudinal study of interstitial lung disease. Rheumatology (Oxford). 2012;51:915\u201320.","journal-title":"Rheumatology (Oxford)"},{"key":"3704_CR12","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1136\/ard.2007.082495","volume":"68","author":"I Miniati","year":"2009","unstructured":"Miniati I, et al. Autologous stem cell transplantation improves microcirculation in systemic sclerosis. Ann Rheum Dis. 2009;68:94\u20138.","journal-title":"Ann Rheum Dis"},{"key":"3704_CR13","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X221084845","volume":"14","author":"M Santana-Gon\u00e7alves","year":"2022","unstructured":"Santana-Gon\u00e7alves M, et al. Autologous hematopoietic stem cell transplantation modifies specific aspects of systemic sclerosis-related microvasculopathy. Ther Adv Musculoskelet Dis. 2022;14:1759720X221084845.","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"3704_CR14","doi-asserted-by":"publisher","first-page":"e1452","DOI":"10.1371\/journal.pone.0001452","volume":"3","author":"JN Fleming","year":"2008","unstructured":"Fleming JN, et al. Capillary regeneration in scleroderma: stem cell therapy reverses phenotype? PLoS One. 2008;3:e1452.","journal-title":"PLoS One"},{"key":"3704_CR15","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1056\/NEJMoa1703327","volume":"378","author":"KM Sullivan","year":"2018","unstructured":"Sullivan KM, et al. Myeloablative autologous stem-cell transplantation for severe scleroderma. N Engl J Med. 2018;378:35\u201347.","journal-title":"N Engl J Med"},{"key":"3704_CR16","doi-asserted-by":"publisher","first-page":"941011","DOI":"10.3389\/fimmu.2022.941011","volume":"13","author":"MY Kawashima-Vasconcelos","year":"2022","unstructured":"Kawashima-Vasconcelos MY, Santana-Gon\u00e7alves M, Zanin-Silva DC, Malmegrim KCR, Oliveira MC. Reconstitution of the immune system and clinical correlates after stem cell transplantation for systemic sclerosis. Front Immunol. 2022;13:941011.","journal-title":"Front Immunol"}],"container-title":["Arthritis Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-025-03704-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-025-03704-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-025-03704-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T10:36:58Z","timestamp":1768387018000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13075-025-03704-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,10]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3704"],"URL":"https:\/\/doi.org\/10.1186\/s13075-025-03704-7","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,10]]},"assertion":[{"value":"6 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was provided by all patients upon participation to ASTIS trial.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"11"}}