{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:11:41Z","timestamp":1791227501454,"version":"4.1.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2019-NR040080"],"award-info":[{"award-number":["RS-2019-NR040080"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Regional Innovation System & Education (RISE) program through the Jeju RISE center, funded by the Ministry of Education (MOE) and the Jeju Special Self-Governing Province, Republic of Korea","award":["2025-RISE-17-001"],"award-info":[{"award-number":["2025-RISE-17-001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"DOI":"10.1186\/s13075-026-03728-7","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:19:23Z","timestamp":1768565963000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["PARP-1 prevents osteoarthritis pathogenesis by inhibiting apoptosis in chondrocytes: an animal study"],"prefix":"10.1186","volume":"28","author":[{"given":"Minhye","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrinmoy","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunji","family":"Heo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myeongyeon","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhui","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Ok","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"issue":"3","key":"3728_CR1","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.cger.2010.03.001","volume":"26","author":"Y Zhang","year":"2010","unstructured":"Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Clin Geriatr Med. 2010;26(3):355\u201369.","journal-title":"Clin Geriatr Med"},{"issue":"11","key":"3728_CR2","doi-asserted-by":"publisher","first-page":"614","DOI":"10.3390\/medicina56110614","volume":"56","author":"MHM Yunus","year":"2020","unstructured":"Yunus MHM, Nordin A, Kamal H. Pathophysiological perspective of osteoarthritis. Medicina. 2020;56(11):614.","journal-title":"Medicina"},{"issue":"1","key":"3728_CR3","doi-asserted-by":"publisher","first-page":"15040","DOI":"10.1038\/boneres.2015.40","volume":"4","author":"W Zhang","year":"2016","unstructured":"Zhang W, Ouyang H, Dass CR, Xu J. Current research on pharmacologic and regenerative therapies for osteoarthritis. Bone Res. 2016;4(1):15040.","journal-title":"Bone Res"},{"key":"3728_CR4","doi-asserted-by":"crossref","unstructured":"Min Y, Kim D, Suminda GGD, Zhao X, Kim M, Zhao Y, Son YO. GSK5182, 4-Hydroxytamoxifen analog, a new potential therapeutic drug for osteoarthritis. Pharmaceuticals (Basel). 2020;13(12):429.","DOI":"10.3390\/ph13120429"},{"issue":"1","key":"3728_CR5","first-page":"74","volume":"4","author":"Q Bian","year":"2012","unstructured":"Bian Q, Wang Y-J, Liu S-F, Li Y-P. Osteoarthritis: genetic factors, animal models, mechanisms, and therapies. FBE. 2012;4(1):74\u2013100.","journal-title":"FBE"},{"issue":"11","key":"3728_CR6","doi-asserted-by":"publisher","first-page":"26035","DOI":"10.3390\/ijms161125943","volume":"16","author":"HS Hwang","year":"2015","unstructured":"Hwang HS, Kim HA. Chondrocyte apoptosis in the pathogenesis of osteoarthritis. Int J Mol Sci. 2015;16(11):26035\u201354.","journal-title":"Int J Mol Sci"},{"issue":"5","key":"3728_CR7","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.joca.2021.03.002","volume":"30","author":"G Aubourg","year":"2022","unstructured":"Aubourg G, Rice SJ, Bruce-Wootton P, Loughlin J. Genetics of osteoarthritis. Osteoarthritis Cartilage. 2022;30(5):636\u201349.","journal-title":"Osteoarthritis Cartilage"},{"key":"3728_CR8","doi-asserted-by":"publisher","first-page":"102651","DOI":"10.1016\/j.dnarep.2019.102651","volume":"81","author":"Y Wang","year":"2019","unstructured":"Wang Y, Luo W, Wang Y. PARP-1 and its associated nucleases in DNA damage response. DNA Repair (Amst). 2019;81:102651.","journal-title":"DNA Repair (Amst)"},{"issue":"4","key":"3728_CR9","doi-asserted-by":"publisher","first-page":"326","DOI":"10.2174\/187153011797881184","volume":"11","author":"F Laudisi","year":"2011","unstructured":"Laudisi F, Sambucci M, Pioli C. Poly (ADP-ribose) polymerase-1 (PARP-1) as immune regulator. Endocr Metab Immune Disord Drug Targets. 2011;11(4):326\u201333.","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"issue":"33","key":"3728_CR10","doi-asserted-by":"publisher","first-page":"22932","DOI":"10.1074\/jbc.274.33.22932","volume":"274","author":"AH Boulares","year":"1999","unstructured":"Boulares AH, Yakovlev AG, Ivanova V, Stoica BA, Wang G, Iyer S, Smulson M. Role of Poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis: CASPASE 3-resistant PARP mutant increases rates of apoptosis in transfected cells*. J Biol Chem. 1999;274(33):22932\u201340.","journal-title":"J Biol Chem"},{"issue":"6","key":"3728_CR11","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1002\/med.21442","volume":"37","author":"J Rajawat","year":"2017","unstructured":"Rajawat J, Shukla N, Mishra DP. Therapeutic targeting of Poly(ADP-Ribose) Polymerase-1 (PARP1) in cancer: current developments, therapeutic strategies, and future opportunities. Med Res Rev. 2017;37(6):1461\u201391.","journal-title":"Med Res Rev"},{"key":"3728_CR12","doi-asserted-by":"publisher","first-page":"290","DOI":"10.3389\/fonc.2013.00290","volume":"3","author":"AN Weaver","year":"2013","unstructured":"Weaver AN, Yang ES. Beyond DNA repair: additional functions of PARP-1 in cancer. Front Oncol. 2013;3:290.","journal-title":"Front Oncol"},{"key":"3728_CR13","doi-asserted-by":"publisher","first-page":"110452","DOI":"10.1016\/j.biopha.2020.110452","volume":"129","author":"MY Ansari","year":"2020","unstructured":"Ansari MY, Ahmad N, Haqqi TM. Oxidative stress and inflammation in osteoarthritis pathogenesis: role of polyphenols. Biomed Pharmacother. 2020;129:110452.","journal-title":"Biomed Pharmacother"},{"key":"3728_CR14","doi-asserted-by":"publisher","first-page":"100950","DOI":"10.1016\/j.molmet.2020.01.014","volume":"38","author":"S Hurtado-Bag\u00e8s","year":"2020","unstructured":"Hurtado-Bag\u00e8s S, Knobloch G, Ladurner AG, Buschbeck M. The taming of PARP1 and its impact on NAD(+) metabolism. Mol Metab. 2020;38:100950.","journal-title":"Mol Metab"},{"issue":"6","key":"3728_CR15","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1093\/abbs\/gmv033","volume":"47","author":"Y Sun","year":"2015","unstructured":"Sun Y, Zhou L, Lv D, Liu H, He T, Wang X. Poly(ADP-ribose) polymerase 1 Inhibition prevents interleukin-1\u03b2-induced inflammation in human Osteoarthritic chondrocytes. Acta Biochim Biophys Sin (Shanghai). 2015;47(6):422\u201330.","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"issue":"2","key":"3728_CR16","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/ki.2012.64","volume":"82","author":"J Kim","year":"2012","unstructured":"Kim J, Long KE, Tang K, Padanilam BJ. Poly(ADP-ribose) polymerase 1 activation is required for cisplatin nephrotoxicity. Kidney Int. 2012;82(2):193\u2013203.","journal-title":"Kidney Int"},{"issue":"1","key":"3728_CR17","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1038\/s41467-017-01868-8","volume":"8","author":"Y-O Son","year":"2017","unstructured":"Son Y-O, Park S, Kwak J-S, Won Y, Choi W-S, Rhee J, Chun C-H, Ryu J-H, Kim D-K, Choi H-S, et al. Estrogen-related receptor \u03b3 causes osteoarthritis by upregulating extracellular matrix-degrading enzymes. Nat Commun. 2017;8(1):2133.","journal-title":"Nat Commun"},{"key":"3728_CR18","doi-asserted-by":"publisher","first-page":"109223","DOI":"10.1016\/j.jnutbio.2022.109223","volume":"112","author":"Y Min","year":"2023","unstructured":"Min Y, Ahn D, Truong TMT, Kim M, Heo Y, Jee Y, Son Y-O, Kang I. Excessive sucrose exacerbates high fat diet-induced hepatic inflammation and fibrosis promoting osteoarthritis in mice model. J Nutr Biochem. 2023;112:109223.","journal-title":"J Nutr Biochem"},{"issue":"Suppl 3","key":"3728_CR19","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","volume":"18","author":"SS Glasson","year":"2010","unstructured":"Glasson SS, Chambers MG, Van Den Berg WB, Little CB. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis Cartilage. 2010;18(Suppl 3):S17\u201323.","journal-title":"Osteoarthritis Cartilage"},{"issue":"9","key":"3728_CR20","doi-asserted-by":"publisher","first-page":"20560","DOI":"10.3390\/ijms160920560","volume":"16","author":"G Musumeci","year":"2015","unstructured":"Musumeci G, Castrogiovanni P, Trovato FM, Weinberg AM, Al-Wasiyah MK, Alqahtani MH, Mobasheri A. Biomarkers of chondrocyte apoptosis and autophagy in osteoarthritis. Int J Mol Sci. 2015;16(9):20560\u201375.","journal-title":"Int J Mol Sci"},{"key":"3728_CR21","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.3389\/fcell.2025.1571448","volume":"13","author":"J Mei","year":"2025","unstructured":"Mei J, Xiao N, Xi Y, Chen X, Zha X, Cui L, Yan F, Xue R, Wang Y, Ma Y. Regulation of apoptosis and interaction with cartilage degeneration in osteoarthritis. Front Cell Dev Biology. 2025;13:2025.","journal-title":"Front Cell Dev Biology"},{"issue":"2","key":"3728_CR22","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1002\/1529-0131(199802)41:2<284::AID-ART12>3.0.CO;2-T","volume":"41","author":"FJ Blanco","year":"1998","unstructured":"Blanco FJ, Guitian R, V\u00e1zquez-Martul E, de Toro FJ, Galdo F. Osteoarthritis chondrocytes die by apoptosis: a possible pathway for osteoarthritis pathology. Arthr Rhuem. 1998;41(2):284\u20139.","journal-title":"Arthr Rhuem"},{"issue":"1","key":"3728_CR23","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13018-024-05055-6","volume":"19","author":"M Guan","year":"2024","unstructured":"Guan M, Yu Q, Zhou G, Wang Y, Yu J, Yang W, Li Z. Mechanisms of chondrocyte cell death in osteoarthritis: implications for disease progression and treatment. J Orthop Surg Res. 2024;19(1):550.","journal-title":"J Orthop Surg Res"},{"issue":"5579","key":"3728_CR24","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1126\/science.1072221","volume":"297","author":"SW Yu","year":"2002","unstructured":"Yu SW, Wang H, Poitras MF, Coombs C, Bowers WJ, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science. 2002;297(5579):259\u201363.","journal-title":"Science"},{"issue":"17","key":"3728_CR25","first-page":"3976","volume":"53","author":"SH Kaufmann","year":"1993","unstructured":"Kaufmann SH, Desnoyers S, Ottaviano Y, Davidson NE, Poirier GG. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res. 1993;53(17):3976\u201385.","journal-title":"Cancer Res"},{"issue":"4","key":"3728_CR26","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1023\/A:1016119328968","volume":"7","author":"C Soldani","year":"2002","unstructured":"Soldani C, Scovassi AI. Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update. Apoptosis. 2002;7(4):321\u20138.","journal-title":"Apoptosis"},{"issue":"1","key":"3728_CR27","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1093\/toxsci\/kfs142","volume":"128","author":"F Zhang","year":"2012","unstructured":"Zhang F, Lau SS, Monks TJ. A dual role for poly(ADP-ribose) polymerase-1 during caspase-dependent apoptosis. Toxicol Sci. 2012;128(1):103\u201314.","journal-title":"Toxicol Sci"},{"issue":"1","key":"3728_CR28","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1134\/S1607672922700028","volume":"508","author":"AL Zakharenko","year":"2023","unstructured":"Zakharenko AL, Malakhova AA, Dyrkheeva NS, Okorokova LS, Medvedev SP, Zakian SM, Kabilov MR, Tupikin AA, Lavrik OI. PARP1 gene knockout suppresses expression of DNA base excision repair genes. Dokl Biochem Biophys. 2023;508(1):6\u201311.","journal-title":"Dokl Biochem Biophys"},{"issue":"8","key":"3728_CR29","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1038\/sj.onc.1208289","volume":"24","author":"A Shibata","year":"2005","unstructured":"Shibata A, Kamada N, Masumura K-i, Nohmi T, Kobayashi S, Teraoka H, Nakagama H, Sugimura T, Suzuki H, Masutani M. Parp-1 deficiency causes an increase of deletion mutations and insertions\/rearrangements in vivo after treatment with an alkylating agent. Oncogene. 2005;24(8):1328\u201337.","journal-title":"Oncogene"},{"issue":"3","key":"3728_CR30","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1093\/toxres\/tfaa110","volume":"10","author":"CM Gong","year":"2021","unstructured":"Gong CM, Xu YF, Liang XS, Mo JL, Zhuang ZX. PARP-1 overexpression does not protect HaCaT cells from DNA damage induced by SiO(2) nanoparticles. Toxicol Res (Camb). 2021;10(3):399\u2013408.","journal-title":"Toxicol Res (Camb)"},{"issue":"2","key":"3728_CR31","doi-asserted-by":"publisher","first-page":"H486","DOI":"10.1152\/ajpheart.00437.2004","volume":"288","author":"JB Pillai","year":"2005","unstructured":"Pillai JB, Russell HM, Raman J, Jeevanandam V, Gupta MP. Increased expression of poly(ADP-ribose) polymerase-1 contributes to caspase-independent myocyte cell death during heart failure. Am J Physiol Heart Circ Physiol. 2005;288(2):H486\u201396.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"8","key":"3728_CR32","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/sj.cdd.4400863","volume":"8","author":"L Tentori","year":"2001","unstructured":"Tentori L, Balduzzi A, Portarena I, Levati L, Vernole P, Gold B, Bonmassar E, Graziani G. Poly (ADP-ribose) polymerase inhibitor increases apoptosis and reduces necrosis induced by a DNA minor groove binding methyl sulfonate ester. Cell Death Differ. 2001;8(8):817\u201328.","journal-title":"Cell Death Differ"},{"issue":"6","key":"3728_CR33","doi-asserted-by":"publisher","first-page":"942","DOI":"10.4161\/cbt.7.6.6198","volume":"7","author":"K Ye","year":"2008","unstructured":"Ye K. PARP inhibitor tilts cell death from necrosis to apoptosis in cancer cells. Cancer Biol Ther. 2008;7(6):942\u20134.","journal-title":"Cancer Biol Ther"},{"issue":"10","key":"3728_CR34","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1007\/s00134-006-0336-x","volume":"32","author":"E Barth","year":"2006","unstructured":"Barth E, Radermacher P, Szab\u00f3 C. The world according to poly(ADP-ribose) polymerase (PARP)\u2014update 2006. Intensive Care Med. 2006;32(10):1470\u20134.","journal-title":"Intensive Care Med"},{"issue":"17","key":"3728_CR35","doi-asserted-by":"publisher","first-page":"4750","DOI":"10.1158\/1078-0432.CCR-13-0516","volume":"19","author":"K Yuan","year":"2013","unstructured":"Yuan K, Sun Y, Zhou T, McDonald J, Chen Y. PARP-1 regulates resistance of pancreatic cancer to TRAIL therapy. Clin Cancer Res. 2013;19(17):4750\u20139.","journal-title":"Clin Cancer Res"},{"issue":"56","key":"3728_CR36","doi-asserted-by":"publisher","first-page":"8136","DOI":"10.1038\/sj.onc.1205056","volume":"20","author":"R Beneke","year":"2001","unstructured":"Beneke R, M\u00f6r\u00f6y T. Inhibition of Poly(ADP-ribose) polymerase activity accelerates T-cell lymphomagenesis in p53 deficient mice. Oncogene. 2001;20(56):8136\u201341.","journal-title":"Oncogene"},{"key":"3728_CR37","doi-asserted-by":"publisher","first-page":"1093939","DOI":"10.3389\/fnut.2022.1093939","volume":"9","author":"R Li","year":"2022","unstructured":"Li R, Luo R, Luo Y, Hou Y, Wang J, Zhang Q, Chen X, Hu L, Zhou J. Biological function, mediate cell death pathway and their potential regulated mechanisms for post-mortem muscle tenderization of PARP1: A review. Front Nutr. 2022;9:1093939.","journal-title":"Front Nutr"},{"key":"3728_CR38","doi-asserted-by":"publisher","first-page":"100046","DOI":"10.1074\/jbc.RA120.014479","volume":"296","author":"M Mashimo","year":"2021","unstructured":"Mashimo M, Onishi M, Uno A, Tanimichi A, Nobeyama A, Mori M, Yamada S, Negi S, Bu X, Kato J, et al. The 89-kDa PARP1 cleavage fragment serves as a cytoplasmic PAR carrier to induce AIF-mediated apoptosis. J Biol Chem. 2021;296:100046.","journal-title":"J Biol Chem"},{"key":"3728_CR39","doi-asserted-by":"publisher","first-page":"103593","DOI":"10.1016\/j.dnarep.2023.103593","volume":"133","author":"W Deeksha","year":"2024","unstructured":"Deeksha W, Rajakumara E. Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2. DNA Repair. 2024;133:103593.","journal-title":"DNA Repair"},{"issue":"5","key":"3728_CR40","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/0092-8674(95)90541-3","volume":"81","author":"M Tewari","year":"1995","unstructured":"Tewari M, Quan LT, O\u2019Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM. Yama\/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell. 1995;81(5):801\u20139.","journal-title":"Cell"},{"issue":"4","key":"3728_CR41","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s00401-009-0559-3","volume":"118","author":"T Sairanen","year":"2009","unstructured":"Sairanen T, Szepesi R, Karjalainen-Lindsberg ML, Saksi J, Paetau A, Lindsberg PJ. Neuronal caspase-3 and PARP-1 correlate differentially with apoptosis and necrosis in ischemic human stroke. Acta Neuropathol. 2009;118(4):541\u201352.","journal-title":"Acta Neuropathol"},{"issue":"7","key":"3728_CR42","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1038\/cr.2012.70","volume":"22","author":"JM Rodr\u00edguez-Vargas","year":"2012","unstructured":"Rodr\u00edguez-Vargas JM, Ruiz-Maga\u00f1a MJ, Ruiz-Ruiz C, Majuelos-Melguizo J, Peralta-Leal A, Rodr\u00edguez MI, Mu\u00f1oz-G\u00e1mez JA, de Almod\u00f3var MR, Siles E, Rivas AL, et al. ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy. Cell Res. 2012;22(7):1181\u201398.","journal-title":"Cell Res"},{"issue":"5","key":"3728_CR43","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1016\/S0002-9440(10)61135-2","volume":"160","author":"CC Franklin","year":"2002","unstructured":"Franklin CC, Krejsa CM, Pierce RH, White CC, Fausto N, Kavanagh TJ. Caspase-3-Dependent cleavage of the Glutamate-L-Cysteine ligase catalytic subunit during apoptotic cell death. Am J Pathol. 2002;160(5):1887\u201394.","journal-title":"Am J Pathol"},{"issue":"4","key":"3728_CR44","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/sj.cdd.4401360","volume":"11","author":"P Tawa","year":"2004","unstructured":"Tawa P, Hell K, Giroux A, Grimm E, Han Y, Nicholson DW, Xanthoudakis S. Catalytic activity of caspase-3 is required for its degradation: stabilization of the active complex by synthetic inhibitors. Cell Death Differ. 2004;11(4):439\u201347.","journal-title":"Cell Death Differ"},{"key":"3728_CR45","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.3389\/fcell.2024.1347126","volume":"12","author":"YT Lee","year":"2024","unstructured":"Lee YT, Mohd Yunus MH, Yazid MD, Ugusman A. Unraveling the path to osteoarthritis management: targeting chondrocyte apoptosis for therapeutic intervention. Front Cell Dev Biology. 2024;12:2024.","journal-title":"Front Cell Dev Biology"},{"issue":"6S","key":"3728_CR46","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.pmrj.2011.05.009","volume":"3","author":"MB Mueller","year":"2011","unstructured":"Mueller MB, Tuan RS. Anabolic\/catabolic balance in pathogenesis of osteoarthritis: identifying molecular targets. PM&R. 2011;3(6S):S3\u201311.","journal-title":"PM&R"},{"issue":"2","key":"3728_CR47","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/ar148","volume":"3","author":"LJ Sandell","year":"2001","unstructured":"Sandell LJ, Aigner T. Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis. Arthritis Res. 2001;3(2):107\u201313.","journal-title":"Arthritis Res"},{"issue":"4","key":"3728_CR48","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1089\/ten.teb.2013.0377","volume":"20","author":"DJ Blasioli","year":"2014","unstructured":"Blasioli DJ, Kaplan DL. The roles of catabolic factors in the development of osteoarthritis. Tissue Eng Part B Rev. 2014;20(4):355\u201363.","journal-title":"Tissue Eng Part B Rev"},{"key":"3728_CR49","first-page":"561459","volume":"20141","author":"P Wojdasiewicz","year":"2014","unstructured":"Wojdasiewicz P, Poniatowski \u0141A, Szukiewicz D. The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis. Mediat Inflamm. 2014;20141:561459.","journal-title":"Mediat Inflamm"},{"issue":"1","key":"3728_CR50","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.joca.2014.10.002","volume":"23","author":"X Wang","year":"2015","unstructured":"Wang X, Hunter D, Xu J, Ding C. Metabolic triggered inflammation in osteoarthritis. Osteoarthr Cartil. 2015;23(1):22\u201330.","journal-title":"Osteoarthr Cartil"},{"issue":"10","key":"3728_CR51","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1038\/nrm.2017.53","volume":"18","author":"A Ray Chaudhuri","year":"2017","unstructured":"Ray Chaudhuri A, Nussenzweig A. The multifaceted roles of PARP1 in DNA repair and chromatin remodelling. Nat Rev Mol Cell Biol. 2017;18(10):610\u201321.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"3728_CR52","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1006\/excr.2001.5293","volume":"269","author":"C Soldani","year":"2001","unstructured":"Soldani C, Lazz\u00e8 MC, Bottone MG, Tognon G, Biggiogera M, Pellicciari CE, Scovassi AI. Poly(ADP-ribose) polymerase cleavage during apoptosis: when and where? Exp Cell Res. 2001;269(2):193\u2013201.","journal-title":"Exp Cell Res"},{"issue":"12","key":"3728_CR53","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1016\/j.freeradbiomed.2010.09.026","volume":"49","author":"B Racz","year":"2010","unstructured":"Racz B, Hanto K, Tapodi A, Solti I, Kalman N, Jakus P, Kovacs K, Debreceni B, Gallyas F Jr., Sumegi B. Regulation of MKP-1 expression and MAPK activation by PARP-1 in oxidative stress: a new mechanism for the cytoplasmic effect of PARP-1 activation. Free Radic Biol Med. 2010;49(12):1978\u201388.","journal-title":"Free Radic Biol Med"},{"issue":"5","key":"3728_CR54","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1038\/sj.cdd.4402088","volume":"14","author":"S Zhang","year":"2007","unstructured":"Zhang S, Lin Y, Kim YS, Hande MP, Liu ZG, Shen HM. c-Jun N-terminal kinase mediates hydrogen peroxide-induced cell death via sustained poly(ADP-ribose) polymerase-1 activation. Cell Death Differ. 2007;14(5):1001\u201310.","journal-title":"Cell Death Differ"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-026-03728-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-026-03728-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-026-03728-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:08:31Z","timestamp":1770772111000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13075-026-03728-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,16]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3728"],"URL":"https:\/\/doi.org\/10.1186\/s13075-026-03728-7","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,16]]},"assertion":[{"value":"20 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"36"}}