{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T02:44:24Z","timestamp":1782787464809,"version":"3.54.5"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":55,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"European Research Council (ERC) under the European Union\u2019s Horizon 2020 research and innovation program","award":["No 742390"],"award-info":[{"award-number":["No 742390"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"DOI":"10.1186\/s13075-026-03767-0","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T11:03:24Z","timestamp":1778065404000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peripheral blood transcriptomic analysis of patients with rheumatoid arthritis associated interstitial lung disease reveals: distinct molecular signature with evidence of humoral and myeloid immunity"],"prefix":"10.1186","volume":"28","author":[{"given":"Sofia","family":"Flouda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Grigoriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Sentis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Grivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos","family":"Malissovas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aggelos","family":"Banos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemin","family":"Kapsala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Filia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dionysis","family":"Nikolopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theofanis","family":"Karageorgas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilios","family":"Tzilas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonis","family":"Fanouriakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios T.","family":"Boumpas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"issue":"12","key":"3767_CR1","doi-asserted-by":"publisher","first-page":"4583","DOI":"10.1093\/rheumatology\/keac329","volume":"61","author":"G McDermott","year":"2022","unstructured":"McDermott G, Sparks JA. Quantitative chest imaging and prediction of mortality in rheumatoid arthritis-associated interstitial lung disease. Rheumatology (Oxford). 2022;61(12):4583\u20134.","journal-title":"Rheumatology (Oxford)"},{"issue":"160","key":"3767_CR2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0011-2021","volume":"30","author":"S Kadura","year":"2021","unstructured":"Kadura S, Raghu G. Rheumatoid arthritis-interstitial lung disease: manifestations and current concepts in pathogenesis and management. Eur Respir Rev. 2021;30(160):210011.","journal-title":"Eur Respir Rev"},{"key":"3767_CR3","doi-asserted-by":"publisher","first-page":"837133","DOI":"10.3389\/fmed.2022.837133","volume":"9","author":"A Laria","year":"2022","unstructured":"Laria A, Lurati AM, Zizzo G, Zaccara E, Mazzocchi D, Re KA, et al. Interstitial Lung Disease in Rheumatoid Arthritis: A Practical Review. Front Med (Lausanne). 2022;9:837133.","journal-title":"Front Med (Lausanne)"},{"issue":"9","key":"3767_CR4","doi-asserted-by":"publisher","first-page":"3014","DOI":"10.1093\/rheumatology\/kead027","volume":"62","author":"SH Chang","year":"2023","unstructured":"Chang SH, Lee JS, Ha YJ, Kim MU, Park CH, Lee JS, et al. Lung function trajectory of rheumatoid arthritis-associated interstitial lung disease. Rheumatology (Oxford). 2023;62(9):3014\u201324.","journal-title":"Rheumatology (Oxford)"},{"issue":"3","key":"3767_CR5","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1097\/BOR.0000000000000703","volume":"32","author":"BR England","year":"2020","unstructured":"England BR, Hershberger D. Management issues in rheumatoid arthritis-associated interstitial lung disease. Curr Opin Rheumatol. 2020;32(3):255\u201363.","journal-title":"Curr Opin Rheumatol"},{"issue":"19","key":"3767_CR6","doi-asserted-by":"publisher","first-page":"14509","DOI":"10.3390\/ijms241914509","volume":"24","author":"Y Kim","year":"2023","unstructured":"Kim Y, Yang HI, Kim KS. Etiology and pathogenesis of rheumatoid arthritis-interstitial lung disease. Int J Mol Sci. 2023;24(19):14509. Available from:\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10572849\/. Cited 2024 Jun 4","journal-title":"Int J Mol Sci."},{"issue":"10","key":"3767_CR7","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1111\/1756-185X.14830","volume":"26","author":"PC Shih","year":"2023","unstructured":"Shih PC, Chang SH, Huo AP, Wei JCC. Navigating the maze of treatment strategies for RA-ILD: insights and innovations for better patient outcomes. Int J Rheum Dis. 2023;26(10):1899\u2013903.","journal-title":"Int J Rheum Dis"},{"issue":"11","key":"3767_CR8","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1002\/art.42162","volume":"74","author":"PA Juge","year":"2022","unstructured":"Juge PA, Granger B, Debray MP, Ebstein E, Louis-Sidney F, Kedra J, et al. A risk score to detect subclinical rheumatoid arthritis-associated interstitial lung disease. Arthritis Rheumatol. 2022;74(11):1755\u201365.","journal-title":"Arthritis Rheumatol"},{"key":"3767_CR9","doi-asserted-by":"publisher","first-page":"152187","DOI":"10.1016\/j.semarthrit.2023.152187","volume":"60","author":"HJ Farquhar","year":"2023","unstructured":"Farquhar HJ, Beckert N, Beckert L, Edwards AL, Matteson EL, Frampton C, et al. Survival of adults with rheumatoid arthritis associated interstitial lung disease - A systematic review and meta-analysis. Semin Arthritis Rheum. 2023;60:152187.","journal-title":"Semin Arthritis Rheum"},{"issue":"12","key":"3767_CR10","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1111\/resp.13848","volume":"25","author":"HC Kim","year":"2020","unstructured":"Kim HC, Lee JS, Lee EY, Ha YJ, Chae EJ, Han M, et al. Risk prediction model in rheumatoid arthritis-associated interstitial lung disease. Respirology. 2020;25(12):1257\u201364.","journal-title":"Respirology"},{"issue":"10","key":"3767_CR11","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1002\/art.40574","volume":"70","author":"P Spagnolo","year":"2018","unstructured":"Spagnolo P, Lee JS, Sverzellati N, Rossi G, Cottin V. The lung in rheumatoid arthritis: focus on interstitial lung disease. Arthritis Rheumatol. 2018;70(10):1544\u201354.","journal-title":"Arthritis Rheumatol"},{"issue":"4","key":"3767_CR12","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1007\/s10067-020-05320-z","volume":"40","author":"Y Dai","year":"2021","unstructured":"Dai Y, Wang W, Yu Y, Hu S. Rheumatoid arthritis-associated interstitial lung disease: an overview of epidemiology, pathogenesis and management. Clin Rheumatol. 2021;40(4):1211\u201320.","journal-title":"Clin Rheumatol"},{"issue":"8","key":"3767_CR13","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1007\/s00296-023-05313-6","volume":"43","author":"GM Koduri","year":"2023","unstructured":"Koduri GM, Podlasek A, Pattapola S, Zhang J, Laila D, Nandagudi A, et al. Four-factor risk score for the prediction of interstitial lung disease in rheumatoid arthritis. Rheumatol Int. 2023;43(8):1515\u201323.","journal-title":"Rheumatol Int"},{"issue":"23","key":"3767_CR14","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1056\/NEJMoa1801562","volume":"379","author":"PA Juge","year":"2018","unstructured":"Juge PA, Lee JS, Ebstein E, Furukawa H, Dobrinskikh E, Gazal S, et al. MUC5B promoter variant and rheumatoid arthritis with interstitial lung disease. N Engl J Med. 2018;379(23):2209\u201319.","journal-title":"N Engl J Med"},{"issue":"10","key":"3767_CR15","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/nrrheum.2014.80","volume":"10","author":"HL Wright","year":"2014","unstructured":"Wright HL, Moots RJ, Edwards SW. The multifactorial role of neutrophils in rheumatoid arthritis. Nat Rev Rheumatol. 2014;10(10):593\u2013601.","journal-title":"Nat Rev Rheumatol"},{"key":"3767_CR16","doi-asserted-by":"publisher","first-page":"964274","DOI":"10.3389\/fimmu.2022.964274","volume":"13","author":"A Grivas","year":"2022","unstructured":"Grivas A, Grigoriou M, Malissovas N, Sentis G, Filia A, Flouda S, et al. Combined \u2013 whole blood and skin fibroblasts- transcriptomic analysis in Psoriatic Arthritis reveals molecular signatures of activity, resistance and early response to treatment. Front Immunol. 2022;13:964274. Available from:\u00a0https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2022.964274\/full.\u00a0Cited 2024 Jun 4.","journal-title":"Front Immunol."},{"issue":"1","key":"3767_CR17","doi-asserted-by":"publisher","first-page":"40","DOI":"10.2119\/2006-000056.Edwards","volume":"13","author":"CJ Edwards","year":"2007","unstructured":"Edwards CJ, Feldman JL, Beech J, Shields KM, Stover JA, Trepicchio WL, et al. Molecular profile of peripheral blood mononuclear cells from patients with rheumatoid arthritis. Mol Med. 2007;13(1):40\u201358.","journal-title":"Mol Med"},{"issue":"2","key":"3767_CR18","doi-asserted-by":"publisher","first-page":"130","DOI":"10.3899\/jrheum.2023-0588","volume":"51","author":"A Wierczeiko","year":"2024","unstructured":"Wierczeiko A, Linke M, Friedrich JP, Koch J, Schwarting A, Krause A, et al. A call for gene expression analysis in whole blood of patients with rheumatoid arthritis (RA) as a biomarker for RA-associated interstitial lung disease. J Rheumatol. 2024;51(2):130\u20133.","journal-title":"J Rheumatol"},{"issue":"9","key":"3767_CR19","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1136\/ard.2010.138461","volume":"69","author":"D Aletaha","year":"2010","unstructured":"Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Ann Rheum Dis. 2010;69(9):1580\u20138.","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"3767_CR20","doi-asserted-by":"publisher","first-page":"e18","DOI":"10.1164\/rccm.202202-0399ST","volume":"205","author":"G Raghu","year":"2022","unstructured":"Raghu G, Remy-Jardin M, Richeldi L, Thomson CC, Inoue Y, et al. Idiopathic pulmonary fibrosis (an update) and progressive pulmonary fibrosis in adults: an official ATS\/ERS\/JRS\/ALAT clinical practice guideline. Am J Respir Crit Care Med. 2022;205(9):e18\u201347.","journal-title":"Am J Respir Crit Care Med"},{"issue":"12","key":"3767_CR21","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1164\/rccm.200611-1685OC","volume":"177","author":"WD Travis","year":"2008","unstructured":"Travis WD, Hunninghake G, King TE Jr, et al. Idiopathic nonspecific interstitial pneumonia: report of an American Thoracic Society project. Am J Respir Crit Care Med. 2008;177(12):1338\u201347 Epub 2008 Apr 3. Erratum in: Am J Respir Crit Care Med.2008 Jul 15;178(2): 211.","journal-title":"Am J Respir Crit Care Med."},{"issue":"1","key":"3767_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/srep23002","volume":"6","author":"MJ Olnes","year":"2016","unstructured":"Olnes MJ, Kotliarov Y, Biancotto A, Cheung F, Chen J, Shi R, et al. Effects of systemically administered hydrocortisone on the human immunome. Sci Rep. 2016;6(1):23002. https:\/\/doi.org\/10.1038\/srep23002.","journal-title":"Sci Rep"},{"issue":"67","key":"3767_CR23","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1111\/j.1541-0420.2011.01616.x","volume":"1","author":"L Wilkinson","year":"2011","unstructured":"Wilkinson L. Ggplot2: elegant graphics for data analysis by H. WICKHAM. Biometrics. 2011;1(67):678\u20139.","journal-title":"Biometrics"},{"issue":"18","key":"3767_CR24","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","volume":"32","author":"Z Gu","year":"2016","unstructured":"Gu Z, Eils R, Schlesner M. Complex heatmaps reveal patterns and correlations in multidimensional genomic data. Bioinformatics. 2016;32(18):2847\u20139.","journal-title":"Bioinformatics"},{"issue":"3","key":"3767_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2021.100141","volume":"2","author":"T Wu","year":"2021","unstructured":"Wu T, Hu E, Xu S, Chen M, Guo P, Dai Z, et al. clusterProfiler 4.0: a universal enrichment tool for interpreting omics data. The Innovation. 2021;2(3):100141.","journal-title":"The Innovation"},{"key":"3767_CR26","doi-asserted-by":"crossref","unstructured":"Dolgalev I. msigdbr: MSigDB Gene Sets for Multiple Organisms in a Tidy Data Format. 2018:7.5.1. Available from: https:\/\/CRAN.R-project.org\/package=msigdbr. Cited 2024 Jul 1","DOI":"10.32614\/CRAN.package.msigdbr"},{"key":"3767_CR27","doi-asserted-by":"crossref","unstructured":"Gao CH, Yu G, Cai P. ggVennDiagram: An Intuitive, Easy-to-Use, and Highly Customizable R Package to Generate Venn Diagram. Front Genet. 2021;12. Available from: https:\/\/www.frontiersin.org\/journals\/genetics\/articles\/10.3389\/fgene.2021.706907\/full. Cited 2024 Jul 16.","DOI":"10.3389\/fgene.2021.706907"},{"key":"3767_CR28","unstructured":"Nikolopoulos D, Loukogiannaki C, Sentis G, Garantziotis P, Manolakou T, Kapsala N, et al. Disentangling the riddle of systemic lupus erythematosus with antiphospholipid syndrome: blood transcriptome analysis reveals a less-pronounced IFN-signature and distinct molecular profiles in venous versus arterial events. Annals of the Rheumatic Diseases. 2024. Available from: https:\/\/ard.bmj.com\/content\/early\/2024\/04\/12\/ard-2024-225664. Cited 2024 Jul 4."},{"issue":"6","key":"3767_CR29","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1016\/j.cell.2017.10.049","volume":"171","author":"A Subramanian","year":"2017","unstructured":"Subramanian A, Narayan R, Corsello SM, Peck DD, Natoli TE, Lu X, et al. A next generation connectivity map: L1000 platform and the first 1,000,000 profiles. Cell. 2017;171(6):1437-1452.e17.","journal-title":"Cell"},{"issue":"169","key":"3767_CR30","doi-asserted-by":"publisher","first-page":"115886","DOI":"10.1016\/j.biopha.2023.115886","volume":"31","author":"Y Chen","year":"2023","unstructured":"Chen Y, Liang R, Shi X, Shen R, Liu L, Liu Y, et al. Targeting kinase ITK treats autoimmune arthritis via orchestrating T cell differentiation and function. Biomed Pharmacother. 2023;31(169):115886.","journal-title":"Biomed Pharmacother"},{"issue":"11","key":"3767_CR31","doi-asserted-by":"publisher","first-page":"3309","DOI":"10.1002\/art.23992","volume":"58","author":"ME Weinblatt","year":"2008","unstructured":"Weinblatt ME, Kavanaugh A, Burgos-Vargas R, Dikranian AH, Medrano-Ramirez G, Morales-Torres JL, et al. Treatment of rheumatoid arthritis with a syk kinase inhibitor: a twelve- week, randomized, placebo-controlled trial. Arthritis Rheum. 2008;58(11):3309\u201318.","journal-title":"Arthritis Rheum"},{"key":"3767_CR32","doi-asserted-by":"crossref","unstructured":"Deng GM, Kyttaris VC, Tsokos GC. Targeting Syk in Autoimmune Rheumatic Diseases. Front Immunol. 2016;7. Available from: https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2016.00078\/full. Cited 2024 Jul 23.","DOI":"10.3389\/fimmu.2016.00078"},{"issue":"5","key":"3767_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-014-0464-6","volume":"16","author":"MA Shelef","year":"2014","unstructured":"Shelef MA, Bennin DA, Yasmin N, Warner TF, Ludwig T, Beggs HE, et al. Focal adhesion kinase is required for synovial fibroblast invasion, but not murine inflammatory arthritis. Arthritis Res Ther. 2014;16(5):464.","journal-title":"Arthritis Res Ther"},{"issue":"5","key":"3767_CR34","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1002\/art.33482","volume":"64","author":"D Lagares","year":"2012","unstructured":"Lagares D, Busnadiego O, Garc\u00eda-Fern\u00e1ndez RA, Kapoor M, Liu S, Carter DE, et al. Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation. Arthritis Rheum. 2012;64(5):1653\u201364.","journal-title":"Arthritis Rheum"},{"key":"3767_CR35","doi-asserted-by":"crossref","unstructured":"Jia G, Ramalingam TR, Heiden JV, Gao X, DePianto D, Morshead KB, et al. An interleukin 6 responsive plasma cell signature is associated with disease progression in systemic sclerosis interstitial lung disease. iScience. 2023;26(11). Available from: https:\/\/www.cell.com\/iscience\/abstract\/S2589-0042(23)02210-1. Cited 2024 Jul 12.","DOI":"10.1016\/j.isci.2023.108133"},{"issue":"7","key":"3767_CR36","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/S2213-2600(14)70069-4","volume":"2","author":"MK Han","year":"2014","unstructured":"Han MK, Zhou Y, Murray S, Tayob N, Noth I, Lama VN, et al. Lung microbiome and disease progression in idiopathic pulmonary fibrosis: an analysis of the COMET study. Lancet Respir Med. 2014;2(7):548\u201356.","journal-title":"Lancet Respir Med"},{"issue":"12","key":"3767_CR37","doi-asserted-by":"publisher","first-page":"3906","DOI":"10.1093\/rheumatology\/keaa621","volume":"59","author":"C Fern\u00e1ndez-D\u00edaz","year":"2020","unstructured":"Fern\u00e1ndez-D\u00edaz C, Casta\u00f1eda S, Melero-Gonz\u00e1lez RB, Ortiz-Sanju\u00e1n F, Juan-Mas A, Carrasco-Cubero C, et al. Abatacept in interstitial lung disease associated with rheumatoid arthritis: national multicenter study of 263 patients. Rheumatology. 2020Dec 1;59(12):3906\u201316.","journal-title":"Rheumatology"},{"issue":"6","key":"3767_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102830","volume":"20","author":"EF Vicente-Rabaneda","year":"2021","unstructured":"Vicente-Rabaneda EF, Atienza-Mateo B, Blanco R, Cavagna L, Ancochea J, Casta\u00f1eda S, et al. Efficacy and safety of abatacept in interstitial lung disease of rheumatoid arthritis: a systematic literature review. Autoimmun Rev. 2021;20(6):102830.","journal-title":"Autoimmun Rev"},{"issue":"11","key":"3767_CR39","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/s41467-019-13853-4","volume":"9","author":"D Regan-Komito","year":"2020","unstructured":"Regan-Komito D, Swann JW, Demetriou P, Cohen ES, Horwood NJ, Sansom SN, et al. GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis. Nat Commun. 2020;9(11):155.","journal-title":"Nat Commun"},{"issue":"2","key":"3767_CR40","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1136\/annrheumdis-2018-213181","volume":"78","author":"E Frangou","year":"2019","unstructured":"Frangou E, Chrysanthopoulou A, Mitsios A, Kambas K, Arelaki S, Angelidou I, et al. REDD1\/autophagy pathway promotes thromboinflammation and fibrosis in human systemic lupus erythematosus (SLE) through NETs decorated with tissue factor (TF) and interleukin-17A (IL-17A). Ann Rheum Dis. 2019;78(2):238\u201348.","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"3767_CR41","doi-asserted-by":"publisher","first-page":"2542","DOI":"10.1002\/eji.201646542","volume":"46","author":"G Papadaki","year":"2016","unstructured":"Papadaki G, Kambas K, Choulaki C, Vlachou K, Drakos E, Bertsias G, et al. Neutrophil extracellular traps exacerbate Th1-mediated autoimmune responses in rheumatoid arthritis by promoting DC maturation. Eur J Immunol. 2016;46(11):2542\u201354.","journal-title":"Eur J Immunol"},{"issue":"10","key":"3767_CR42","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1002\/art.43194","volume":"77","author":"F Rivellese","year":"2025","unstructured":"Rivellese F, Pontarini E, Fossati-Jimack L, Moura RA, Rom\u00e3o VC, Fonseca JE, et al. Comparative analysis of circulating and synovial immune cells in early untreated rheumatoid arthritis and their relationship with molecular pathology and disease outcomes. Arthritis Rheumatol. 2025;77(10):1349\u201361.","journal-title":"Arthritis Rheumatol"},{"issue":"12","key":"3767_CR43","doi-asserted-by":"publisher","first-page":"638066","DOI":"10.3389\/fimmu.2021.638066","volume":"8","author":"D Rychkov","year":"2021","unstructured":"Rychkov D, Neely J, Oskotsky T, Yu S, Perlmutter N, Nititham J, et al. Cross-tissue transcriptomic analysis leveraging machine learning approaches identifies new biomarkers for rheumatoid arthritis. Front Immunol. 2021;8(12):638066.","journal-title":"Front Immunol"},{"issue":"10","key":"3767_CR44","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1136\/annrheumdis-2021-222069","volume":"81","author":"E Frangou","year":"2022","unstructured":"Frangou E, Garantziotis P, Grigoriou M, Banos A, Nikolopoulos D, Pieta A, et al. Cross-species transcriptome analysis for early detection and specific therapeutic targeting of human lupus nephritis. Ann Rheum Dis. 2022;81(10):1409\u201319. https:\/\/doi.org\/10.1136\/annrheumdis-2021-222069.","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"3767_CR45","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1136\/annrheumdis-2020-217116","volume":"79","author":"L Beretta","year":"2020","unstructured":"Beretta L, Barturen G, Vigone B, Bellocchi C, Hunzelmann N, De Langhe E, et al. Genome-wide whole blood transcriptome profiling in a large European cohort of systemic sclerosis patients. Ann Rheum Dis. 2020;79(9):1218\u201326. https:\/\/doi.org\/10.1136\/annrheumdis-2020-217116.","journal-title":"Ann Rheum Dis"},{"issue":"8","key":"3767_CR46","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1002\/art.38671","volume":"66","author":"J Sellam","year":"2014","unstructured":"Sellam J, Marion-Thore S, Dumont F, Jacques S, Garchon HJ, Rouanet S, et al. Use of whole-blood transcriptomic profiling to highlight several pathophysiologic pathways associated with response to rituximab in patients with rheumatoid arthritis: data from a randomized, controlled, open-label trial. Arthritis Rheumatol. 2014;66(8):2015\u201325.","journal-title":"Arthritis Rheumatol"},{"issue":"9","key":"3767_CR47","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1016\/j.celrep.2019.07.091","volume":"28","author":"MJ Lewis","year":"2019","unstructured":"Lewis MJ, Barnes MR, Blighe K, Goldmann K, Rana S, Hackney JA, et al. Molecular portraits of early rheumatoid arthritis identify clinical and treatment response phenotypes. Cell Rep. 2019;28(9):2455-2470.e5.","journal-title":"Cell Rep"},{"issue":"4","key":"3767_CR48","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1111\/imm.13891","volume":"174","author":"SN Bulusu","year":"2025","unstructured":"Bulusu SN, Bavikatte AN, Shah S, Murthy SSN, Kommoju V, Mariaselvam CM, et al. Renal and peripheral blood transcriptome signatures that predict treatment response in proliferative lupus nephritis-a prospective study. Immunology. 2025;174(4):470\u201380.","journal-title":"Immunology"},{"issue":"2","key":"3767_CR49","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1136\/annrheumdis-2020-217230","volume":"80","author":"P Spagnolo","year":"2021","unstructured":"Spagnolo P, Distler O, Ryerson CJ, Tzouvelekis A, Lee JS, Bonella F, et al. Mechanisms of progressive fibrosis in connective tissue disease (CTD)-associated interstitial lung diseases (ILDs). Ann Rheum Dis. 2021;80(2):143\u201350. https:\/\/doi.org\/10.1136\/annrheumdis-2020-217230.","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"3767_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2024.103636","volume":"23","author":"J Narv\u00e1ez","year":"2024","unstructured":"Narv\u00e1ez J, Aguilar-Coll M, Roig-Kim M, Maym\u00f3-Paituvi P, Palacios-Olid J, Nolla JM, et al. Janus kinase inhibitors in rheumatoid arthritis-associated interstitial lung disease: a systematic review and meta-analysis. Autoimmun Rev. 2024;23(10):103636. https:\/\/doi.org\/10.1016\/j.autrev.2024.103636.","journal-title":"Autoimmun Rev"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-026-03767-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-026-03767-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-026-03767-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T02:09:56Z","timestamp":1782785396000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13075-026-03767-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,6]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3767"],"URL":"https:\/\/doi.org\/10.1186\/s13075-026-03767-0","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,6]]},"assertion":[{"value":"27 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was reviewed and approved by Attikon University Hospital Research Ethic Committee (Athens, Greece, protocol103\/6\u20133-2014). The study was conducted in accordance with ethical guidelines of the Declaration of Helsinki. The patients\/participants provided their written informed consent to participate.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"135"}}