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Ethical approval for this study was granted by the University of Calgary (Conjoint Health Research Ethics Board, REB17\u20131563), the Hospital for Sick Children (Clinicial Trials Ontario CTO#1771) for Canada and by the Ethical Board of Utrecht (18\u2013474) for the Netherlands. Ethics boards in Canada are guided by the Tri-Council Policy Statement.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"N\/A.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"DAM reports relationships with Illumina Inc that includes: travel reimbursement; International Society for Pharmacoeconomics and Outcomes Research Inc that includes: speaking and lecture fees and travel reimbursement; Office of Health Economics that includes: consulting or advisory; Analytica that includes: consulting or advisory; Novartis that includes: consulting or advisory; Public Health Agency of Canada that includes: board membership. RSMY reports a relationship with AstraZeneca that includes: funding or grants; Amgen that includes: funding or grants; Sobi that includes: speaking and lecture fees and travel reimbursement. SJV reports a relationship with Sobi Inc that includes: consulting or advisory, funding grants, and speaking and lecture fees; Novartis that includes: consulting or advisory and speaking and lecture fees. JFS reports a relationship with Pfizer Inc that includes: consulting or advisory, funding grants, and speaking and lecture fees; Bristol Myers Squibb Co that includes: board membership; ERN-RITA that includes: funding grants. All other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"106"}}