{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:52:42Z","timestamp":1777949562145,"version":"3.51.4"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":40,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["BMRPA81"],"award-info":[{"award-number":["BMRPA81"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"DOI":"10.1186\/s13075-026-03795-w","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T08:35:42Z","timestamp":1774427742000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The association between methotrexate metabolism-related gene polymorphisms and therapeutic efficacy and toxicity in patients with rheumatoid arthritis"],"prefix":"10.1186","volume":"28","author":[{"given":"Ding-Ping","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-Ping","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Tzu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuang-Hui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"issue":"1","key":"3795_CR1","doi-asserted-by":"publisher","first-page":"5631","DOI":"10.1038\/s41598-021-84957-5","volume":"11","author":"PY Leong","year":"2021","unstructured":"Leong PY, Huang JY, Chiou JY, Bai YC, Wei JC. The prevalence and incidence of systemic lupus erythematosus in Taiwan: a nationwide population-based study. Sci Rep. 2021;11(1):5631. https:\/\/doi.org\/10.1038\/s41598-021-84957-5.","journal-title":"Sci Rep"},{"key":"3795_CR2","doi-asserted-by":"publisher","first-page":"102308","DOI":"10.1016\/j.coph.2022.102308","volume":"67","author":"G Braverman","year":"2022","unstructured":"Braverman G, Bridges SL, Moreland LW. Tapering biologic DMARDs in rheumatoid arthritis. Curr Opin Pharmacol. 2022;67:102308. https:\/\/doi.org\/10.1016\/j.coph.2022.102308.","journal-title":"Curr Opin Pharmacol"},{"issue":"9","key":"3795_CR3","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1097\/FPC.0b013e328334338f","volume":"20","author":"G Zaza","year":"2010","unstructured":"Zaza G, Cheok M, Krynetskaia N, Thorn C, Stocco G, Hebert JM, et al. Thiopurine pathway. Pharmacogenet Genom. 2010;20(9):573\u20134. https:\/\/doi.org\/10.1097\/FPC.0b013e328334338f.","journal-title":"Pharmacogenet Genom"},{"issue":"1","key":"3795_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1136\/ard-2022-223356","volume":"82","author":"JS Smolen","year":"2023","unstructured":"Smolen JS, Landew\u00e9 RBM, Bergstra SA, Kerschbaumer A, Sepriano A, Aletaha D, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update. Ann Rheum Dis. 2023;82(1):3\u201318. https:\/\/doi.org\/10.1136\/ard-2022-223356.","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"3795_CR5","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1007\/s10067-024-06892-w","volume":"43","author":"AM Nomair","year":"2024","unstructured":"Nomair AM, Abdelati A, Dwedar FI, Elnemr R, Kamel YN, Nomeir HM. The impact of folate pathway variants on the outcome of methotrexate therapy in rheumatoid arthritis patients. Clin Rheumatol. 2024;43(3):971\u201383. https:\/\/doi.org\/10.1007\/s10067-024-06892-w.","journal-title":"Clin Rheumatol"},{"key":"3795_CR6","doi-asserted-by":"publisher","first-page":"e80943","DOI":"10.7554\/eLife.80943","volume":"11","author":"H Einarsson","year":"2022","unstructured":"Einarsson H, Salvatore M, Vaagens\u00f8 C, Alcaraz N, Bornholdt J, Rennie S, et al. Promoter sequence and architecture determine expression variability and confer robustness to genetic variants. Elife. 2022;11:e80943. https:\/\/doi.org\/10.7554\/eLife.80943.","journal-title":"Elife"},{"issue":"10","key":"3795_CR7","doi-asserted-by":"publisher","first-page":"a034728","DOI":"10.1101\/cshperspect.a034728","volume":"11","author":"C Mayr","year":"2019","unstructured":"Mayr C. What Are 3\u2019 UTRs Doing? Cold Spring Harb Perspect Biol. 2019;11(10):a034728. https:\/\/doi.org\/10.1101\/cshperspect.a034728.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"3795_CR8","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-1-60327-411-1_1","volume":"578","author":"BS Shastry","year":"2009","unstructured":"Shastry BS. SNPs: impact on gene function and phenotype. Methods Mol Biol. 2009;578:3\u201322. https:\/\/doi.org\/10.1007\/978-1-60327-411-1_1.","journal-title":"Methods Mol Biol"},{"issue":"5 Suppl 39","key":"3795_CR9","first-page":"S93","volume":"23","author":"J Fransen","year":"2005","unstructured":"Fransen J, van Riel PL. The Disease Activity Score and the EULAR response criteria. Clin Exp Rheumatol. 2005;23(5 Suppl 39):S93\u20139.","journal-title":"Clin Exp Rheumatol"},{"key":"3795_CR10","doi-asserted-by":"publisher","first-page":"44015","DOI":"10.1038\/srep44015","volume":"7","author":"Q Qiu","year":"2017","unstructured":"Qiu Q, Huang J, Shu X, Fan H, Zhou Y, Xiao C. Polymorphisms and Pharmacogenomics for the Clinical Efficacy of Methotrexate in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-analysis. Sci Rep. 2017;7:44015. https:\/\/doi.org\/10.1038\/srep44015.","journal-title":"Sci Rep"},{"issue":"9","key":"3795_CR11","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1111\/jdv.16440","volume":"34","author":"M Chen","year":"2020","unstructured":"Chen M, Chen W, Liu P, Yan K, Lv C, Zhang M, et al. The impacts of gene polymorphisms on methotrexate in Chinese psoriatic patients. J Eur Acad Dermatol Venereol. 2020;34(9):2059\u201365. https:\/\/doi.org\/10.1111\/jdv.16440.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"1","key":"3795_CR12","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/cts.13130","volume":"15","author":"RS Mehta","year":"2022","unstructured":"Mehta RS, Taylor ZL, Martin LJ, Rosen MJ, Ramsey LB. SLCO1B1 *15 allele is associated with methotrexate-induced nausea in pediatric patients with inflammatory bowel disease. Clin Transl Sci. 2022;15(1):63\u20139. https:\/\/doi.org\/10.1111\/cts.13130.","journal-title":"Clin Transl Sci"},{"key":"3795_CR13","doi-asserted-by":"publisher","DOI":"10.1101\/2023.09.07.555071","author":"C Shen","year":"2025","unstructured":"Shen C, Adams MJ, Davyson E, Iveson M, McIntosh AM, Shen XY. The linear and non-linear effects of CYP2C19 metaboliser status on DNA methylation: a methylome-wide association study. bioRxiv preprint. 2025. https:\/\/doi.org\/10.1101\/2023.09.07.555071.","journal-title":"bioRxiv preprint"},{"issue":"4","key":"3795_CR14","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1016\/j.apsb.2023.12.019","volume":"14","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Huang J, Huang S, Liu J, Deng L, Liang C, et al. Construction and characterization of a humanized SLCO1B1 rat model with its application in evaluating the uptake of different statins. Acta Pharm Sin B. 2024;14(4):1592\u2013604. https:\/\/doi.org\/10.1016\/j.apsb.2023.12.019.","journal-title":"Acta Pharm Sin B"},{"issue":"8","key":"3795_CR15","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1056\/NEJMoa0801936","volume":"359","author":"E Link","year":"2008","unstructured":"Link E, Parish S, Armitage J, Bowman L, Heath S, Matsuda F, et al. SLCO1B1 Variants and Statin-Induced Myopathy \u2014 A Genomewide Study | New England Journal of Medicine. N Engl J Med. 2008;359(8):789\u201399. https:\/\/doi.org\/10.1056\/NEJMoa0801936.","journal-title":"N Engl J Med"},{"issue":"3","key":"3795_CR16","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/tpj.2010.92","volume":"12","author":"LR Brunham","year":"2012","unstructured":"Brunham LR, Lansberg PJ, Zhang L, Miao F, Carter C, Hovingh GK, et al. Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin. Pharmacogenomics J. 2012;12(3):233\u20137. https:\/\/doi.org\/10.1038\/tpj.2010.92.","journal-title":"Pharmacogenomics J"},{"issue":"12","key":"3795_CR17","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.3390\/metabo12121159","volume":"12","author":"L Fernandes Silva","year":"2022","unstructured":"Fernandes Silva L, Ravi R, Vangipurapu J, Oravilahti A, Laakso M. Effects of SLCO1B1 Genetic Variant on Metabolite Profile in Participants on Simvastatin Treatment. Metabolites. 2022;12(12):1159. https:\/\/doi.org\/10.3390\/metabo12121159.","journal-title":"Metabolites"},{"issue":"6","key":"3795_CR18","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1007\/s00228-020-03058-w","volume":"77","author":"Y Wu","year":"2021","unstructured":"Wu Y, Fang F, Wang Z, Wen P, Fan J. The influence of recipient SLCO1B1 rs2291075 polymorphism on tacrolimus dose\u2013corrected trough concentration in the early period after liver transplantation. Eur J Clin Pharmacol. 2021;77(6):859\u201367. https:\/\/doi.org\/10.1007\/s00228-020-03058-w.","journal-title":"Eur J Clin Pharmacol"},{"issue":"4","key":"3795_CR19","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1515\/raon-2017-0040","volume":"51","author":"BF Kotnik","year":"2017","unstructured":"Kotnik BF, Jazbec J, Grabar PB, Rodriguez-Antona C, Dolzan V. Association between SLC19A1 Gene Polymorphism and High Dose Methotrexate Toxicity in Childhood Acute Lymphoblastic Leukaemia and Non Hodgkin Malignant Lymphoma: Introducing a Haplotype based Approach. Radiol Oncol. 2017;51(4):455\u201362. https:\/\/doi.org\/10.1515\/raon-2017-0040.","journal-title":"Radiol Oncol"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-026-03795-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-026-03795-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-026-03795-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:00:17Z","timestamp":1777860017000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13075-026-03795-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,25]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3795"],"URL":"https:\/\/doi.org\/10.1186\/s13075-026-03795-w","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,25]]},"assertion":[{"value":"25 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Institutional Review Board of Chang Gung Memorial Hospital has reviewed and approved the study. The approval IDs are 202500541B0. All study subjects provided informed consent, and the study was conducted following relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"104"}}