{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T02:58:52Z","timestamp":1768445932747,"version":"3.49.0"},"reference-count":31,"publisher":"Mattioli1885","issue":"1","license":[{"start":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T00:00:00Z","timestamp":1668816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T00:00:00Z","timestamp":1668816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ultrasound J"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Increases in the diameter of the optic nerve sheath (ONSD) on ultrasound are associated with high intracranial pressure (hICP). The normal value varies with altitude and the population studied. The objective of this study is to describe the normal values of the ONSD in a healthy adult population of the city of Bogot\u00e1, Colombia, at 2640\u00a0meters above sea level (masl).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>A prospective observational study was conducted on a total of 247 healthy individuals recruited from May 2021 to May 2022 who were subjected to the color, low power, optic disk, safety, elevated frequency, dual (CLOSED) protocol for measuring the bilateral ONSD adjusted to the eyeball transverse diameter (ETD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 230 individuals were analyzed; the average ONSD of the right eye (RE) was 0.449\u00a0cm (range 0.288\u20130.7) and that of the left eye (LE) was 0.454\u00a0cm (range 0.285\u20130.698); the correlation between RE and LE was 0.93 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009\n                      <jats:italic>0.005),<\/jats:italic>\n                      and the correlation of the ONSD\/ETD ratios for the RE and LE was lower (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.79,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009\n                      <jats:italic>0.005).<\/jats:italic>\n                      A total of 10.8% of the studied population had values greater than 0.55\u00a0cm.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The median ONSD and ONSD\/ETD ratio in the city of Bogot\u00e1 are similar to those described in other populations; however, approximately 10.8% of the healthy population may present higher values, which would limit the use of ONSD on its own for clinical decision-making, only repeated measurements with significant changes in the ONSD and ONSD\/ETD or asymmetries between the measurements of both eyes linked to clinical findings would allow the diagnosis of hICP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13089-022-00295-1","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T19:03:26Z","timestamp":1668798206000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Optic nerve sheath diameter at high altitude: standardized measures in healthy volunteers"],"prefix":"10.5826","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4020-3729","authenticated-orcid":false,"given":"Edith Elianna","family":"Rodr\u00edguez Aparicio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0412-5452","authenticated-orcid":false,"given":"Jorge Armando","family":"Carrizosa Gonzalez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7089-018X","authenticated-orcid":false,"given":"David Rene","family":"Rodriguez Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27750","published-online":{"date-parts":[[2022,11,19]]},"reference":[{"issue":"2","key":"295_CR1","first-page":"113","volume":"4","author":"A Monro","year":"1783","unstructured":"Monro A (1783) Observations on the structure and functions of the nervous system, illustrated with tables. 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The person shown in Fig.\u00a0\n                      \n                      provided informed consent for the use of their photograph and disclosure.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"46"}}