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Limited evidence exists for an association between early-stage CA impairments and SAH patient outcomes. The objective of this prospective study was to explore associations between CA impairments detected in early post-SAH snapshot examinations and patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The pilot observational study included 29 SAH patients whose CA status was estimated 2\u20133 days after spontaneous aneurysm rupture and a control group of 15 healthy volunteers for comparison. Inflatable leg recovery boots (reboots.com, Germany) were used for the safe controlled generation of arterial blood pressure (ABP) changes necessary for reliable CA examination. At least 5 inflation\u2012deflation cycles of leg recovery boots with a 2\u20133\u00a0min period were used during examinations. CA status was assessed according to the delay time (\u2206T\n                      <jats:sub>CBFV<\/jats:sub>\n                      ) measured between ABP(t) and cerebral blood flow velocity (CBFV(t)) signals during artificially induced ABP changes at boot deflation cycle. CBFV was measured in middle cerebral artery by using transcranial Doppler device.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Statistically significant differences in \u2206T\n                      <jats:sub>CBFV<\/jats:sub>\n                      were found between SAH patients with unfavorable outcomes (\u2206T\n                      <jats:sub>CBFV<\/jats:sub>\n                      = 1.37\u2009\u00b1\u20091.23\u00a0s) and those with favorable outcomes (\u2206T\n                      <jats:sub>CBFV<\/jats:sub>\n                      = 2.86\u2009\u00b1\u20090.99\u00a0s) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Early assessment of baroreflex sensitivity (BRS) during the deflation cycle showed statistically significant differences between the DCI and non-DCI patient groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      A relatively small delay of \u2206T\n                      <jats:sub>CBFV<\/jats:sub>\n                      &lt;1.6\u00a0s between CBFV(t) and ABP(t) waves could be an early warning sign associated with unfavorable outcomes in SAH patients. The BRS during boot deflation can be used as a biomarker for the prediction of DCI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      ClinicalTrials.gov Identifier: NCT06028906. Registered 31 August 2023 - Retrospectively registered,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT06028906\">https:\/\/www.clinicaltrials.gov\/study\/NCT06028906<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13089-024-00371-8","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T09:02:02Z","timestamp":1713171722000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impaired cerebral autoregulation detected in early prevasospasm period is associated with unfavorable outcome after spontaneous subarachnoid hemorrhage: an observational prospective pilot study"],"prefix":"10.5826","volume":"16","author":[{"given":"Edvinas","family":"Chaleckas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilma","family":"Putnynaite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indre","family":"Lapinskiene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidanas","family":"Preiksaitis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindaugas","family":"Serpytis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulius","family":"Rocka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laimonas","family":"Bartusis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8964-0738","authenticated-orcid":false,"given":"Vytautas","family":"Petkus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arminas","family":"Ragauskas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27750","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"key":"371_CR1","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1161\/STROKEAHA.118.023902","volume":"50","author":"CE van Donkelaar","year":"2019","unstructured":"van Donkelaar CE, Bakker NA, Birks J, Veeger NJGM, Metzemaekers JDM, Molyneux AJ et al (2019) Prediction of Outcome after Aneurysmal Subarachnoid Hemorrhage. 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Participants and\/or their legal guardians signed a written informed consent to participate in the study and use their anonymized clinical data for retrospective analysis.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication of photography was obtained from the volunteer in Fig.\u00a01. A copy of the consent form is available for review by the Editor of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"V.Pe., E.C., V.Pu., S.R. and M.S. received a research grant from the Research Council of Lithuania (Grant No. MIP-20-216). V.Pe., A.P., I.L., S.R. and M.S. received a research grant from the European Regional Development Fund (projects No 01.2.2-LMT-K-718-03-0091) under grant agreement with the Research Council of Lithuania (LMTLT). A.R. and L.B. declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"24"}}