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Conventional pain management strategies, including opioids, are often insufficient and associated with significant side effects. The erector spinae plane block (ESPB) is an inter-fascial regional anesthesia technique that can be considered in managing abdominal pain. Besides being a simple block performed, ESPB is also very effective because it provides visceral, somatic and neuropathic pain coverage. This case series highlights the potential role of ESPB as an adjunctive therapy for acute pain management of pancreatic cancer patients at the emergency department, with discussion on its technical aspect, advantages and limitations.<\/jats:p>","DOI":"10.1186\/s13089-025-00461-1","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T11:16:37Z","timestamp":1762254997000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Erector spinae plane block for acute pain management of pancreatic cancer at the emergency department"],"prefix":"10.5826","volume":"17","author":[{"given":"Osman","family":"Adi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan Pei","family":"Fong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azma Haryaty","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhamad Rasydan Abd","family":"Ghani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahridan","family":"Fathil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27750","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"issue":"27","key":"461_CR1","doi-asserted-by":"publisher","first-page":"4298","DOI":"10.3748\/wjg.v27.i27.4298","volume":"27","author":"JX Hu","year":"2021","unstructured":"Hu JX, Zhao CF, Chen WB, Liu QC, Li QW, Lin YY, Gao F (2021) Pancreatic cancer: A review of epidemiology, trend, and risk factors. 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