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However, the prognostic value of pre-DM in patients with myocardial infarction with nonobstructive coronary arteries (MINOCA) remains unclear.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A total of 1179 MINOCA patients were prospectively recruited and divided into normoglycemia (NG), pre-DM, and DM groups according to glycated hemoglobin (HbA<jats:sub>1c<\/jats:sub>) levels or past history. The primary endpoint was a composite of major adverse cardiovascular events (MACE), including all-cause death, nonfatal MI, nonfatal stroke, revascularization and hospitalization for unstable angina or heart failure. Kaplan\u2013Meier and Cox regression analyses were performed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Patients with pre-DM and DM had a significantly higher incidence of MACE compared with NG group (10.8%, 16.1%, 19.4%; p\u2009=\u20090.003) over the median follow-up of 41.7\u00a0months. After multivariate adjustment, both pre-DM and DM were significantly associated with an increased risk of MACE (NG as reference; pre-DM: 1.45, 95% CI 1.03\u20132.09, p\u2009=\u20090.042; DM: HR 1.79, 95% CI 1.20\u20132.66, p\u2009=\u20090.005). At subgroup analysis, pre-DM remained a robust risk factor of MACE compared to NG. In addition, pre-DM had a similar impact as DM on long-term prognosis in patients with MINOCA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Pre-DM defined as raised HbA<jats:sub>1c<\/jats:sub> was associated with a poor prognosis in patients with MINOCA. Routine assessment of HbA<jats:sub>1c<\/jats:sub> enables an early recognition of pre-DM and thus may facilitate risk stratification in this specific population.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13098-021-00721-9","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T16:44:32Z","timestamp":1632501872000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Impact of prediabetes on long-term cardiovascular outcomes in patients with myocardial infarction with nonobstructive coronary arteries"],"prefix":"10.1186","volume":"13","author":[{"given":"Side","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjian","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sizhuang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuze","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyue","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,24]]},"reference":[{"issue":"10","key":"721_CR1","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.2337\/dc11-2462","volume":"35","author":"ST Nauta","year":"2012","unstructured":"Nauta ST, Deckers JW, Akkerhuis KM, van Domburg RT. 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