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Sensitivity analysis was performed under three models (dominant, recessive and allele model), and the pooled ORs and 95%CI were calculated. Funnel plots and Begger\u2019s regression test were employed to test the publication bias.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The meta-analysis included 4777 participants (2116 cases and 2661 controls). The <jats:italic>IRS1<\/jats:italic> rs1801278 (C\/T) were not significant associated with GDM risk under the dominant and allele models, OR (95%CI)\u2009=\u20091.22 (0.88\u20131.70) and 1.24 (0.91\u20131.68), respectively (both <jats:italic>p<\/jats:italic>\u2009values were more than 0.05). But we also found the <jats:italic>IRS1<\/jats:italic> rs1801278 (C\/T) were significant associated with GDM risk under the recessive model, OR (95%CI)\u2009=\u20090.37 (0.16\u20130.86), <jats:italic>p<\/jats:italic>\u2009=\u20090.030. Our results showed that none of the studies affected the quality of the pooled OR. We also found no significant publication bias existed in this meta study for three genetic models, <jats:italic>P<\/jats:italic><jats:sub>TT + CT <jats:italic>vs.<\/jats:italic> CC<\/jats:sub> = 0.445; <jats:italic>P<\/jats:italic><jats:sub>CC+CT <jats:italic>vs.<\/jats:italic> TT<\/jats:sub>= 0.095; <jats:italic>P<\/jats:italic><jats:sub>C <jats:italic>vs.<\/jats:italic> T<\/jats:sub> = 0.697.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>this meta-analysis indicated that <jats:italic>IRS1<\/jats:italic> rs1801278 (C\/T) was associated with the GDM risk under the recessive model but was not associated with the GDM risk under dominant and allele models.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13098-024-01289-w","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T17:02:12Z","timestamp":1709744532000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association between insulin receptor substrate 1 gene polymorphism rs1801278 and gestational diabetes mellitus: an updated meta- analysis"],"prefix":"10.1186","volume":"16","author":[{"given":"Lili","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,6]]},"reference":[{"issue":"6","key":"1289_CR1","first-page":"538","volume":"16","author":"A Homayouni","year":"2020","unstructured":"Homayouni A, Bagheri N, Mohammad-Alizadeh-Charandabi S, Kashani N, Mobaraki-Asl N, Mirghafurvand M, Asgharian H, Ansari F, Pourjafar H. 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