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Con and Mod did not receive any special treatment, only as a control observation. The latter two groups of mice received electroacupuncture treatment for 4 weeks. Mouse triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol(LDL-C), and cholesterin(CHO) levels were detected by colorimetric assay. Enzyme-linked immunoassay (ELISA) was used to detect insulin(INS) levels. Liver histopathologic changes and hepatic glycogen synthesis were observed by HE and PAS staining. The mRNA and protein expression of insulin receptor substrate-1(IRS1), Phosphatidylinositol 3-kinase(PI3K), protein kinase B (AKT), AMPK, and ACC were detected by Western blot and qRT-PCR.The results show that compared with Mod, TG, LDL, CHO, and INS levels of Acu\u2009+\u2009AMPK and Acu\u2009+\u2009ACC mice were significantly reduced (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05), and the HDL levels were significantly increased (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05), the steatotic degeneration of mice hepatocytes was reduced to different degrees, and the hepatocyte glycogen particles were increased, and the latter two groups had a decrease in AKT, ACC mRNA expression was reduced (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05), PI3K protein expression was increased, and AKT and ACC protein expression was reduced (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05), in addition, protein expression of AMPK was increased and IRS1 protein expression was reduced in Acu\u2009+\u2009ACC (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). The study showed that electroacupuncture improves glucose-lipid metabolism disorders in db\/db mice, and this mechanism is related to the AMPK\/ACC signaling pathway.\n                  <\/jats:p>","DOI":"10.1186\/s13098-024-01416-7","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T01:25:16Z","timestamp":1721870716000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["\u201cAdjusting internal organs and dredging channelon\u201d electroacupuncture glycolipid metabolism disorders in NAFLD mice by mediating the AMPK\/ACC signaling pathway"],"prefix":"10.1186","volume":"16","author":[{"given":"Xinyu","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuyu","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5375-7558","authenticated-orcid":false,"given":"Haipeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"1416_CR1","unstructured":"Jiao G, Xue X, Xianglu R, et al. 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