{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T22:06:16Z","timestamp":1793484376913,"version":"4.5.0"},"reference-count":142,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Natural Science Foundation of Shanghai","award":["20ZR1454400"],"award-info":[{"award-number":["20ZR1454400"]}]},{"name":"Natural Science Foundation of Shanghai","award":["20ZR1454400"],"award-info":[{"award-number":["20ZR1454400"]}]},{"name":"Natural Science Foundation of Shanghai","award":["20ZR1454400"],"award-info":[{"award-number":["20ZR1454400"]}]},{"name":"Natural Science Foundation of Shanghai","award":["20ZR1454400"],"award-info":[{"award-number":["20ZR1454400"]}]},{"name":"Natural Science Foundation of Shanghai","award":["20ZR1454400"],"award-info":[{"award-number":["20ZR1454400"]}]},{"name":"Natural Science Foundation of Shanghai","award":["20ZR1454400"],"award-info":[{"award-number":["20ZR1454400"]}]},{"name":"Natural Science Foundation of Shanghai","award":["20ZR1454400"],"award-info":[{"award-number":["20ZR1454400"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetol Metab Syndr"],"DOI":"10.1186\/s13098-025-01965-5","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T09:31:42Z","timestamp":1760520702000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Perilipins: key targets for regulating lipid metabolism and alleviating abnormal lipid metabolism through exercise"],"prefix":"10.1186","volume":"17","author":[{"given":"Yan-Jun","family":"Niu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Qi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Bo","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"1965_CR1","doi-asserted-by":"publisher","first-page":"110773","DOI":"10.1016\/j.diabres.2023.110773","volume":"202","author":"C Boutari","year":"2023","unstructured":"Boutari C, DeMarsilis A, Mantzoros CS. Obesity and diabetes. Diabetes Res Clin Pract. 2023;202:110773.","journal-title":"Diabetes Res Clin Pract"},{"issue":"Suppl","key":"1965_CR2","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.3350\/cmh.2022.0367","volume":"29","author":"C Gofton","year":"2023","unstructured":"Gofton C, Upendran Y, Zheng M, George J. MAFLD: how is it different from NAFLD? Clin Mol Hepatol. 2023;29(Suppl):S17\u201331.","journal-title":"Clin Mol Hepatol"},{"issue":"11","key":"1965_CR3","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/s41580-021-00390-6","volume":"22","author":"DE James","year":"2021","unstructured":"James DE, St\u00f6ckli J, Birnbaum MJ. The aetiology and molecular landscape of insulin resistance. Nat Rev Mol Cell Biol. 2021;22(11):751\u201371.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7","key":"1965_CR4","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.molmed.2015.04.004","volume":"21","author":"AL Robbins","year":"2015","unstructured":"Robbins AL, Savage DB. The genetics of lipid storage and human lipodystrophies. Trends Mol Med. 2015;21(7):433\u20138.","journal-title":"Trends Mol Med"},{"issue":"4","key":"1965_CR5","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1080\/17446651.2018.1500894","volume":"13","author":"M Piche","year":"2018","unstructured":"Piche M, Poirier P. Obesity, ectopic fat and cardiac metabolism. Expert Rev Endocrinol Metab. 2018;13(4):213\u201321.","journal-title":"Expert Rev Endocrinol Metab"},{"issue":"4","key":"1965_CR6","doi-asserted-by":"publisher","first-page":"101196","DOI":"10.1016\/j.jbc.2021.101196","volume":"297","author":"WT King","year":"2021","unstructured":"King WT, Axelrod CL, Zunica ERM, Noland RC, Davuluri G, Fujioka H, et al. Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics. J Biol Chem. 2021;297(4):101196.","journal-title":"J Biol Chem"},{"issue":"3","key":"1965_CR7","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/s41580-018-0085-z","volume":"20","author":"JA Olzmann","year":"2019","unstructured":"Olzmann JA, Carvalho P. Dynamics and functions of lipid droplets. Nat Rev Mol Cell Biol. 2019;20(3):137\u201355.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"1965_CR8","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.cell.2009.11.005","volume":"139","author":"RV Farese","year":"2009","unstructured":"Farese RV, Walther TC. Lipid droplets finally get a little r-e-s-p-e-c-t. Cell. 2009;139(5):855\u201360.","journal-title":"Cell"},{"key":"1965_CR9","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/j.bbalip.2017.07.009","volume":"1862","author":"S Carole","year":"2017","unstructured":"Carole S, Dawn LB. The perilipin family of lipid droplet proteins: gatekeepers of intracellular lipolysis. Biochimica et biophysica acta. Mol Cell Biology Lipids. 2017;1862:1221\u201332.","journal-title":"Mol Cell Biology Lipids"},{"key":"1965_CR10","doi-asserted-by":"crossref","unstructured":"Zhu J, Guo L. Exercise-regulated lipolysis: its role and mechanism in health and diseases. J Adv Res. 2025;75:291\u2013309.","DOI":"10.1016\/j.jare.2024.11.031"},{"key":"1965_CR11","doi-asserted-by":"crossref","unstructured":"Bosch M, Sanchez-Alvarez M, Fajardo A, Kapetanovic R, Steiner B, Dutra F et al. Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense. Science 2020;370(6514):eaay8085.","DOI":"10.1126\/science.aay8085"},{"issue":"6","key":"1965_CR12","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.devcel.2008.10.015","volume":"15","author":"DT Rutkowski","year":"2008","unstructured":"Rutkowski DT, Wu J, Back SH, Callaghan MU, Ferris SP, Iqbal J, et al. UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell. 2008;15(6):829\u201340.","journal-title":"Dev Cell"},{"issue":"12","key":"1965_CR13","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1016\/j.bbalip.2014.09.012","volume":"1841","author":"M Bosma","year":"2014","unstructured":"Bosma M, Dapito DH, Drosatos-Tampakaki Z, Huiping-Son N, Huang L, Kersten S, et al. Sequestration of fatty acids in triglycerides prevents Endoplasmic reticulum stress in an in vitro model of cardiomyocyte lipotoxicity. Biochimica et biophysica acta (BBA) -. Mol Cell Biology Lipids. 2014;1841(12):1648\u201355.","journal-title":"Mol Cell Biology Lipids"},{"issue":"1","key":"1965_CR14","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s12944-017-0521-7","volume":"16","author":"G Onal","year":"2017","unstructured":"Onal G, Kutlu O, Gozuacik D, Dokmeci Emre S. Lipid droplets in health and disease. Lipids Health Dis. 2017;16(1):128.","journal-title":"Lipids Health Dis"},{"issue":"6","key":"1965_CR15","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1016\/j.cell.2019.04.001","volume":"177","author":"MS Ioannou","year":"2019","unstructured":"Ioannou MS, Jackson J, Sheu S, Chang C, Weigel AV, Liu H, et al. Neuron-astrocyte metabolic coupling protects against activity-induced fatty acid toxicity. Cell. 2019;177(6):1522\u201335.","journal-title":"Cell"},{"issue":"5","key":"1965_CR16","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.tcb.2021.01.004","volume":"31","author":"E Herker","year":"2021","unstructured":"Herker E, Vieyres G, Beller M, Krahmer N, Bohnert M. Lipid droplet contact sites in health and disease. Trends Cell Biol. 2021;31(5):345\u201358.","journal-title":"Trends Cell Biol"},{"issue":"8","key":"1965_CR17","doi-asserted-by":"publisher","first-page":"5352","DOI":"10.1074\/jbc.M805768200","volume":"284","author":"SJ Stone","year":"2009","unstructured":"Stone SJ, Levin MC, Zhou P, Han J, Walther TC, Farese RV. The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria. J Biol Chem. 2009;284(8):5352\u201361.","journal-title":"J Biol Chem"},{"issue":"18","key":"1965_CR18","doi-asserted-by":"publisher","first-page":"2592","DOI":"10.1016\/j.devcel.2021.08.015","volume":"56","author":"X Lyu","year":"2021","unstructured":"Lyu X, Wang J, Wang J, Yin Y, Zhu Y, Li L, et al. A gel-like condensation of Cidec generates lipid-permeable plates for lipid droplet fusion. Dev Cell. 2021;56(18):2592\u2013606.","journal-title":"Dev Cell"},{"issue":"22","key":"1965_CR19","doi-asserted-by":"publisher","first-page":"7833","DOI":"10.1073\/pnas.0802063105","volume":"105","author":"V Puri","year":"2008","unstructured":"Puri V, Ranjit S, Konda S, Nicoloro SM, Straubhaar J, Chawla A, et al. Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc Natl Acad Sci U S A. 2008;105(22):7833\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"1965_CR20","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1111\/tra.12717","volume":"21","author":"FJ Chen","year":"2019","unstructured":"Chen FJ, Yin Y, Chua BT, Li P. CIDE family proteins control lipid homeostasis and the development of metabolic diseases. Traffic. 2019;21(1):94\u2013105.","journal-title":"Traffic"},{"issue":"18","key":"1965_CR21","doi-asserted-by":"publisher","first-page":"15707","DOI":"10.1074\/jbc.M110.207779","volume":"286","author":"H Wang","year":"2011","unstructured":"Wang H, Bell M, Sreenivasan U, Sreenevasan U, Hu H, Liu J, et al. Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein. J Biol Chem. 2011;286(18):15707\u201315.","journal-title":"J Biol Chem"},{"key":"1965_CR22","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1242\/jcs.119768","volume":"125","author":"K Hsieh","year":"2012","unstructured":"Hsieh K, Lee YK, Londos C, Raaka BM, Dalen KT, Kimmel AR. Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets. J Cell Sci. 2012;125:4067\u201376.","journal-title":"J Cell Sci"},{"key":"1965_CR23","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1146\/annurev-nutr-071813-105410","volume":"36","author":"AR Kimmel","year":"2016","unstructured":"Kimmel AR, Sztalryd C. The perilipins: major cytosolic lipid droplet-associated proteins and their roles in cellular lipid storage, mobilization, and systemic homeostasis. Annu Rev Nutr. 2016;36:471\u2013509.","journal-title":"Annu Rev Nutr"},{"issue":"12","key":"1965_CR24","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/nrm3699","volume":"14","author":"AR Thiam","year":"2013","unstructured":"Thiam AR, Farese RV Jr, Walther TC. The biophysics and cell biology of lipid droplets. Nat Rev Mol Cell Biol. 2013;14(12):775\u201386.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7","key":"1965_CR25","doi-asserted-by":"publisher","first-page":"e103062","DOI":"10.1371\/journal.pone.0103062","volume":"9","author":"RR Mason","year":"2014","unstructured":"Mason RR, Meex RCR, Russell AP, Canny BJ, Watt MJ, Moro C. Cellular localization and associations of the major lipolytic proteins in human skeletal muscle at rest and during exercise. PLoS ONE. 2014;9(7):e103062.","journal-title":"PLoS ONE"},{"issue":"3","key":"1965_CR26","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1194\/jlr.R000034","volume":"51","author":"AR Kimmel","year":"2010","unstructured":"Kimmel AR, Brasaemle DL, McAndrews-Hill M, Sztalryd C, Londos C. Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins. J Lipid Res. 2010;51(3):468\u201371.","journal-title":"J Lipid Res"},{"issue":"2","key":"1965_CR27","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.bbrc.2013.01.113","volume":"432","author":"THM Grahn","year":"2013","unstructured":"Grahn THM, Zhang Y, Lee M, Sommer AG, Mostoslavsky G, Fried SK, et al. FSP27 and PLIN1 interaction promotes the formation of large lipid droplets in human adipocytes. Biochem Biophys Res Commun. 2013;432(2):296\u2013301.","journal-title":"Biochem Biophys Res Commun"},{"key":"1965_CR28","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1038\/ncomms2581","volume":"4","author":"Z Sun","year":"2013","unstructured":"Sun Z, Gong J, Wu H, Xu W, Wu L, Xu D, et al. Perilipin1 promotes unilocular lipid droplet formation through the activation of fsp27 in adipocytes. Nat Commun. 2013;4:1594.","journal-title":"Nat Commun"},{"issue":"4","key":"1965_CR29","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1074\/jbc.R111.309088","volume":"287","author":"DL Brasaemle","year":"2012","unstructured":"Brasaemle DL, Wolins NE. Packaging of fat: an evolving model of lipid droplet assembly and expansion. J Biol Chem. 2012;287(4):2273\u20139.","journal-title":"J Biol Chem"},{"key":"1965_CR30","doi-asserted-by":"crossref","unstructured":"Pourteymour S, Lee S, Langleite TM, Eckardt K, Hjorth M, Bindesboll C et al. Perilipin 4 in human skeletal muscle: localization and effect of physical activity. Physiol Rep 2015;3(8):e12481.","DOI":"10.14814\/phy2.12481"},{"issue":"4","key":"1965_CR31","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1007\/s12035-020-02217-5","volume":"58","author":"L Zhu","year":"2021","unstructured":"Zhu L, Hu F, Li C, Zhang C, Hang R, Xu R. Perilipin 4 protein: an impending target for amyotrophic lateral sclerosis. Mol Neurobiol. 2021;58(4):1723\u201337.","journal-title":"Mol Neurobiol"},{"issue":"7","key":"1965_CR32","doi-asserted-by":"publisher","first-page":"E770","DOI":"10.1152\/ajpendo.00523.2012","volume":"304","author":"W Chen","year":"2013","unstructured":"Chen W, Chang B, Wu X, Li L, Sleeman M, Chan L. Inactivation of plin4 downregulates plin5 and reduces cardiac lipid accumulation in mice. Am J Physiol Endocrinol Metab. 2013;304(7):E770\u20139.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"1965_CR33","doi-asserted-by":"publisher","first-page":"2122856","DOI":"10.1155\/2022\/2122856","volume":"2022","author":"X Cui","year":"2022","unstructured":"Cui X, Wang J, Zhang Y, Wei J, Wang Y. Plin5, a new target in diabetic cardiomyopathy. Oxid Med Cell Longev. 2022;2022:2122856.","journal-title":"Oxid Med Cell Longev"},{"key":"1965_CR34","doi-asserted-by":"crossref","unstructured":"Bohnert M. Wrapping up the fats-a structure of the lipid droplet biogenesis protein Seipin. J Cell Biol. 2018;217(12):4053\u201354.","DOI":"10.1083\/jcb.201811021"},{"issue":"10 Pt B","key":"1965_CR35","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/j.bbalip.2017.07.009","volume":"1862","author":"C Sztalryd","year":"2017","unstructured":"Sztalryd C, Brasaemle DL. The perilipin family of lipid droplet proteins: gatekeepers of intracellular lipolysis. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862(10 Pt B):1221\u201332.","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"issue":"30","key":"1965_CR36","doi-asserted-by":"publisher","first-page":"21704","DOI":"10.1074\/jbc.M702223200","volume":"282","author":"J Kovsan","year":"2007","unstructured":"Kovsan J, Ben-Romano R, Souza SC, Greenberg AS, Rudich A. Regulation of adipocyte lipolysis by degradation of the perilipin protein: nelfinavir enhances lysosome-mediated perilipin proteolysis. J Biol Chem. 2007;282(30):21704\u201311.","journal-title":"J Biol Chem"},{"key":"1965_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2021.101141","volume":"85","author":"R Rakotonirina-Ricquebourg","year":"2022","unstructured":"Rakotonirina-Ricquebourg R, Costa V, Teixeira V. Hello from the other side: membrane contact of lipid droplets with other organelles and subsequent functional implications. Prog Lipid Res. 2022;85:101141.","journal-title":"Prog Lipid Res"},{"key":"1965_CR38","doi-asserted-by":"crossref","unstructured":"Khaddaj R, Mari M, Cottier S, Reggiori F, Schneiter R. The surface of lipid droplets constitutes a barrier for Endoplasmic reticulum-resident integral membrane proteins. J Cell Sci. 2022;135(5):jcs256206.","DOI":"10.1242\/jcs.256206"},{"issue":"1","key":"1965_CR39","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s12944-017-0473-y","volume":"16","author":"H Itabe","year":"2017","unstructured":"Itabe H, Yamaguchi T, Nimura S, Sasabe N. Perilipins: a diversity of intracellular lipid droplet proteins. Lipids Health Dis. 2017;16(1):83.","journal-title":"Lipids Health Dis"},{"issue":"7","key":"1965_CR40","doi-asserted-by":"publisher","first-page":"C728","DOI":"10.1152\/ajpcell.00448.2011","volume":"303","author":"AL McIntosh","year":"2012","unstructured":"McIntosh AL, Senthivinayagam S, Moon KC, Gupta S, Lwande JS, Murphy CC, et al. Direct interaction of plin2 with lipids on the surface of lipid droplets: a live cell FRET analysis. Am J Physiol Cell Physiol. 2012;303(7):C728\u201342.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"2","key":"1965_CR41","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1080\/15548627.2015.1124226","volume":"12","author":"S Kaushik","year":"2016","unstructured":"Kaushik S, Cuervo AM. AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA. Autophagy. 2016;12(2):432\u20138.","journal-title":"Autophagy"},{"issue":"7","key":"1965_CR42","doi-asserted-by":"publisher","first-page":"5126","DOI":"10.1074\/jbc.M110.180711","volume":"286","author":"JG Granneman","year":"2011","unstructured":"Granneman JG, Moore HP, Mottillo EP, Zhu Z, Zhou L. Interactions of perilipin-5 (plin5) with adipose triglyceride lipase. J Biol Chem. 2011;286(7):5126\u201335.","journal-title":"J Biol Chem"},{"key":"1965_CR43","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.molmet.2018.08.004","volume":"17","author":"S Daemen","year":"2018","unstructured":"Daemen S, Gemmink A, Brouwers B, Meex R, Huntjens PR, Schaart G, et al. Distinct lipid droplet characteristics and distribution unmask the apparent contradiction of the athlete\u2019s paradox. Mol Metab. 2018;17:71\u201381.","journal-title":"Mol Metab"},{"issue":"3","key":"1965_CR44","doi-asserted-by":"publisher","first-page":"167045","DOI":"10.1016\/j.bbadis.2024.167045","volume":"1870","author":"C Fang","year":"2024","unstructured":"Fang C, Liu S, Yang W, Zheng G, Zhou F, Gao X, et al. Exercise ameliorates lipid droplet metabolism disorder by the PLIN2-LIPA axis-mediated lipophagy in mouse model of non-alcoholic fatty liver disease. Biochim Biophys Acta Mol Basis Dis. 2024;1870(3):167045.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"1965_CR45","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8176","volume":"6","author":"A Herms","year":"2015","unstructured":"Herms A, Bosch M, Reddy BJ, Schieber NL, Fajardo A, Ruperez C, et al. AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation. Nat Commun. 2015;6:7176.","journal-title":"Nat Commun"},{"issue":"4","key":"1965_CR46","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.cmet.2018.03.003","volume":"27","author":"IY Benador","year":"2018","unstructured":"Benador IY, Veliova M, Mahdaviani K, Petcherski A, Wikstrom JD, Assali EA, et al. Mitochondria bound to lipid droplets have unique bioenergetics, composition, and dynamics that support lipid droplet expansion. Cell Metab. 2018;27(4):869\u201385.","journal-title":"Cell Metab"},{"issue":"2","key":"1965_CR47","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1097\/MOL.0000000000000057","volume":"25","author":"AR Kimmel","year":"2014","unstructured":"Kimmel AR, Sztalryd C. Perilipin 5, a lipid droplet protein adapted to mitochondrial energy utilization. Curr Opin Lipidol. 2014;25(2):110\u20137.","journal-title":"Curr Opin Lipidol"},{"issue":"5","key":"1965_CR48","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.devcel.2019.07.021","volume":"50","author":"R Ugrankar","year":"2019","unstructured":"Ugrankar R, Bowerman J, Hariri H, Chandra M, Chen K, Bossanyi M, et al. Drosophila Snazarus regulates a lipid droplet population at plasma membrane-droplet contacts in adipocytes. Dev Cell. 2019;50(5):557.","journal-title":"Dev Cell"},{"key":"1965_CR49","doi-asserted-by":"crossref","unstructured":"Thiam AR, Dugail I. Lipid droplet-membrane contact sites - from protein binding to function. J Cell Sci. 2019;132(12):jcs230169.","DOI":"10.1242\/jcs.230169"},{"issue":"2","key":"1965_CR50","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/nri2921","volume":"11","author":"N Ouchi","year":"2011","unstructured":"Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol. 2011;11(2):85\u201397.","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"1965_CR51","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1093\/cvr\/cvu214","volume":"105","author":"S Liu","year":"2015","unstructured":"Liu S, Geng B, Zou L, Wei S, Wang W, Deng J, et al. Development of hypertrophic cardiomyopathy in perilipin-1 null mice with adipose tissue dysfunction. Cardiovasc Res. 2015;105(1):20\u201330.","journal-title":"Cardiovasc Res"},{"issue":"1","key":"1965_CR52","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1038\/s41598-020-57428-6","volume":"10","author":"Y Mizunoe","year":"2020","unstructured":"Mizunoe Y, Kobayashi M, Hoshino S, Tagawa R, Itagawa R, Hoshino A, et al. Cathepsin b overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes. Sci Rep. 2020;10(1):634.","journal-title":"Sci Rep"},{"issue":"8","key":"1965_CR53","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1056\/NEJMoa1007487","volume":"364","author":"S Gandotra","year":"2011","unstructured":"Gandotra S, Le Dour C, Bottomley W, Cervera P, Giral P, Reznik Y, et al. Perilipin deficiency and autosomal dominant partial lipodystrophy. N Engl J Med. 2011;364(8):740\u20138.","journal-title":"N Engl J Med"},{"key":"1965_CR54","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00467","volume":"9","author":"S Zhang","year":"2018","unstructured":"Zhang S, Liu G, Xu C, Liu L, Zhang Q, Xu Q, et al. Perilipin 1 mediates lipid metabolism homeostasis and inhibits inflammatory cytokine synthesis in bovine adipocytes. Front Immunol. 2018;9:467.","journal-title":"Front Immunol"},{"issue":"11","key":"1965_CR55","doi-asserted-by":"publisher","first-page":"6494","DOI":"10.1073\/pnas.101042998","volume":"98","author":"JT Tansey","year":"2001","unstructured":"Tansey JT, Sztalryd C, Gruia-Gray J, Roush DL, Zee JV, Gavrilova O, et al. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc Natl Acad Sci U S A. 2001;98(11):6494\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"1965_CR56","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1074\/jbc.M605770200","volume":"282","author":"H Miyoshi","year":"2007","unstructured":"Miyoshi H, Perfield JN, Souza SC, Shen WJ, Zhang HH, Stancheva ZS, et al. Control of adipose triglyceride lipase action by Serine 517 of perilipin a globally regulates protein kinase a-stimulated lipolysis in adipocytes. J Biol Chem. 2007;282(2):996\u20131002.","journal-title":"J Biol Chem"},{"issue":"3","key":"1965_CR57","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1210\/jc.2003-031388","volume":"89","author":"PA Kern","year":"2004","unstructured":"Kern PA, Di Gregorio G, Lu T, Rassouli N, Ranganathan G. Perilipin expression in human adipose tissue is elevated with obesity. J Clin Endocrinol Metab. 2004;89(3):1352\u20138.","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"1965_CR58","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1038\/oby.2003.128","volume":"11","author":"Y Wang","year":"2003","unstructured":"Wang Y, Sullivan S, Trujillo M, Lee MJ, Schneider SH, Brolin RE, et al. Perilipin expression in human adipose tissues: effects of severe obesity, gender, and depot. Obes Res. 2003;11(8):930\u20136.","journal-title":"Obes Res"},{"issue":"1","key":"1965_CR59","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/s41467-023-44559-3","volume":"15","author":"Y Wang","year":"2024","unstructured":"Wang Y, Nguyen HP, Xue P, Xie Y, Yi D, Lin F, et al. Apol6 associates with lipid droplets and disrupts perilipin1-HSL interaction to inhibit lipolysis. Nat Commun. 2024;15(1):186.","journal-title":"Nat Commun"},{"issue":"1","key":"1965_CR60","doi-asserted-by":"publisher","first-page":"4734","DOI":"10.1038\/s41598-019-41329-4","volume":"9","author":"M Varghese","year":"2019","unstructured":"Varghese M, Kimler VA, Ghazi FR, Rathore GK, Perkins GA, Ellisman MH, et al. Adipocyte lipolysis affects perilipin 5 and cristae organization at the cardiac lipid droplet-mitochondrial interface. Sci Rep. 2019;9(1):4734.","journal-title":"Sci Rep"},{"issue":"23","key":"1965_CR61","doi-asserted-by":"publisher","first-page":"15837","DOI":"10.1074\/jbc.M601097200","volume":"281","author":"H Miyoshi","year":"2006","unstructured":"Miyoshi H, Souza SC, Zhang HH, Strissel KJ, Christoffolete MA, Kovsan J, et al. Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms. J Biol Chem. 2006;281(23):15837\u201344.","journal-title":"J Biol Chem"},{"issue":"50","key":"1965_CR62","doi-asserted-by":"publisher","first-page":"34538","DOI":"10.1074\/jbc.M109.068478","volume":"284","author":"JG Granneman","year":"2009","unstructured":"Granneman JG, Moore HP, Krishnamoorthy R, Rathod M. Perilipin controls lipolysis by regulating the interactions of AB-hydrolase containing 5 (abhd5) and adipose triglyceride lipase (atgl). J Biol Chem. 2009;284(50):34538\u201344.","journal-title":"J Biol Chem"},{"issue":"9","key":"1965_CR63","doi-asserted-by":"publisher","first-page":"4278","DOI":"10.1210\/en.2012-1127","volume":"153","author":"J Pagnon","year":"2012","unstructured":"Pagnon J, Matzaris M, Stark R, Meex RC, Macaulay SL, Brown W, et al. Identification and functional characterization of protein kinase A phosphorylation sites in the major lipolytic protein, adipose triglyceride lipase. Endocrinology. 2012;153(9):4278\u201389.","journal-title":"Endocrinology"},{"issue":"4","key":"1965_CR64","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/s41580-020-0210-7","volume":"21","author":"M Giacomello","year":"2020","unstructured":"Giacomello M, Pyakurel A, Glytsou C, Scorrano L. The cell biology of mitochondrial membrane dynamics. Nat Rev Mol Cell Biol. 2020;21(4):204\u201324.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"12","key":"1965_CR65","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1091\/mbc.E17-09-0538","volume":"29","author":"M Rogne","year":"2018","unstructured":"Rogne M, Chu D, K\u00fcntziger TM, Mylonakou M, Collas P, Tasken K. OPA1-anchored PKA phosphorylates perilipin 1 on s522 and s497 in adipocytes differentiated from human adipose stem cells. Mol Biol Cell. 2018;29(12):1487\u2013501.","journal-title":"Mol Biol Cell"},{"key":"1965_CR66","doi-asserted-by":"crossref","unstructured":"Takahashi Y, Shinoda A, Kamada H, Shimizu M, Inoue J, Sato R. Perilipin2 plays a positive role in adipocytes during lipolysis by escaping proteasomal degradation. Sci Rep. 2016;6(1):20975.","DOI":"10.1038\/srep20975"},{"key":"1965_CR67","doi-asserted-by":"crossref","first-page":"154396","DOI":"10.1016\/j.metabol.2020.154396","volume":"113","author":"Y Okamatsu-Ogura","year":"2020","unstructured":"Okamatsu-Ogura Y, Kuroda M, Tsutsumi R, Tsubota A, Saito M, Kimura K, et al. UCP1-dependent and UCP1-independent metabolic changes induced by acute cold exposure in brown adipose tissue of mice. Metabolism. 2020;113:154396.","journal-title":"Metabolism"},{"issue":"5","key":"1965_CR68","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1194\/jlr.M035063","volume":"54","author":"JL McManaman","year":"2013","unstructured":"McManaman JL, Bales ES, Orlicky DJ, Jackman M, MacLean PS, Cain S, et al. Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease. J Lipid Res. 2013;54(5):1346\u201359.","journal-title":"J Lipid Res"},{"issue":"2","key":"1965_CR69","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/apt.18059","volume":"60","author":"AB Koenig","year":"2024","unstructured":"Koenig AB, Tan A, Abdelaal H, Monge F, Younossi ZM, Goodman ZD. Review article: hepatic steatosis and its associations with acute and chronic liver diseases. Aliment Pharmacol Ther. 2024;60(2):167\u2013200.","journal-title":"Aliment Pharmacol Ther"},{"issue":"4","key":"1965_CR70","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1017\/S0029665113001249","volume":"72","author":"CD Byrne","year":"2013","unstructured":"Byrne CD. Ectopic fat, insulin resistance and non-alcoholic fatty liver disease. Proc Nutr Soc. 2013;72(4):412\u20139.","journal-title":"Proc Nutr Soc"},{"issue":"6","key":"1965_CR71","doi-asserted-by":"publisher","first-page":"3441","DOI":"10.1002\/hep.32048","volume":"74","author":"M Garcia-Macia","year":"2021","unstructured":"Garcia-Macia M, Santos-Ledo A, Leslie J, Paish HL, Collins AL, Scott RS, et al. A mammalian target of rapamycin-perilipin 3 (mTORC1-plin3) pathway is essential to activate lipophagy and protects against hepatosteatosis. Hepatology. 2021;74(6):3441\u201359.","journal-title":"Hepatology"},{"key":"1965_CR72","doi-asserted-by":"crossref","unstructured":"Piazzolla VA, Mangia A. Noninvasive diagnosis of NAFLD and NASH. Cells. 2020;9(4):1005.","DOI":"10.3390\/cells9041005"},{"issue":"4","key":"1965_CR73","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.jhep.2019.06.021","volume":"71","author":"ZM Younossi","year":"2019","unstructured":"Younossi ZM, Golabi P, de Avila L, Paik JM, Srishord M, Fukui N, et al. The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: a systematic review and meta-analysis. J Hepatol. 2019;71(4):793\u2013801.","journal-title":"J Hepatol"},{"key":"1965_CR74","doi-asserted-by":"crossref","unstructured":"Sanchez PBM, Krizanac M, Weiskirchen R, Asimakopoulos A. Understanding the role of perilipin 5 in non-alcoholic fatty liver disease and its role in hepatocellular carcinoma: a review of novel insights. Int J Mol Sci. 2021;22(10):5284.","DOI":"10.3390\/ijms22105284"},{"issue":"6","key":"1965_CR75","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/nrendo.2015.61","volume":"11","author":"J Sargent","year":"2015","unstructured":"Sargent J. The lipid-droplet-coating protein perilipin-5 in fast-twitch muscle fibres confers metabolic protection. Nat Rev Endocrinol. 2015;11(6):316.","journal-title":"Nat Rev Endocrinol"},{"issue":"11","key":"1965_CR76","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1194\/jlr.M079764","volume":"58","author":"YZ Feng","year":"2017","unstructured":"Feng YZ, Lund J, Li Y, Knabenes IK, Bakke SS, Kase ET, et al. Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation. J Lipid Res. 2017;58(11):2147\u201361.","journal-title":"J Lipid Res"},{"issue":"12","key":"1965_CR77","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1139\/apnm-2019-0966","volume":"45","author":"D Nocetti","year":"2020","unstructured":"Nocetti D, Espinosa A, Pino-De LFF, Sacrist\u00e1n C, Bucarey JL, Ruiz P, et al. Lipid droplets are both highly oxidized and plin2-covered in hepatocytes of diet-induced obese mice. Appl Physiol Nutr Metab. 2020;45(12):1368\u201376.","journal-title":"Appl Physiol Nutr Metab"},{"issue":"11","key":"1965_CR78","doi-asserted-by":"publisher","first-page":"3445","DOI":"10.3390\/ijms19113445","volume":"19","author":"Y Jin","year":"2018","unstructured":"Jin Y, Tan Y, Chen L, Liu Y, Ren Z. Reactive oxygen species induces lipid droplet accumulation in HepG2 cells by increasing perilipin 2 expression. Int J Mol Sci. 2018;19(11):3445.","journal-title":"Int J Mol Sci"},{"issue":"8","key":"1965_CR79","doi-asserted-by":"publisher","first-page":"2132","DOI":"10.1194\/jlr.M004515","volume":"51","author":"BH Chang","year":"2010","unstructured":"Chang BH, Li L, Saha P, Chan L. Absence of adipose differentiation related protein upregulates hepatic VLDL secretion, relieves hepatosteatosis, and improves whole body insulin resistance in leptin-deficient mice. J Lipid Res. 2010;51(8):2132\u201342.","journal-title":"J Lipid Res"},{"issue":"7","key":"1965_CR80","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1080\/15548627.2017.1319544","volume":"13","author":"T Tsai","year":"2017","unstructured":"Tsai T, Chen E, Li L, Saha P, Lee H, Huang L, et al. The constitutive lipid droplet protein PLIN2 regulates autophagy in liver. Autophagy. 2017;13(7):1130\u201344.","journal-title":"Autophagy"},{"issue":"5","key":"1965_CR81","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1161\/ATVBAHA.111.241497","volume":"32","author":"R Lehner","year":"2012","unstructured":"Lehner R, Lian J, Quiroga AD. Lumenal lipid metabolism: implications for lipoprotein assembly. Arterioscler Thromb Vasc Biol. 2012;32(5):1087\u201393.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"46","key":"1965_CR82","doi-asserted-by":"publisher","first-page":"24231","DOI":"10.1074\/jbc.M116.759795","volume":"291","author":"AE Libby","year":"2016","unstructured":"Libby AE, Bales E, Orlicky DJ, McManaman JL. Perilipin-2 deletion impairs hepatic lipid accumulation by interfering with sterol regulatory element-binding protein (SREBP) activation and altering the hepatic lipidome. J Biol Chem. 2016;291(46):24231\u201346.","journal-title":"J Biol Chem"},{"issue":"5","key":"1965_CR83","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097118","volume":"9","author":"RM Carr","year":"2014","unstructured":"Carr RM, Peralta G, Yin X, Ahima RS. Absence of perilipin 2 prevents hepatic steatosis, glucose intolerance and ceramide accumulation in alcohol-fed mice. PLoS ONE. 2014;9(5):e97118.","journal-title":"PLoS ONE"},{"issue":"12","key":"1965_CR84","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1194\/jlr.M017939","volume":"52","author":"H Wang","year":"2011","unstructured":"Wang H, Sreenivasan U, Hu H, Saladino A, Polster BM, Lund LM, et al. Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria. J Lipid Res. 2011;52(12):2159\u201368.","journal-title":"J Lipid Res"},{"issue":"12","key":"1965_CR85","doi-asserted-by":"publisher","first-page":"2751","DOI":"10.1194\/jlr.M700359-JLR200","volume":"48","author":"LL Listenberger","year":"2007","unstructured":"Listenberger LL, Ostermeyer-Fay AG, Goldberg EB, Brown WJ, Brown DA. Adipocyte differentiation-related protein reduces the lipid droplet association of adipose triglyceride lipase and slows triacylglycerol turnover. J Lipid Res. 2007;48(12):2751\u201361.","journal-title":"J Lipid Res"},{"issue":"45","key":"1965_CR86","doi-asserted-by":"publisher","first-page":"34341","DOI":"10.1074\/jbc.M602497200","volume":"281","author":"C Sztalryd","year":"2006","unstructured":"Sztalryd C, Bell M, Lu X, Mertz P, Hickenbottom S, Chang BH, et al. Functional compensation for adipose differentiation-related protein (ADFP) by tip47 in an ADFP null embryonic cell line. J Biol Chem. 2006;281(45):34341\u20138.","journal-title":"J Biol Chem"},{"key":"1965_CR87","doi-asserted-by":"crossref","unstructured":"Dias AA, Bello AA, Bigay J, Franckhauser C, Gautier R, Cazareth J et al. Surface tension-driven sorting of human perilipins on lipid droplets. J Cell Biol. 2024;223(12):e202403064.","DOI":"10.1083\/jcb.202403064"},{"issue":"50","key":"1965_CR88","doi-asserted-by":"publisher","first-page":"27965","DOI":"10.1021\/acs.jafc.4c08430","volume":"72","author":"J Lu","year":"2024","unstructured":"Lu J, Zhou H, Hu J, Zhang R, Meng Z, Guan S. Apigenin reduces lipid droplet accumulation in hepatocytes by enhancing chaperone-mediated autophagy via AMPK. J Agric Food Chem. 2024;72(50):27965\u201377.","journal-title":"J Agric Food Chem"},{"issue":"12","key":"1965_CR89","doi-asserted-by":"publisher","first-page":"3418","DOI":"10.2337\/db06-0399","volume":"55","author":"NE Wolins","year":"2006","unstructured":"Wolins NE, Quaynor BK, Skinner JR, Tzekov A, Croce MA, Gropler MC, et al. OXPAT\/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization. Diabetes. 2006;55(12):3418\u201328.","journal-title":"Diabetes"},{"issue":"3","key":"1965_CR90","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1002\/hep.27409","volume":"61","author":"C Wang","year":"2015","unstructured":"Wang C, Zhao Y, Gao X, Le Li, Yuan Y, Liu F, et al. Perilipin 5 improves hepatic lipotoxicity by inhibiting lipolysis. Hepatology (Baltimore MD). 2015;61(3):870\u201382.","journal-title":"Hepatology (Baltimore MD)"},{"issue":"6","key":"1965_CR91","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.3390\/cells9061346","volume":"9","author":"A Asimakopoulou","year":"2020","unstructured":"Asimakopoulou A, Engel KM, Gassler N, Bracht T, Sitek B, Buhl EM, et al. Deletion of perilipin 5 protects against hepatic injury in nonalcoholic fatty liver disease via missing inflammasome activation. Cells. 2020;9(6):1346.","journal-title":"Cells"},{"issue":"9","key":"1965_CR92","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.3390\/cells10092184","volume":"10","author":"R Cierpka","year":"2021","unstructured":"Cierpka R, Weiskirchen R, Asimakopoulos A. Perilipin 5 ameliorates hepatic stellate cell activation via SMAD2\/3 and SNAIL signaling pathways and suppresses STAT3 activation. Cells. 2021;10(9):2184.","journal-title":"Cells"},{"issue":"1","key":"1965_CR93","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s10020-023-00740-4","volume":"29","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Xu J, Zhou D, Ye T, Zhou P, Liu Z, et al. Swimming exercise ameliorates insulin resistance and nonalcoholic fatty liver by negatively regulating PPARgamma transcriptional network in mice fed high fat diet. Mol Med. 2023;29(1):150.","journal-title":"Mol Med"},{"key":"1965_CR94","doi-asserted-by":"crossref","unstructured":"Yang Y, Li X, Liu Z, Ruan X, Wang H, Zhang Q et al. Moderate treadmill exercise alleviates NAFLD by regulating the biogenesis and autophagy of lipid droplet. Nutrients. 2022;14(22):4910.","DOI":"10.3390\/nu14224910"},{"issue":"5","key":"1965_CR95","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/hep4.1056","volume":"1","author":"RJ Schulze","year":"2017","unstructured":"Schulze RJ, Drizyte K, Casey CA, McNiven MA. Hepatic lipophagy: new insights into autophagic catabolism of lipid droplets in the liver. Hepatol Commun. 2017;1(5):359\u201369.","journal-title":"Hepatol Commun"},{"key":"1965_CR96","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101635","volume":"36","author":"Y Gao","year":"2020","unstructured":"Gao Y, Zhang W, Zeng L, Bai H, Li J, Zhou J, et al. Exercise and dietary intervention ameliorate high-fat diet-induced NAFLD and liver aging by inducing lipophagy. Redox Biol. 2020;36:101635.","journal-title":"Redox Biol"},{"issue":"4","key":"1965_CR97","doi-asserted-by":"publisher","first-page":"773","DOI":"10.2337\/db09-9028","volume":"58","author":"RA DeFronzo","year":"2009","unstructured":"DeFronzo RA. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 2009;58(4):773\u201395.","journal-title":"Diabetes"},{"issue":"1","key":"1965_CR98","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1152\/jappl.2000.89.1.81","volume":"89","author":"I Janssen","year":"2000","unstructured":"Janssen I, Heymsfield SB, Wang ZM, Ross R. Skeletal muscle mass and distribution in 468 men and women aged 18\u201388 year. J Appl Physiol (1985). 2000;89(1):81\u20138.","journal-title":"J Appl Physiol (1985)"},{"issue":"3","key":"1965_CR99","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2022.151869","volume":"124","author":"V Fachada","year":"2022","unstructured":"Fachada V, Rahkila P, Fachada N, Turpeinen T, Kujala UM, Kainulainen H. Enlarged PLIN5-uncoated lipid droplets in inner regions of skeletal muscle type II fibers associate with type 2 diabetes. Acta Histochem. 2022;124(3):151869.","journal-title":"Acta Histochem"},{"key":"1965_CR100","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2024.101277","volume":"97","author":"M Flores-Opazo","year":"2024","unstructured":"Flores-Opazo M, Kopinke D, Helmbacher F, Fernandez-Verdejo R, Tunon-Suarez M, Lynch GS, et al. Fibro-adipogenic progenitors in physiological adipogenesis and intermuscular adipose tissue remodeling. Mol Aspects Med. 2024;97:101277.","journal-title":"Mol Aspects Med"},{"key":"1965_CR101","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2010\/476279","volume":"2010","author":"MA Abdul-Ghani","year":"2010","unstructured":"Abdul-Ghani MA, DeFronzo RA. Pathogenesis of insulin resistance in skeletal muscle. J Biomed Biotechnol. 2010;2010:1\u201319.","journal-title":"J Biomed Biotechnol"},{"issue":"5","key":"1965_CR102","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1007\/s00125-016-3865-z","volume":"59","author":"A Gemmink","year":"2016","unstructured":"Gemmink A, Bosma M, Kuijpers HJ, Hoeks J, Schaart G, van Zandvoort MA, et al. Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans. Diabetologia. 2016;59(5):1040\u20138.","journal-title":"Diabetologia"},{"issue":"24","key":"1965_CR103","doi-asserted-by":"publisher","first-page":"7273","DOI":"10.1113\/JP275346","volume":"595","author":"GC Hayward","year":"2017","unstructured":"Hayward GC, Fenech RK, Yang AJ, Baranowski BJ. The role of PLIN protein in healthy lipid storage and lipid droplet expansion. J Physiol. 2017;595(24):7273\u20134.","journal-title":"J Physiol"},{"issue":"10","key":"1965_CR104","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1016\/j.bbalip.2017.07.010","volume":"1862","author":"A Gemmink","year":"2017","unstructured":"Gemmink A, Goodpaster BH, Schrauwen P, Hesselink MKC. Intramyocellular lipid droplets and insulin sensitivity, the human perspective. Biochimica et Biophysica Acta (BBA). 2017;1862(10):1242\u20139.","journal-title":"Biochimica et Biophysica Acta (BBA)"},{"issue":"3","key":"1965_CR105","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2022.100172","volume":"63","author":"B Kien","year":"2022","unstructured":"Kien B, Kolleritsch S, Kunowska N, Heier C, Chalhoub G, Tilp A, et al. Lipid droplet-mitochondria coupling via perilipin 5 augments respiratory capacity but is dispensable for FA oxidation. J Lipid Res. 2022;63(3):100172.","journal-title":"J Lipid Res"},{"issue":"2","key":"1965_CR106","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s00418-011-0888-x","volume":"137","author":"M Bosma","year":"2012","unstructured":"Bosma M, Minnaard R, Sparks LM, Schaart G, Losen M, de Baets MH, et al. The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria. Histochem Cell Biol. 2012;137(2):205\u201316.","journal-title":"Histochem Cell Biol"},{"issue":"4","key":"1965_CR107","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.bbalip.2013.01.007","volume":"1831","author":"M Bosma","year":"2013","unstructured":"Bosma M, Sparks LM, Hooiveld GJ, Jorgensen JA, Houten SM, Schrauwen P, et al. Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity. Biochim Biophys Acta. 2013;1831(4):844\u201352.","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"1965_CR108","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2020.158852","volume":"1866","author":"A Gemmink","year":"2021","unstructured":"Gemmink A, Daemen S, Brouwers B, Hoeks J, Schaart G, Knoops K, et al. Decoration of myocellular lipid droplets with perilipins as a marker for in vivo lipid droplet dynamics: a super-resolution microscopy study in trained athletes and insulin resistant individuals. Biochimica et Biophysica Acta (BBA). 2021;1866(2):158852.","journal-title":"Biochimica et Biophysica Acta (BBA)"},{"issue":"8","key":"1965_CR109","doi-asserted-by":"publisher","first-page":"2757","DOI":"10.2337\/db14-1035","volume":"64","author":"LA Harris","year":"2015","unstructured":"Harris LA, Skinner JR, Shew TM, Pietka TA, Abumrad NA, Wolins NE. Perilipin 5-driven lipid droplet accumulation in skeletal muscle stimulates the expression of fibroblast growth factor 21. Diabetes. 2015;64(8):2757\u201368.","journal-title":"Diabetes"},{"issue":"2","key":"1965_CR110","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s11745-014-3985-5","volume":"50","author":"RE MacPherson","year":"2015","unstructured":"MacPherson RE, Castelli LM, Miotto PM, Frendo-Cumbo S, Milburn A, Roy BD, et al. A maternal high fat diet has long-lasting effects on skeletal muscle lipid and PLIN protein content in rat offspring at young adulthood. Lipids. 2015;50(2):205\u201317.","journal-title":"Lipids"},{"issue":"6","key":"1965_CR111","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.molmet.2014.06.002","volume":"3","author":"RR Mason","year":"2014","unstructured":"Mason RR, Mokhtar R, Matzaris M, Selathurai A, Kowalski GM, Mokbel N, et al. PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle. Mol Metab. 2014;3(6):652\u201363.","journal-title":"Mol Metab"},{"issue":"8","key":"1965_CR112","doi-asserted-by":"publisher","first-page":"R644","DOI":"10.1152\/ajpregu.00418.2012","volume":"304","author":"REK MacPherson","year":"2013","unstructured":"MacPherson REK, Ramos SV, Vandenboom R, Roy BD, Peters SJ. Skeletal muscle PLIN proteins, ATGL and CGI-58, interactions at rest and following stimulated contraction. Am J Physiol Regul Integr Comp Physiol. 2013;304(8):R644\u201350.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"5","key":"1965_CR113","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1161\/ATVBAHA.108.182675","volume":"29","author":"I Buers","year":"2009","unstructured":"Buers I, Robenek H, Lorkowski S, Nitschke Y, Severs NJ, Hofnagel O. TIP47, a lipid cargo protein involved in macrophage triglyceride metabolism. Arterioscler Thromb Vasc Biol. 2009;29(5):767\u201373.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"1965_CR114","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1083\/jcb.200812042","volume":"185","author":"AV Bulankina","year":"2009","unstructured":"Bulankina AV, Deggerich A, Wenzel D, Mutenda K, Wittmann JG, Rudolph MG, et al. TIP47 functions in the biogenesis of lipid droplets. J Cell Biol. 2009;185(4):641\u201355.","journal-title":"J Cell Biol"},{"issue":"8","key":"1965_CR115","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.molmet.2016.06.007","volume":"5","author":"M Kleinert","year":"2016","unstructured":"Kleinert M, Parker BL, Chaudhuri R, Fazakerley DJ, Serup A, Thomas KC, et al. MTORC2 and AMPK differentially regulate muscle triglyceride content via perilipin 3. Mol Metab. 2016;5(8):646\u201355.","journal-title":"Mol Metab"},{"issue":"6","key":"1965_CR116","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1038\/ncb3166","volume":"17","author":"S Kaushik","year":"2015","unstructured":"Kaushik S, Cuervo AM. Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis. Nat Cell Biol. 2015;17(6):759\u201370.","journal-title":"Nat Cell Biol"},{"issue":"11","key":"1965_CR117","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.2337\/db11-1402","volume":"61","author":"M Bosma","year":"2012","unstructured":"Bosma M, Hesselink MK, Sparks LM, Timmers S, Ferraz MJ, Mattijssen F, et al. Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels. Diabetes. 2012;61(11):2679\u201390.","journal-title":"Diabetes"},{"key":"1965_CR118","doi-asserted-by":"publisher","DOI":"10.1038\/srep38310","volume":"6","author":"C Laurens","year":"2016","unstructured":"Laurens C, Bourlier V, Mairal A, Louche K, Badin P, Mouisel E, et al. Perilipin 5 fine-tunes lipid oxidation to metabolic demand and protects against lipotoxicity in skeletal muscle. Sci Rep. 2016;6:38310.","journal-title":"Sci Rep"},{"key":"1965_CR119","doi-asserted-by":"publisher","first-page":"618322","DOI":"10.3389\/fcell.2020.618322","volume":"8","author":"L Cui","year":"2020","unstructured":"Cui L, Liu P. Two types of contact between lipid droplets and mitochondria. Front Cell Dev Biol. 2020;8:618322.","journal-title":"Front Cell Dev Biol"},{"issue":"3","key":"1965_CR120","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1113\/jphysiol.2012.240952","volume":"591","author":"SO Shepherd","year":"2013","unstructured":"Shepherd SO, Cocks M, Tipton KD, Ranasinghe AM, Barker TA, Burniston JG, et al. Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5. J Physiol. 2013;591(3):657\u201375.","journal-title":"J Physiol"},{"issue":"4","key":"1965_CR121","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1113\/expphysiol.2014.084434","volume":"100","author":"SV Ramos","year":"2015","unstructured":"Ramos SV, Turnbull PC, MacPherson RE, LeBlanc PJ, Ward WE, Peters SJ. Changes in mitochondrial perilipin 3 and perilipin 5 protein content in rat skeletal muscle following endurance training and acute stimulated contraction. Exp Physiol. 2015;100(4):450\u201362.","journal-title":"Exp Physiol"},{"issue":"16","key":"1965_CR122","doi-asserted-by":"publisher","first-page":"5587","DOI":"10.1113\/JP274374","volume":"595","author":"SO Shepherd","year":"2017","unstructured":"Shepherd SO, Strauss JA, Wang Q, Dube JJ, Goodpaster B, Mashek DG, et al. Training alters the distribution of perilipin proteins in muscle following acute free fatty acid exposure. J Physiol. 2017;595(16):5587\u2013601.","journal-title":"J Physiol"},{"issue":"3","key":"1965_CR123","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091675","volume":"9","author":"JD Covington","year":"2014","unstructured":"Covington JD, Galgani JE, Moro C, LaGrange JM, Zhang Z, Rustan AC, et al. Skeletal muscle perilipin 3 and coatomer proteins are increased following exercise and are associated with fat oxidation. PLoS ONE. 2014;9(3):e91675.","journal-title":"PLoS ONE"},{"issue":"10","key":"1965_CR124","doi-asserted-by":"publisher","first-page":"2472","DOI":"10.2337\/db11-1832","volume":"61","author":"E Phielix","year":"2012","unstructured":"Phielix E, Meex R, Ouwens DM, Sparks L, Hoeks J, Schaart G, et al. High oxidative capacity due to chronic exercise training attenuates lipid-induced insulin resistance. Diabetes. 2012;61(10):2472\u20138.","journal-title":"Diabetes"},{"issue":"5","key":"1965_CR125","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1113\/JP275182","volume":"596","author":"A Gemmink","year":"2018","unstructured":"Gemmink A, Daemen S, Brouwers B, Huntjens PR, Schaart G, Moonen-Kornips E, et al. Dissociation of intramyocellular lipid storage and insulin resistance in trained athletes and type 2 diabetes patients; involvement of perilipin 5? J Physiol. 2018;596(5):857\u201368.","journal-title":"J Physiol"},{"issue":"11","key":"1965_CR126","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1016\/j.bbalip.2018.08.016","volume":"1863","author":"A Gemmink","year":"2018","unstructured":"Gemmink A, Daemen S, Kuijpers H, Schaart G, Duimel H, Lopez-Iglesias C, et al. Super-resolution microscopy localizes perilipin 5 at lipid droplet-mitochondria interaction sites and at lipid droplets juxtaposing to perilipin 2. Biochimica et Biophysica Acta (BBA). 2018;1863(11):1423\u201332.","journal-title":"Biochimica et Biophysica Acta (BBA)"},{"issue":"10","key":"1965_CR127","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12154","volume":"2","author":"SV Ramos","year":"2014","unstructured":"Ramos SV, MacPherson REK, Turnbull PC, Bott KN, LeBlanc P, Ward WE, et al. Higher PLIN5 but not PLIN3 content in isolated skeletal muscle mitochondria following acute in vivo contraction in rat hindlimb. Physiol Rep. 2014;2(10):e12154.","journal-title":"Physiol Rep"},{"issue":"3","key":"1965_CR128","doi-asserted-by":"publisher","first-page":"249","DOI":"10.3390\/cells8030249","volume":"8","author":"X Li","year":"2019","unstructured":"Li X, Li Z, Zhao M, Nie Y, Liu P, Zhu Y, et al. Skeletal muscle lipid droplets and the athlete\u2019s paradox. Cells. 2019;8(3):249.","journal-title":"Cells"},{"issue":"5","key":"1965_CR129","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1113\/JP275505","volume":"596","author":"NE Wolins","year":"2018","unstructured":"Wolins NE, Mittendorfer B. The athlete\u2019s paradox. J Physiol. 2018;596(5):755\u20136.","journal-title":"J Physiol"},{"issue":"9","key":"1965_CR130","doi-asserted-by":"publisher","DOI":"10.3390\/nu13093160","volume":"13","author":"KA Byun","year":"2021","unstructured":"Byun KA, Oh S, Son M, Oh SE, Park CH, Son KH, et al. Dieckol-attenuated high-fat diet induced muscle atrophy by modulating muscular deposition of lipid droplets. Nutrients. 2021;13(9):3160.","journal-title":"Nutrients"},{"issue":"5","key":"1965_CR131","doi-asserted-by":"publisher","first-page":"677","DOI":"10.2337\/diabetes.49.5.677","volume":"49","author":"DE Kelley","year":"2000","unstructured":"Kelley DE, Mandarino LJ. Fuel selection in human skeletal muscle in insulin resistance: a reexamination. Diabetes. 2000;49(5):677\u201383.","journal-title":"Diabetes"},{"issue":"6","key":"1965_CR132","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.semcdb.2012.01.003","volume":"23","author":"L Poulsen","year":"2012","unstructured":"Poulsen L, Siersbaek M, Mandrup S. PPARs: fatty acid sensors controlling metabolism. Semin Cell Dev Biol. 2012;23(6):631\u20139.","journal-title":"Semin Cell Dev Biol"},{"issue":"8","key":"1965_CR133","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1139\/apnm-2018-0729","volume":"44","author":"W Z","year":"2019","unstructured":"Z W, F B, C H, W T, G J. Oleic acid-induced perilipin 5 expression and lipid droplets formation are regulated by the PI3k\/PPAR\u03b1 pathway in HepG2 cells. Appl Physiol Nutr Metab. 2019;44(8):840\u20138.","journal-title":"Appl Physiol Nutr Metab"},{"key":"1965_CR134","doi-asserted-by":"publisher","first-page":"118868","DOI":"10.1016\/j.lfs.2020.118868","volume":"266","author":"TA Diniz","year":"2021","unstructured":"Diniz TA, de Lima JE, Teixeira AA, Biondo LA, Da RL, Valadao IC, et al. Aerobic training improves NAFLD markers and insulin resistance through AMPK-PPAR-alpha signaling in obese mice. Life Sci. 2021;266:118868.","journal-title":"Life Sci"},{"issue":"2","key":"1965_CR135","doi-asserted-by":"publisher","first-page":"175","DOI":"10.2174\/18715303113139990003","volume":"13","author":"PA Subramani","year":"2013","unstructured":"Subramani PA, Reddy MC, Narala VR. The need for physiologically relevant peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands. Endocr Metab Immune Disord Drug Targets. 2013;13(2):175\u201383.","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"1965_CR136","doi-asserted-by":"publisher","first-page":"122567","DOI":"10.1016\/j.lfs.2024.122567","volume":"345","author":"DG de Melo","year":"2024","unstructured":"de Melo DG, Da Cruz Rodrigues VC, de Sa Pereira GJ, de Campos TDP, Dos Santos Canciglieri R, Pauli JR, et al. Effects of aerobic exercise on the regulation of mitochondrial carrier homolog-2 and its influence on the catabolic and anabolic activity of lipids in the mesenteric adipose tissue of obese mice. Life Sci. 2024;345:122567.","journal-title":"Life Sci"},{"issue":"45","key":"1965_CR137","doi-asserted-by":"publisher","first-page":"13850","DOI":"10.1073\/pnas.1516004112","volume":"112","author":"R Schreiber","year":"2015","unstructured":"Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, et al. Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015;112(45):13850\u20135.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1965_CR138","doi-asserted-by":"publisher","first-page":"12723","DOI":"10.1038\/ncomms12723","volume":"7","author":"VI Gallardo-Montejano","year":"2016","unstructured":"Gallardo-Montejano VI, Saxena G, Kusminski CM, Yang C, McAfee JL, Hahner L, et al. Nuclear perilipin 5 integrates lipid droplet lipolysis with PGC-1alpha\/SIRT1-dependent transcriptional regulation of mitochondrial function. Nat Commun. 2016;7:12723.","journal-title":"Nat Commun"},{"issue":"12","key":"1965_CR139","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1038\/ijo.2017.170","volume":"41","author":"SO Shepherd","year":"2017","unstructured":"Shepherd SO, Cocks M, Meikle PJ, Mellett NA, Ranasinghe AM, Barker TA, et al. Lipid droplet remodelling and reduced muscle ceramides following sprint interval and moderate-intensity continuous exercise training in obese males. Int J Obes (Lond). 2017;41(12):1745\u201354.","journal-title":"Int J Obes (Lond)"},{"issue":"34","key":"1965_CR140","doi-asserted-by":"publisher","first-page":"16866","DOI":"10.1073\/pnas.1903642116","volume":"116","author":"J Mahamid","year":"2019","unstructured":"Mahamid J, Tegunov D, Maiser A, Arnold J, Leonhardt H, Plitzko JM, et al. Liquid-crystalline phase transitions in lipid droplets are related to cellular states and specific organelle association. Proc Natl Acad Sci U S A. 2019;116(34):16866\u201371.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"1965_CR141","doi-asserted-by":"publisher","first-page":"R1271","DOI":"10.1152\/ajpregu.00472.2006","volume":"292","author":"MA Tarnopolsky","year":"2007","unstructured":"Tarnopolsky MA, Rennie CD, Robertshaw HA, Fedak-Tarnopolsky SN, Devries MC, Hamadeh MJ. Influence of endurance exercise training and sex on intramyocellular lipid and mitochondrial ultrastructure, substrate use, and mitochondrial enzyme activity. Am J Physiol Regul Integr Comp Physiol. 2007;292(3):R1271\u20138.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"5","key":"1965_CR142","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.bbamcr.2015.01.020","volume":"1853","author":"J Yu","year":"2015","unstructured":"Yu J, Zhang S, Cui L, Wang W, Na H, Zhu X, et al. Lipid droplet remodeling and interaction with mitochondria in mouse brown adipose tissue during cold treatment. Biochim Biophys Acta. 2015;1853(5):918\u201328.","journal-title":"Biochim Biophys Acta"}],"container-title":["Diabetology &amp; Metabolic Syndrome"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13098-025-01965-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13098-025-01965-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13098-025-01965-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:04:53Z","timestamp":1760526293000},"score":1,"resource":{"primary":{"URL":"https:\/\/dmsjournal.biomedcentral.com\/articles\/10.1186\/s13098-025-01965-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,15]]},"references-count":142,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1965"],"URL":"https:\/\/doi.org\/10.1186\/s13098-025-01965-5","relation":{},"ISSN":["1758-5996"],"issn-type":[{"value":"1758-5996","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,15]]},"assertion":[{"value":"19 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":".","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"392"}}