{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T13:14:46Z","timestamp":1766150086956,"version":"3.48.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetol Metab Syndr"],"DOI":"10.1186\/s13098-025-02017-8","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T13:12:30Z","timestamp":1766149950000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LncRNA NBR2 affects pancreatic \u03b2-cell function in type 2 diabetes mellitus by targeting miR-646"],"prefix":"10.1186","volume":"17","author":[{"given":"Mengmeng","family":"Pu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linling","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junli","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianjun","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"issue":"9","key":"2017_CR1","doi-asserted-by":"publisher","first-page":"640","DOI":"10.7326\/M18-0222","volume":"168","author":"JJ Chamberlain","year":"2018","unstructured":"Chamberlain JJ, Johnson EL, Leal S, Rhinehart AS, Shubrook JH, Peterson L. Cardiovascular disease and risk management: review of the American Diabetes Association standards of medical care in diabetes 2018. Ann Intern Med. 2018;168(9):640\u201350.","journal-title":"Ann Intern Med"},{"issue":"6","key":"2017_CR2","doi-asserted-by":"publisher","first-page":"3661","DOI":"10.1016\/j.clnu.2021.04.029","volume":"40","author":"Z Wan","year":"2021","unstructured":"Wan Z, Song L, Hu L, Lei X, Huang Y, Lv Y, et al. The role of systemic inflammation in the association between serum 25-hydroxyvitamin D and type 2 diabetes mellitus. Clin Nutr. 2021;40(6):3661\u20137.","journal-title":"Clin Nutr"},{"key":"2017_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108078","volume":"162","author":"A Sinclair","year":"2020","unstructured":"Sinclair A, Saeedi P, Kaundal A, Karuranga S, Malanda B, Williams R. Diabetes and global ageing among 65-99-year-old adults: findings from the international diabetes federation diabetes atlas, 9(th) edition. Diabetes Res Clin Pract. 2020;162:108078.","journal-title":"Diabetes Res Clin Pract"},{"issue":"2","key":"2017_CR4","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1007\/s40200-021-00899-9","volume":"20","author":"A Okamoto","year":"2021","unstructured":"Okamoto A, Yokokawa H, Nagamine T, Fukuda H, Hisaoka T, Naito T. Efficacy and safety of semaglutide in glycemic control, body weight management, lipid profiles and other biomarkers among obese type 2 diabetes patients initiated or switched to semaglutide from other GLP-1 receptor agonists. J Diabetes Metab Disord. 2021;20(2):2121\u20138.","journal-title":"J Diabetes Metab Disord"},{"issue":"4","key":"2017_CR5","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.cmet.2017.03.015","volume":"25","author":"C Aguayo-Mazzucato","year":"2017","unstructured":"Aguayo-Mazzucato C, van Haaren M, Mruk M, Lee TB Jr., Crawford C, Hollister-Lock J, et al. Beta cell aging markers have heterogeneous distribution and are induced by insulin resistance. Cell Metab. 2017;25(4):898\u2013910. e5.","journal-title":"Cell Metab"},{"issue":"3","key":"2017_CR6","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1055\/a-1247-4978","volume":"130","author":"Z Cao","year":"2022","unstructured":"Cao Z, Yao F, Lang Y, Feng X, Elevated Circulating. LINC-P21 serves as a diagnostic biomarker of type 2 diabetes mellitus and regulates pancreatic beta-cell function by sponging miR-766-3p to upregulate NR3C2. Exp Clin Endocrinol Diabetes. 2022;130(3):156\u201364.","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"1","key":"2017_CR7","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12880-5","volume":"10","author":"A Ardestani","year":"2019","unstructured":"Ardestani A, Li S, Annamalai K, Lupse B, Geravandi S, Dobrowolski A, et al. Neratinib protects pancreatic beta cells in diabetes. Nat Commun. 2019;10(1):5015.","journal-title":"Nat Commun"},{"issue":"6","key":"2017_CR8","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1007\/s10517-022-05473-8","volume":"172","author":"OI Brovkina","year":"2022","unstructured":"Brovkina OI, Pronina IV, Burdennyy AM, Uroshlev LA, Filippova EA, Fridman MV, et al. The role of long non-coding RNA CCAT1 and SNHG14 in activation of some protein-coding genes associated with the development of ovarian cancer. Bull Exp Biol Med. 2022;172(6):760\u20134.","journal-title":"Bull Exp Biol Med"},{"key":"2017_CR9","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/978-1-4939-6716-2_10","volume":"1543","author":"M Magistri","year":"2017","unstructured":"Magistri M, Velmeshev D. Identification of long noncoding RNAs associated to human disease susceptibility. Methods Mol Biol. 2017;1543:197\u2013208.","journal-title":"Methods Mol Biol"},{"key":"2017_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00200","volume":"5","author":"V Kameswaran","year":"2014","unstructured":"Kameswaran V, Kaestner KH. The missing lnc(RNA) between the pancreatic beta-cell and diabetes. Front Genet. 2014;5:200.","journal-title":"Front Genet"},{"issue":"8","key":"2017_CR11","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.2337\/dbi18-0001","volume":"67","author":"RA Singer","year":"2018","unstructured":"Singer RA, Sussel L. Islet long noncoding rnas: a playbook for discovery and characterization. Diabetes. 2018;67(8):1461\u201370.","journal-title":"Diabetes"},{"issue":"1","key":"2017_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/s40246-018-0173-3","volume":"12","author":"C Sathishkumar","year":"2018","unstructured":"Sathishkumar C, Prabu P, Mohan V, Balasubramanyam M. Linking a role of LncRNAs (long non-coding RNAs) with insulin resistance, accelerated senescence, and inflammation in patients with type 2 diabetes. Hum Genomics. 2018;12(1):41.","journal-title":"Hum Genomics"},{"issue":"24","key":"2017_CR13","doi-asserted-by":"publisher","first-page":"3471","DOI":"10.1080\/15384101.2016.1249545","volume":"15","author":"X Liu","year":"2016","unstructured":"Liu X, Gan B. LncRNA NBR2 modulates cancer cell sensitivity to phenformin through GLUT1. Cell Cycle. 2016;15(24):3471\u201381.","journal-title":"Cell Cycle"},{"issue":"5","key":"2017_CR14","doi-asserted-by":"publisher","first-page":"13667","DOI":"10.1080\/21655979.2022.2062527","volume":"13","author":"C Zhu","year":"2022","unstructured":"Zhu C, Wang M, Yu X, Shui X, Tang L, Chen Z, et al. LncRNA NBR2 attenuates angiotensin II-induced myocardial hypertrophy through repressing ER stress via activating LKB1\/AMPK\/Sirt1 pathway. Bioengineered. 2022;13(5):13667\u201379.","journal-title":"Bioengineered"},{"issue":"1","key":"2017_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/s13062-023-00392-8","volume":"18","author":"L Kan","year":"2023","unstructured":"Kan L, Yang M, Zhang H. Long noncoding RNA PSMA3-AS1 functions as a competing endogenous RNA to promote gastric cancer progression by regulating the miR-329-3p\/ALDOA axis. Biol Direct. 2023;18(1):36.","journal-title":"Biol Direct"},{"issue":"11","key":"2017_CR16","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1080\/02713683.2022.2110264","volume":"47","author":"H Cao","year":"2022","unstructured":"Cao H, Xu X, Wang K, Li C. Down-regulation of circCOL1A2 suppresses the dysfunction of Diabetes-Related retinal microvascular endothelial cells via miR-646\/FGF7 axis. Curr Eye Res. 2022;47(11):1525\u201333.","journal-title":"Curr Eye Res"},{"key":"2017_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2020.559267","volume":"7","author":"Y Luo","year":"2020","unstructured":"Luo Y, Guo J, Xu P, Gui R. Long non-coding RNA GAS5 maintains insulin secretion by regulating multiple miRNAs in INS-1 832\/13 cells. Front Mol Biosci. 2020;7:559267.","journal-title":"Front Mol Biosci"},{"issue":"10","key":"2017_CR18","first-page":"11316","volume":"13","author":"Q Chen","year":"2021","unstructured":"Chen Q, He Y, Wang X, Zhu Y, Huang Y, Cao J, et al. LncRNA PTGS2 regulates islet beta-cell function through the miR-146a-5p\/RBP4 axis and its diagnostic value in type 2 diabetes mellitus. Am J Transl Res. 2021;13(10):11316\u201328.","journal-title":"Am J Transl Res"},{"issue":"9","key":"2017_CR20","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1055\/a-2077-5177","volume":"55","author":"L Liu","year":"2023","unstructured":"Liu L, Li Y, Zhang X. LncRNA LINC01018 screens type 2 diabetes mellitus and regulates beta cell function through modulating miR-499a-5p. Horm Metab Res. 2023;55(9):642\u20138.","journal-title":"Horm Metab Res"},{"key":"2017_CR21","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4010764","volume":"2019","author":"X Kong","year":"2019","unstructured":"Kong X, Liu CX, Wang GD, Yang H, Yao XM, Hua Q, et al. LncRNA LEGLTBC functions as a CeRNA to antagonize the effects of miR-34a on the downregulation of SIRT1 in glucolipotoxicity-induced INS-1 beta cell oxidative stress and apoptosis. Oxid Med Cell Longev. 2019;2019:4010764.","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"2017_CR22","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.bbrc.2019.09.001","volume":"519","author":"H Qi","year":"2019","unstructured":"Qi H, Yao L, Liu Q. Microrna-96 regulates pancreatic beta cell function under the pathological condition of diabetes mellitus through targeting Foxo1 and Sox6. Biochem Biophys Res Commun. 2019;519(2):294\u2013301.","journal-title":"Biochem Biophys Res Commun"},{"key":"2017_CR23","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.2147\/DMSO.S369012","volume":"15","author":"A Aladel","year":"2022","unstructured":"Aladel A, Verma AK, Dabeer S, Ahmad I, Alshahrani MY, AboHassan MS, et al. Association of LncRNA LINC01173 expression with vitamin-D and vitamin B12 level among type 2 diabetes patients. Diabetes Metab Syndr Obes. 2022;15:2535\u201343.","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"9","key":"2017_CR24","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-019-1196-4","volume":"19","author":"AA Christensen","year":"2019","unstructured":"Christensen AA, Gannon M. The beta cell in type 2 diabetes. Curr Diab Rep. 2019;19(9):81.","journal-title":"Curr Diab Rep"},{"issue":"7","key":"2017_CR25","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/s41574-020-0355-7","volume":"16","author":"DL Eizirik","year":"2020","unstructured":"Eizirik DL, Pasquali L, Cnop M. Pancreatic beta-cells in type 1 and type 2 diabetes mellitus: different pathways to failure. Nat Rev Endocrinol. 2020;16(7):349\u201362.","journal-title":"Nat Rev Endocrinol"},{"key":"2017_CR26","doi-asserted-by":"publisher","first-page":"720866","DOI":"10.3389\/fphar.2021.720866","volume":"12","author":"X Lv","year":"2021","unstructured":"Lv X, Zhao Y, Yang X, Han H, Ge Y, Zhang M, et al. Berberine potentiates insulin secretion and prevents beta-cell dysfunction through the miR-204\/SIRT1 signaling pathway. Front Pharmacol. 2021;12:720866.","journal-title":"Front Pharmacol"},{"issue":"1","key":"2017_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-024-01755-6","volume":"24","author":"T Xu","year":"2024","unstructured":"Xu T, Shen T, Yang S, Li Y, Liu L, Du L. Clinical significance of circulating long non-coding RNA SNHG1 in type 2 diabetes mellitus and its association with cell proliferation of pancreatic beta-cell. BMC Endocr Disord. 2024;24(1):225.","journal-title":"BMC Endocr Disord"},{"issue":"2","key":"2017_CR28","first-page":"646","volume":"13","author":"J Wang","year":"2021","unstructured":"Wang J, Zhao Y, Tang Y, Li F, Chen X. The role of lncRNA-MEG\/miR-21-5p\/PDCD4 axis in spinal cord injury. Am J Transl Res. 2021;13(2):646\u201358.","journal-title":"Am J Transl Res"},{"issue":"3","key":"2017_CR29","doi-asserted-by":"publisher","first-page":"383","DOI":"10.23876\/j.krcp.21.015","volume":"40","author":"NJ Cho","year":"2021","unstructured":"Cho NJ, Kim DY, Kwon SH, Ha TW, Kim HK, Lee MR, et al. Urinary exosomal microRNA profiling in type 2 diabetes patients taking dipeptidyl peptidase-4 inhibitor compared with sulfonylurea. Kidney Res Clin Pract. 2021;40(3):383\u201391.","journal-title":"Kidney Res Clin Pract"},{"key":"2017_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.144654","volume":"747","author":"H Sun","year":"2020","unstructured":"Sun H, Kang X. Hsa_circ_0041795 contributes to human retinal pigment epithelial cells (ARPE 19) injury induced by high glucose via sponging miR-646 and activating VEGFC. Gene. 2020;747:144654.","journal-title":"Gene"},{"issue":"3","key":"2017_CR31","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1177\/11206721211020200","volume":"32","author":"Q Zeng","year":"2022","unstructured":"Zeng Q, Luo Y, Fang J, Xu S, Hu YH, Yin M. Circ_0000615 promotes high glucose-induced human retinal pigment epithelium cell apoptosis, inflammation and oxidative stress via miR-646\/YAP1 axis in diabetic retinopathy. Eur J Ophthalmol. 2022;32(3):1584\u201395.","journal-title":"Eur J Ophthalmol"}],"container-title":["Diabetology & Metabolic Syndrome"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13098-025-02017-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13098-025-02017-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13098-025-02017-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T13:12:31Z","timestamp":1766149951000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13098-025-02017-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2017"],"URL":"https:\/\/doi.org\/10.1186\/s13098-025-02017-8","relation":{},"ISSN":["1758-5996"],"issn-type":[{"value":"1758-5996","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,19]]},"assertion":[{"value":"21 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by The Ethics Committee of Yantai Yantaishan Hospital. All procedures performed in studies involving human participants were in accordance with the 1964 Helsinki Declaration and later versions.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}],"article-number":"454"}}