{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:57:00Z","timestamp":1793163420346,"version":"4.5.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Zhejiang Traditional Medicine and Technology Program","award":["2024ZR114"],"award-info":[{"award-number":["2024ZR114"]}]},{"name":"Hangzhou Municipal Health Commission Project","award":["A20231278"],"award-info":[{"award-number":["A20231278"]}]},{"name":"Zhejiang Province Medical and Health Technology Plan Project","award":["2024KY219"],"award-info":[{"award-number":["2024KY219"]}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["82505280"],"award-info":[{"award-number":["82505280"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetol Metab Syndr"],"DOI":"10.1186\/s13098-026-02085-4","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T11:46:15Z","timestamp":1768304775000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Celastrol mitigates diabetic kidney disease by inhibiting ferroptosis via the SIRT1\/NRF2\/GPX4 pathway"],"prefix":"10.1186","volume":"18","author":[{"given":"Yue-wen","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-jiao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-wei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-ya","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru-chun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"issue":"12","key":"2085_CR1","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.2215\/CJN.11491116","volume":"12","author":"RZ Alicic","year":"2017","unstructured":"Alicic RZ, Rooney MT, Tuttle KR. Diabetic kidney disease: challenges, progress, and possibilities. Clin J Am Soc Nephrology: CJASN. 2017;12(12):2032\u201345.","journal-title":"Clin J Am Soc Nephrology: CJASN"},{"issue":"2","key":"2085_CR2","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.kint.2022.05.012","volume":"102","author":"KR Tuttle","year":"2022","unstructured":"Tuttle KR, Agarwal R, Alpers CE, Bakris GL, Brosius FC, Kolkhof P, Uribarri J. Molecular mechanisms and therapeutic targets for diabetic kidney disease. Kidney Int. 2022;102(2):248\u201360.","journal-title":"Kidney Int"},{"issue":"4","key":"2085_CR3","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.mcna.2023.03.004","volume":"107","author":"S Gupta","year":"2023","unstructured":"Gupta S, Dominguez M, Golestaneh L. Diabetic kidney disease: an update. Med Clin North Am. 2023;107(4):689\u2013705.","journal-title":"Med Clin North Am"},{"issue":"6","key":"2085_CR4","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","volume":"25","author":"SJ Dixon","year":"2024","unstructured":"Dixon SJ, Olzmann JA. The cell biology of ferroptosis. Nat Rev Mol Cell Biol. 2024;25(6):424\u201342.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"2085_CR5","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"X Jiang","year":"2021","unstructured":"Jiang X, Stockwell BR, Conrad M. Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol. 2021;22(4):266\u201382.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"35","key":"2085_CR6","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202300379","volume":"62","author":"F Zeng","year":"2023","unstructured":"Zeng F, Nijiati S, Tang L, Ye J, Zhou Z, Chen X. Ferroptosis detection: from approaches to applications. Angew Chem Int Ed Engl. 2023;62(35):e202300379.","journal-title":"Angew Chem Int Ed Engl"},{"key":"2085_CR7","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.freeradbiomed.2022.01.012","volume":"180","author":"GH Chen","year":"2022","unstructured":"Chen GH, Song CC, Pantopoulos K, Wei XL, Zheng H, Luo Z. Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway. Free Radic Biol Med. 2022;180:95\u2013107.","journal-title":"Free Radic Biol Med"},{"issue":"10","key":"2085_CR8","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.18399","volume":"28","author":"K Li","year":"2024","unstructured":"Li K, Fan C, Chen J, Xu X, Lu C, Shao H, et al. Role of oxidative stress-induced ferroptosis in cancer therapy. J Cell Mol Med. 2024;28(10):e18399.","journal-title":"J Cell Mol Med"},{"issue":"12","key":"2085_CR9","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1089\/ars.2016.6664","volume":"25","author":"JC Jha","year":"2016","unstructured":"Jha JC, Banal C, Chow BS, Cooper ME, Jandeleit-Dahm K. Diabetes and kidney disease: role of oxidative stress. Antioxid Redox Signal. 2016;25(12):657\u201384.","journal-title":"Antioxid Redox Signal"},{"issue":"15","key":"2085_CR10","doi-asserted-by":"publisher","first-page":"5348","DOI":"10.7150\/thno.87416","volume":"13","author":"Y Fan","year":"2023","unstructured":"Fan Y, Yuan Y, Xiong M, Jin M, Zhang D, Yang D, Liu C, Petersen RB, Huang K, Peng A, et al. Tet1 deficiency exacerbates oxidative stress in acute kidney injury by regulating superoxide dismutase. Theranostics. 2023;13(15):5348\u201364.","journal-title":"Theranostics"},{"key":"2085_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2024.101279","volume":"97","author":"K Muzammil","year":"2024","unstructured":"Muzammil K, Sabah Ghnim Z, Saeed Gataa I, Fawzi Al-Hussainy A, Ali Soud N, Adil M, et al. NRF2-mediated regulation of lipid pathways in viral infection. Mol Aspects Med. 2024;97:101279.","journal-title":"Mol Aspects Med"},{"key":"2085_CR12","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","volume":"53","author":"Q Ma","year":"2013","unstructured":"Ma Q. Role of NRF2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol. 2013;53:401\u201326.","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"2085_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116512","volume":"174","author":"W Zhang","year":"2024","unstructured":"Zhang W, Liu Y, Liao Y, Zhu C, Zou Z. GPX4, ferroptosis, and diseases. Biomed pharmacotherapy = Biomedecine Pharmacotherapie. 2024;174:116512.","journal-title":"Biomed pharmacotherapy = Biomedecine Pharmacotherapie"},{"key":"2085_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2024.110944","volume":"393","author":"W Zhao","year":"2024","unstructured":"Zhao W, Nikolic-Paterson DJ, Li K, Li Y, Wang Y, Chen X, et al. Selenium binding protein 1 protects renal tubular epithelial cells from ferroptosis by upregulating glutathione peroxidase 4. Chemico-Biological Interactions. 2024;393:110944.","journal-title":"Chemico-Biological Interactions"},{"key":"2085_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103417","volume":"78","author":"Q Zheng","year":"2024","unstructured":"Zheng Q, Xing J, Li X, Tang X, Zhang D. PRDM16 suppresses ferroptosis to protect against sepsis-associated acute kidney injury by targeting the NRF2\/GPX4 axis. Redox Biol. 2024;78:103417.","journal-title":"Redox Biol"},{"key":"2085_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.133307","volume":"465","author":"B Dong","year":"2024","unstructured":"Dong B, Jiang Y, Shi B, Zhang Z, Zhang Z. Selenomethionine alleviates Decabromodiphenyl ether-induced oxidative stress and ferroptosis via the NRF2\/GPX4 pathway in the chicken brain. J Hazard Mater. 2024;465:133307.","journal-title":"J Hazard Mater"},{"key":"2085_CR17","doi-asserted-by":"crossref","unstructured":"Wang L, Zhang X, Xiong X, Zhu H, Chen R, Zhang S, et al. Nrf2 regulates oxidative stress and its role in cerebral ischemic stroke. Antioxidants. 2022; 11(12):2377.","DOI":"10.3390\/antiox11122377"},{"issue":"14","key":"2085_CR18","doi-asserted-by":"publisher","first-page":"5510","DOI":"10.7150\/ijbs.99592","volume":"20","author":"Y Zhu","year":"2024","unstructured":"Zhu Y, Meng Y, Zhang J, Liu R, Shen S, Gu L, et al. Recent trends in anti-tumor mechanisms and molecular targets of Celastrol. Int J Biol Sci. 2024;20(14):5510\u201330.","journal-title":"Int J Biol Sci"},{"issue":"4","key":"2085_CR19","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1002\/ptr.6314","volume":"33","author":"M Zhang","year":"2019","unstructured":"Zhang M, Chen Y, Yang MJ, Fan XR, Xie H, Zhang L, Nie YS, Yan M. Celastrol attenuates renal injury in diabetic rats via MAPK\/NF-\u03baB pathway. Phytother Res. 2019;33(4):1191\u20138.","journal-title":"Phytother Res"},{"issue":"1","key":"2085_CR20","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1186\/s12906-020-03050-y","volume":"20","author":"Y Nie","year":"2020","unstructured":"Nie Y, Fu C, Zhang H, Zhang M, Xie H, Tong X, Li Y, Hou Z, Fan X, Yan M. Celastrol slows the progression of early diabetic nephropathy in rats via the PI3K\/AKT pathway. BMC Complement Med Ther. 2020;20(1):321.","journal-title":"BMC Complement Med Ther"},{"key":"2085_CR21","doi-asserted-by":"crossref","unstructured":"Faheem H, Alawadhi R, Basha E, Ismail R, Ibrahim HA, Elshamy AM, Motawea SM, Seleem MA, Elkordy A, Homouda AA et al. Ameliorating Immune-dependent Inflammation and Apoptosis by Targeting TLR4\/MYD88\/NF-\u03baB Pathway by Celastrol Mitigates the Diabetic Reproductive Dysfunction. Physiological genomics 2025;53(7):103-114.","DOI":"10.1152\/physiolgenomics.00072.2024"},{"key":"2085_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110584","volume":"122","author":"Y Tang","year":"2023","unstructured":"Tang Y, Wan F, Tang X, Lin Y, Zhang H, Cao J, et al. Celastrol attenuates diabetic nephropathy by upregulating SIRT1-mediated inhibition of EZH2related wnt\/\u03b2-catenin signaling. Int Immunopharmacol. 2023;122:110584.","journal-title":"Int Immunopharmacol"},{"key":"2085_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115333","volume":"166","author":"M Pan","year":"2023","unstructured":"Pan M, Wang Z, Wang Y, Jiang X, Fan Y, Gong F, et al. Celastrol alleviated acute kidney injury by inhibition of ferroptosis through Nrf2\/GPX4 pathway. Biomed Pharmacother. 2023;166:115333.","journal-title":"Biomed Pharmacother"},{"issue":"21","key":"2085_CR24","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1177\/15353702221118087","volume":"247","author":"YW Tang","year":"2022","unstructured":"Tang YW, Yang RC, Wan F, Tang XL, Zhang HQ, Lin Y. Celastrol attenuates renal injury in 5\/6 nephrectomized rats via inhibiting epithelial-mesenchymal transition and transforming growth factor-\u03b21\/Smad3 pathway. Experimental Biology Med (Maywood NJ). 2022;247(21):1947\u201355.","journal-title":"Experimental Biology Med (Maywood NJ)"},{"key":"2085_CR25","doi-asserted-by":"crossref","unstructured":"Mathew AV, Kayampilly P, Byun J, Nair V, Afshinnia F, Chai B, et al. Tubular dysfunction impairs renal excretion of Pseudouridine in diabetic kidney disease. Am J Physiol-Ren Physiol. 2024;326(1):F30-8.","DOI":"10.1152\/ajprenal.00252.2022"},{"issue":"7","key":"2085_CR26","first-page":"5987","volume":"16","author":"C Hou","year":"2024","unstructured":"Hou C, Zhong B, Gu S, Wang Y, Ji L. Identification and validation of the biomarkers related to ferroptosis in calcium oxalate nephrolithiasis. Aging. 2024;16(7):5987\u20136007.","journal-title":"Aging"},{"issue":"1","key":"2085_CR27","doi-asserted-by":"publisher","first-page":"e21198","DOI":"10.1096\/fj.202001138RR","volume":"35","author":"Y Jiang","year":"2021","unstructured":"Jiang Y, Xie F, Lv X, Wang S, Liao X, Yu Y, Dai Q, Zhang Y, Meng J, Hu G, et al. Mefunidone ameliorates diabetic kidney disease in STZ and db\/db mice. FASEB Journal: Official Publication Federation Am Soc Experimental Biology. 2021;35(1):e21198.","journal-title":"FASEB Journal: Official Publication Federation Am Soc Experimental Biology"},{"issue":"1","key":"2085_CR28","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2024.2343817","volume":"46","author":"J Song","year":"2024","unstructured":"Song J, Chen Y, Chen Y, Qiu M, Xiang W, Ke B, et al. DKK3 promotes renal fibrosis by increasing MFF-mediated mitochondrial dysfunction in Wnt\/\u03b2-catenin pathway-dependent manner. Ren Fail. 2024;46(1):2343817.","journal-title":"Ren Fail"},{"issue":"4","key":"2085_CR29","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta delta C(T)) method. Methods San Diego Calif. 2001;25(4):402\u20138.","journal-title":"Methods San Diego Calif"},{"issue":"4","key":"2085_CR30","doi-asserted-by":"publisher","first-page":"115","DOI":"10.15586\/aei.v50i4.623","volume":"50","author":"W Peipei","year":"2022","unstructured":"Peipei W, Ping W, Miaomiao Y, Shuo W. Sevoflurane ameliorates LPS-induced inflammatory injury of HK-2 cells through Sirtuin1\/NF-\u03baB pathway. Allergol Immunopathol Madr. 2022;50(4):115\u201323.","journal-title":"Allergol Immunopathol Madr"},{"issue":"2","key":"2085_CR31","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1056\/NEJMe2406408","volume":"391","author":"WG Herrington","year":"2024","unstructured":"Herrington WG, Haynes R. Diabetic kidney disease - Semaglutide flows into the mainstream. N Engl J Med. 2024;391(2):178\u20139.","journal-title":"N Engl J Med"},{"issue":"1","key":"2085_CR32","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-025-06074-5","volume":"23","author":"Z Zhu","year":"2025","unstructured":"Zhu Z, Luan G, Wu S, Song Y, Shen S, Wu K, et al. Single-cell atlas reveals multi-faced responses of Losartan on tubular mitochondria in diabetic kidney disease. J Transl Med. 2025;23(1):90.","journal-title":"J Transl Med"},{"key":"2085_CR33","doi-asserted-by":"crossref","unstructured":"Garofalo C, Borrelli S, Liberti ME, Andreucci M, Conte G, Minutolo R, et al. SGLT2 inhibitors: nephroprotective efficacy and side effects. Medicina (Kaunas, Lithuania). 2019;55(6):268.","DOI":"10.3390\/medicina55060268"},{"key":"2085_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112794","volume":"141","author":"J Liu","year":"2024","unstructured":"Liu J, Yang K, Zhou L, Deng J, Rong G, Shi L, et al. A new strategy for Astragaloside IV in the treatment of diabetic kidney disease: analyzing the regulation of ferroptosis and mitochondrial function of renal tubular epithelial cells. Int Immunopharmacol. 2024;141:112794.","journal-title":"Int Immunopharmacol"},{"issue":"7","key":"2085_CR35","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1007\/s40618-023-02267-1","volume":"47","author":"C Liu","year":"2024","unstructured":"Liu C, Zhong M, Jin X, Zhu J, Cheng Y, Li L, et al. Sleeve gastrectomy links the attenuation of diabetic kidney disease to the inhibition of renal tubular ferroptosis through down-regulating TGF-\u03b21\/Smad3 signaling pathway. J Endocrinol Invest. 2024;47(7):1763\u201376.","journal-title":"J Endocrinol Invest"},{"issue":"1","key":"2085_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-00931-8","volume":"8","author":"J Wang","year":"2022","unstructured":"Wang J, Wang Y, Liu Y, Cai X, Huang X, Fu W, et al. Ferroptosis, a new target for treatment of renal injury and fibrosis in a 5\/6 nephrectomy-induced CKD rat model. Cell Death Discov. 2022;8(1):127.","journal-title":"Cell Death Discov"},{"issue":"7","key":"2085_CR37","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/s41589-023-01528-7","volume":"20","author":"Q Zhang","year":"2024","unstructured":"Zhang Q, Sun T, Yu F, Liu W, Gao J, Chen J, et al. PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury. Nat Chem Biol. 2024;20(7):835\u201346.","journal-title":"Nat Chem Biol"},{"key":"2085_CR38","doi-asserted-by":"crossref","unstructured":"Al-Tantawy SM, Eraky SM, Eissa LA. Novel therapeutic target for diabetic kidney disease through downregulation of miRNA-192-5p and miRNA-21-5p by celastrol: implication of autophagy, oxidative stress, and fibrosis. Naunyn Schmiedebergs Arch Pharmacol. 2025;398(6):6915-6928.","DOI":"10.1007\/s00210-024-03669-5"},{"key":"2085_CR39","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.molimm.2018.10.021","volume":"104","author":"X Zhan","year":"2018","unstructured":"Zhan X, Yan C, Chen Y, Wei X, Xiao J, Deng L, Yang Y, Qiu P, Chen Q. Celastrol antagonizes high glucose-evoked podocyte injury, inflammation and insulin resistance by restoring the HO-1-mediated autophagy pathway. Mol Immunol. 2018;104:61\u20138.","journal-title":"Mol Immunol"},{"issue":"4","key":"2085_CR40","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1586\/14779072.2.4.473","volume":"2","author":"N Perico","year":"2004","unstructured":"Perico N, Ruggenenti P, Remuzzi G. Losartan in diabetic nephropathy. Expert Rev Cardiovasc Ther. 2004;2(4):473\u201383.","journal-title":"Expert Rev Cardiovasc Ther"},{"issue":"Pt 2","key":"2085_CR41","doi-asserted-by":"publisher","first-page":"130761","DOI":"10.1016\/j.ijbiomac.2024.130761","volume":"264","author":"Q Jin","year":"2024","unstructured":"Jin Q, Liu T, Ma F, Fu T, Yang L, Mao H, Wang Y, Peng L, Li P, Zhan Y. Roles of Sirt1 and its modulators in diabetic microangiopathy: A review. Int J Biol Macromol. 2024;264(Pt 2):130761.","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"2085_CR42","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-022-00860-0","volume":"20","author":"Y Zheng","year":"2022","unstructured":"Zheng Y, Li L, Chen B, Fang Y, Lin W, Zhang T, et al. Chlorogenic acid exerts neuroprotective effect against hypoxia-ischemia brain injury in neonatal rats by activating Sirt1 to regulate the Nrf2-NF-\u03baB signaling pathway. Cell Commun Signal. 2022;20(1):84.","journal-title":"Cell Commun Signal"},{"issue":"2","key":"2085_CR43","first-page":"193","volume":"25","author":"J Zhang","year":"2022","unstructured":"Zhang J, Zhao X, Zhu H, Wang J, Ma J, Gu M. Crocin protects the renal tubular epithelial cells against high glucose-induced injury and oxidative stress via regulation of the SIRT1\/Nrf2 pathway. Iran J Basic Med Sci. 2022;25(2):193\u20137.","journal-title":"Iran J Basic Med Sci"},{"issue":"9","key":"2085_CR44","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.1002\/tox.23855","volume":"38","author":"M Zhang","year":"2023","unstructured":"Zhang M, Qiang Y. Catalpol ameliorates inflammation and oxidative stress via regulating Sirt1 and activating Nrf2\/HO-1 signaling against acute kidney injury. Environ Toxicol. 2023;38(9):2182\u201391.","journal-title":"Environ Toxicol"},{"key":"2085_CR45","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.857067","volume":"13","author":"Z Qiongyue","year":"2022","unstructured":"Qiongyue Z, Xin Y, Meng P, Sulin M, Yanlin W, Xinyi L, et al. Post-treatment with Irisin attenuates acute kidney injury in sepsis mice through anti-ferroptosis via the SIRT1\/Nrf2 pathway. Front Pharmacol. 2022;13:857067.","journal-title":"Front Pharmacol"},{"issue":"1","key":"2085_CR46","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2024.2327495","volume":"46","author":"L Zhang","year":"2024","unstructured":"Zhang L, Wang X, Chang L, Ren Y, Sui M, Fu Y, et al. Quercetin improves diabetic kidney disease by inhibiting ferroptosis and regulating the Nrf2 in streptozotocin-induced diabetic rats. Ren Fail. 2024;46(1):2327495.","journal-title":"Ren Fail"},{"issue":"1","key":"2085_CR47","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-023-00631-8","volume":"29","author":"L Xu","year":"2023","unstructured":"Xu L, Cai J, Li C, Yang M, Duan T, Zhao Q, et al. 4-octyl Itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling. Mol Med. 2023;29(1):58.","journal-title":"Mol Med"},{"issue":"15","key":"2085_CR48","doi-asserted-by":"publisher","first-page":"3991","DOI":"10.1111\/bph.15834","volume":"179","author":"J Hu","year":"2022","unstructured":"Hu J, Gu W, Ma N, Fan X, Ci X. Leonurine alleviates ferroptosis in cisplatin-induced acute kidney injury by activating the Nrf2 signalling pathway. Br J Pharmacol. 2022;179(15):3991\u20134009.","journal-title":"Br J Pharmacol"},{"issue":"1","key":"2085_CR49","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03362-4","volume":"12","author":"C Chen","year":"2021","unstructured":"Chen C, Wang D, Yu Y, Zhao T, Min N, Wu Y, et al. Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI. Cell Death Dis. 2021;12(1):65.","journal-title":"Cell Death Dis"},{"key":"2085_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114981","volume":"164","author":"J Gu","year":"2023","unstructured":"Gu J, Shi YN, Zhu N, Li HF, Zhang CJ, Qin L. Celastrol functions as an emerging manager of lipid metabolism: mechanism and therapeutic potential. Biomed Pharmacother. 2023;164:114981.","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"2085_CR51","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00834-8","volume":"8","author":"L Guo","year":"2017","unstructured":"Guo L, Luo S, Du Z, Zhou M, Li P, Fu Y, et al. Targeted delivery of Celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis. Nat Commun. 2017;8(1):878.","journal-title":"Nat Commun"},{"key":"2085_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107100","volume":"201","author":"L Huang","year":"2024","unstructured":"Huang L, Huang XH, Yang X, Hu JQ, Zhu YZ, Yan PY, et al. Novel nano-drug delivery system for natural products and their application. Pharmacol Res. 2024;201:107100.","journal-title":"Pharmacol Res"}],"container-title":["Diabetology &amp; Metabolic Syndrome"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13098-026-02085-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13098-026-02085-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13098-026-02085-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T04:20:07Z","timestamp":1776745207000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13098-026-02085-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,13]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2085"],"URL":"https:\/\/doi.org\/10.1186\/s13098-026-02085-4","relation":{},"ISSN":["1758-5996"],"issn-type":[{"value":"1758-5996","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,13]]},"assertion":[{"value":"10 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2026","order":6,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":7,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised: The authors Equal contribution has been added in the article PDF.","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The experiments were conducted in accordance with the guidelines of Zhejiang Chinese Medical University and were approved by the Laboratory Animal Care and Use Committee of Zhejiang Chinese Medical University (Approval No. IACUC-20240401-25). Clinical trial number: not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"55"}}