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It was previously shown that the mycotoxin deoxynivalenol (DON) as well as\n                      <jats:italic>Campylobacter (C.) jejuni<\/jats:italic>\n                      have a negative impact on gut integrity. Recently, it was demonstrated that DON increased the load of\n                      <jats:italic>C. jejuni<\/jats:italic>\n                      in the gut and inner organs. Based on this finding, it was hypothesized the DON metabolite (deepoxy-deoxynivalenol, DOM-1) should be able to reduce the negative effects of DON on colonization and translocation of\n                      <jats:italic>C. jejuni<\/jats:italic>\n                      in broilers, since it lacks the epoxide ring, which is responsible for the toxicity of DON.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 180 broiler chickens were housed in floor pens on wood shavings with feed and water provided ad libitum. Birds were divided into six groups (n\u2009=\u200930 with 5 replicates\/group): 1. Control, 2. DOM-1, 3. DON, 4. DOM-1\u2009+\u2009\n                      <jats:italic>C. jejuni<\/jats:italic>\n                      , 5. DON\u2009+\u2009\n                      <jats:italic>C. jejuni<\/jats:italic>\n                      , 6.\n                      <jats:italic>C. jejuni<\/jats:italic>\n                      . At day 14, birds of groups 4, 5 and 6 were orally inoculated via feeding tube (gavage) with 1-ml of a PBS suspension containing 1\u2009\u00d7\u200910\n                      <jats:sup>8<\/jats:sup>\n                      \u00a0CFU of\n                      <jats:italic>C. jejuni<\/jats:italic>\n                      NCTC 12744. The performance parameters: body weight (BW), body weight gain (BWG), and feed intake of the birds were determined. At 7, 14, and 21\u00a0days post infection, samples from liver, spleen, duodenum, jejunum and cecum were aseptically collected and processed for bacteriological investigations\n                      <jats:italic>.<\/jats:italic>\n                      Finally, at each killing time point, segments of duodenum, jejunum and cecum were harvested and prepared for Ussing chamber studies to measure the paracellular mannitol fluxes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant decrease in body weight was observed for chickens receiving the DON diet with or without\n                      <jats:italic>C. jejuni<\/jats:italic>\n                      compared to the other groups. Furthermore, it was found that the co-exposure of birds to DON and\n                      <jats:italic>C. jejuni<\/jats:italic>\n                      resulted in a higher\n                      <jats:italic>C. jejuni<\/jats:italic>\n                      load not only in the gut but also in liver and spleen due to increased paracellular permeability of the duodenum, jejunum and cecum. On the contrary, DOM-1 supplementation in the feed improved the birds\u2019 performance and led to a better feed conversion ratio throughout the trial. Furthermore, DOM-1 did not negatively affect gut permeability and decreased the\n                      <jats:italic>C. jejuni<\/jats:italic>\n                      counts in the intestine and internal organs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Altogether, the presence of DOM-1 in the feed as a result of the enzymatic biotransformation of DON leads to a lower\n                      <jats:italic>C. jejuni<\/jats:italic>\n                      count in the intestine and better feed conversion ratio. Moreover, this study demonstrates that the detoxification product of DON, DOM-1, does not have negative effects on the gastrointestinal tract and reduces the\n                      <jats:italic>Campylobacter<\/jats:italic>\n                      burden in chickens and also the risk for human infection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13099-021-00440-6","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T04:03:11Z","timestamp":1625284991000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Deepoxy-deoxynivalenol (DOM-1), a derivate of deoxynivalenol (DON), exhibits less toxicity on intestinal barrier function, Campylobacter jejuni colonization and translocation in broiler chickens"],"prefix":"10.1186","volume":"13","author":[{"given":"Daniel","family":"Ruhnau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Hess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Doupovec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Grenier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dian","family":"Schatzmayr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0843-2089","authenticated-orcid":false,"given":"Wageha","family":"Awad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,3]]},"reference":[{"key":"440_CR1","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3390\/toxins10040149","volume":"10","author":"AF Logrieco","year":"2018","unstructured":"Logrieco AF, Miller JD, Eskola M, Krska R, Ayalew A, Bandyopadhyay R, Battilani P, Bhatnagar D, Chulze S, De Saeger S, Li P, Perrone G, Poapolathep A, Rahayu ES, Shephard GS, Stepman F, Zhang H, Leslie JF. 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