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The aim of the present study, was to investigate the hypothesis that streptozotocin (STZ)-induced T1DM in Balb\/c mice when treated with crude polysaccharide from seaweed,\n                    <jats:italic>Dictyopteris divaricata<\/jats:italic>\n                    (CDDP) depicts improvement in diabetes-related symptoms. Treatment with CDDP resulted in decreased body weight loss, improved food consumption and water intake disbalances. The CDDP effectively improved fasting blood glucose, oral glucose tolerance (OGTT), serum insulin, insulin secretion, rejuvenation of \u03b2-cells mass, serum lipid profile and pro-inflammatory cytokines levels. Additionally, treatment with CDDP increased the population of beneficial bacteria such as\n                    <jats:italic>Firmicutes, Bacteroidetes<\/jats:italic>\n                    and\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    at phylum, family and genus levels by 16S rRNA sequencing. Furthermore, immunohistological examination confirmed that CDDP reduces the inflammation and restored the structural morphology of colon and upraised the levels of insulin receptor substrate-1 (IRS\n                    <jats:italic>-<\/jats:italic>\n                    1), Mucin-2 (MUC-2) and tight-junction proteins (TJs) whereby maintaining the gut structures and barrier permeability. Thus, the above presented data, highlights the safe and therapeutic effects of crude polysaccharide (CDDP) from\n                    <jats:italic>D. divaricata<\/jats:italic>\n                    in the treatment and restoration of T1DM disorders and can be used as a food supplement alternative to diabetes medicine.\n                  <\/jats:p>","DOI":"10.1186\/s13099-022-00512-1","type":"journal-article","created":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T03:02:27Z","timestamp":1663383747000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Effect of crude polysaccharide from seaweed, Dictyopteris divaricata (CDDP) on gut microbiota restoration and anti-diabetic activity in streptozotocin (STZ)-induced T1DM mice"],"prefix":"10.1186","volume":"14","author":[{"given":"Nimra Zafar","family":"Siddiqui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ata Ur","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed","family":"Yousuf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif Iqbal","family":"khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabeel Ahmed","family":"Farooqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizhu","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,17]]},"reference":[{"issue":"1","key":"512_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1472-6882-13-267","volume":"13","author":"J Hu","year":"2013","unstructured":"Hu J, Pang W, Bai S, Zheng Z, Wu X. 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