{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:23:12Z","timestamp":1790889792644,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gut Pathog"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Recently, the oral oncobacterium <jats:italic>Fusobacterium nucleatum<\/jats:italic> (<jats:italic>F. nucleatum<\/jats:italic>), has been linked with ulcerative colitis (UC). Here, we aim to investigate whether Fecal Microbiota Transplantation (FMT) can alleviate UC by restoring gut microbiota and eliminating oral-derived <jats:italic>F. nucleatum<\/jats:italic>\u00a0and virulence factor <jats:italic>fadA<\/jats:italic>.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Method<\/jats:title>\n                <jats:p>C57BL\/6J mice were randomly divided into a healthy control group (HC), Dextran Sulfate Sodium group (DSS), oral inoculation group (OR), upper FMT group (UFMT), and lower FMT group (LFMT). Disease activity index, body weight, survival rate, and histopathological scores were used to measure the severity of colitis. The function of the intestinal mucosal barrier was evaluated by performing immunohistochemical staining of the tight junction protein Occludin. Real-time PCR was used to assess the relative abundance of the <jats:italic>nusG<\/jats:italic> gene and the virulence gene <jats:italic>fadA<\/jats:italic>. Cytokine levels were detected by ELISA. Full-length sequencing of 16S rRNA was used to analyze the changes and composition of gut microbiota.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Findings<\/jats:title>\n                <jats:p>Oral incubation of <jats:italic>F. nucleatum<\/jats:italic> further exacerbated the severity of colitis and gut dysbiosis. <jats:italic>Peptostreptococcaceae<\/jats:italic>, <jats:italic>Enterococcaceae<\/jats:italic>, and <jats:italic>Escherichia coli<\/jats:italic> were significantly enriched in OR mice. However, LFMT mice showed an obvious decrease in disease activity and were more effective in restoring gut microbiota and eliminating <jats:italic>F. nucleatum<\/jats:italic> than UFMT mice. <jats:italic>Bacteroidota<\/jats:italic>, <jats:italic>Lachnospiraceae<\/jats:italic>, and <jats:italic>Prevotellaceae<\/jats:italic> were mainly enriched bacteria in LFMT mice. In addition, Genera such as <jats:italic>Lactobacillus<\/jats:italic>, <jats:italic>Allobaculum<\/jats:italic>, and <jats:italic>Bacteroidales<\/jats:italic> were found negative correlation with TNF-\u03b1, IL-1\u03b2, and IL-6. Genera like <jats:italic>Romboutsia<\/jats:italic>, <jats:italic>Escherichia Shigella<\/jats:italic>, <jats:italic>Enterococcus<\/jats:italic>, and <jats:italic>Clostridium<\/jats:italic> were found positively correlated with TNF-\u03b1, IL-1\u03b2, and IL-6.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Oral incubation of <jats:italic>F. nucleatum<\/jats:italic> further exacerbates the severity and dysbiosis in DSS-induced colitis mice. Besides, lower tract FMT can ameliorate colitis by restoring the gut microbiota diversity and eliminating <jats:italic>F. nucleatum<\/jats:italic> and virulence factor\u00a0<jats:italic>fadA<\/jats:italic>.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13099-024-00633-9","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T14:02:42Z","timestamp":1723125762000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Lower fecal microbiota transplantation ameliorates ulcerative colitis by eliminating oral-derived Fusobacterium nucleatum and virulence factor"],"prefix":"10.1186","volume":"16","author":[{"given":"Dong-Hao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zong-Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shou-Bin","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"issue":"10401","key":"633_CR1","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","volume":"402","author":"C Le Berre","year":"2023","unstructured":"Le Berre C, Honap S, Peyrin-Biroulet L. 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