{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:52:40Z","timestamp":1793145160463,"version":"4.5.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Shanghai Natural Science Foundation Project","award":["22ZR1453500"],"award-info":[{"award-number":["22ZR1453500"]}]},{"name":"the Jiading District Natural Science Foundation Project","award":["JDKW-2022-0042"],"award-info":[{"award-number":["JDKW-2022-0042"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gut Pathog"],"DOI":"10.1186\/s13099-024-00675-z","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T12:24:19Z","timestamp":1736339059000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Profile of intestinal fungal microbiota in acute pancreatitis patients and healthy individuals"],"prefix":"10.1186","volume":"17","author":[{"given":"Meng-Qi","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao-Yan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Yan","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Ying","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao-Li","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"issue":"1","key":"675_CR1","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1136\/gutjnl-2012-302779","volume":"62","author":"PA Banks","year":"2013","unstructured":"Banks PA, Bollen TL, Dervenis C, et al. Acute Pancreatitis classification Working Group. Classification of acute pancreatitis\u20132012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013;62(1):102\u201311.","journal-title":"Gut"},{"issue":"11","key":"675_CR2","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1136\/gutjnl-2016-313595","volume":"66","author":"SM Van Dijk","year":"2017","unstructured":"Van Dijk SM, Hallensleben NDL, van Santvoort HC, et al. Dutch Pancreatitis Study Group. Acute pancreatitis: recent advances through randomised trials. Gut. 2017;66(11):2024\u201332.","journal-title":"Gut"},{"key":"675_CR3","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1097\/MCG.0b013e3182652096","volume":"46","author":"G Capurso","year":"2012","unstructured":"Capurso G, Zerboni G, Signoretti M, et al. Role of the gut barrier in acute pancreatitis. J Clin Gastroenterol. 2012;46:46\u201351.","journal-title":"J Clin Gastroenterol"},{"issue":"18","key":"675_CR4","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.3748\/wjg.v26.i18.2187","volume":"26","author":"XY Li","year":"2020","unstructured":"Li XY, He C, Zhu Y, et al. Role of gut microbiota on intestinal barrier function in acute pancreatitis. World J Gastroenterol. 2020;26(18):2187\u201393.","journal-title":"World J Gastroenterol"},{"issue":"4","key":"675_CR5","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1053\/j.gastro.2022.06.038","volume":"163","author":"Y Lin","year":"2022","unstructured":"Lin Y, Lau HC, Liu Y, et al. Altered mycobiota signatures and enriched pathogenic aspergillus rambellii are Associated with Colorectal Cancer based on Multicohort Fecal metagenomic analyses. Gastroenterology. 2022;163(4):908\u201321.","journal-title":"Gastroenterology"},{"issue":"7777","key":"675_CR6","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/s41586-019-1608-2","volume":"574","author":"B Aykut","year":"2019","unstructured":"Aykut B, Pushalkar S, Chen R, et al. The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL. Nature. 2019;574(7777):264\u20137.","journal-title":"Nature"},{"key":"675_CR7","doi-asserted-by":"publisher","first-page":"1127369","DOI":"10.3389\/fcimb.2023.1127369","volume":"13","author":"X Hu","year":"2023","unstructured":"Hu X, Han Z, Zhou R, et al. Altered gut microbiota in the early stage of acute pancreatitis were related to the occurrence of acute respiratory distress syndrome. Front Cell Infect Microbiol. 2023;13:1127369.","journal-title":"Front Cell Infect Microbiol"},{"issue":"4","key":"675_CR8","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s00535-018-1529-0","volume":"54","author":"Y Zhu","year":"2019","unstructured":"Zhu Y, He C, Li X, et al. Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice. J Gastroenterol. 2019;54(4):347\u201358.","journal-title":"J Gastroenterol"},{"issue":"2","key":"675_CR9","doi-asserted-by":"publisher","first-page":"330","DOI":"10.3390\/ijms18020330","volume":"18","author":"QH Sam","year":"2017","unstructured":"Sam QH, Chang MW, Chai LY. The fungal mycobiome and its Interaction with gut Bacteria in the host. Int J Mol Sci. 2017;18(2):330.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"675_CR10","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s40168-017-0373-4","volume":"5","author":"AK Nash","year":"2017","unstructured":"Nash AK, Auchtung TA, Wong MC, et al. The gut mycobiome of the human Microbiome Project healthy cohort. Microbiome. 2017;5(1):153.","journal-title":"Microbiome"},{"issue":"6","key":"675_CR11","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.3348\/kjr.2015.16.6.1253","volume":"16","author":"M Seong","year":"2015","unstructured":"Seong M, Kang TW, Ha SY. Pancreatic candidiasis that mimics a malignant pancreatic cystic tumor on magnetic resonance imaging: a Case Report in an Immunocompetent patient. Korean J Radiol. 2015;16(6):1253\u20136.","journal-title":"Korean J Radiol"},{"issue":"12","key":"675_CR12","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1097\/00003246-199812000-00031","volume":"26","author":"A Hoerauf","year":"1998","unstructured":"Hoerauf A, Hammer S, M\u00fcller-Myhsok B, et al. Intra-abdominal Candida infection during acute necrotizing pancreatitis has a high prevalence and is associated with increased mortality. Crit Care Med. 1998;26(12):2010\u20135.","journal-title":"Crit Care Med"},{"issue":"5","key":"675_CR13","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1111\/j.1440-1746.2008.05712.x","volume":"24","author":"R Kochhar","year":"2009","unstructured":"Kochhar R, Ahammed SK, Chakrabarti A, et al. Prevalence and outcome of fungal infection in patients with severe acute pancreatitis. J Gastroenterol Hepatol. 2009;24(5):743\u20137.","journal-title":"J Gastroenterol Hepatol"},{"issue":"3","key":"675_CR14","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1097\/MCG.0000000000001467","volume":"55","author":"RR Singh","year":"2021","unstructured":"Singh RR, Mitchell W, David Y, et al. Pancreatic fungal infection in patients with necrotizing pancreatitis: a systematic review and Meta-analysis. J Clin Gastroenterol. 2021;55(3):218\u201326.","journal-title":"J Clin Gastroenterol"},{"issue":"6","key":"675_CR15","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1136\/gutjnl-2015-310746","volume":"66","author":"H Sokol","year":"2017","unstructured":"Sokol H, Leducq V, Aschard H, et al. Fungal microbiota dysbiosis in IBD. Gut. 2017;66(6):1039\u201348.","journal-title":"Gut"},{"issue":"11\u201312","key":"675_CR16","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1111\/apt.15523","volume":"50","author":"S Lam","year":"2019","unstructured":"Lam S, Zuo T, Ho M, et al. Review article: fungal alterations in inflammatory bowel diseases. Aliment Pharmacol Ther. 2019;50(11\u201312):1159\u201371.","journal-title":"Aliment Pharmacol Ther"},{"issue":"6","key":"675_CR17","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1111\/j.1440-1746.2011.06685.x","volume":"26","author":"R Kochhar","year":"2011","unstructured":"Kochhar R, Noor MT, Wig J. Fungal infections in severe acute pancreatitis. J Gastroenterol Hepatol. 2011;26(6):952\u20139.","journal-title":"J Gastroenterol Hepatol"},{"issue":"6","key":"675_CR18","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1093\/clinids\/20.6.1526","volume":"20","author":"WR Jarvis","year":"1995","unstructured":"Jarvis WR. Epidemiology of nosocomial fungal infections; with emphasis on Candida species. Clin Infect Dis. 1995;20(6):1526\u201330.","journal-title":"Clin Infect Dis"},{"issue":"1","key":"675_CR19","doi-asserted-by":"publisher","first-page":"3663","DOI":"10.1038\/s41467-018-06103-6","volume":"9","author":"T Zuo","year":"2018","unstructured":"Zuo T, Wong SH, Cheung CP, et al. Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection. Nat Commun. 2018;9(1):3663.","journal-title":"Nat Commun"},{"issue":"7","key":"675_CR20","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.1053\/j.gastro.2021.02.069","volume":"160","author":"Y Cao","year":"2021","unstructured":"Cao Y, Wang L, Ke S, et al. Fecal mycobiota combined with host Immune factors distinguish Clostridioides difficile infection from asymptomatic carriage. Gastroenterology. 2021;160(7):2328\u201339.","journal-title":"Gastroenterology"},{"issue":"12","key":"675_CR21","doi-asserted-by":"publisher","first-page":"3016","DOI":"10.3390\/biomedicines10123016","volume":"10","author":"P Tian","year":"2022","unstructured":"Tian P, Gao J, Liang L, et al. Fecal microbiota transplantation could improve chronic diarrhea in Cynomolgus Monkey by alleviating inflammation and modulating gut microbiota. Biomedicines. 2022;10(12):3016.","journal-title":"Biomedicines"},{"issue":"5","key":"675_CR22","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1111\/jam.14553","volume":"128","author":"R Kaur","year":"2020","unstructured":"Kaur R, Kaur J, Kaur M, et al. An endophytic penicillium oxalicum isolated from Citrus limon possesses antioxidant and genoprotective potential. J Appl Microbiol. 2020;128(5):1400\u201313.","journal-title":"J Appl Microbiol"},{"key":"675_CR23","doi-asserted-by":"publisher","first-page":"1033823","DOI":"10.3389\/fmicb.2022.1033823","volume":"13","author":"W Weng","year":"2022","unstructured":"Weng W, Li R, Zhang Y, et al. Polyketides isolated from an endophyte penicillium oxalicum 2021CDF-3 inhibit pancreatic tumor growth. Front Microbiol. 2022;13:1033823.","journal-title":"Front Microbiol"},{"issue":"20","key":"675_CR24","doi-asserted-by":"publisher","first-page":"9994","DOI":"10.1039\/D1FO02022F","volume":"12","author":"N Liu","year":"2021","unstructured":"Liu N, Chen X, Song J, Chen M, Gong P, Jia W, Li G. Hypoglycemic effects of Auricularia auricula polysaccharides on high fat diet and streptozotocin-induced diabetic mice using metabolomics analysis. Food Funct. 2021;12(20):9994\u201310007.","journal-title":"Food Funct"},{"key":"675_CR25","doi-asserted-by":"publisher","first-page":"125662","DOI":"10.1016\/j.ijbiomac.2023.125662","volume":"246","author":"Y Shu","year":"2023","unstructured":"Shu Y, Huang Y, Dong W, et al. The polysaccharides from Auricularia auricula alleviate non-alcoholic fatty liver disease via modulating gut microbiota and bile acids metabolism. Int J Biol Macromol. 2023;246:125662.","journal-title":"Int J Biol Macromol"},{"key":"675_CR26","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.jare.2023.08.003","volume":"52","author":"X Zong","year":"2023","unstructured":"Zong X, Zhang H, Zhu L, et al. Auricularia auricula polysaccharides attenuate obesity in mice through gut commensal Papillibacter cinnamivorans. J Adv Res. 2023;52:203\u201318.","journal-title":"J Adv Res"},{"issue":"11","key":"675_CR27","doi-asserted-by":"publisher","first-page":"6030","DOI":"10.1002\/ptr.7215","volume":"35","author":"R Ahmad","year":"2021","unstructured":"Ahmad R, Riaz M, Khan A, Aljamea A, Algheryafi M, Sewaket D, Alqathama A. Ganoderma Lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties. Phytother Res. 2021;35(11):6030\u201362.","journal-title":"Phytother Res"},{"issue":"9","key":"675_CR28","doi-asserted-by":"publisher","first-page":"2152","DOI":"10.3390\/nu15092152","volume":"15","author":"Y Tian","year":"2023","unstructured":"Tian Y, Gou W, Ma Y, Shuai M, Liang X, Fu Y, Zheng JS. The short-term variation of human gut mycobiome in response to Dietary intervention of different macronutrient distributions. Nutrients. 2023;15(9):2152.","journal-title":"Nutrients"},{"issue":"4","key":"675_CR29","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.pan.2017.05.392","volume":"17","author":"H Sternby","year":"2017","unstructured":"Sternby H, Hartman H, Johansen D, et al. IL-6 and CRP are superior in early differentiation between mild and non-mild acute pancreatitis. Pancreatology. 2017;17(4):550\u20134.","journal-title":"Pancreatology"}],"container-title":["Gut Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13099-024-00675-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13099-024-00675-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13099-024-00675-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T13:05:49Z","timestamp":1736341549000},"score":1,"resource":{"primary":{"URL":"https:\/\/gutpathogens.biomedcentral.com\/articles\/10.1186\/s13099-024-00675-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,8]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["675"],"URL":"https:\/\/doi.org\/10.1186\/s13099-024-00675-z","relation":{},"ISSN":["1757-4749"],"issn-type":[{"value":"1757-4749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,8]]},"assertion":[{"value":"19 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study followed the Helsinki declaration. This research was approved by the research ethics boards of Shanghai General Hospital, and written informed consent to participate in the study was obtained from all the patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1"}}