{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T04:24:20Z","timestamp":1786940660539,"version":"build-2736575974"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":67,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Opening Project Fund of National Facility for Translational Medicine","award":["TMSK-2024-105"],"award-info":[{"award-number":["TMSK-2024-105"]}]},{"name":"Opening Project Fund of National Facility for Translational Medicine","award":["TMSK-2024-301"],"award-info":[{"award-number":["TMSK-2024-301"]}]},{"name":"\"Sit Less, Move More\" Health Management Model under the Active Health Framework, supported by the Shanghai Philosophy and Social Science Planning Project","award":["2022ZTY003"],"award-info":[{"award-number":["2022ZTY003"]}]},{"name":"Sedentary Behavior Patterns from a Health Management Perspective, funded by the Arts Young Talents Cultivation Program","award":["2023QN050"],"award-info":[{"award-number":["2023QN050"]}]},{"name":"Theory and Application under the Perspective of Active Health, a sub-project of the Key Program of the National Natural Science Foundation of China","award":["62132013"],"award-info":[{"award-number":["62132013"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Sports Sci Med Rehabil"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Normal-weight obesity (NWO) describes individuals with a normal body mass index (BMI) but elevated adiposity, potentially underestimating cardiometabolic risk. Mixed exercise may be particularly relevant for NWO, as it targets body composition, visceral adiposity, and cardiorespiratory fitness rather than weight loss alone. This study examined 12-week changes in DXA-derived body composition, regional adiposity, cardiorespiratory fitness, and cardiometabolic biomarkers in women with NWO and obesity (OB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sixty-seven women aged 22\u201345 years who completed baseline and post-intervention assessments were included in the per-protocol analysis (NWO\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200932; OB\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200935). Participants were classified using predefined BMI and DXA-derived body fat criteria. Changes in outcomes were evaluated using 2\u2009\u00d7\u20092 mixed-model repeated-measures ANOVA, with false discovery rate correction applied to within-group contrasts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 12 weeks, body weight and BMI decreased in the OB group but remained unchanged in the NWO group. Both groups demonstrated favorable changes in body composition. Total fat mass decreased from 24.68\u2009\u00b1\u20094.76 to 22.75\u2009\u00b1\u20093.84\u00a0kg in NWO and from 31.31\u2009\u00b1\u20093.91 to 29.46\u2009\u00b1\u20094.29\u00a0kg in OB, while total lean mass increased from 33.38\u2009\u00b1\u20094.00 to 34.70\u2009\u00b1\u20094.97\u00a0kg in NWO and from 39.04\u2009\u00b1\u20095.87 to 39.53\u2009\u00b1\u20095.90\u00a0kg in OB. Reductions were also observed across regional fat depots, including visceral adipose tissue (VAT), android fat, and gynoid fat. VAT decreased by \u2212\u200958.2\u00a0g (95% CI, \u2212\u200995.3 to \u2212\u200921.1) in NWO and \u2212\u200977.1\u00a0g (95% CI, \u2212\u2009109.4 to \u2212\u200944.8) in OB, with parallel reductions in android and gynoid fat mass. The android-to-gynoid ratio showed minimal change. Cardiorespiratory fitness improved in both groups, with VO\u2082max increasing by 3.73 mL\u00b7kg\n                      <jats:sup>\u2212\u20091<\/jats:sup>\n                      \u00b7min\n                      <jats:sup>\u2212\u20091<\/jats:sup>\n                      (95% CI, 0.75 to 6.72) in NWO and 3.03 mL\u00b7kg\n                      <jats:sup>\u2212\u20091<\/jats:sup>\n                      \u00b7min\n                      <jats:sup>\u2212\u20091<\/jats:sup>\n                      (95% CI, 1.45 to 4.61) in OB. No significant group\u00d7time interactions were observed. Routine fasting cardiometabolic biomarkers showed limited or inconsistent changes after correction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A 12-week supervised mixed-exercise program improved adiposity and cardiorespiratory fitness in women with NWO and OB, independent of weight loss in NWO. No phenotype-specific differences were detected. These findings highlight the importance of assessing body composition beyond BMI, although causal inference is limited by the single-arm design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>ChiCTR2100047173, registered on 9 June 2021, retrospectively registered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13102-026-01796-5","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T04:45:01Z","timestamp":1781153101000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in visceral adiposity, body composition, and cardiometabolic profiles following a supervised mixed exercise program in women with normal-weight obesity and obesity"],"prefix":"10.1186","volume":"18","author":[{"given":"Chuanzhi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngai","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhide","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinfei","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siman","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"1796_CR1","doi-asserted-by":"crossref","unstructured":"Afshin A, Forouzanfar MH, Reitsma MB, Sur P, Estep K, Lee A, Marczak L, Mokdad AH, Moradi-Lakeh M, Naghavi M et al. 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