{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T02:10:08Z","timestamp":1751681408040,"version":"3.41.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T00:00:00Z","timestamp":1528416000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculty of Pharmacy and Pharmaceutical Sciences, Monash University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Res Notes"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13104-018-3495-2","type":"journal-article","created":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T12:09:24Z","timestamp":1528459764000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of the 5-HT4 receptor agonist tegaserod on the expression of GRK2 and GRK6 in the rat gastrointestinal tract"],"prefix":"10.1186","volume":"11","author":[{"given":"Teshome","family":"Nedi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian M.","family":"Coupar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1514-0909","authenticated-orcid":false,"given":"Helen R.","family":"Irving","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,6,8]]},"reference":[{"key":"3495_CR1","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1053\/j.gastro.2006.11.002","volume":"132","author":"MD Gershon","year":"2007","unstructured":"Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology. 2007;132:397\u2013414.","journal-title":"Gastroenterology"},{"key":"3495_CR2","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s00210-008-0276-9","volume":"377","author":"DT Beattie","year":"2008","unstructured":"Beattie DT, Smith JAM. Serotonin pharmacology in the gastrointestinal tract: a review. Naunyn-Schmiedeberg\u2019s Arch Pharmacol. 2008;377:181\u2013203.","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol."},{"key":"3495_CR3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.tins.2006.11.002","volume":"30","author":"PG McLean","year":"2007","unstructured":"McLean PG, Borman RA, Lee K. 5-HT in the enteric nervous system: gut function and neuropharmacology. Trends Neurosci. 2007;30:9\u201313.","journal-title":"Trends Neurosci"},{"key":"3495_CR4","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1046\/j.1365-2036.2001.01103.x","volume":"15","author":"L Degen","year":"2001","unstructured":"Degen L, Matzinger D, Merz M, Appel-Dingemanse S, Osborne S, Luchinger S, Bertold R, Maecke H, Beglinger C. Tegaserod, a 5-HT4 receptor partial agonist, accelerates gastric emptying and gastrointestinal transit in healthy male subjects. Aliment Pharmacol Ther. 2001;15:1745\u201351.","journal-title":"Aliment Pharmacol Ther."},{"key":"3495_CR5","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/S0016-5085(00)70251-4","volume":"118","author":"CM Prather","year":"2000","unstructured":"Prather CM, Camilleri M, Zinsmeister AR, McKinzie S, Thomforde G. Tegaserod accelerates orocecal transit in patients with constipation-predominant irritable bowel syndrome. Gastroenterology. 2000;118:463\u20138.","journal-title":"Gastroenterology"},{"key":"3495_CR6","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/j.1365-2982.2007.01059.x","volume":"20","author":"JH Maeyer De","year":"2008","unstructured":"De Maeyer JH, Lefebvre RA, Schuurkes JAJ. 5-HT4 receptor agonists: similar but not the same. Neurogastroenterol Motil. 2008;20:99\u2013112.","journal-title":"Neurogastroenterol Motil"},{"key":"3495_CR7","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1046\/j.1365-2036.2003.01449.x","volume":"17","author":"B Coffin","year":"2003","unstructured":"Coffin B, Farmachidi JP, Rueegg P, Bastie A, Bouhassira D. Tegaserod, a 5-HT4 receptor partial agonist, decreases sensitivity to rectal distension in healthy subjects. Aliment Pharmacol Ther. 2003;17:577\u201385.","journal-title":"Aliment Pharmacol Ther."},{"key":"3495_CR8","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/j.1365-2982.2005.00723.x","volume":"18","author":"B Greenwood-Van Meerveld","year":"2006","unstructured":"Greenwood-Van Meerveld B, Venkova K, Hicks G, Dennis E, Crowell MD. Activation of peripheral 5-HT4 receptors attenuates colonic sensitivity to intraluminal distension. Neurogastroenterol Motil. 2006;18:76\u201386.","journal-title":"Neurogastroenterol Motil"},{"key":"3495_CR9","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/S0016-5085(98)70203-3","volume":"115","author":"JR Grider","year":"1998","unstructured":"Grider JR, Foxx-Orenstein AE, Jin JG. 5-Hydroxytryptamine4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine. Gastroenterology. 1998;115:370\u201380.","journal-title":"Gastroenterology"},{"issue":"844\u201354","key":"3495_CR10","first-page":"e4","volume":"142","author":"JM Hoffman","year":"2012","unstructured":"Hoffman JM, Tyler K, MacEachern SJ, Balemba OB, Johnson AC, Brooks EM, Zhao H, Swain GM, Moses PL, Galligan JJ, et al. Activation of colonic mucosal 5-HT4 receptors accelerates propulsive motility and inhibits visceral hypersensitivity. Gastroenterology. 2012;142(844\u201354):e4.","journal-title":"Gastroenterology"},{"key":"3495_CR11","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1254\/jphs.94.144","volume":"94","author":"SW Ji","year":"2004","unstructured":"Ji SW, Park H, Chung JP, Lee SI, Lee YH. Effects of tegaserod on ileal peristalsis of guinea pig in vitro. J Pharmacol Sci. 2004;94:142\u201352.","journal-title":"J Pharmacol Sci."},{"key":"3495_CR12","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1136\/gutjnl-2016-311629","volume":"67","author":"C McGuire","year":"2017","unstructured":"McGuire C, Boundouki G, Hockley JRF, Reed D, Cibert-Goton V, Peiris M, Kung V, Broad J, Aziz Q, Chan C, et al. Ex vivo study of human visceral nociceptors. Gut. 2017;67:86\u201396.","journal-title":"Gut"},{"key":"3495_CR13","doi-asserted-by":"publisher","first-page":"G1148","DOI":"10.1152\/ajpgi.00245.2005","volume":"289","author":"M Liu","year":"2005","unstructured":"Liu M, Geddis MS, Wen Y, Setlik W, Gershon MD. Expression and function of 5-HT4 receptors in the mouse enteric nervous system. Am J Physiol Gastrointest Liver Physiol. 2005;289:G1148\u201363.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"3495_CR14","first-page":"319","volume":"290","author":"JR Grider","year":"2006","unstructured":"Grider JR. Desensitization of the peristaltic reflex induced by mucosal stimulation with the selective 5-HT4 agonist tegaserod. Am J Physiol. 2006;290:319\u201327.","journal-title":"Am J Physiol"},{"key":"3495_CR15","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.bcp.2010.09.003","volume":"81","author":"T Nedi","year":"2011","unstructured":"Nedi T, White PJ, Coupar IM, Irving HR. Tissue dependent differences in G-protein coupled receptor kinases associated with 5-HT4 receptor desensitization in the rat gastro-intestinal tract. Biochem Pharmacol. 2011;81:123\u201333.","journal-title":"Biochem Pharmacol"},{"key":"3495_CR16","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/S0026-895X(25)09161-8","volume":"42","author":"H Ansanay","year":"1992","unstructured":"Ansanay H, Sebben M, Bockaert J, Dumuis A. Characterization of homologous 5-hydroxytryptamine4 receptor desensitization in colliculi neurons. Mol Pharmacol. 1992;42:808\u201316.","journal-title":"Mol Pharmacol"},{"key":"3495_CR17","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0022-3565(25)24565-7","volume":"272","author":"P Rond\u00e9","year":"1995","unstructured":"Rond\u00e9 P, Ansanay H, Dumuis A, Miller R, Bockaert J. Homologous desensitization of 5-hydroxytryptamine4 receptors in rat esophagus: functional and second messenger studies. J Pharmacol Exp Ther. 1995;272:977\u201383.","journal-title":"J Pharmacol Exp Ther."},{"key":"3495_CR18","doi-asserted-by":"publisher","first-page":"2706","DOI":"10.1038\/emboj.2009.215","volume":"28","author":"G Barthet","year":"2009","unstructured":"Barthet G, Carrat G, Cassier E, Barker B, Gaven F, Pillot M, Framery B, Pellissier LP, Augier J, Kang DS, et al. \u0392-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling. EMBO J. 2009;28:2706\u201318.","journal-title":"EMBO J"},{"key":"3495_CR19","doi-asserted-by":"publisher","first-page":"27924","DOI":"10.1074\/jbc.M502272200","volume":"280","author":"G Barthet","year":"2005","unstructured":"Barthet G, Gaven F, Framery B, Shinjo K, Nakamura T, Claeysen S, Bockaert J, Dumuis A. Uncoupling and endocytosis of 5-hydroxytryptamine 4 receptors: distinct molecular events with different GRK2 requirements. J Biol Chem. 2005;280:27924\u201334.","journal-title":"J Biol Chem"},{"key":"3495_CR20","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.cellsig.2009.11.004","volume":"22","author":"O Mnie-Filali","year":"2010","unstructured":"Mnie-Filali O, Amraei MG, Benmbarek S, Archer-Lahlou E, Pe\u00f1as-Cazorla R, Vilar\u00f3 MT, Boye SM, Pi\u00f1eyro G. Serotonin 4 receptor (5-HT4R) internalization is isoform-specific: effects of 5-HT and RS67333 on isoforms A and B. Cell Signal. 2010;22:501\u20139.","journal-title":"Cell Signal"},{"key":"3495_CR21","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1124\/jpet.107.131987","volume":"325","author":"MR Ahmed","year":"2008","unstructured":"Ahmed MR, Gurevich V, Dalby KN, Benovic JL, Gurevich EV. Haloperidol and clozapine differentially affect the expression of arrestins, receptor kinases, and extracellular signal-regulated kinase activation. J Pharmacol Exp Ther. 2008;325:276\u201383.","journal-title":"J Pharmacol Exp Ther."},{"key":"3495_CR22","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/S0028-3908(02)00147-8","volume":"43","author":"X Fan","year":"2002","unstructured":"Fan X, Zhang J, Zhang X, Yue W, Ma L. Acute and chronic morphine treatments and morphine withdrawal differentially regulate GRK2 and GRK5 gene expression in rat brain. Neuropharmacol. 2002;43:809\u201316.","journal-title":"Neuropharmacol."},{"key":"3495_CR23","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1016\/S0028-3908(02)00306-4","volume":"443","author":"A Miralles","year":"2002","unstructured":"Miralles A, Asensio VJ, Garcia-Sevilla JA. Acute treatment with the cyclic antidepressant desipramine, but not fluoxetine, increases membrane-associated G protein-coupled receptor kinases 2\/3 in rat brain. Neuropharmacol. 2002;443:1249\u201357.","journal-title":"Neuropharmacol."},{"key":"3495_CR24","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S0306-4522(02)00073-8","volume":"112","author":"A Diaz","year":"2002","unstructured":"Diaz A, Pazos A, Florez J, Ayesta FJ, Santana V, Hurle MA. Regulation of mu-opioid receptors, G-protein-coupled receptor kinases and beta-arrestin 2 in the rat brain after chronic opioid receptor antagonism. Neuroosci. 2002;112:345\u201353.","journal-title":"Neuroosci."},{"key":"3495_CR25","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1046\/j.1471-4159.2001.00268.x","volume":"77","author":"MA Hurle","year":"2001","unstructured":"Hurle MA. Changes in the expression of G protein-coupled receptor kinases and beta-arrestin 2 in rat brain during opioid tolerance and supersensitivity. J Neurochem. 2001;77:486\u201392.","journal-title":"J Neurochem"},{"key":"3495_CR26","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1146\/annurev.neuro.27.070203.144206","volume":"27","author":"RR Gainetdinov","year":"2004","unstructured":"Gainetdinov RR, Premont RT, Bohn LM, Lefkowitz RJ, Caron MG. Desensitization of G protein-coupled receptors and neuronal functions. Annu Rev Neurosci. 2004;27:107\u201344.","journal-title":"Annu Rev Neurosci"},{"key":"3495_CR27","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.vascn.2005.08.004","volume":"53","author":"SR Armstrong","year":"2006","unstructured":"Armstrong SR, McCullough JL, Beattie DT. Measurement of 5-HT4 receptor-mediated esophageal responses by digital sonomicrometry in the anesthetized rat. J Pharmacol Toxicol Meth. 2006;53:198\u2013205.","journal-title":"J Pharmacol Toxicol Meth."},{"key":"3495_CR28","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s00210-008-0281-z","volume":"378","author":"DT Beattie","year":"2008","unstructured":"Beattie DT, Armstrong SR, Shaw JP, Marquess D, Sandlund C, Smith JA, Taylor JA, Humphrey PP. The in vivo gastrointestinal activity of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity. Naunyn-Schmiedeberg\u2019s Arch Pharmacol. 2008;378:139\u201347.","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"key":"3495_CR29","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.phrs.2006.01.003","volume":"53","author":"JL McCullough","year":"2006","unstructured":"McCullough JL, Armstrong SR, Hegde SS, Beattie DT. The 5-HT2B antagonist and 5-HT4 agonist activities of tegaserod in the anaesthetized rat. Pharmacol Res. 2006;53:353\u20138.","journal-title":"Pharmacol Res"},{"key":"3495_CR30","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/sj.bjp.0705929","volume":"143","author":"DT Beattie","year":"2004","unstructured":"Beattie DT, Smith JA, Marquess D, Vickery RG, Armstrong SR, Pulido-Rios T, McCullough JL, Sandlund C, Richardson C, Mai N, Humphrey PP. The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo. Br J Pharmacol. 2004;143:549\u201360.","journal-title":"Br J Pharmacol"},{"key":"3495_CR31","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/BF00169544","volume":"343","author":"GS Baxter","year":"1991","unstructured":"Baxter GS, Craig DA, Clarke DE. 5-Hydroxytryptamine4 receptors mediate relaxation of the rat oesophageal tunica muscularis mucosae. Naunyn-Schmiedeberg\u2019s Arch Pharmacol. 1991;343:439\u201346.","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol."},{"key":"3495_CR32","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s00441-006-0181-9","volume":"325","author":"DP Poole","year":"2006","unstructured":"Poole DP, Xu B, Koh SL, Hunne B, Coupar IM, Irving HR, Shinjo K, Furness JB. Identification of neurons that express 5-hydroxytryptamine-4 receptors in the intestine. Cell Tissue Res. 2006;325:413\u201322.","journal-title":"Cell Tissue Res."},{"key":"3495_CR33","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1146\/annurev.physiol.69.022405.154731","volume":"69","author":"RT Premont","year":"2007","unstructured":"Premont RT, Gainetdinov RR. Physiological roles of G protein-coupled receptor kinases and arrestins. Annu Rev Physiol. 2007;69:511\u201334.","journal-title":"Annu Rev Physiol"},{"key":"3495_CR34","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.cellsig.2017.04.015","volume":"36","author":"SW Bahouth","year":"2017","unstructured":"Bahouth SW, Nooh MM. Barcoding of GPCR trafficking and signaling through the various trafficking roadmaps by compartmentalized signaling networks. Cell Signal. 2017;36:42\u201355.","journal-title":"Cell Signal"},{"key":"3495_CR35","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S0165-6147(99)01351-6","volume":"20","author":"RB Clark","year":"1999","unstructured":"Clark RB, Knoll BJ, Barber R. Partial agonists and G protein-coupled receptor desensitization. Trends Pharmacol Sci. 1999;20:279\u201386.","journal-title":"Trends Pharmacol Sci"},{"key":"3495_CR36","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1016\/j.neuroscience.2008.04.036","volume":"154","author":"E Burgos-Ramos","year":"2008","unstructured":"Burgos-Ramos E, Puebla-Jimenez L, Arilla-Ferreiro E. Minocycline provides protection against beta-amyloid(25-35)-induced alterations of the somatostatin signaling pathway in the rat temporal cortex. Neurooscience. 2008;154:1458\u201366.","journal-title":"Neurooscience."},{"key":"3495_CR37","first-page":"1","volume":"2009","author":"A Matuzany-Ruban","year":"2009","unstructured":"Matuzany-Ruban A, Golan M, Miroshnik N, Schreiber G, Avissar S. Normalization of GRK2 protein and mRNA measures in patients with depression predict response to antidepressants. Int J Neuropsychopharmacol. 2009;2009:1\u20139.","journal-title":"Int J Neuropsychopharmacol"},{"key":"3495_CR38","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.intimp.2007.01.019","volume":"7","author":"H Wu","year":"2007","unstructured":"Wu H, Wei W, Song L, Zhang L, Chen Y, Hu X. Paeoniflorin induced immune tolerance of mesenteric lymph node lymphocytes via enhancing beta 2-adrenergic receptor desensitization in rats with adjuvant arthritis. Int Immunopharmacol. 2007;7:662\u201373.","journal-title":"Int Immunopharmacol"},{"key":"3495_CR39","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.ejphar.2004.03.015","volume":"489","author":"N Dzimiri","year":"2004","unstructured":"Dzimiri N, Muiya P, Andres E, Al-Halees Z. Differential functional expression of human myocardial G protein receptor kinases in left ventricular cardiac diseases. Eur J Pharmacol. 2004;489:162\u201377.","journal-title":"Eur J Pharmacol"},{"key":"3495_CR40","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0169-328X(02)00144-4","volume":"101","author":"M Grange-Midroit","year":"2002","unstructured":"Grange-Midroit M, Garcia-Sevilla JA, Ferrer-Alcon M, La Harpe R, Walzer C, Guimon J. G protein-coupled receptor kinases, beta-arrestin-2 and associated regulatory proteins in the human brain: postmortem changes, effect of age and subcellular distribution. Brain Res Mol Brain Res. 2002;101:39\u201351.","journal-title":"Brain Res Mol Brain Res"}],"container-title":["BMC Research Notes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13104-018-3495-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13104-018-3495-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13104-018-3495-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T01:32:46Z","timestamp":1751679166000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcresnotes.biomedcentral.com\/articles\/10.1186\/s13104-018-3495-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,8]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["3495"],"URL":"https:\/\/doi.org\/10.1186\/s13104-018-3495-2","relation":{},"ISSN":["1756-0500"],"issn-type":[{"type":"electronic","value":"1756-0500"}],"subject":[],"published":{"date-parts":[[2018,6,8]]},"assertion":[{"value":"21 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"362"}}