{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:42:16Z","timestamp":1782272536203,"version":"3.54.5"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T00:00:00Z","timestamp":1569456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T00:00:00Z","timestamp":1569456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Res Notes"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Thrombocytopenia is an abnormal decrease in blood platelets, which can affect the prognosis of people living with HIV (PLHIV). In order to assess the burden of this haematological disorder, we evaluated the frequency of thrombocytopenia according to antiretroviral drug combinations, viremia and the immune status of PLHIV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A cross-sectional and analytical study was conducted from June to November 2016 among 310 PLHIV at the \u201cChantal BIYA\u201d International Reference Centre, Yaound\u00e9, Cameroon. Overall rate of thrombocytopenia was 19.0% (59\/310). The rate of thrombocytopenia was 64.6% (42\/65) versus 6.9% (17\/245) in ART-na\u00efve versus ART-treated patients respectively, p\u2009&lt;\u20090.0001. Following viral load, rate of thrombocytopenia was 15.8% (20\/130) in those with undetectable viral load, and 34.1% (27\/79) with viral loads\u2009&gt;\u20093 log\n                      <jats:sub>10<\/jats:sub>\n                      RNA\/ml (p\u2009=\u20090.03). As concerns CD4-count, rate of thrombocytopenia was 16.2% (42\/259) in those with\u2009\u2265\u2009200 CD4\/mm\n                      <jats:sup>3<\/jats:sup>\n                      versus 33.3% (17\/51) with\u2009&lt;\u2009200 CD4\/mm\n                      <jats:sup>3<\/jats:sup>\n                      (p\u2009=\u20090.0003). After adjusting for sex, ART, viral load and CD4, Viral load and ART exposure were significantly associated with decreased risk of thrombocytopenia (p\u2009&lt;\u20090.05). Thrombocytopenia occurs especially among ART-na\u00efve, high viremia and severe immune-compromised patients. Interestingly, ART coverage appears as an independent factor in preventing the occurrence of thrombocytopenia.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13104-019-4664-7","type":"journal-article","created":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T01:12:51Z","timestamp":1569460371000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Thrombocytopenia according to antiretroviral drug combinations, viremia and CD4 lymphocytes among HIV-infected patients in Cameroon: a snapshot from the City of Yaound\u00e9"],"prefix":"10.1186","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9358-8661","authenticated-orcid":false,"given":"Alex Durand","family":"Nka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Martin","family":"Sosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Fokam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yagai","family":"Bouba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Teto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Simo Rachel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Tiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junie","family":"Yimga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias Nchiwan","family":"Nukenine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aubin Joseph","family":"Nanfack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9sir\u00e9","family":"Takou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z\u00e9lateur","family":"Aroga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Colizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Ndjolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,26]]},"reference":[{"issue":"1","key":"4664_CR1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/j.1365-2141.1981.00031.x","volume":"48","author":"C Giles","year":"1981","unstructured":"Giles C. The platelet count and mean platelet volume. Br J Haematol. 1981;48(1):31\u20137.","journal-title":"Br J Haematol"},{"key":"4664_CR2","unstructured":"Thrombocytopenia (low platelet count)\u2014symptoms and causes [Internet]. Mayo Clinic. Disponible sur: \n                    http:\/\/www.mayoclinic.org\/diseases-conditions\/thrombocytopenia\/symptoms-causes\/syc-20378293\n                    \n                  . Accessed 16 Oct 2018."},{"key":"4664_CR3","unstructured":"Viral load testing capacity still weak in sub-Saharan Africa, 7-country study finds [Internet]. Disponible sur: \n                    http:\/\/www.aidsmap.com\/Viral-load-testing-capacity-still-weak-in-sub-Saharan-Africa-7-country-study-finds\/page\/3107907\n                    \n                  . 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Trop Med Int Health TM IH. 2010;15(5):580\u20133.","journal-title":"Trop Med Int Health TM IH"},{"issue":"4","key":"4664_CR6","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s13149-015-0444-3","volume":"108","author":"NE Essomba","year":"2015","unstructured":"Essomba NE, Mbatchou Ngahane BH, Nida M, Temfack E, Mapoure Njankouo Y, Abeng RL, et al. Profil clinique et immunologique des patients infect\u00e9s par le VIH \u00e0 l\u2019initiation du traitement antir\u00e9troviral \u00e0 Douala. Bull Soci\u00e9t\u00e9 Pathol Exot. 2015;108(4):255\u201361.","journal-title":"Bull Soci\u00e9t\u00e9 Pathol Exot"},{"issue":"5","key":"4664_CR7","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1097\/MBC.0000000000000066","volume":"25","author":"L Tene","year":"2014","unstructured":"Tene L, Tagny CT, Mintya-Ndoumba A, Fossi VN, Mbanya D. Haemostatic trends in HIV-infected individuals in Yaound\u00e9, Cameroon: a pilot study. Blood Coagul Fibrinolysis Int J Haemost Thromb. 2014;25(5):422\u20135.","journal-title":"Blood Coagul Fibrinolysis Int J Haemost Thromb"},{"key":"4664_CR8","doi-asserted-by":"publisher","first-page":"109","DOI":"10.2147\/JBM.S80857","volume":"6","author":"IM Taremwa","year":"2015","unstructured":"Taremwa IM, Muyindike WR, Muwanguzi E, Boum Y, Natukunda B. Prevalence of HIV-related thrombocytopenia among clients at Mbarara Regional Referral Hospital, Mbarara, southwestern Uganda. J Blood Med. 2015;6:109\u201313.","journal-title":"J Blood Med"},{"issue":"6","key":"4664_CR9","first-page":"758","volume":"8","author":"K Alaei","year":"2002","unstructured":"Alaei K, Alaei A, Mansoori D. Thrombocytopenia in HIV-infected patients, Islamic Republic of Iran. 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Immunodefic Rev. 1990;2(3):221\u201331.","journal-title":"Immunodefic Rev"},{"issue":"3","key":"4664_CR12","first-page":"331","volume":"12","author":"D Mbanya","year":"2002","unstructured":"Mbanya D, Tapko J-B, Azowe F, Kaptue L. Aetiologic factors and clinical features associated with thrombocytopenia in Cameroonese adults: the importance of Plasmodium falciparum malaria. Sante Montrouge Fr. 2002;12(3):331\u20135.","journal-title":"Sante Montrouge Fr"},{"key":"4664_CR13","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1756-0500-7-5","volume":"7","author":"Y Wondimeneh","year":"2014","unstructured":"Wondimeneh Y, Muluye D, Ferede G. Prevalence and associated factors of thrombocytopenia among HAART-naive HIV-positive patients at Gondar University Hospital, northwest Ethiopia. BMC Res Notes. 2014;7:5.","journal-title":"BMC Res Notes"},{"issue":"1","key":"4664_CR14","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1054\/blre.2001.0188","volume":"16","author":"A Scaradavou","year":"2002","unstructured":"Scaradavou A. HIV-related thrombocytopenia. Blood Rev. 2002;16(1):73\u20136.","journal-title":"Blood Rev"},{"key":"4664_CR15","doi-asserted-by":"crossref","unstructured":"Wankah PN, Tagny CT, Mbanya DNS. Profile of blood cell abnormalities among antiretroviral therapy na\u00efve HIV patients attending the Yaounde University Teaching Hospital, Cameroon. BMC Hematol [Internet]. 8 sept 2014;14. Disponible sur: \n                    https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4164737\/\n                    \n                  . Accessed 18 Sept 2018.","DOI":"10.1186\/2052-1839-14-15"},{"key":"4664_CR16","unstructured":"Keith Henry MD. Risk for HIV-Related Thrombocytopenia Plunges in the Combination ART Era. NEJM J Watch [Internet]. 19 nov 2014;2014. Disponible sur: \n                    https:\/\/www.jwatch.org\/NA36334\/2014\/11\/19\/risk-hiv-related-thrombocytopenia-plunges-combination-art\n                    \n                  . Accessed 15 Nov 2019."}],"container-title":["BMC Research Notes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13104-019-4664-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13104-019-4664-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13104-019-4664-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T19:12:02Z","timestamp":1600974722000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcresnotes.biomedcentral.com\/articles\/10.1186\/s13104-019-4664-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,26]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["4664"],"URL":"https:\/\/doi.org\/10.1186\/s13104-019-4664-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.2.13357\/v1","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.2.13357\/v2","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.2.9478\/v1","asserted-by":"object"}]},"ISSN":["1756-0500"],"issn-type":[{"value":"1756-0500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,26]]},"assertion":[{"value":"15 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study obtained ethical clearance from the Institutional Review Board of the University of Douala (N\u00b0CEI-UD\/544\/04\/2016\/T) and also authorization from CIRCB where the study was conducted. The participants freely signed informed consent forms, which were written in French and English (with respect to the first language of the participant), while the minors (<\u200916\u00a0years) gave their assent in addition to parent\/guardian consent.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"632"}}