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Exploratory analyses tested the relationship between bipolar disorder symptoms and hours of sleep, and levels of pain, social and task-based stress. We report an analysis of data from a two-arm, parallel group study (bipolar disorder group N\u2009=\u200910 and healthy control group N\u2009=\u200910, with 70% completion rate of 14-day surveys). Surveys of bipolar disorder symptoms, social stressors and sleep hours were completed on a smartphone at unexpected times in an Ecological Momentary Assessment paradigm twice a day. Multi-level models adjusted for potential subject heterogeneity were adopted to test the difference between the bipolar disorder and health control groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Within-person variability of mood, energy, speed of thoughts, impulsivity, pain and perception of skill of tasks was significantly higher in the bipolar disorder group compared to health controls. Elevated bipolar disorder symptom domains in the evening were associated with reduced sleep time that night. Stressors were associated with worsening of bipolar disorder symptoms. Detection of symptoms when an individual is experiencing difficulty allows personalized, focused interventions.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13104-019-4834-7","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T17:02:48Z","timestamp":1575478968000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Use of ecological momentary assessment to detect variability in mood, sleep and stress in bipolar disorder"],"prefix":"10.1186","volume":"12","author":[{"given":"Han","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahlia","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatesh Basappa","family":"Krishnamurthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Millett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly A.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika F. 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CM receives salary support through the Sackler Scholars in Psychobiology Program. KR has received grant funding through National Center for Advancing Translational Sciences of the National Institutes of Health under Award Number 2KL2TR000434, the Heinz C. Prechter Research Program, and the Richard Tam Foundation. LZ has received grant funding from the Pennsylvania State University, Penn State Clinical and Translational Science Institute and the National Institutes of Health. ES receives a stipend from the Journal of Clinical Psychiatry for an associate editorship, and has received grant funding from the National Institutes of Health and the Stanley Medical Research Institute. MW has received grant funding from the Pennsylvania State University, Pennsylvania Department of Health, Penn State Clinical and Translational Science Institute, Grant No. KL2 TR 126-4, the National Institutes of Health, BioAdvance, and the Children\u2019s Miracle Network at Penn State.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"791"}}