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The adrenal gland is the most commonly affected endocrine organ in TB infection. We assessed factors associated with functional adrenal insufficiency (FAI) among TB-HIV patients with and without drug-resistance in Uganda. Patients with drug-sensitive and drug-resistant TB were enrolled and examined for clinical signs and symptoms of FAI with an early morning serum cortisol level obtained. FAI was defined as early morning serum cortisol\u2009&lt;\u2009414 nmol\/\/L. Associations with FAI were modeled using multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We screened 311 TB patients and enrolled 272. Of these, 117 (43%) had drug-resistant TB. Median age was 32 years (IQR 18\u201366) and 66% were men. The proportion with FAI was 59.8%. Mean cortisol levels were lower in participants with drug-resistant than susceptible TB (317.4 versus 488.5 nmol\/L; p\u2009&lt;\u20090.001\n                      <jats:bold>)<\/jats:bold>\n                      . In multivariable analyses, drug-resistant TB (aOR 4.61; 95% CI 2.3\u20139.1; p\u2009\n                      <jats:bold>&lt;\u2009<\/jats:bold>\n                      0.001), treatment duration\u2009&gt;\u20091 month (aOR 2.86; 95% CI 1.4\u20135.5; p\u2009=\u20090.002) and abdominal pain (aOR 2.06; 95% CI 1.04\u20134.09; p\u2009=\u20090.038) were significantly associated with FAI. Early morning serum cortisol levels should be quantified in TB-HIV co-infected patients with drug-resistant TB.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13104-020-05064-8","type":"journal-article","created":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T11:02:45Z","timestamp":1587294165000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Functional adrenal insufficiency among tuberculosis-human immunodeficiency virus co-infected patients: a cross-sectional study in Uganda"],"prefix":"10.1186","volume":"13","author":[{"given":"Agnes Bwanika","family":"Naggirinya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Mujugira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.","family":"Meya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene Andia","family":"Biraro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezekiel","family":"Mupere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Worodria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukari C.","family":"Manabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,4,19]]},"reference":[{"key":"5064_CR1","doi-asserted-by":"publisher","first-page":"2342857","DOI":"10.1155\/2019\/2342857","volume":"2019","author":"DD Nassoro","year":"2019","unstructured":"Nassoro DD, Mkhoi ML, Sabi I, Meremo AJ, Lawala PS, Mwakyula IH. 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All study participants provided written informed consent prior to study procedures.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"224"}}