{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T15:40:05Z","timestamp":1740152405024,"version":"3.37.3"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Res Notes"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Objectives<\/jats:title>\n<jats:p>The study aimed to determine the effect of oxymetazoline nasal spray on the patency of the fistula created after dacryocystorhinostomy, specifically: to compare the success of fistula formation with oxymetazoline versus placebo, and to compare the incidence of post-operative congestion, pain and bleeding with oxymetazoline versus placebo.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The study was a single-center, randomized controlled, triple-masked study involving the patients of the Plastic-Lacrimal service of a national university hospital. Block randomization was done. Dacryocystorhinostomy was performed by a single-masked surgeon. The intervention group used oxymetazoline. The placebo group used sodium chloride. The data were collected by another masked investigator. The study showed no significant difference in terms of congestion, pain and epistaxis between the two groups at day 2 post-operation. The patency, presence of silicone tube, granuloma formation, and presence of bleeding on both day 2 and day 16 post-operation had no difference between the two groups. This study doesn\u2019t support the use of oxymetazoline nasal spray after DCR, since it does not decrease the symptoms of congestion, pain and epistaxis after DCR. Aside from being an additional expense for patients, it also does not affect fistula formation and success rate of the surgery.<\/jats:p>\n<jats:p><jats:italic>Trial registration<\/jats:italic> Australian New Zealand Clinical Trial Registry: ACTRN12619001394134, Date registered 10\/11\/2019, Retrospectively Registered.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s13104-020-05076-4","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T21:02:27Z","timestamp":1588366947000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A randomized controlled trial on the effects of oxymetazoline nasal spray after dacryocystorhinostomy among adult patients"],"prefix":"10.1186","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1306-3727","authenticated-orcid":false,"given":"George Michael N.","family":"Sosuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felice Katrina T.","family":"Ranche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Kenneth D.","family":"Lagunzad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,1]]},"reference":[{"issue":"3","key":"5076_CR1","doi-asserted-by":"publisher","first-page":"191","DOI":"10.4103\/0974-620X.106106","volume":"5","author":"MJ Ali","year":"2012","unstructured":"Ali MJ, et al. External dacryocystorhinostomy: tips and tricks. Oman J Ophthalmol. 2012;5(3):191.","journal-title":"Oman J Ophthalmol"},{"key":"5076_CR2","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1136\/bjo.82.7.786","volume":"82","author":"E Ezra","year":"1998","unstructured":"Ezra E, et al. Ultrasonic assessment of rhinostomy size following external dacryocystorhinostomy. Br J Ophthalmol. 1998;82:786\u20139.","journal-title":"Br J Ophthalmol"},{"key":"5076_CR3","unstructured":"Burkat CN. et al. (2014). Dacryocystorhinostomy. Retrieved from http:\/\/eyewiki.aao.org\/Dacryocystorhinostomy#Surgical_follow_up on July 17, 2016 2232H."},{"issue":"1","key":"5076_CR4","first-page":"85","volume":"6","author":"P Matreja","year":"2012","unstructured":"Matreja P, et al. Efficacy of fluticasone and oxymetazoline as the treatment for allergic rhinitis. 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Laryngoscope. 2013;123(4):852\u20138. https:\/\/doi.org\/10.1002\/lary.23966.","journal-title":"Laryngoscope"},{"key":"5076_CR7","volume-title":"Endocrinology: adult and pediatric","author":"WL Bi","year":"2016","unstructured":"Bi WL, Dun IF, Laws ER Jr. Endocrinology: adult and pediatric. Amsterdam Netherland: Elsevier; 2016."},{"key":"5076_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-019-0337-8","author":"JW Reid","year":"2019","unstructured":"Reid JW, Rotenberg BW, Sowerby LJ. Contemporary decongestant practices of Canadian otolaryngologists for endoscopic sinus surgery. J Otolaryngol- Head Neck Surg. 2019. https:\/\/doi.org\/10.1186\/s40463-019-0337-8.","journal-title":"J Otolaryngol- Head Neck Surg"},{"key":"5076_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22183","author":"E Da\u011fli","year":"2018","unstructured":"Da\u011fli E, Ocak E, Mirici E, Kaya M, Acar A. Effects of early postoperative nasal decongestant on symptom relief after septoplasty. Int Forum Allergy Rhinology. 2018. https:\/\/doi.org\/10.1002\/alr.22183.","journal-title":"Int Forum Allergy Rhinology"}],"container-title":["BMC Research Notes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13104-020-05076-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13104-020-05076-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13104-020-05076-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T13:00:17Z","timestamp":1620046817000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcresnotes.biomedcentral.com\/articles\/10.1186\/s13104-020-05076-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,1]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["5076"],"URL":"https:\/\/doi.org\/10.1186\/s13104-020-05076-4","relation":{},"ISSN":["1756-0500"],"issn-type":[{"type":"electronic","value":"1756-0500"}],"subject":[],"published":{"date-parts":[[2020,5,1]]},"assertion":[{"value":"6 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Approval and adherence to the tenets of the Declaration of Helsinki was assessed by the University of the Philippines Manila Research Ethics Board (UPMREB) with Code (OVS) 2017\u2011183\u201101 approved April 24, 2017). This study was a randomized controlled trial; patient anonymity and confidentiality were and are protected and preserved with identifiable data omitted. Informed written consent was obtained from each study participant.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"236"}}