{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:40:55Z","timestamp":1787020855509,"version":"build-2736575974"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Res Notes"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The The impact of a hospital antimicrobial stewardship was determined on antimicrobial-resistant,\n                      <jats:italic>Clostridioides difficile<\/jats:italic>\n                      rates and the amount of antimicrobial consumed in cancer patients.The intervention effects of antimicrobial stewardship (ASP) plans in 2017\u20132018 and 2018\u20132019 were respectively evaluated among hematology\/oncology and bone marrow transplant patients in Ayatollah Taleghani University Hospital, Tehran, Iran. In this interventional quasi-experimental study, the ASP repository was utilized to capture four survey questions encompassed in these immunocompromised patients: amount of antibiotics (meropenem and vancomycin) consumption gr-year, the number of positive\n                      <jats:italic>Clostridioides difficile<\/jats:italic>\n                      infection and multidrug-resistant positive cases in blood cultures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The number of MDR cases in the periods of 2017\u20132018 and 2018\u20132019 were 145 and 75, respectively (p\u2009=\u20090.011). A significant reduction in all positive blood cultures from 2017\u20132018 to 2018\u20132019 was found (p\u2009=\u20090.001). 574 patients admitted to our hospital in these periods of 2017- 2018 and 2018- 2019were assessed for MPM and VMN use. The amounts of MPM prescriptions in 2018\u20132019 was significantly decreased from 22464 to 17262\u00a0g (p\u2009=\u20090.043). The significant reduction in antibiotic consumption, MDR organisms, and CDI can highly promote patients\u2019 health and decreasing medical costs and long-term defects for patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13104-020-05085-3","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T04:06:47Z","timestamp":1589861207000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Impact of an antimicrobial stewardship program in the antimicrobial-resistant and prevalence of clostridioides difficile infection and amount of antimicrobial consumed in cancer patients"],"prefix":"10.1186","volume":"13","author":[{"given":"Masoud","family":"Mardani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Abolghasemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Shabani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"issue":"6","key":"5085_CR1","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1016\/j.jmii.2015.10.006","volume":"50","author":"C-T Wu","year":"2017","unstructured":"Wu C-T, Chen C-L, Lee H-Y, Chang C-J, Liu P-Y, Li C-Y, et al. Decreased antimicrobial resistance and defined daily doses after implementation of a clinical culture-guided antimicrobial stewardship program in a local hospital. J Microbiol Immunol Infect. 2017;50(6):846\u201356.","journal-title":"J Microbiol Immunol Infect"},{"issue":"1","key":"5085_CR2","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s13756-018-0400-7","volume":"7","author":"JS Wathne","year":"2018","unstructured":"Wathne JS, Kleppe LKS, Harthug S, Blix HS, Nilsen RM, Charani E, et al. The effect of antibiotic stewardship interventions with stakeholder involvement in hospital settings: a multicentre, cluster-randomized controlled intervention study. 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Infect Dis Clin North Am. 2018;32(3):535\u201350.","journal-title":"Infect Dis Clin North Am"},{"issue":"6","key":"5085_CR5","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1111\/ctr.12733","volume":"30","author":"M So","year":"2016","unstructured":"So M, Yang DY, Bell C, Humar A, Morris A, Husain S. Solid organ transplant patients: are there opportunities for antimicrobial stewardship? Clin Trans. 2016;30(6):659\u201368.","journal-title":"Clin Trans"},{"issue":"4","key":"5085_CR6","first-page":"5","volume":"1","author":"N Khan","year":"2019","unstructured":"Khan N, Rahman B. Infections After Bone Marrow Transplantation in Children \u2013A Retrospective Analysis. Sci J Paediatr. 2019;1(4):5\u20138.","journal-title":"Sci J Paediatr"},{"issue":"4","key":"5085_CR7","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1097\/QCO.0000000000000380","volume":"30","author":"E Robilotti","year":"2017","unstructured":"Robilotti E, Holubar M, Seo SK, Deresinski S. Feasibility and applicability of antimicrobial stewardship in immunocompromised patients. Curr Opin Infect Dis. 2017;30(4):346\u201353.","journal-title":"Curr Opin Infect Dis"},{"key":"5085_CR8","doi-asserted-by":"crossref","unstructured":"Seo SK, Lo K, Abbo LM. Current state of antimicrobial stewardship at solid organ and hematopoietic cell transplant centers in the United States. Infection Control Hospital Epidemiology. 2016. 37(10):1195\u20131200.","DOI":"10.1017\/ice.2016.149"},{"issue":"2","key":"5085_CR9","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s40506-019-00189-2","volume":"11","author":"M So","year":"2019","unstructured":"So M. Antimicrobial stewardship in patients with hematological malignancies: key considerations. Curr Treat Options Infect Dis. 2019;11(2):161\u20136.","journal-title":"Curr Treat Options Infect Dis"},{"key":"5085_CR10","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/541340","author":"J Tanwar","year":"2014","unstructured":"Tanwar J, Das S, Fatima Z, Hameed S. Multidrug resistance: an emerging crisis. Interdisciplinary Perspect Infect Dis. 2014. https:\/\/doi.org\/10.1155\/2014\/541340.","journal-title":"Interdisciplinary Perspect Infect Dis"},{"issue":"1","key":"5085_CR11","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s40121-016-0139-5","volume":"6","author":"BR Lee","year":"2017","unstructured":"Lee BR, Goldman JL, Yu D, Myers AL, Stach LM, Hedican E, et al. Clinical impact of an antibiotic stewardship program at a children\u2019s hospital. 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Am J Infect Control. 2013;41(2):145\u20138.","journal-title":"Am J Infect Control"}],"container-title":["BMC Research Notes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13104-020-05085-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13104-020-05085-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13104-020-05085-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T19:49:39Z","timestamp":1621367379000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcresnotes.biomedcentral.com\/articles\/10.1186\/s13104-020-05085-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,19]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["5085"],"URL":"https:\/\/doi.org\/10.1186\/s13104-020-05085-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.2.17475\/v2","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.2.17475\/v1","asserted-by":"object"}]},"ISSN":["1756-0500"],"issn-type":[{"value":"1756-0500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,19]]},"assertion":[{"value":"16 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the human research ethics committee of Shahid Beheshti University of Medical Sciences, Tehran, Iran (Grant No. 9820), and it was carried out in accordance with the approved guidelines. Written consent informed was obtained from all participants.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"246"}}