{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:57:58Z","timestamp":1791813478968,"version":"4.3.4"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Res Notes"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The objectives of this study were to investigate the antifungal susceptibility and genetic diversity of\n                      <jats:italic>Candida albicans<\/jats:italic>\n                      isolated from HIV\n                      <jats:sup>+<\/jats:sup>\n                      patients with oropharyngeal candidiasis. A total of 50\n                      <jats:italic>C. albicans<\/jats:italic>\n                      isolates were cultured on Sabouraud glucose agar containing chloramophenicol. The antifungal susceptibility of the isolates against fluconazole, clotrimazole, nystatin, amphotericin B, ketoconazole and flucytosine was assessed using disc diffusion method. The genetic diversity of\n                      <jats:italic>C. albicans<\/jats:italic>\n                      isolates was determined using random amplified polymorphic DNA marker.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The inhibition zones ranged from 4\u2009\u00b1\u20091.8 to 40\u2009\u00b1\u20093.8\u00a0mm for fluconazole, 7\u2009\u00b1\u20091.0 to 37\u2009\u00b1\u20091.8\u00a0mm for ketoconazole, 14\u2009\u00b1\u20090.8 to24\u2009\u00b1\u20090.8\u00a0mm for amphotericin B, 25\u2009\u00b1\u20090.0 to 33\u2009\u00b1\u20090.0\u00a0mm for nystatin and 7\u2009\u00b1\u20094.2 to 40\u2009\u00b1\u20090.0\u00a0mm for clotrimazole. At 90% similarity, three distinct groups were observed. The smallest cluster composed of 3 isolates, whereas the largest one composed of 17 isolates. 32% (16\/50), 28% (14\/50) and 14% (7\/50) were resistant to fluconazole, ketoconazole and clotrimazole, respectively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13104-021-05498-8","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T04:05:43Z","timestamp":1615349143000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Genetic diversity and antifungal susceptibility of Candida albicans isolates from Iranian HIV-infected patients with oral candidiasis"],"prefix":"10.1186","volume":"14","author":[{"given":"Iradj Ashrafi","family":"Tamai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1412-0890","authenticated-orcid":false,"given":"Babak","family":"Pakbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahar Nayeri","family":"Fasaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,10]]},"reference":[{"issue":"4","key":"5498_CR1","doi-asserted-by":"publisher","first-page":"ftw018","DOI":"10.1093\/femspd\/ftw018","volume":"74","author":"C Tsui","year":"2016","unstructured":"Tsui C, Kong EF, Jabra-Rizk MA. 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Authorization to perform this investigation at the Imam Khomeini hospital was obtained from the Infectious diseases department of Imam Khomeini hospital, Tehran Univesity of Medical Science.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Before taking samples, written informed consent was obtained from each patient at the present study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"93"}}