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This study was designed to investigate the effects of clonidine and yohimbine, an alpha-2 (<jats:italic>\u03b1<\/jats:italic><jats:sub>2<\/jats:sub>) adrenoceptor agonist and antagonist respectively in the tail flick and hot plate tests.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A significant difference in tail flick latency was noted between saline control and 30\u00a0\u00b5g\/kg clonidine, which was reduced after administration of 30\u00a0\u00b5g\/kg yohimbine. A significant difference in hot plate latency was also noted between saline control and 30\u00a0\u00b5g\/kg clodinine during the periods 30, 45, 60, 75 and 90\u00a0min after administration, and between saline control and 10\u00a0\u00b5g\/kg clonidine during 30\u00a0min after administration. The hot plate latency by 30\u00a0\u00b5g\/kg clonidine was also reduced by 30\u00a0\u00b5g\/kg yohimbine during 30\u00a0min after administration. Since the tail-flick and hot plate tests mediate the effects at spinal and supraspinal levels respectively, the present study indicates the presence and involvement of noradrenergic receptors in thermal antinociception at spinal and supraspinal levels of the NMR, similar to what has been found in other mammals.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13104-021-05607-7","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T20:04:41Z","timestamp":1621281881000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The effects of clonidine and yohimbine in the tail flick and hot plate tests in the naked mole rat (Heterocephalus glaber)"],"prefix":"10.1186","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1473-768X","authenticated-orcid":false,"given":"R. 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The study also adhered to prevention of cruelty to animals act, chapter 360, laws of Kenya and where applicable to Directive 2010\/63\/EU of the European Parliament and of the Council on the protection of animals used for scientific purposes. The study was also approved by the biosafety, animal use and ethics committee of the Faculty of Veterinary Medicine, University of Nairobi (Ref; FVM BAUEC\/2020\/275).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"191"}}