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The <jats:italic>CYP21A2<\/jats:italic> gene encodes for the steroid 21-hydroxylase enzyme which is required for the biosynthesis of mineralocorticoids and glucocorticoids, two main components of the stress response in humans. Variants in the <jats:italic>CYP21A2<\/jats:italic> gene could influence risk of late-life depression, but this has not been examined. This study investigated possible associations between five variants in the <jats:italic>CYP21A2<\/jats:italic> gene and late-life depression in 1007 older community-dwelling men and women.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In multivariate logistic regression model, significant associations were found between three single-nucleotide polymorphisms (<jats:italic>rs389883<\/jats:italic>, <jats:italic>rs437179<\/jats:italic>, and <jats:italic>rs630379<\/jats:italic>) and depression in women specifically (OR ranging from 1.51 to 1.68, p-values 0.025 to 0.0045), and the two latter remained significant after correction for multiple testing. Variants of the <jats:italic>CYP21A2<\/jats:italic> gene appear as susceptibility factors for late-life depression in a sex-specific manner, independently of somatic and neuropsychiatric comorbidity.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13104-021-05616-6","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:03:24Z","timestamp":1621933404000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Steroid 21-hydroxylase gene variants and late-life depression"],"prefix":"10.1186","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1149-4320","authenticated-orcid":false,"given":"Marie-Laure","family":"Ancelin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Norton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Ritchie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Chaudieu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,25]]},"reference":[{"key":"5616_CR1","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.psyneuen.2013.12.004","volume":"41","author":"M Belvederi Murri","year":"2014","unstructured":"Belvederi Murri M, Pariante C, Mondelli V, Masotti M, Atti AR, Mellacqua Z, Antonioli M, Ghio L, Menchetti M, Zanetidou S, et al. 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The study has been approved by the Ethical Committee of Sud M\u00e9diterran\u00e9e III and University Hospital of Kremlin-Bic\u00eatre, France.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"203"}}