{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T10:27:59Z","timestamp":1782988079605,"version":"3.54.5"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Competitive State Research Financing of the Expert Responsibility Area of Tampere University Hospital"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Res Notes"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>From previous studies, it is known that the association between fibromyalgia and thyroid autoimmunity diseases exists. On the other hand, it was recently suggested that in many cases thyroid hormone treatment might be unnecessary. The aim of our study is to explore the thyroid hormone treatment among primary health care fibromyalgia patients. Our study is cross-sectional and based on fibromyalgia study from the city of Nokia Health Center. Clinical examination was performed to participants, patients filled five questionnaires and information from electronic patient records was gathered. In addition to other parameters, we studied patient\u2019s thyroid function levels at the beginning of thyroid hormone treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>From those patients participating in the study (n\u2009=\u2009103), 34% (n\u2009=\u200933) had thyroid hormone treatment. From those taking thyroid hormone treatment, 48% (n\u2009=\u200916) had information regarding the initial TSH and T4-V levels at the beginning of the treatment. 37% (n\u2009=\u20096) of them had normal thyroid function. Small sample size and data gathered from single health center effects on the generalizability of our findings. However, we suggest further studies to confirm the potential association between fibromyalgia and inappropriate thyroid hormone treatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13104-022-05971-y","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T12:03:01Z","timestamp":1645704181000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Excess use of thyroid hormone treatment among patients with fibromyalgia: a cross-sectional study in primary health care"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1819-2229","authenticated-orcid":false,"given":"Varinen","family":"Aleksi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosunen","family":"Elise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuomas H.","family":"Koskela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,24]]},"reference":[{"key":"5971_CR1","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1001\/jama.2014.3266","volume":"311","author":"DJ Clauw","year":"2014","unstructured":"Clauw DJ. Fibromyalgia: a clinical review. JAMA. 2014;311:1547\u201355.","journal-title":"JAMA"},{"key":"5971_CR2","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1055\/s-0032-1309008","volume":"120","author":"JH Suk","year":"2012","unstructured":"Suk JH, Lee JH, Kim JM. Association between thyroid autoimmunity and fibromyalgia. Exp Clin Endocrinol Diabetes. 2012;120:401\u20134.","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"5971_CR3","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1111\/1756-185X.12964","volume":"20","author":"K Nishioka","year":"2017","unstructured":"Nishioka K, Uchida T, Usui C, et al. High prevalence of anti-TSH receptor antibody in fibromyalgia syndrome. Int J Rheum Dis. 2017;20:685\u201390.","journal-title":"Int J Rheum Dis"},{"issue":"1","key":"5971_CR4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s00228-010-0884-4","volume":"67","author":"LJ Virta","year":"2011","unstructured":"Virta LJ, Eskelinen SI. Prevalence of hypothyroidism in Finland\u2013a nationwide prescription study. European J Clin Pharmacol. 2011;67(1):73\u20137.","journal-title":"European J Clin Pharmacol"},{"issue":"4","key":"5971_CR5","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/S2213-8587(16)30276-5","volume":"5","author":"R Rodriguez-Gutierrez","year":"2017","unstructured":"Rodriguez-Gutierrez R, Maraka S, Ospina NS, et al. Levothyroxine overuse: time for an about face? Lancet Diabet Endocrinol. 2017;5(4):246.","journal-title":"Lancet Diabet Endocrinol"},{"key":"5971_CR6","unstructured":"Soininen M. Joka kolmas tyroksiinihoito voi olla turha 2017; 72: 410."},{"issue":"41","key":"5971_CR7","first-page":"2607","volume":"106","author":"J Calissendorff","year":"2009","unstructured":"Calissendorff J, Lehtihet M. Antithyroid drug-induced agranulocytosis. A rare but dreaded condition. Lakartidningen. 2009;106(41):2607\u20138.","journal-title":"Lakartidningen"},{"issue":"12","key":"5971_CR8","first-page":"1200","volume":"22","author":"JR Garber","year":"2012","unstructured":"Garber JR, Cobin RH, Gharib H, Hennessey JV, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American association of clinical endocrinologists and the American thyroid association. Endocr Pract. 2012;22(12):1200\u201335.","journal-title":"Endocr Pract"},{"issue":"4","key":"5971_CR9","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1001\/archinte.160.4.526","volume":"160","author":"GJ Canaris","year":"2000","unstructured":"Canaris GJ, Manowitz NR, Mayor G, Ridgway EC, et al. The Colorado thyroid disease prevalence study. Arch Intern Med. 2000;160(4):526\u201334.","journal-title":"Arch Intern Med"},{"issue":"7","key":"5971_CR10","first-page":"472","volume":"91","author":"C Kodner","year":"2015","unstructured":"Kodner C. Common questions about the diagnosis and management of fibromyalgia. Am Fam Physician. 2015;91(7):472\u20138.","journal-title":"Am Fam Physician"},{"issue":"5","key":"5971_CR11","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1097\/MED.0000000000000089","volume":"21","author":"MH Samuels","year":"2014","unstructured":"Samuels MH. Psychiatric and cognitive manifestations of hypothyroidism. Curr Opin Endocrinol Diabetes Obes. 2014;21(5):377\u201383. https:\/\/doi.org\/10.1097\/MED.0000000000000089.","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"5971_CR12","unstructured":"Schalin-J\u00e4ntti C. Hypotyreoosi. http:\/\/www.terveysportti.fi\/dtk\/ltk\/koti?p_haku=hypotyreoosi. Accessed 31 Oct 2017."},{"issue":"10","key":"5971_CR13","doi-asserted-by":"publisher","first-page":"4591","DOI":"10.1210\/jcem.86.10.7961","volume":"86","author":"JW Chu","year":"2001","unstructured":"Chu JW, Crapo LM. The treatment of subclinical hypothyroidism is seldom necessary. J Clin Endocrinol Metab. 2001;86(10):4591\u20139.","journal-title":"J Clin Endocrinol Metab"},{"key":"5971_CR14","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003419","author":"HC Villar","year":"2007","unstructured":"Villar HC, Saconato HF, Valente O, Atallah AN, et al. Thyroid hormone replacement for subclinical hypothyroidism. Cochrane Database Syst Rev. 2007. https:\/\/doi.org\/10.1002\/14651858.CD003419.","journal-title":"Cochrane Database Syst Rev"},{"issue":"318","key":"5971_CR15","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.jneuroim.2018.02.013","volume":"15","author":"M Bo","year":"2018","unstructured":"Bo M, Niegowska M, Arru G, Sechi E, Mariotto S, Mancinelli C, Farinazzo A, Alberti D, Gajofatto A, Ferrari S, Capra R, Monaco S, Sechi G, Sechi LA. Mycobacterium avium subspecies paratuberculosis and myelin basic protein specific epitopes are highly recognized by sera from patients with Neuromyelitis optica spectrum disorder. J Neuroimmunol. 2018;15(318):97\u2013102. https:\/\/doi.org\/10.1016\/j.jneuroim.2018.02.013 (Epub 2018).","journal-title":"J Neuroimmunol"},{"issue":"5","key":"5971_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097621.PMID:24830306;PMCID:PMC4022723","volume":"9","author":"S Masala","year":"2014","unstructured":"Masala S, Cossu D, Palermo M, Sechi LA. Recognition of zinc transporter 8 and MAP3865c homologous epitopes by Hashimoto\u2019s thyroiditis subjects from Sardinia: a common target with type 1 diabetes? PLoS ONE. 2014;9(5): e97621. https:\/\/doi.org\/10.1371\/journal.pone.0097621.PMID:24830306;PMCID:PMC4022723.","journal-title":"PLoS ONE"},{"issue":"2","key":"5971_CR17","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1007\/s12016-015-8509-4","volume":"49","author":"AT Borchers","year":"2015","unstructured":"Borchers AT, Gershwin ME. Fibromyalgia: a critical and comprehensive review. Clin Rev Allergy Immunol. 2015;49(2):100\u201351. https:\/\/doi.org\/10.1007\/s12016-015-8509-4.","journal-title":"Clin Rev Allergy Immunol"}],"container-title":["BMC Research Notes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13104-022-05971-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13104-022-05971-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13104-022-05971-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T12:08:15Z","timestamp":1645704495000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcresnotes.biomedcentral.com\/articles\/10.1186\/s13104-022-05971-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,24]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["5971"],"URL":"https:\/\/doi.org\/10.1186\/s13104-022-05971-y","relation":{},"ISSN":["1756-0500"],"issn-type":[{"value":"1756-0500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,24]]},"assertion":[{"value":"28 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Regional Ethics Committee of Tampere University Hospital has approved the study plan (R15041). All participants have given their written consent to participate in the study and for the publication of results.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"83"}}