{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:41:41Z","timestamp":1787020901757,"version":"build-2736575974"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Res Notes"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Constantly high glycemia levels might influence outcomes in the management of patients undergoing surgery for diabetic foot infections (DFI). In our center for DFI, we performed a case\u2013control study using a multivariate Cox regression model. Patients developing a new DFI could participate in the study several times.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1013 different DFI episodes in 586 individual adult patients (type I diabetes 148 episodes [15%], 882 [87%] with osteomyelitis; median antibiotic therapy of 21\u00a0days), professional diabetes counselling was provided by a specialized diabetes nurse in 195 episodes (19%). At admission, blood glucose levels were elevated in 110 episodes (11%). Treatments normalized glycemia on postoperative day 3 in 353 episodes (35%) and on day 7 for 321 (32%) episodes. Glycemia levels entirely normalized for 367 episodes (36%) until the end of hospitalization. Overall, treatment of DFI episodes failed in 255 of 1013 cases (25%), requiring surgical revision. By multivariate analysis, neither the provision of diabetes counseling, nor attaining normalizations of daily glycemic levels at day 3, day 7, or overall, influenced the ultimate incidence of clinical failures. Thus, the rapidity or success of achieving normoglycemia do not appear to influence the risk of treatment failure for operated DFI episodes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13104-022-06150-9","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T21:37:36Z","timestamp":1658957856000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Correction of hyperglycemia after surgery for diabetic foot infection and its association with clinical outcomes"],"prefix":"10.1186","volume":"15","author":[{"given":"C\u00e9line S.","family":"Moret","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madlaina","family":"Sch\u00f6ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix W. A.","family":"Waibel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elin","family":"Winkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina","family":"Grest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina S.","family":"Liechti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Burkhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Holy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin C.","family":"Berli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"Lipsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5552-0973","authenticated-orcid":false,"given":"Ilker","family":"U\u00e7kay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"6150_CR1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3109\/23744235.2015.1082620","volume":"48","author":"M Al-Mayahi","year":"2016","unstructured":"Al-Mayahi M, Cian A, Kressmann B, De Kalbermatten B, Rohner P, Egloff M, et al. Associations of diabetes mellitus with orthopaedic infections. Infect Dis (Lond). 2016;48:70\u20133.","journal-title":"Infect Dis (Lond)"},{"key":"6150_CR2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/aje\/kwx049","volume":"186","author":"A Mor","year":"2017","unstructured":"Mor A, Dekkers OM, Nielsen JS, Beck-Nielsen H, S\u00f8rensen HT, Reimar WT. Impact of glycemic control on risk of infections in patients with type 2 diabetes: a population-based cohort study. Am J Epidemiol. 2017;186:227\u201336.","journal-title":"Am J Epidemiol"},{"key":"6150_CR3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/1062860613489339","volume":"29","author":"A Qaseem","year":"2014","unstructured":"Qaseem A, Chou R, Humphrey LL, Shekelle P. Inpatient glycemic control: best practice advice from the clinical guidelines committee of the American college of physicians. Am J Med Qual. 2014;29:95\u20138.","journal-title":"Am J Med Qual"},{"key":"6150_CR4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/QCO.0000000000000243","volume":"29","author":"I U\u00e7kay","year":"2016","unstructured":"U\u00e7kay I, Gariani K, Dubois-Ferri\u00e8re V, Suv\u00e0 D, Lipsky BA. Diabetic foot infections: recent literature and cornerstones of management. Curr Opin Infect Dis. 2016;29:145\u201352.","journal-title":"Curr Opin Infect Dis"},{"key":"6150_CR5","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13063-019-4006-z","volume":"21","author":"F Waibel","year":"2020","unstructured":"Waibel F, Berli M, Catanzaro S, Sairanen K, Sch\u00f6ni M, B\u00f6ni T, et al. Optimization of the antibiotic management of diabetic foot infections: protocol for two randomized controlled trials. Trials. 2020;21:54.","journal-title":"Trials"},{"key":"6150_CR6","doi-asserted-by":"crossref","first-page":"32802","DOI":"10.1002\/dmrr.3280","volume":"36","author":"BA Lipsky","year":"2020","unstructured":"Lipsky BA, Senneville E, Abbas ZG, Arag\u00f3n-S\u00e1nchez J, Diggle M, Embil JM, et al. Guidelines on the diagnosis and treatment of foot infection in people with diabetes (IWGDF 2019 update). Diabetes Metab Res Rev. 2020;36:32802.","journal-title":"Diabetes Metab Res Rev"},{"key":"6150_CR7","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/dom.13507","volume":"21","author":"K Gariani","year":"2019","unstructured":"Gariani K, Lebowitz D, von Dach E, Kressmann B, Lipsky BA, U\u00e7kay I. Remission in diabetic foot infections: duration of antibiotic therapy and other possible associated factors. Diabetes Obes Metab. 2019;21:244\u201351.","journal-title":"Diabetes Obes Metab"},{"key":"6150_CR8","doi-asserted-by":"crossref","first-page":"00298","DOI":"10.1002\/edm2.298","volume":"5","author":"I U\u00e7kay","year":"2022","unstructured":"U\u00e7kay I, Sch\u00f6ni M, Berli MC, Niggli F, Noschajew E, Lipsky BA, Waibel FWA. The association of chronic, enhanced immunosuppression with outcomes of diabetic foot infections. Endocrinol Diabetes Metab. 2022;5:00298.","journal-title":"Endocrinol Diabetes Metab"},{"key":"6150_CR9","doi-asserted-by":"publisher","DOI":"10.1177\/10711007221088552","author":"E Winkler","year":"2022","unstructured":"Winkler E, Sch\u00f6ni M, Kr\u00e4henb\u00fchl N, U\u00e7kay I, Waibel FWA. Foot osteomyelitis location and rates of primary or secondary major amputations in patients with diabetes. Foot Ankle Int. 2022. https:\/\/doi.org\/10.1177\/10711007221088552.","journal-title":"Foot Ankle Int."},{"key":"6150_CR10","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1056\/NEJMoa0810625","volume":"360","author":"S Finfer","year":"2009","unstructured":"Finfer S, Chittock DR, Yu-Shuo Su S, Blair D, Foster D, Dhingra V, NICE-SUGAR Study Investigators, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360:1283\u201397.","journal-title":"N Engl J Med"},{"key":"6150_CR11","volume":"34","author":"KL Lane","year":"2020","unstructured":"Lane KL, Abusamaan MS, Fesseha Voss B, Thurber EG, Al-Hajri N, Gopakumar S, et al. Glycemic control and diabetic foot ulcer outcomes: a systematic review and meta-analysis of observational studies. 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The informed consent is written.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"264"}}