{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T21:38:19Z","timestamp":1788730699943,"version":"build-2803163510"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T00:00:00Z","timestamp":1722038400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T00:00:00Z","timestamp":1722038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004481","name":"University of Tehran","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004481","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Res Notes"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>Vitamin D deficiency and variations in the vitamin D binding protein (VDBP) gene may play a role in the development of Polycystic ovary syndrome (PCOS). This study aims to investigate the association of the rs4588 polymorphism with PCOS in Iranian women, as well as its association with infertility and recurrent pregnancy loss (RPL) in these patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The analysis revealed statistically significant differences in the distributions of genotypes and alleles of the rs4588 polymorphism among the three groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). The AC genotype and A allele showed an association with an elevated risk of PCOS and infertility. In this study, no association was found between genotypes and alleles of the rs4588 polymorphism and the risk of RPL in women with PCOS. Subjects with the AA or AC genotype exhibited significantly higher levels of LDL compared to those with the CC genotype.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13104-024-06857-x","type":"journal-article","created":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T15:01:42Z","timestamp":1722092502000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of rs4588 polymorphism in vitamin D binding protein gene with polycystic ovarian syndrome in Iranian women: a case-control study"],"prefix":"10.1186","volume":"17","author":[{"given":"Leila Nazarpoor","family":"Akbari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Kheirollahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akram","family":"Vatannejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hediyeh","family":"Hamidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,27]]},"reference":[{"key":"6857_CR1","doi-asserted-by":"publisher","first-page":"263349412091103","DOI":"10.1177\/2633494120911038","volume":"14","author":"YV Louwers","year":"2020","unstructured":"Louwers YV, Laven JS. Characteristics of polycystic ovary syndrome throughout life. Therapeutic Adv Reproductive Health. 2020;14:2633494120911038.","journal-title":"Therapeutic Adv Reproductive Health"},{"issue":"1","key":"6857_CR2","first-page":"1","volume":"2","author":"R Azziz","year":"2016","unstructured":"Azziz R, et al. Polycystic ovary syndrome. Nat Reviews Disease Primers. 2016;2(1):1\u201318.","journal-title":"Nat Reviews Disease Primers"},{"issue":"1","key":"6857_CR3","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","volume":"81","author":"TR ESHRE","year":"2004","unstructured":"ESHRE TR, Group A-SPCW. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81(1):19\u201325.","journal-title":"Fertil Steril"},{"issue":"10","key":"6857_CR4","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1080\/09513590.2021.1958310","volume":"37","author":"J Coll\u00e9e","year":"2021","unstructured":"Coll\u00e9e J, et al. Polycystic ovarian syndrome and infertility: overview and insights of the putative treatments. Gynecol Endocrinol. 2021;37(10):869\u201374.","journal-title":"Gynecol Endocrinol"},{"key":"6857_CR5","doi-asserted-by":"publisher","first-page":"314","DOI":"10.14310\/horm.2002.1505","volume":"13","author":"N Pluchino","year":"2014","unstructured":"Pluchino N, et al. Hormonal causes of recurrent pregnancy loss (RPL). Hormones. 2014;13:314\u201322.","journal-title":"Hormones"},{"key":"6857_CR6","doi-asserted-by":"crossref","unstructured":"Condorelli RA, et al. PCOS and diabetes mellitus: from insulin resistance to altered beta pancreatic function, a link in evolution. Taylor & Francis; 2017. pp. 665\u20137.","DOI":"10.1080\/09513590.2017.1342240"},{"issue":"8","key":"6857_CR7","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.steroids.2013.04.009","volume":"78","author":"A Dokras","year":"2013","unstructured":"Dokras A. Cardiovascular disease risk in women with PCOS. Steroids. 2013;78(8):773\u20136.","journal-title":"Steroids"},{"key":"6857_CR8","doi-asserted-by":"crossref","unstructured":"Navaratnarajah R, Pillay OC, Hardiman P. Polycystic ovary syndrome and endometrial cancer. Seminars in reproductive medicine. \u00a9 Thieme Medical; 2008.","DOI":"10.1055\/s-2007-992926"},{"issue":"1","key":"6857_CR9","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jsmc.2007.11.001","volume":"3","author":"E Tasali","year":"2008","unstructured":"Tasali E, Van Cauter E, Ehrmann DA. Polycystic ovary syndrome and obstructive sleep apnea. Sleep Med Clin. 2008;3(1):37\u201346.","journal-title":"Sleep Med Clin"},{"key":"6857_CR10","unstructured":"Kolhe JV et al. PCOS and depression: common links and potential targets. Reproductive Sci, 2022: p. 1\u201318."},{"issue":"9","key":"6857_CR11","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1017\/S0033291718002076","volume":"49","author":"AL Damone","year":"2019","unstructured":"Damone AL, et al. Depression, anxiety and perceived stress in women with and without PCOS: a community-based study. Psychol Med. 2019;49(9):1510\u201320.","journal-title":"Psychol Med"},{"key":"6857_CR12","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1385\/ENDO:30:1:27","volume":"30","author":"A Gorry","year":"2006","unstructured":"Gorry A, White DM, Franks S. Infertility in polycystic ovary syndrome: focus on low-dose gonadotropin treatment. Endocrine. 2006;30:27\u201333.","journal-title":"Endocrine"},{"issue":"1","key":"6857_CR13","doi-asserted-by":"publisher","first-page":"37","DOI":"10.4103\/2230-8210.107830","volume":"17","author":"S Kamalanathan","year":"2013","unstructured":"Kamalanathan S, Sahoo JP, Sathyapalan T. Pregnancy in polycystic ovary syndrome. Indian J Endocrinol Metabol. 2013;17(1):37\u201343.","journal-title":"Indian J Endocrinol Metabol"},{"issue":"4","key":"6857_CR14","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.4314\/ahs.v20i4.45","volume":"20","author":"F Gokosmanoglu","year":"2020","unstructured":"Gokosmanoglu F, Onmez A, Ergen\u00e7 H. The relationship between vitamin D deficiency and polycystic ovary syndrome. Afr Health Sci. 2020;20(4):1880\u20136.","journal-title":"Afr Health Sci"},{"issue":"2","key":"6857_CR15","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1210\/jc.2018-00750","volume":"104","author":"SF Butts","year":"2019","unstructured":"Butts SF, et al. Vitamin D deficiency is associated with poor ovarian stimulation outcome in PCOS but not unexplained infertility. J Clin Endocrinol Metabolism. 2019;104(2):369\u201378.","journal-title":"J Clin Endocrinol Metabolism"},{"key":"6857_CR16","first-page":"519457","volume":"11","author":"L Wang","year":"2020","unstructured":"Wang L, Yang X. Vitamin D deficiency is associated with metabolic risk factors in women with polycystic ovary syndrome: a cross-sectional study in Shaanxi China. Front Endocrinol. 2020;11:519457.","journal-title":"Front Endocrinol"},{"key":"6857_CR17","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ejogrb.2018.08.001","volume":"229","author":"KD Mogili","year":"2018","unstructured":"Mogili KD, et al. Prevalence of vitamin D deficiency in infertile women with polycystic ovarian syndrome and its association with metabolic syndrome\u2013A prospective observational study. Eur J Obstet Gynecol Reproductive Biology. 2018;229:15\u20139.","journal-title":"Eur J Obstet Gynecol Reproductive Biology"},{"key":"6857_CR18","doi-asserted-by":"crossref","unstructured":"Piao C et al. Effect of vitamin D on pregnancy in women with polycystic ovary syndrome: a retrospective and prospective study. Reprod Biomed Online, 2024: p. 103909.","DOI":"10.1016\/j.rbmo.2024.103909"},{"issue":"2","key":"6857_CR19","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.ctcp.2012.01.005","volume":"18","author":"R dehghani Firouzabadi","year":"2012","unstructured":"dehghani Firouzabadi R, et al. Therapeutic effects of calcium & vitamin D supplementation in women with PCOS. Complement Ther Clin Pract. 2012;18(2):85\u20138.","journal-title":"Complement Ther Clin Pract"},{"issue":"6","key":"6857_CR20","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1002\/cbf.2835","volume":"30","author":"RF Chun","year":"2012","unstructured":"Chun RF. New perspectives on the vitamin D binding protein. Cell Biochem Funct. 2012;30(6):445\u201356.","journal-title":"Cell Biochem Funct"},{"key":"6857_CR21","doi-asserted-by":"publisher","first-page":"484325","DOI":"10.3389\/fendo.2019.00910","volume":"10","author":"R Bouillon","year":"2020","unstructured":"Bouillon R, et al. Vitamin D binding protein: a historic overview. Front Endocrinol. 2020;10:484325.","journal-title":"Front Endocrinol"},{"issue":"01","key":"6857_CR22","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1055\/a-0759-7533","volume":"51","author":"J Kuliczkowska-Plaksej","year":"2019","unstructured":"Kuliczkowska-Plaksej J, et al. Serum vitamin D binding protein level associated with metabolic cardiovascular risk factors in women with the polycystic ovary syndrome. Horm Metab Res. 2019;51(01):54\u201361.","journal-title":"Horm Metab Res"},{"issue":"7","key":"6857_CR23","doi-asserted-by":"publisher","first-page":"3656","DOI":"10.1210\/en.2008-0042","volume":"149","author":"LA Zella","year":"2008","unstructured":"Zella LA, et al. Vitamin D-binding protein influences total circulating levels of 1, 25-dihydroxyvitamin D3 but does not directly modulate the bioactive levels of the hormone in vivo. Endocrinology. 2008;149(7):3656\u201367.","journal-title":"Endocrinology"},{"issue":"6","key":"6857_CR24","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.1016\/j.bpj.2008.12.3904","volume":"96","author":"S Teng","year":"2009","unstructured":"Teng S, et al. Modeling effects of human single nucleotide polymorphisms on protein-protein interactions. Biophys J. 2009;96(6):2178\u201388.","journal-title":"Biophys J"},{"issue":"2","key":"6857_CR25","doi-asserted-by":"publisher","first-page":"933","DOI":"10.3390\/ijms23020933","volume":"23","author":"D Rozmus","year":"2022","unstructured":"Rozmus D, et al. rs7041 and rs4588 polymorphisms in vitamin D binding protein gene (VDBP) and the risk of diseases. Int J Mol Sci. 2022;23(2):933.","journal-title":"Int J Mol Sci"},{"key":"6857_CR26","doi-asserted-by":"publisher","first-page":"460694","DOI":"10.3389\/fendo.2019.00317","volume":"10","author":"DD Bikle","year":"2019","unstructured":"Bikle DD, Schwartz J. Vitamin D binding protein, total and free vitamin D levels in different physiological and pathophysiological conditions. Front Endocrinol. 2019;10:460694.","journal-title":"Front Endocrinol"},{"issue":"8","key":"6857_CR27","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1002\/jbmr.1926","volume":"28","author":"Z Zhang","year":"2013","unstructured":"Zhang Z, et al. An analysis of the association between the vitamin D pathway and serum 25-hydroxyvitamin D levels in a healthy Chinese population. J Bone Miner Res. 2013;28(8):1784\u201392.","journal-title":"J Bone Miner Res"},{"key":"6857_CR28","doi-asserted-by":"publisher","first-page":"1281112","DOI":"10.3389\/fendo.2023.1281112","volume":"14","author":"D Do\u011fan","year":"2023","unstructured":"Do\u011fan D, et al. Genetic influence on urinary vitamin D binding protein excretion and serum levels: a focus on rs4588 C\u2009>\u2009A polymorphism in the GC gene. Front Endocrinol. 2023;14:1281112.","journal-title":"Front Endocrinol"},{"issue":"11","key":"6857_CR29","doi-asserted-by":"publisher","first-page":"e0242256","DOI":"10.1371\/journal.pone.0242256","volume":"15","author":"X Zhang","year":"2020","unstructured":"Zhang X, Gao B, Xu B. No association between the vitamin D-binding protein (DBP) gene polymorphisms (rs7041 and rs4588) and multiple sclerosis and type 1 diabetes mellitus: a meta-analysis. PLoS ONE. 2020;15(11):e0242256.","journal-title":"PLoS ONE"},{"issue":"4","key":"6857_CR30","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1139\/apnm-2015-0284","volume":"41","author":"N Almesri","year":"2016","unstructured":"Almesri N, et al. Independent associations of polymorphisms in vitamin D binding protein (GC) and vitamin D receptor (VDR) genes with obesity and plasma 25OHD3 levels demonstrate sex dimorphism. Appl Physiol Nutr Metab. 2016;41(4):345\u201353.","journal-title":"Appl Physiol Nutr Metab"},{"issue":"4","key":"6857_CR31","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1111\/resp.12277","volume":"19","author":"T Ishii","year":"2014","unstructured":"Ishii T, et al. Association of group component genetic variations in COPD and COPD exacerbation in a Japanese population. Respirology. 2014;19(4):590\u20135.","journal-title":"Respirology"},{"issue":"3","key":"6857_CR32","doi-asserted-by":"publisher","first-page":"e12740","DOI":"10.1111\/sji.12740","volume":"89","author":"MS Fawzy","year":"2019","unstructured":"Fawzy MS, et al. Association of group-specific component exon 11 polymorphisms with bronchial asthma in children and adolescents. Scand J Immunol. 2019;89(3):e12740.","journal-title":"Scand J Immunol"},{"issue":"2","key":"6857_CR33","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1080\/01635581.2022.2156551","volume":"75","author":"S Ghazaey Zidanloo","year":"2023","unstructured":"Ghazaey Zidanloo S, Jahantigh D, Amini N, Vitamin D-B. Protein and Acute myeloid leukemia: a Genetic Association Analysis in combination with Vitamin D Levels. Nutr Cancer. 2023;75(2):470\u201381.","journal-title":"Nutr Cancer"},{"key":"6857_CR34","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s00394-016-1357-z","volume":"57","author":"D Haldar","year":"2018","unstructured":"Haldar D, et al. Association of VDBP and CYP2R1 gene polymorphisms with vitamin D status in women with polycystic ovarian syndrome: a north Indian study. Eur J Nutr. 2018;57:703\u201311.","journal-title":"Eur J Nutr"},{"key":"6857_CR35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12902-018-0327-2","volume":"19","author":"DK Song","year":"2019","unstructured":"Song DK, et al. Vitamin D receptor and binding protein polymorphisms in women with polycystic ovary syndrome: a case control study. BMC Endocr Disorders. 2019;19:1\u20138.","journal-title":"BMC Endocr Disorders"},{"key":"6857_CR36","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jbi.2014.02.013","volume":"48","author":"K Hajian-Tilaki","year":"2014","unstructured":"Hajian-Tilaki K. Sample size estimation in diagnostic test studies of biomedical informatics. J Biomed Inform. 2014;48:193\u2013204.","journal-title":"J Biomed Inform"},{"issue":"2","key":"6857_CR37","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/0020-7292(94)90230-5","volume":"46","author":"J Sciarra","year":"1994","unstructured":"Sciarra J. Infertility: an international health problem. Int J Gynecol Obstet. 1994;46(2):155\u201363.","journal-title":"Int J Gynecol Obstet"},{"key":"6857_CR38","unstructured":"Khan R, Talaulikar V, Shehata H. Recurrent pregnancy loss."},{"issue":"12","key":"6857_CR39","doi-asserted-by":"publisher","first-page":"e0208059","DOI":"10.1371\/journal.pone.0208059","volume":"13","author":"M Shanaki","year":"2018","unstructured":"Shanaki M, et al. Lower circulating levels of CTRP12 and CTRP13 in polycystic ovarian syndrome: irrespective of obesity. PLoS ONE. 2018;13(12):e0208059.","journal-title":"PLoS ONE"},{"issue":"7","key":"6857_CR40","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1002\/iub.2272","volume":"72","author":"A Sadeghi","year":"2020","unstructured":"Sadeghi A, et al. Circulating levels of C1q\/TNF-\u03b1\u2010related protein 6 (CTRP6) in polycystic ovary syndrome. IUBMB Life. 2020;72(7):1449\u201359.","journal-title":"IUBMB Life"},{"key":"6857_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12944-020-01410-8","volume":"19","author":"A Kheirollahi","year":"2020","unstructured":"Kheirollahi A, et al. Evaluation of lipid ratios and triglyceride-glucose index as risk markers of insulin resistance in Iranian polycystic ovary syndrome women. Lipids Health Dis. 2020;19:1\u20139.","journal-title":"Lipids Health Dis"},{"issue":"4","key":"6857_CR42","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1515\/jomb-2017-0015","volume":"36","author":"S Tarighi","year":"2017","unstructured":"Tarighi S, et al. Association between two common polymorphisms of vitamin D binding protein and the risk of coronary artery disease: a case-control study. J Med Biochem. 2017;36(4):349.","journal-title":"J Med Biochem"},{"key":"6857_CR43","doi-asserted-by":"publisher","first-page":"1610246","DOI":"10.3389\/pore.2022.1610246","volume":"28","author":"M Amiri","year":"2022","unstructured":"Amiri M, et al. Association between Vitamin D Binding Protein Gene Polymorphism (rs7041), Vitamin D Receptor, and 25-Hydroxyvitamin D serum levels with prostate Cancer in kurdish Population in West of Iran. Pathol Oncol Res. 2022;28:1610246.","journal-title":"Pathol Oncol Res"},{"issue":"3","key":"6857_CR44","doi-asserted-by":"publisher","first-page":"e0173695","DOI":"10.1371\/journal.pone.0173695","volume":"12","author":"BR Santos","year":"2017","unstructured":"Santos BR, Lecke SB, Spritzer PM. Genetic variant in vitamin D-binding protein is associated with metabolic syndrome and lower 25-hydroxyvitamin D levels in polycystic ovary syndrome: a cross-sectional study. PLoS ONE. 2017;12(3):e0173695.","journal-title":"PLoS ONE"},{"key":"6857_CR45","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.jsbmb.2017.07.012","volume":"177","author":"N Naderpoor","year":"2018","unstructured":"Naderpoor N, et al. Bioavailable and free 25-hydroxyvitamin D and vitamin D binding protein in polycystic ovary syndrome: relationships with obesity and insulin resistance. J Steroid Biochem Mol Biol. 2018;177:209\u201315.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"6857_CR46","doi-asserted-by":"publisher","first-page":"621845","DOI":"10.3389\/fendo.2021.621845","volume":"12","author":"Y Liu","year":"2021","unstructured":"Liu Y, et al. Triglyceride induced metabolic inflammation: potential connection of insulin resistance and recurrent pregnancy loss. Front Endocrinol. 2021;12:621845.","journal-title":"Front Endocrinol"},{"key":"6857_CR47","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.ygcen.2017.12.007","volume":"260","author":"N Malini","year":"2018","unstructured":"Malini N, George KR. Evaluation of different ranges of LH: FSH ratios in polycystic ovarian syndrome (PCOS)\u2013Clinical based case control study. Gen Comp Endocrinol. 2018;260:51\u20137.","journal-title":"Gen Comp Endocrinol"},{"issue":"5","key":"6857_CR48","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1530\/EJE-11-0134","volume":"164","author":"E Wehr","year":"2011","unstructured":"Wehr E, et al. Vitamin D-associated polymorphisms are related to insulin resistance and vitamin D deficiency in polycystic ovary syndrome. Eur J Endocrinol. 2011;164(5):741\u20139.","journal-title":"Eur J Endocrinol"},{"issue":"9","key":"6857_CR49","first-page":"875","volume":"19","author":"HG Tehrani","year":"2014","unstructured":"Tehrani HG, Mostajeran F, Shahsavari S. The effect of calcium and vitamin D supplementation on menstrual cycle, body mass index and hyperandrogenism state of women with poly cystic ovarian syndrome. J Res Med Sciences: Official J Isfahan Univ Med Sci. 2014;19(9):875.","journal-title":"J Res Med Sciences: Official J Isfahan Univ Med Sci"},{"issue":"3","key":"6857_CR50","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.nutres.2012.02.001","volume":"32","author":"HR Ardabili","year":"2012","unstructured":"Ardabili HR, Gargari BP, Farzadi L. Vitamin D supplementation has no effect on insulin resistance assessment in women with polycystic ovary syndrome and vitamin D deficiency. Nutr Res. 2012;32(3):195\u2013201.","journal-title":"Nutr Res"},{"issue":"11","key":"6857_CR51","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1089\/gtmb.2015.0058","volume":"19","author":"ZM Lafi","year":"2015","unstructured":"Lafi ZM, et al. Association of rs7041 and rs4588 polymorphisms of the vitamin D binding protein and the rs10741657 polymorphism of CYP2R1 with vitamin D status among Jordanian patients. Genetic Test Mol Biomarkers. 2015;19(11):629\u201336.","journal-title":"Genetic Test Mol Biomarkers"},{"key":"6857_CR52","doi-asserted-by":"publisher","first-page":"100822","DOI":"10.1016\/j.mgene.2020.100822","volume":"26","author":"M Harishankar","year":"2020","unstructured":"Harishankar M, et al. Association of rs7041 and rs4588 polymorphisms of vitamin D binding protein gene in pulmonary tuberculosis. Meta Gene. 2020;26:100822.","journal-title":"Meta Gene"},{"key":"6857_CR53","doi-asserted-by":"publisher","first-page":"1281112","DOI":"10.3389\/fendo.2023.1281112","volume":"14","author":"D Do\u011fan","year":"2023","unstructured":"Do\u011fan D, \u00d6zcan EG, \u00c7ak\u0131r D\u00dc. Genetic influence on urinary vitamin D binding protein excretion and serum levels: a focus on rs4588 C\u2009>\u2009A polymorphism in the GC gene. Front Endocrinol. 2023;14:1281112.","journal-title":"Front Endocrinol"},{"issue":"8","key":"6857_CR54","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.3390\/genes12081176","volume":"12","author":"B Rivera-Paredez","year":"2021","unstructured":"Rivera-Paredez B, et al. Association of GC variants with bone mineral density and serum VDBP concentrations in Mexican population. Genes. 2021;12(8):1176.","journal-title":"Genes"},{"issue":"3","key":"6857_CR55","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1159\/000348847","volume":"79","author":"BR Santos","year":"2013","unstructured":"Santos BR, et al. Variations in the vitamin D-binding protein (DBP) gene are related to lower 25-hydroxyvitamin D levels in healthy girls: a cross-sectional study. Hormone Res Paediatrics. 2013;79(3):162\u20138.","journal-title":"Hormone Res Paediatrics"},{"issue":"1","key":"6857_CR56","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/nbu.12656","volume":"49","author":"HW Tsang","year":"2024","unstructured":"Tsang HW, et al. Association of vitamin D-binding protein polymorphisms and serum 25 (OH) D concentration varies among Chinese healthy infants of different VDR\u2010FokI genotypes: a multi\u2010centre cross\u2010sectional study. Nutr Bull. 2024;49(1):63\u201372.","journal-title":"Nutr Bull"},{"issue":"1","key":"6857_CR57","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1210\/jc.2016-2930","volume":"102","author":"P Yao","year":"2017","unstructured":"Yao P, et al. Effects of genetic and nongenetic factors on total and bioavailable 25 (OH) D responses to vitamin D supplementation. J Clin Endocrinol Metabolism. 2017;102(1):100\u201310.","journal-title":"J Clin Endocrinol Metabolism"},{"issue":"5","key":"6857_CR58","doi-asserted-by":"publisher","first-page":"465","DOI":"10.2217\/bmm-2018-0029","volume":"12","author":"P Karuwanarint","year":"2018","unstructured":"Karuwanarint P, et al. Vitamin D-binding protein and its polymorphisms as a predictor for metabolic syndrome. Biomark Med. 2018;12(5):465\u201373.","journal-title":"Biomark Med"},{"key":"6857_CR59","doi-asserted-by":"publisher","first-page":"765","DOI":"10.6061\/clinics\/2015(11)09","volume":"70","author":"AS Melo","year":"2015","unstructured":"Melo AS, Ferriani RA, Navarro PA. Treatment of infertility in women with polycystic ovary syndrome: approach to clinical practice. Clinics. 2015;70:765\u20139.","journal-title":"Clinics"},{"issue":"11","key":"6857_CR60","doi-asserted-by":"publisher","first-page":"3321","DOI":"10.1093\/humrep\/des280","volume":"27","author":"B Rudick","year":"2012","unstructured":"Rudick B, et al. Characterizing the influence of vitamin D levels on IVF outcomes. Hum Reprod. 2012;27(11):3321\u20137.","journal-title":"Hum Reprod"},{"key":"6857_CR61","doi-asserted-by":"crossref","unstructured":"Zhao T et al. The Association Between GC Gene Polymorphisms and Metabolic Syndrome in Chinese Rural Population: A Case\u2013Control Study. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2022: pp. 165\u2013174.","DOI":"10.2147\/DMSO.S346528"},{"issue":"10","key":"6857_CR62","doi-asserted-by":"publisher","first-page":"e0165157","DOI":"10.1371\/journal.pone.0165157","volume":"11","author":"Y Wang","year":"2016","unstructured":"Wang Y, et al. The associations of serum lipids with vitamin D status. PLoS ONE. 2016;11(10):e0165157.","journal-title":"PLoS ONE"},{"issue":"3","key":"6857_CR63","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1079\/BJN2001508","volume":"87","author":"T Vaskonen","year":"2002","unstructured":"Vaskonen T, et al. Effects of calcium and plant sterols on serum lipids in obese Zucker rats on a low-fat diet. Br J Nutr. 2002;87(3):239\u201345.","journal-title":"Br J Nutr"},{"issue":"7","key":"6857_CR64","doi-asserted-by":"publisher","first-page":"125","DOI":"10.3390\/metabo9070125","volume":"9","author":"MR Kim","year":"2019","unstructured":"Kim MR, Jeong SJ. Relationship between vitamin D level and lipid profile in non-obese children. Metabolites. 2019;9(7):125.","journal-title":"Metabolites"}],"container-title":["BMC Research Notes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13104-024-06857-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13104-024-06857-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13104-024-06857-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T16:06:10Z","timestamp":1722096370000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcresnotes.biomedcentral.com\/articles\/10.1186\/s13104-024-06857-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,27]]},"references-count":64,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["6857"],"URL":"https:\/\/doi.org\/10.1186\/s13104-024-06857-x","relation":{},"ISSN":["1756-0500"],"issn-type":[{"value":"1756-0500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,27]]},"assertion":[{"value":"3 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1975 Helsinki declaration as revised in 2008. The present research was approved by the Ethics Committee of Ibn Sina Infertility Center. Informed consent was obtained by means of a written informed consent form prior to beginning the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"207"}}