{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T04:13:51Z","timestamp":1730434431515,"version":"3.28.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004869","name":"Universit\u00e4t M\u00fcnster","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004869","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Res Notes"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>This study investigated gene polymorphisms in the interleukin-4 (IL-4) and its receptor alpha (IL-4R\u03b1) gene regions in human hosts with uncomplicated malaria.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Data description<\/jats:title>\n                <jats:p>Blood samples were obtained from a case-control study conducted at the Sogakope district hospital in the Volta region of Ghana. Thick blood films were made and used to detect the presence and levels of parasitaemia in the patient samples. Genotyping of IL-4 (150\u00a0C\/T) and the IL-4R\u03b1 (Pro-478-Ser) polymorphisms in the promoter regions and receptor gene was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) after DNA extraction. The data are useful in determining genetic polymorphisms (allele and genotypic frequencies) of IL-4 and its alpha receptor. In addition, they are useful when comparing levels of parasite density and haematological parameters between genotypic variants of IL-4 and IL-4R\u03b1. These data contribute to our understanding of the genetic basis of malaria susceptibility, particularly in the population of the Volta region of Ghana.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13104-024-06984-5","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T13:02:20Z","timestamp":1730379740000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interleukin-4 and its receptor alpha in paediatric uncomplicated malaria patients from a Ghanaian case-control study"],"prefix":"10.1186","volume":"17","author":[{"given":"Patrick","family":"Diaba-Nuhoho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"6984_CR1","unstructured":"NMSP. National Malaria Strategic Plan (NMSP) 2021\u20132025. National malaria control programme. Ghana Health Service (GHS). Ghana Health Service (GHS), Accra. 2020. https:\/\/ghs.gov.gh\/wp-content\/uploads\/2022\/10\/Malaria-STRATEGIC-PLAN-today-1.pdf. Assessed 27\/04\/2024."},{"key":"6984_CR2","unstructured":"MIS. Ghana Malaria Indicator Survey 2019. Ghana Statistical Service (GSS), Ghana Health Service (GHS), and ICF. Ghana Statistical Service (GSS), Ghana Health Service (GHS), and ICF, Accra. 2020. https:\/\/dhsprogram.com\/pubs\/pdf\/MIS35\/MIS35.pdf. Assessed 27\/04\/2024."},{"key":"6984_CR3","doi-asserted-by":"publisher","first-page":"1285411","DOI":"10.3389\/fimmu.2024.1285411","volume":"15","author":"SP Segbefia","year":"2024","unstructured":"Segbefia SP, Asandem DA, Amoah LE, Kusi KA. Cytokine gene polymorphisms implicated in the pathogenesis of Plasmodium falciparum infection outcome. Front Immunol. 2024;15:1285411. https:\/\/doi.org\/10.3389\/fimmu.2024.1285411.","journal-title":"Front Immunol"},{"issue":"5162","key":"6984_CR4","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1126\/science.8178175","volume":"264","author":"DG Marsh","year":"1994","unstructured":"Marsh DG, Neely JD, Breazeale DR, Ghosh B, Freidhoff LR, Ehrlich-Kautzky E, et al. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science. 1994;264(5162):1152\u20136. https:\/\/doi.org\/10.1126\/science.8178175.","journal-title":"Science"},{"issue":"2","key":"6984_CR5","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1086\/301967","volume":"63","author":"P Rihet","year":"1998","unstructured":"Rihet P, Traor\u00e9 Y, Abel L, Aucan C, Traor\u00e9-Leroux T, Fumoux F. Malaria in humans: Plasmodium falciparum blood infection levels are linked to chromosome 5q31-q33. Am J Hum Genet. 1998;63(2):498\u2013505. https:\/\/doi.org\/10.1086\/301967.","journal-title":"Am J Hum Genet"},{"issue":"6","key":"6984_CR6","doi-asserted-by":"publisher","first-page":"705","DOI":"10.4269\/ajtmh.1998.58.705","volume":"58","author":"A Garcia","year":"1998","unstructured":"Garcia A, Marquet S, Bucheton B, Hillaire D, Cot M, Fievet N, et al. Linkage analysis of blood Plasmodium falciparum levels: interest of the 5q31-q33 chromosome region. Am J Trop Med Hyg. 1998;58(6):705\u20139. https:\/\/doi.org\/10.4269\/ajtmh.1998.58.705.","journal-title":"Am J Trop Med Hyg"},{"key":"6984_CR7","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1159\/000058847","volume":"80","author":"M Troye-Blomberg","year":"2002","unstructured":"Troye-Blomberg M. Genetic regulation of malaria infection in humans. Chem Immunol. 2002;80:243\u201352. https:\/\/doi.org\/10.1159\/000058847.","journal-title":"Chem Immunol"},{"issue":"14","key":"6984_CR8","doi-asserted-by":"publisher","first-page":"5484","DOI":"10.1073\/pnas.87.14.5484","volume":"87","author":"M Troye-Blomberg","year":"1990","unstructured":"Troye-Blomberg M, Riley EM, Kabilan L, Holmberg M, Perlmann H, Andersson U, et al. Production by activated human T cells of interleukin 4 but not interferon-gamma is associated with elevated levels of serum antibodies to activating malaria antigens. Proc Natl Acad Sci U S A. 1990;87(14):5484\u20138. https:\/\/doi.org\/10.1073\/pnas.87.14.5484.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"6984_CR9","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1046\/j.1365-2249.1997.4401337.x","volume":"109","author":"G Elghazali","year":"1997","unstructured":"Elghazali G, Perlmann H, Rutta AS, Perlmann P, Troye-Blomberg M. Elevated plasma levels of IgE in Plasmodium falciparum-primed individuals reflect an increased ratio of IL-4 to interferon-gamma (IFN-gamma)-producing cells. Clin Exp Immunol. 1997;109(1):84\u20139. https:\/\/doi.org\/10.1046\/j.1365-2249.1997.4401337.x.","journal-title":"Clin Exp Immunol"},{"issue":"6","key":"6984_CR10","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1179\/2295333715y.0000000042","volume":"70","author":"AB Elhussein","year":"2015","unstructured":"Elhussein AB, Huneif MA, Naeem A, Fadlelseed OE, Babiker WG, Rahma NE, et al. Correlation of interleukin-4 levels with Plasmodium falciparum malaria parasitaemia in Sudanese children. 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Interleukin-4 and its receptor alpha in paediatric uncomplicated malaria. Harv Dataverse. 2024;V3. https:\/\/doi.org\/10.7910\/DVN\/VY6SVX.","DOI":"10.7910\/DVN\/VY6SVX"}],"container-title":["BMC Research Notes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13104-024-06984-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13104-024-06984-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13104-024-06984-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T13:03:40Z","timestamp":1730379820000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcresnotes.biomedcentral.com\/articles\/10.1186\/s13104-024-06984-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,31]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["6984"],"URL":"https:\/\/doi.org\/10.1186\/s13104-024-06984-5","relation":{},"ISSN":["1756-0500"],"issn-type":[{"value":"1756-0500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,31]]},"assertion":[{"value":"28 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Ethical and Protocol Review Committee of the School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana approved this project. Written informed consent was obtained from all patients before inclusion.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The author declares no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"328"}}