{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:37:33Z","timestamp":1786117053933,"version":"build-2736575974"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":65,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007797","name":"University of Helsinki","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007797","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Res Notes"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Epilepsy and traumatic brain injury have a bidirectional relationship. This study aimed to report the prevalences of antemortem epilepsy diagnosis, seizure history, epilepsy-related and traumatic neuropathological findings, as well as background characteristics, among neuropathologically examined medico-legal autopsy cases with acute head injuries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The sample included 82 cases from Helsinki, Finland, from the years 2016\u20142022. Of the sample, 17 cases had an epilepsy diagnosis or documented seizure history (\u201cEpilepsy\/Seizure Group\u201d), whereas 65 did not (\u201cNo Seizure Group\u201d). The most frequent epilepsy-related neuropathological findings were hippocampal atrophy and mossy fibre sprouting. Of background characteristics, the Epilepsy\/Seizure Group had a higher prevalence of old head injuries (41.2% vs. 7.7%) and chronic alcohol use (41.2% vs. 18.5%) than the No Seizure Group. There were no statistically significant differences in acute head injuries or secondary neuropathological findings, except for a lower prevalence of oedema in the Epilepsy\/Seizure Group (17.6% vs. 47.7%). Even though the Epilepsy\/Seizure Group had a higher prevalence of old head injuries and chronic alcohol use, the prevalences of acute head injuries were not higher. Larger studies are needed to further explore whether individuals with epilepsy or seizure history are susceptible to distinct head injury types or circumstances.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13104-026-07894-4","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:37:04Z","timestamp":1780418224000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of epilepsy and seizure history in Finnish neuropathologically examined medico-legal autopsy cases with acute head injuries"],"prefix":"10.1186","volume":"19","author":[{"given":"Gaia","family":"Narayan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petteri","family":"Oura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"issue":"4","key":"7894_CR1","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1111\/epi.12550","volume":"55","author":"RS Fisher","year":"2014","unstructured":"Fisher RS, Acevedo C, Arzimanoglou A, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014;55(4):475\u201382.","journal-title":"Epilepsia"},{"issue":"3","key":"7894_CR2","doi-asserted-by":"publisher","first-page":"e203","DOI":"10.1016\/S2468-2667(24)00302-5","volume":"10","author":"GBD Epilepsy Collaborators","year":"2025","unstructured":"GBD Epilepsy Collaborators. Global, regional, and national burden of epilepsy, 1990\u20132021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Public Health. 2025;10(3):e203\u201327.","journal-title":"Lancet Public Health"},{"issue":"1","key":"7894_CR3","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1002\/epi4.12292","volume":"21","author":"E Dahl-Hansen","year":"2018","unstructured":"Dahl-Hansen E, Koht J, Syvertsen M. Epilepsy at different ages-Etiologies in a Norwegian population. 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Ethical approval and informed consent were not required, as this was a register-based study. In Finland, neither legislation (Medical Research Act 488\/1999) nor guidelines of the Finnish National Board on Research Integrity (TENK) require ethical review for research based purely on registry data. Research permit to use the data was obtained from the Finnish Institute for Health and Welfare (THL\/1802\/6.02.00\/2023).","order":1,"name":"Ethics","label":"<b>Ethics approval and consent to participate<\/b>","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"<b>Consent for publication<\/b>","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"318"}}